{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T03:28:28Z","timestamp":1791084508602,"version":"4.1.0"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2010,12,26]],"date-time":"2010-12-26T00:00:00Z","timestamp":1293321600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nat Chem Biol"],"published-print":{"date-parts":[[2011,2]]},"DOI":"10.1038\/nchembio.497","type":"journal-article","created":{"date-parts":[[2010,12,26]],"date-time":"2010-12-26T17:57:24Z","timestamp":1293386244000},"page":"106-112","source":"Crossref","is-referenced-by-count":260,"title":["Nox2 redox signaling maintains essential cell populations in the brain"],"prefix":"10.1038","volume":"7","author":[{"given":"Bryan C","family":"Dickinson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Peltier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Stone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David V","family":"Schaffer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher J","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2010,12,26]]},"reference":[{"key":"BFnchembio497_CR1","doi-asserted-by":"publisher","first-page":"1597","DOI":"10.1126\/science.1684251","volume":"254","author":"RA Floyd","year":"1991","unstructured":"Floyd, R.A. Oxidative damage to behavior during aging. Science 254, 1597 (1991).","journal-title":"Science"},{"key":"BFnchembio497_CR2","doi-asserted-by":"publisher","first-page":"7124","DOI":"10.1073\/pnas.78.11.7124","volume":"78","author":"D Harman","year":"1981","unstructured":"Harman, D. The aging process. Proc. Natl. Acad. Sci. USA 78, 7124\u20137128 (1981).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFnchembio497_CR3","doi-asserted-by":"publisher","first-page":"S18","DOI":"10.1038\/nrn1434","volume":"10","author":"JK Andersen","year":"2004","unstructured":"Andersen, J.K. Oxidative stress in neurodegeneration: cause or consequence? Nat. Med. 10, S18\u2013S25 (2004).","journal-title":"Nat. Med."},{"key":"BFnchembio497_CR4","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1152\/physrev.00044.2005","volume":"87","author":"K Bedard","year":"2007","unstructured":"Bedard, K. & Krause, K.H. The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology. Physiol. Rev. 87, 245\u2013313 (2007).","journal-title":"Physiol. Rev."},{"key":"BFnchembio497_CR5","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1038\/nri1312","volume":"4","author":"JD Lambeth","year":"2004","unstructured":"Lambeth, J.D. NOX enzymes and the biology of reactive oxygen. Nat. Rev. Immunol. 4, 181\u2013189 (2004).","journal-title":"Nat. Rev. Immunol."},{"key":"BFnchembio497_CR6","doi-asserted-by":"publisher","first-page":"8010","DOI":"10.1073\/pnas.130135897","volume":"97","author":"M Geiszt","year":"2000","unstructured":"Geiszt, M., Kopp, J.B., V\u00e1rnai, P. & Leto, T.L. Identification of renox, an NAD(P)H oxidase in kidney. Proc. Natl. Acad. Sci. USA 97, 8010\u20138014 (2000).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFnchembio497_CR7","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1038\/43459","volume":"401","author":"YA Suh","year":"1999","unstructured":"Suh, Y.A. et al. Cell transformation by the superoxide-generating oxidase Mox1. Nature 401, 79\u201382 (1999).","journal-title":"Nature"},{"key":"BFnchembio497_CR8","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1126\/science.270.5234.296","volume":"270","author":"M Sundaresan","year":"1995","unstructured":"Sundaresan, M., Yu, Z.X., Ferrans, V.J., Irani, K. & Finkel, T. Requirement for generation of H2O2 for platelet-derived growth factor signal transduction. Science 270, 296\u2013299 (1995).","journal-title":"Science"},{"key":"BFnchembio497_CR9","doi-asserted-by":"publisher","first-page":"1882","DOI":"10.1126\/science.1130481","volume":"312","author":"SG Rhee","year":"2006","unstructured":"Rhee, S.G. H2O2, a necessary evil for cell signaling. Science 312, 1882\u20131883 (2006).","journal-title":"Science"},{"key":"BFnchembio497_CR10","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1038\/nrm2256","volume":"8","author":"B D'Autr\u00e9aux","year":"2007","unstructured":"D'Autr\u00e9aux, B. & Toledano, M.B. ROS as signalling molecules: mechanisms that generate specificity in ROS homeostasis. Nat. Rev. Mol. Cell Biol. 8, 813\u2013824 (2007).","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"BFnchembio497_CR11","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.cbpa.2008.01.021","volume":"12","author":"LB Poole","year":"2008","unstructured":"Poole, L.B. & Nelson, K.J. Discovering mechanisms of signaling-mediated cysteine oxidation. Curr. Opin. Chem. Biol. 12, 18\u201324 (2008).","journal-title":"Curr. Opin. Chem. Biol."