{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T15:54:14Z","timestamp":1792166054139,"version":"4.4.0"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2016,1,12]],"date-time":"2016-01-12T00:00:00Z","timestamp":1452556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2016,1,12]],"date-time":"2016-01-12T00:00:00Z","timestamp":1452556800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nat Commun"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Anaplastic large cell lymphoma (ALCL) is a peripheral T-cell lymphoma presenting mostly in children and young adults. The natural progression of this disease is largely unknown as is the identity of its true cell of origin. Here we present a model of peripheral ALCL pathogenesis where the malignancy is initiated in early thymocytes, before T-cell receptor (TCR) \u03b2-rearrangement, which is bypassed in CD4\/NPM\u2013ALK transgenic mice following Notch1 expression. However, we find that a TCR is required for thymic egress and development of peripheral murine tumours, yet this TCR must be downregulated for T-cell lymphomagenesis. In keeping with this, clonal TCR rearrangements in human ALCL are predominantly in-frame, but often aberrant, with clonal TCR\u03b1 but no comparable clonal TCR\u03b2 rearrangement, yielding events that would not normally be permissive for survival during thymic development. Children affected by ALCL may thus harbour thymic lymphoma\u2010initiating cells capable of seeding relapse after chemotherapy.<\/jats:p>","DOI":"10.1038\/ncomms10087","type":"journal-article","created":{"date-parts":[[2016,1,12]],"date-time":"2016-01-12T06:41:47Z","timestamp":1452580907000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":91,"title":["Anaplastic large cell lymphoma arises in thymocytes and requires transient TCR expression for thymic egress"],"prefix":"10.1038","volume":"7","author":[{"given":"Tim I. M.","family":"Malcolm","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1625-3785","authenticated-orcid":false,"given":"Patrick","family":"Villarese","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camilla J.","family":"Fairbairn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence","family":"Lamant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Am\u00e9lie","family":"Trinquand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. Elizabeth","family":"Hook","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. A. Amos","family":"Burke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence","family":"Brugi\u00e8res","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine","family":"Hughes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Payet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olaf","family":"Merkel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana-Iris","family":"Schiefer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibraheem","family":"Ashankyty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shahid","family":"Mian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariusz","family":"Wasik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3801-9896","authenticated-orcid":false,"given":"Martin","family":"Turner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lukas","family":"Kenner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vahid","family":"Asnafi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Macintyre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzanne D.","family":"Turner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,1,12]]},"reference":[{"key":"BFncomms10087_CR1","doi-asserted-by":"publisher","first-page":"1281","DOI":"10.1126\/science.8122112","volume":"263","author":"SW Morris","year":"1994","unstructured":"Morris, S. W. et al. Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin's lymphoma. Science 263, 1281\u20131284 (1994) .","journal-title":"Science"},{"key":"BFncomms10087_CR2","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1182\/blood.V66.4.848.848","volume":"66","author":"H Stein","year":"1985","unstructured":"Stein, H. et al. The expression of the Hodgkin's disease associated antigen Ki-1 in reactive and neoplastic lymphoid tissue: evidence that Reed-Sternberg cells and histiocytic malignancies are derived from activated lymphoid cells. Blood 66, 848\u2013858 (1985) .","journal-title":"Blood"},{"key":"BFncomms10087_CR3","doi-asserted-by":"crossref","first-page":"4005","DOI":"10.1182\/blood.V88.10.4005.bloodjournal88104005","volume":"88","author":"HD Foss","year":"1996","unstructured":"Foss, H. D. et al. Anaplastic large-cell lymphomas of T-cell and null-cell phenotype express cytotoxic molecules. Blood 88, 4005\u20134011 (1996) .","journal-title":"Blood"},{"key":"BFncomms10087_CR4","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/0145-2126(89)90134-3","volume":"13","author":"H Herbst","year":"1989","unstructured":"Herbst, H. et al. Immunoglobulin and T-cell receptor gene rearrangements in Hodgkin's disease and Ki-1-positive anaplastic large cell lymphoma: dissociation between phenotype and genotype. Leuk. Res. 13, 103\u2013116 (1989) .","journal-title":"Leuk. Res."},{"key":"BFncomms10087_CR5","first-page":"124","volume":"4","author":"JD Pearson","year":"2011","unstructured":"Pearson, J. D., Lee, J., Bacani, J. T., Lai, R. & Ingham, R. J. NPM-ALK and the JunB transcription factor regulate the expression of cytotoxic molecules in ALK-positive, anaplastic large cell lymphoma. Int. J. Clin. Exp. Pathol. 4, 124\u2013133 (2011) .","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"BFncomms10087_CR6","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1182\/blood.V89.3.980","volume":"89","author":"L Krenacs","year":"1997","unstructured":"Krenacs, L. et al. Cytotoxic cell antigen expression in anaplastic large cell lymphomas of T- and null-cell type and Hodgkin's disease: evidence for distinct cellular origin. Blood 89, 980\u2013989 (1997) .","journal-title":"Blood"},{"key":"BFncomms10087_CR7","doi-asserted-by":"publisher","first-page":"9964","DOI":"10.1073\/pnas.0603507103","volume":"103","author":"M Kasprzycka","year":"2006","unstructured":"Kasprzycka, M., Marzec, M., Liu, X., Zhang, Q. & Wasik, M. A. Nucleophosmin\/anaplastic lymphoma kinase (NPM\/ALK) oncoprotein induces the T regulatory cell phenotype by activating STAT3. Proc. Natl Acad. Sci. USA 103, 9964\u20139969 (2006) .","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFncomms10087_CR8","doi-asserted-by":"publisher","first-page":"6881","DOI":"10.1182\/blood-2011-05-354654","volume":"118","author":"H Matsuyama","year":"2011","unstructured":"Matsuyama, H. et al. miR-135b mediates NPM-ALK-driven oncogenicity and renders IL-17-producing immunophenotype to anaplastic large cell lymphoma. Blood 118, 6881\u20136892 (2011) .","journal-title":"Blood"},{"key":"BFncomms10087_CR9","doi-asserted-by":"publisher","first-page":"3358","DOI":"10.1182\/blood-2004-03-1037","volume":"104","author":"I Bonzheim","year":"2004","unstructured":"Bonzheim, I. et al. Anaplastic large cell lymphomas lack the expression of T-cell receptor molecules or molecules of proximal T-cell receptor signaling. Blood 104, 3358\u20133360 (2004) .","journal-title":"Blood"},{"key":"BFncomms10087_CR10","doi-asserted-by":"publisher","first-page":"8611","DOI":"10.1158\/0008-5472.CAN-09-2655","volume":"69","author":"C Ambrogio","year":"2009","unstructured":"Ambrogio, C. et al. NPM-ALK oncogenic tyrosine kinase controls T-cell identity by transcriptional regulation and epigenetic silencing in lymphoma cells. Cancer Res. 69, 8611\u20138619 (2009) .","journal-title":"Cancer Res."},{"key":"BFncomms10087_CR11","doi-asserted-by":"publisher","first-page":"1843","DOI":"10.1038\/onc.2014.112","volume":"34","author":"N Moti","year":"2014","unstructured":"Moti, N. et al. Anaplastic large cell lymphoma-propagating cells are detectable by side population analysis and possess an expression profile reflective of a primitive origin. Oncogene 34, 1843\u20131852 (2014) .","journal-title":"Oncogene"},{"key":"BFncomms10087_CR12","doi-asserted-by":"publisher","first-page":"1919","DOI":"10.1182\/blood-2002-05-1343","volume":"101","author":"R Chiarle","year":"2003","unstructured":"Chiarle, R. et al. NPM-ALK transgenic mice spontaneously develop T-cell lymphomas and plasma cell tumors. Blood 101, 1919\u20131927 (2003) .","journal-title":"Blood"},{"key":"BFncomms10087_CR13","doi-asserted-by":"publisher","first-page":"1069","DOI":"10.1093\/intimm\/dxh108","volume":"16","author":"J Laurent","year":"2004","unstructured":"Laurent, J., Bosco, N., Marche, P. N. & Ceredig, R. New insights into the proliferation and differentiation of early mouse thymocytes. Int. Immunol. 