},{"key":"BFnchembio497_CR12","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1016\/j.cell.2010.01.009","volume":"140","author":"HA Woo","year":"2010","unstructured":"Woo, H.A. et al. Inactivation of peroxiredoxin I by phosphorylation allows localized H2O2 accumulation for cell signaling. Cell 140, 517\u2013528 (2010).","journal-title":"Cell"},{"key":"BFnchembio497_CR13","doi-asserted-by":"publisher","first-page":"996","DOI":"10.1038\/nature08119","volume":"459","author":"P Niethammer","year":"2009","unstructured":"Niethammer, P., Grabher, C., Look, A.T. & Mitchison, T.J. A tissue-scale gradient of hydrogen peroxide mediates rapid wound detection in zebrafish. Nature 459, 996\u2013999 (2009).","journal-title":"Nature"},{"key":"BFnchembio497_CR14","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1021\/cb900258z","volume":"5","author":"CE Paulsen","year":"2010","unstructured":"Paulsen, C.E. & Carroll, K.S. Orchestrating redox signaling networks through regulatory cysteine switches. ACS Chem. Biol. 5, 47\u201362 (2010).","journal-title":"ACS Chem. Biol."},{"key":"BFnchembio497_CR15","doi-asserted-by":"publisher","first-page":"15681","DOI":"10.1073\/pnas.1005776107","volume":"107","author":"EW Miller","year":"2010","unstructured":"Miller, E.W., Dickinson, B.C. & Chang, C.J. Aquaporin-3 mediates hydrogen peroxide uptake to regulate downstream intracellular signaling. Proc. Natl. Acad. Sci. USA 107, 15681\u201315686 (2010).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFnchembio497_CR16","doi-asserted-by":"publisher","first-page":"2252","DOI":"10.1161\/01.STR.28.11.2252","volume":"28","author":"CE Walder","year":"1997","unstructured":"Walder, C.E. et al. Ischemic stroke injury is reduced in mice lacking a functional NADPH oxidase. Stroke 28, 2252\u20132258 (1997).","journal-title":"Stroke"},{"key":"BFnchembio497_CR17","doi-asserted-by":"publisher","first-page":"1908","DOI":"10.1038\/sj.jcbfm.9600491","volume":"27","author":"L Park","year":"2007","unstructured":"Park, L., Anrather, J., Girouard, H., Zhou, P. & Iadecola, C. Nox2-derived reactive oxygen species mediate neurovascular dysregulation in the aging mouse brain. J. Cereb. Blood Flow Metab. 27, 1908\u20131918 (2007).","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"BFnchembio497_CR18","doi-asserted-by":"publisher","first-page":"1645","DOI":"10.1126\/science.1148045","volume":"318","author":"MM Behrens","year":"2007","unstructured":"Behrens, M.M. et al. Ketamine-induced loss of phenotype of fast-spiking interneurons is mediated by NADPH-oxidase. Science 318, 1645\u20131647 (2007).","journal-title":"Science"},{"key":"BFnchembio497_CR19","doi-asserted-by":"publisher","first-page":"1347","DOI":"10.1073\/pnas.0711568105","volume":"105","author":"L Park","year":"2008","unstructured":"Park, L. et al. Nox2-derived radicals contribute to neurovascular and behavioral dysfunction in mice overexpressing the amyloid precursor protein. Proc. Natl. Acad. Sci. USA 105, 1347\u20131352 (2008).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFnchembio497_CR20","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1096\/fj.03-0983fje","volume":"18","author":"W Zhang","year":"2004","unstructured":"Zhang, W. et al. Neuroprotective effect of dextromethorphan in the MPTP Parkinson's disease model: role of NADPH oxidase. FASEB J. 18, 589\u2013591 (2004).","journal-title":"FASEB J."