16, 1069\u20131080 (2004) .","journal-title":"Int. Immunol."},{"key":"BFncomms10087_CR14","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/0092-8674(94)90169-4","volume":"76","author":"KA Hogquist","year":"1994","unstructured":"Hogquist, K. A. et al. T cell receptor antagonist peptides induce positive selection. Cell 76, 17\u201327 (1994) .","journal-title":"Cell"},{"key":"BFncomms10087_CR15","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1002\/pro.2240","volume":"22","author":"L Federici","year":"2013","unstructured":"Federici, L. & Falini, B. Nucleophosmin mutations in acute myeloid leukemia: a tale of protein unfolding and mislocalization. Protein Sci. 22, 545\u2013556 (2013) .","journal-title":"Protein Sci."},{"key":"BFncomms10087_CR16","doi-asserted-by":"publisher","first-page":"740","DOI":"10.1016\/j.cellsig.2006.09.007","volume":"19","author":"SD Turner","year":"2007","unstructured":"Turner, S. D., Yeung, D., Hadfield, K., Cook, S. J. & Alexander, D. R. The NPM-ALK tyrosine kinase mimics TCR signalling pathways, inducing NFAT and AP-1 by RAS-dependent mechanisms. Cell. Signal. 19, 740\u2013747 (2007) .","journal-title":"Cell. Signal."},{"key":"BFncomms10087_CR17","doi-asserted-by":"publisher","first-page":"3441","DOI":"10.1038\/sj.emboj.7601761","volume":"26","author":"AP Kelly","year":"2007","unstructured":"Kelly, A. P. et al. Notch-induced T cell development requires phosphoinositide-dependent kinase 1. EMBO J. 26, 3441\u20133450 (2007) .","journal-title":"EMBO J."},{"key":"BFncomms10087_CR18","doi-asserted-by":"publisher","first-page":"4669","DOI":"10.1200\/JCO.2011.36.5411","volume":"29","author":"L Lamant","year":"2011","unstructured":"Lamant, L. et al. Prognostic impact of morphologic and phenotypic features of childhood ALK-positive anaplastic large-cell lymphoma: results of the ALCL99 study. J. Clin. Oncol. 29, 4669\u20134676 (2011) .","journal-title":"J. Clin. Oncol."},{"key":"BFncomms10087_CR19","doi-asserted-by":"crossref","first-page":"2076","DOI":"10.1182\/blood.V91.6.2076","volume":"91","author":"D Benharroch","year":"1998","unstructured":"Benharroch, D. et al. ALK-positive lymphoma: a single disease with a broad spectrum of morphology. Blood 91, 2076\u20132084 (1998) .","journal-title":"Blood"},{"key":"BFncomms10087_CR20","doi-asserted-by":"publisher","first-page":"11977","DOI":"10.1073\/pnas.1100319108","volume":"108","author":"Q Zhang","year":"2011","unstructured":"Zhang, Q. et al. IL-2R common gamma-chain is epigenetically silenced by nucleophosphin-anaplastic lymphoma kinase (NPM-ALK) and acts as a tumor suppressor by targeting NPM-ALK. Proc. Natl Acad. Sci. USA 108, 11977\u201311982 (2011) .","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFncomms10087_CR21","doi-asserted-by":"publisher","first-page":"3186","DOI":"10.1002\/eji.200636164","volume":"36","author":"CM Smith","year":"2006","unstructured":"Smith, C. M. et al. CD4+ T cells specific for a model latency-associated antigen fail to control a gammaherpesvirus in vivo. Eur. J. Immunol. 36, 3186\u20133197 (2006) .","journal-title":"Eur. J. Immunol."},{"key":"BFncomms10087_CR22","doi-asserted-by":"publisher","first-page":"1128","DOI":"10.1038\/sj.leu.2403797","volume":"19","author":"SD Turner","year":"2005","unstructured":"Turner, S. D. & Alexander, D. R. What have we learnt from mouse models of NPM-ALK-induced lymphomagenesis? Leukemia 19, 1128\u20131134 (2005) .","journal-title":"Leukemia"},{"key":"BFncomms10087_CR23","first-page":"3275","volume":"26","author":"SD Turner","year":"2006","unstructured":"Turner, S. D., Merz, H., Yeung, D. & Alexander, D. R. CD2 promoter regulated nucleophosmin-anaplastic lymphoma kinase in transgenic mice causes B lymphoid malignancy. Anticancer Res. 26, 3275\u20133279 (2006) .","journal-title":"Anticancer Res."