},{"key":"BFnchembio497_CR21","doi-asserted-by":"publisher","first-page":"2481","DOI":"10.1089\/ars.2009.2578","volume":"11","author":"S Sorce","year":"2009","unstructured":"Sorce, S. & Krause, K.H. NOX enzymes in the central nervous system: from signaling to disease. Antioxid. Redox Signal. 11, 2481\u20132504 (2009).","journal-title":"Antioxid. Redox Signal."},{"key":"BFnchembio497_CR22","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1176\/appi.psy.45.3.230","volume":"45","author":"M Pao","year":"2004","unstructured":"Pao, M. et al. Cognitive function in patients with Chronic Granulomatous Disease: a preliminary report. Psychosomatics 45, 230\u2013234 (2004).","journal-title":"Psychosomatics"},{"key":"BFnchembio497_CR23","doi-asserted-by":"publisher","first-page":"5908","DOI":"10.1128\/MCB.00269-06","volume":"26","author":"KT Kishida","year":"2006","unstructured":"Kishida, K.T. et al. Synaptic plasticity deficits and mild memory impairments in mouse models of chronic granulomatous disease. Mol. Cell. Biol. 26, 5908\u20135920 (2006).","journal-title":"Mol. Cell. Biol."},{"key":"BFnchembio497_CR24","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1016\/j.cell.2008.01.033","volume":"132","author":"C Zhao","year":"2008","unstructured":"Zhao, C., Deng, W. & Gage, F.H. Mechanisms and functional implications of adult neurogenesis. Cell 132, 645\u2013660 (2008).","journal-title":"Cell"},{"key":"BFnchembio497_CR25","doi-asserted-by":"publisher","first-page":"8487","DOI":"10.1523\/JNEUROSCI.19-19-08487.1999","volume":"19","author":"TD Palmer","year":"1999","unstructured":"Palmer, T.D., Markakis, E.A., Willhoite, A.R., Safar, F. & Gage, F.H. Fibroblast growth factor-2 activates a latent neurogenic program in neural stem cells from diverse regions of the adult CNS. J. Neurosci. 19, 8487\u20138497 (1999).","journal-title":"J. Neurosci."},{"key":"BFnchembio497_CR26","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1038\/nchembio.85","volume":"4","author":"CC Winterbourn","year":"2008","unstructured":"Winterbourn, C.C. Reconciling the chemistry and biology of reactive oxygen species. Nat. Chem. Biol. 4, 278\u2013286 (2008).","journal-title":"Nat. Chem. Biol."},{"key":"BFnchembio497_CR27","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1038\/nrd1330","volume":"3","author":"KJ Barnham","year":"2004","unstructured":"Barnham, K.J., Masters, C.L. & Bush, A.I. Neurodegenerative diseases and oxidative stress. Nat. Rev. Drug Discov. 3, 205\u2013214 (2004).","journal-title":"Nat. Rev. Drug Discov."},{"key":"BFnchembio497_CR28","doi-asserted-by":"publisher","first-page":"620","DOI":"10.1016\/j.cbpa.2007.09.018","volume":"11","author":"EW Miller","year":"2007","unstructured":"Miller, E.W. & Chang, C.J. Fluorescent probes for nitric oxide and hydrogen peroxide in cell signaling. Curr. Opin. Chem. Biol. 11, 620\u2013625 (2007).","journal-title":"Curr. Opin. Chem. Biol."},{"key":"BFnchembio497_CR29","doi-asserted-by":"publisher","first-page":"15392","DOI":"10.1021\/ja0441716","volume":"126","author":"MCY Chang","year":"2004","unstructured":"Chang, M.C.Y., Pralle, A., Isacoff, E.Y. & Chang, C.J. A selective, cell-permeable optical probe for hydrogen peroxide in living cells. J. Am. Chem. Soc. 126, 15392\u201315393 (2004).","journal-title":"J. Am. Chem. Soc."},{"key":"BFnchembio497_CR30","doi-asserted-by":"publisher","first-page":"16652","DOI":"10.1021\/ja054474f","volume":"127","author":"EW Miller","year":"2005","unstructured":"Miller, E.W., Albers, A.E., Pralle, A., Isacoff, E.Y. & Chang, C.J. Boronate-based fluorescent probes for imaging cellular hydrogen peroxide. J. Am. Chem. Soc. 127, 16652\u201316659 (2005).","journal-title":"J. Am. Chem. Soc."},{"key":"BFnchembio497_CR31","doi-asserted-by":"publisher","first-page":"9640","DOI":"10.1021\/ja063308k","volume":"128","author":"AE Albers","year":"2006","unstructured":"Albers, A.E., Okreglak, V.S. & Chang, C.J. A FRET-based approach to ratiometric fluorescence detection of hydrogen peroxide. J. Am. Chem. Soc. 128, 9640\u20139641 (2006).","journal-title":"J. Am. Chem. Soc."},{"key":"BFnchembio497_CR32","doi-asserted-by":"publisher","first-page":"5948","DOI":"10.1016\/j.bmcl.2008.08.035","volume":"18","author":"AE Albers","year":"2008","unstructured":"Albers, A.E., Dickinson, B.C., Miller, E.W. & Chang, C.J. A red-emitting naphthofluorescein-based fluorescent probe for selective detection of hydrogen peroxide in living cells. Bioorg. Med. Chem. Lett. 18, 5948\u20135950 (2008).","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"BFnchembio497_CR33","doi-asserted-by":"publisher","first-page":"4455","DOI":"10.1021\/ja100117u","volume":"132","author":"D Srikun","year":"2010","unstructured":"Srikun, D., Albers, A.E., Nam, C.I., Ivarone, A.T. & Chang, C.J. Organelle-targetable fluorescent probes for imaging hydrogen peroxide in living cells via SNAP-tag protein labeling. J. Am. Chem. Soc. 132, 4455\u20134465 (2010).","journal-title":"J. Am. Chem. Soc."},{"key":"BFnchembio497_CR34","doi-asserted-by":"publisher","first-page":"9638","DOI":"10.1021\/ja802355u","volume":"130","author":"BC Dickinson","year":"2008","unstructured":"Dickinson, B.C. & Chang, C.J. A targetable fluorescent probe for imaging hydrogen peroxide in the mitochondria of living cells. J. Am. Chem. Soc. 130, 9638\u20139639 (2008).","journal-title":"J. Am. Chem. Soc."},{"key":"BFnchembio497_CR35","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/j.cbpa.2009.10.014","volume":"14","author":"BC Dickinson","year":"2010","unstructured":"Dickinson, B.C., Srikun, D. & Chang, C.J. Mitochondrial-targeted fluorescent probes for reactive oxygen species. Curr. Opin. Chem. Biol. 14, 50\u201356 (2010).","journal-title":"Curr. Opin. Chem. Biol."},{"key":"BFnchembio497_CR36","doi-asserted-by":"publisher","first-page":"4596","DOI":"10.1021\/ja711480f","volume":"130","author":"D Srikun","year":"2008","unstructured":"Srikun, D., Miller, E.W., Domaille, D.W. & Chang, C.J. An ICT-based approach to ratiometric fluorescence imaging of hydrogen peroxide produced in living cells. J. Am. Chem. Soc. 130, 4596\u20134597 (2008).","journal-title":"J. Am. Chem. Soc."},{"key":"BFnchembio497_CR37","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1038\/nchembio871","volume":"3","author":"EW Miller","year":"2007","unstructured":"Miller, E.W., Tulyathan, O., Isacoff, E.Y. & Chang, C.J. Molecular imaging of hydrogen peroxide produced for cell signaling. Nat. Chem. Biol. 3, 263\u2013267 (2007).","journal-title":"Nat. Chem. Biol."},{"key":"BFnchembio497_CR38","doi-asserted-by":"publisher","first-page":"5906","DOI":"10.1021\/ja1014103","volume":"132","author":"BC Dickinson","year":"2010","unstructured":"Dickinson, B.C., Huynh, C. & Chang, C.J. A palette of fluorescent probes with varying emission colors for imaging hydrogen peroxide signaling in living cells. J. Am. Chem. Soc. 132, 5906\u20135915 (2010).","journal-title":"J. Am. Chem. Soc."},{"key":"BFnchembio497_CR39","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1038\/290527a0","volume":"290","author":"RY Tsien","year":"1981","unstructured":"Tsien, R.Y. A non-disruptive technique for loading calcium buffers and indicators into cells. Nature 290, 527\u2013528 (1981).","journal-title":"Nature"},{"key":"BFnchembio497_CR40","doi-asserted-by":"publisher","first-page":"10189","DOI":"10.1021\/ja902511p","volume":"131","author":"S Izumi","year":"2009","unstructured":"Izumi, S., Urano, Y., Hanaoka, K., Terai, T. & Nagano, T. A simple and effective strategy to increase the sensitivity of fluorescence probes in living cells. J. Am. Chem. Soc. 131, 10189\u201310200 (2009).","journal-title":"J. Am. Chem. Soc."},{"key":"BFnchembio497_CR41","doi-asserted-by":"publisher","first-page":"2318","DOI":"10.1021\/ol1006289","volume":"12","author":"MD Pluth","year":"2010","unstructured":"Pluth, M.D., McQuade, L.E. & Lippard, S.J. Cell-trappable fluorescent probes for nitric oxide visualization in living cells. Org. Lett. 12, 2318\u20132321 (2010).","journal-title":"Org. Lett."},{"key":"BFnchembio497_CR42","doi-asserted-by":"publisher","first-page":"9535","DOI":"10.1021\/ic1012507","volume":"49","author":"LE McQuade","year":"2010","unstructured":"McQuade, L.E. & Lippard, S.J. Cell-trappable quinoline-derivatized fluoresceins for selective and reversible biological Zn(ii) detection. Inorg. Chem. 49, 9535\u20139545 (2010).","journal-title":"Inorg. Chem."