},{"key":"BFncomms10087_CR24","doi-asserted-by":"publisher","first-page":"7750","DOI":"10.1038\/sj.onc.1207048","volume":"22","author":"SD Turner","year":"2003","unstructured":"Turner, S. D., Tooze, R., Maclennan, K. & Alexander, D. R. Vav-promoter regulated oncogenic fusion protein NPM-ALK in transgenic mice causes B-cell lymphomas with hyperactive Jun kinase. Oncogene 22, 7750\u20137761 (2003) .","journal-title":"Oncogene"},{"key":"BFncomms10087_CR25","first-page":"3191","volume":"25","author":"R Jager","year":"2005","unstructured":"Jager, R. et al. Mice transgenic for NPM-ALK develop non-Hodgkin lymphomas. Anticancer Res. 25, 3191\u20133196 (2005) .","journal-title":"Anticancer Res."},{"key":"BFncomms10087_CR26","doi-asserted-by":"publisher","first-page":"5230","DOI":"10.4049\/jimmunol.172.9.5230","volume":"172","author":"M Ciofani","year":"2004","unstructured":"Ciofani, M. et al. Obligatory role for cooperative signaling by pre-TCR and Notch during thymocyte differentiation. J. Immunol. 172, 5230\u20135239 (2004) .","journal-title":"J. Immunol."},{"key":"BFncomms10087_CR27","doi-asserted-by":"publisher","first-page":"639","DOI":"10.3109\/10428194.2013.807510","volume":"55","author":"MR Kamstrup","year":"2014","unstructured":"Kamstrup, M. R. et al. The importance of Notch signaling in peripheral T-cell lymphomas. Leuk. Lymphoma 55, 639\u2013644 (2014) .","journal-title":"Leuk. Lymphoma"},{"key":"BFncomms10087_CR28","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1038\/ng.2874","volume":"46","author":"E Papaemmanuil","year":"2014","unstructured":"Papaemmanuil, E. et al. RAG-mediated recombination is the predominant driver of oncogenic rearrangement in ETV6-RUNX1 acute lymphoblastic leukemia. Nat. Genet. 46, 116\u2013125 (2014) .","journal-title":"Nat. Genet."},{"key":"BFncomms10087_CR29","doi-asserted-by":"publisher","first-page":"449","DOI":"10.3324\/haematol.2009.015024","volume":"95","author":"L Lamant","year":"2010","unstructured":"Lamant, L. et al. Cutaneous presentation of ALK-positive anaplastic large cell lymphoma following insect bites: evidence for an association in five cases. Haematologica 95, 449\u2013455 (2010) .","journal-title":"Haematologica"},{"key":"BFncomms10087_CR30","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1146\/annurev-immunol-032713-120216","volume":"32","author":"YH Chien","year":"2014","unstructured":"Chien, Y. H., Meyer, C. & Bonneville, M. gammadelta T cells: first line of defense and beyond. Annu. Rev. Immunol. 32, 121\u2013155 (2014) .","journal-title":"Annu. Rev. Immunol."},{"key":"BFncomms10087_CR31","doi-asserted-by":"publisher","first-page":"1026","DOI":"10.1182\/blood-2009-06-227579","volume":"115","author":"J Iqbal","year":"2010","unstructured":"Iqbal, J. et al. Molecular signatures to improve diagnosis in peripheral T-cell lymphoma and prognostication in angioimmunoblastic T-cell lymphoma. Blood 115, 1026\u20131036 (2010) .","journal-title":"Blood"},{"key":"BFncomms10087_CR32","doi-asserted-by":"publisher","first-page":"1843","DOI":"10.1038\/onc.2014.112","volume":"34","author":"N Moti","year":"2015","unstructured":"Moti, N. et al. Anaplastic large cell lymphoma-propagating cells are detectable by side population analysis and possess an expression profile reflective of a primitive origin. Oncogene 34, 1843\u20131852 (2015) .","journal-title":"Oncogene"},{"key":"BFncomms10087_CR33","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1038\/leu.2011.209","volume":"26","author":"C Laurent","year":"2012","unstructured":"Laurent, C. et al. Circulating t(2;5)-positive cells can be detected in cord blood of healthy newborns. Leukemia 26, 188\u2013190 (2012) .","journal-title":"Leukemia"},{"key":"BFncomms10087_CR34","doi-asserted-by":"crossref","unstructured":"Delsol, G. [The 2008 WHO lymphoma classification]. Ann. Pathol. Spec No 1 (1), S20\u2013S24 (2008) .","DOI":"10.1016\/j.annpat.2008.09.002"},{"key":"BFncomms10087_CR35","doi-asserted-by":"publisher","first-page":"2693","DOI":"10.1182\/blood-2002-08-2438","volume":"101","author":"V Asnafi","year":"2003","unstructured":"Asnafi, V. et al. Analysis of TCR, pT alpha, and RAG-1 in T-acute lymphoblastic leukemias improves understanding of early human T-lymphoid lineage commitment. Blood 101, 2693\u20132703 (2003) .","journal-title":"Blood"},{"key":"BFncomms10087_CR36","doi-asserted-by":"publisher","first-page":"1143","DOI":"10.1038\/sj.leu.2401750","volume":"14","author":"E Delabesse","year":"2000","unstructured":"Delabesse, E. et al. Rapid, multifluorescent TCRG Vgamma and Jgamma typing: application to T cell acute lymphoblastic leukemia and to the detection of minor clonal populations. Leukemia 14, 1143\u20131152 (2000) .","journal-title":"Leukemia"},{"key":"BFncomms10087_CR37","doi-asserted-by":"publisher","first-page":"2257","DOI":"10.1038\/sj.leu.2403202","volume":"17","author":"JJ van Dongen","year":"2003","unstructured":"van Dongen, J. J. et al. Design and standardization of PCR primers and protocols for detection of clonal immunoglobulin and T-cell receptor gene recombinations in suspect lymphoproliferations: report of the BIOMED-2 Concerted Action BMH4-CT98-3936. Leukemia 17, 2257\u20132317 (2003) .","journal-title":"Leukemia"},{"key":"BFncomms10087_CR38","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1016\/j.ccr.2012.02.013","volume":"21","author":"S Dadi","year":"2012","unstructured":"Dadi, S. et al. TLX homeodomain oncogenes mediate T cell maturation arrest in T-ALL via interaction with ETS1 and suppression of TCRalpha gene expression. Cancer Cell 21, 563\u2013576 (2012) .","journal-title":"Cancer Cell"},{"key":"BFncomms10087_CR39","doi-asserted-by":"publisher","first-page":"2318","DOI":"10.1038\/sj.leu.2403135","volume":"17","author":"J Gabert","year":"2003","unstructured":"Gabert, J. et al. Standardization and quality control studies of 'real-time' quantitative reverse transcriptase polymerase chain reaction of fusion gene transcripts for residual disease detection in leukemia\u2014a Europe Against Cancer program. Leukemia 17, 2318\u20132357 (2003) .","journal-title":"Leukemia"},{"key":"BFncomms10087_CR40","doi-asserted-by":"publisher","first-page":"2758","DOI":"10.1128\/IAI.01604-07","volume":"76","author":"CM Nagamine","year":"2008","unstructured":"Nagamine, C. M. et al. Helicobacter hepaticus infection promotes colon tumorigenesis in the BALB\/c-Rag2(\u2212\/\u2212) Apc(Min\/+) mouse. Infect. Immun. 76, 2758\u20132766 (2008) .","journal-title":"Infect. Immun."},{"key":"BFncomms10087_CR41","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1186\/1471-2172-6-20","volume":"6","author":"KO Wright","year":"2005","unstructured":"Wright, K. O., Murray, D. A., Crispe, N. I. & Pierce, R. H. Quantitative PCR for detection of the OT-1 transgene. BMC Immunol. 6, 20 (2005) .","journal-title":"BMC Immunol."},{"key":"BFncomms10087_CR42","doi-asserted-by":"publisher","first-page":"1699","DOI":"10.1038\/nm.2966","volume":"18","author":"D Laimer","year":"2012","unstructured":"Laimer, D. et al. PDGFR blockade is a rational and effective therapy for NPM-ALK-driven lymphomas. Nat. Med. 18, 1699\u20131704 (2012) .","journal-title":"Nat. Med."},{"key":"BFncomms10087_CR43","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1126\/science.1188063","volume":"329","author":"P Li","year":"2010","unstructured":"Li, P. et al. Reprogramming of T cells to natural killer-like cells upon Bcl11b deletion. Science 329, 85\u201389 (2010) .","journal-title":"Science"}],"container-title":["Nature Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/ncomms10087.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/ncomms10087","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/ncomms10087.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,4]],"date-time":"2023-01-04T06:52:10Z","timestamp":1672815130000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/ncomms10087"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1,12]]},"references-count":43,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2016,4,22]]}},"alternative-id":["BFncomms10087"],"URL":"https:\/\/doi.org\/10.1038\/ncomms10087","relation":{},"ISSN":["2041-1723"],"issn-type":[{"value":"2041-1723","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,1,12]]},"assertion":[{"value":"21 July 2015","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 November 2015","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 January 2016","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing financial interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"10087"}}