},{"key":"BFnchembio497_CR43","doi-asserted-by":"publisher","first-page":"8525","DOI":"10.1073\/pnas.0914794107","volume":"107","author":"LE McQuade","year":"2010","unstructured":"McQuade, L.E. et al. Visualization of nitric oxide production in the mouse main olfactory bulb by a cell-trappable copper(II) fluorescent probe. Proc. Natl. Acad. Sci. USA 107, 8525\u20138530 (2010).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFnchembio497_CR44","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1016\/S0891-5849(99)00061-1","volume":"27","author":"SL Hempel","year":"1999","unstructured":"Hempel, S.L., Buettner, G.R., O\u2032Malley, Y.Q., Wessels, D.A. & Flaherty, D.M. Dihydrofluorescein diacetate is superior for detecting intracellular oxidants: comparison with 2\u2032,7\u2032-dichlorodihydrofluorescein diacetate, 5(and 6)-carboxy-2\u2032,7\u2032-dichlorodihydrofluorescein diacetate, and dihydrorhodamine 123. Free Radic. Biol. Med. 27, 146\u2013159 (1999).","journal-title":"Free Radic. Biol. Med."},{"key":"BFnchembio497_CR45","doi-asserted-by":"publisher","first-page":"15038","DOI":"10.1073\/pnas.0601945103","volume":"103","author":"KM Robinson","year":"2006","unstructured":"Robinson, K.M. et al. Selective fluorescent imaging of superoxide in vivo using ethidium-based probes. Proc. Natl. Acad. Sci. USA 103, 15038\u201315043 (2006).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFnchembio497_CR46","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1038\/ncb1700","volume":"10","author":"T Prozorovski","year":"2008","unstructured":"Prozorovski, T. et al. Sirt1 contributes critically to the redox-dependent fate of neural progenitors. Nat. Cell Biol. 10, 385\u2013394 (2008).","journal-title":"Nat. Cell Biol."},{"key":"BFnchembio497_CR47","doi-asserted-by":"publisher","first-page":"16419","DOI":"10.1073\/pnas.0407396101","volume":"101","author":"J Kwon","year":"2004","unstructured":"Kwon, J. et al. Reversible oxidation and inactivation of the tumor suppressor PTEN in cells stimulated with peptide growth factors. Proc. Natl. Acad. Sci. USA 101, 16419\u201316424 (2004).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFnchembio497_CR48","doi-asserted-by":"publisher","first-page":"1348","DOI":"10.1002\/dneu.20506","volume":"67","author":"J Peltier","year":"2007","unstructured":"Peltier, J., O\u2032Neill, A. & Schaffer, D.V. PI3K\/Akt and CREB regulate adult neural hippocampal progenitor proliferation and differentiation. Dev. Neurobiol. 67, 1348\u20131361 (2007).","journal-title":"Dev. Neurobiol."},{"key":"BFnchembio497_CR49","doi-asserted-by":"publisher","first-page":"20336","DOI":"10.1074\/jbc.M111899200","volume":"277","author":"SR Lee","year":"2002","unstructured":"Lee, S.R. et al. Reversible inactivation of the tumor suppressor PTEN by H2O2. J. Biol. Chem. 277, 20336\u201320342 (2002).","journal-title":"J. Biol. Chem."},{"key":"BFnchembio497_CR50","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1016\/j.stem.2007.09.002","volume":"1","author":"H Suh","year":"2007","unstructured":"Suh, H. et al. In vivo fate analysis reveals the multipotent and self-renewal capacities of Sox2+ neural stem cells in the adult hippocampus. Cell Stem Cell 1, 515\u2013528 (2007).","journal-title":"Cell Stem Cell"}],"container-title":["Nature Chemical Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/nchembio.497.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nchembio.497","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nchembio.497.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T19:49:24Z","timestamp":1684439364000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/nchembio.497"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,12,26]]},"references-count":50,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2011,2]]}},"alternative-id":["BFnchembio497"],"URL":"https:\/\/doi.org\/10.1038\/nchembio.497","relation":{},"ISSN":["1552-4450","1552-4469"],"issn-type":[{"value":"1552-4450","type":"print"},{"value":"1552-4469","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,12,26]]}}}