{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T16:56:23Z","timestamp":1791564983997,"version":"4.3.4"},"reference-count":52,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2015,12,7]],"date-time":"2015-12-07T00:00:00Z","timestamp":1449446400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2015,12,7]],"date-time":"2015-12-07T00:00:00Z","timestamp":1449446400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nat Commun"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The direct conversion of fibroblasts to induced dopaminergic (iDA) neurons and other cell types demonstrates the plasticity of cell fate. The low efficiency of these relatively fast conversions suggests that kinetic barriers exist to safeguard cell-type identity. Here we show that suppression of p53, in conjunction with cell cycle arrest at G1 and appropriate extracellular environment, markedly increase the efficiency in the transdifferentiation of human fibroblasts to iDA neurons by Ascl1, Nurr1, Lmx1a and miR124. The conversion is dependent on Tet1, as G1 arrest, p53 knockdown or expression of the reprogramming factors induces Tet1 synergistically. Tet1 knockdown abolishes the transdifferentiation while its overexpression enhances the conversion. The iDA neurons express markers for midbrain DA neurons and have active dopaminergic transmission. Our results suggest that overcoming these kinetic barriers may enable highly efficient epigenetic reprogramming in general and will generate patient-specific midbrain DA neurons for Parkinson\u2019s disease research and therapy.<\/jats:p>","DOI":"10.1038\/ncomms10100","type":"journal-article","created":{"date-parts":[[2015,12,7]],"date-time":"2015-12-07T06:16:37Z","timestamp":1449468997000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":117,"title":["Cell cycle and p53 gate the direct conversion of human fibroblasts to dopaminergic neurons"],"prefix":"10.1038","volume":"6","author":[{"given":"Houbo","family":"Jiang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhimin","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaoyang","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haley A.","family":"Schilling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zihua","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaomin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengdi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,12,7]]},"reference":[{"key":"BFncomms10100_CR1","doi-asserted-by":"publisher","first-page":"987","DOI":"10.1016\/0092-8674(87)90585-X","volume":"51","author":"RL Davis","year":"1987","unstructured":"Davis, R. L., Weintraub, H. & Lassar, A. B. Expression of a single transfected cDNA converts fibroblasts to myoblasts. Cell 51, 987\u20131000 (1987).","journal-title":"Cell"},{"key":"BFncomms10100_CR2","doi-asserted-by":"publisher","first-page":"678","DOI":"10.1016\/j.stem.2012.05.005","volume":"10","author":"S Yamanaka","year":"2012","unstructured":"Yamanaka, S. Induced pluripotent stem cells: past, present, and future. Cell Stem Cell 10, 678\u2013684 (2012).","journal-title":"Cell Stem Cell"},{"key":"BFncomms10100_CR3","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1038\/nature08592","volume":"462","author":"J Hanna","year":"2009","unstructured":"Hanna, J. et al. Direct cell reprogramming is a stochastic process amenable to acceleration. Nature 462, 595\u2013601 (2009).","journal-title":"Nature"},{"key":"BFncomms10100_CR4","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1016\/j.stem.2008.10.002","volume":"3","author":"Y Zhao","year":"2008","unstructured":"Zhao, Y. et al. Two supporting factors greatly improve the efficiency of human iPSC generation. Cell Stem Cell 3, 475\u2013479 (2008).","journal-title":"Cell Stem Cell"},{"key":"BFncomms10100_CR5","doi-asserted-by":"publisher","first-page":"1140","DOI":"10.1038\/nature08311","volume":"460","author":"T Kawamura","year":"2009","unstructured":"Kawamura, T. et al. Linking the p53 tumour suppressor pathway to somatic cell reprogramming. Nature 460, 1140\u20131144 (2009).","journal-title":"Nature"},{"key":"BFncomms10100_CR6","doi-asserted-by":"publisher","first-page":"1136","DOI":"10.1038\/nature08290","volume":"460","author":"H Li","year":"2009","unstructured":"Li, H. et al. The Ink4\/Arf locus is a barrier for iPS cell reprogramming. Nature 460, 1136\u20131139 (2009).","journal-title":"Nature"},{"key":"BFncomms10100_CR7","doi-asserted-by":"publisher","first-page":"1149","DOI":"10.1038\/nature08287","volume":"460","author":"RM Marion","year":"2009","unstructured":"Marion, R. M. et al. A p53-mediated DNA damage response limits reprogramming to ensure iPS cell genomic integrity. Nature 460, 1149\u20131153 (2009).","journal-title":"Nature"},{"key":"BFncomms10100_CR8","doi-asserted-by":"publisher","first-page":"1145","DOI":"10.1038\/nature08285","volume":"460","author":"J Utikal","year":"2009","unstructured":"Utikal, J. et al. Immortalization eliminates a roadblock during cellular reprogramming into iPS cells. Nature 460, 1145\u20131148 (2009).","journal-title":"Nature"},{"key":"BFncomms10100_CR9","doi-asserted-by":"publisher","first-page":"1132","DOI":"10.1038\/nature08235","volume":"460","author":"H Hong","year":"2009","unstructured":"Hong, H. et al. Suppression of induced pluripotent stem cell generation by the p53-p21 pathway. Nature 460, 1132\u20131135 (2009).","journal-title":"Nature"},{"key":"BFncomms10100_CR10","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1038\/nature10284","volume":"476","author":"M Caiazzo","year":"2011","unstructured":"Caiazzo, M. et al. Direct generation of functional dopaminergic neurons from mouse and human fibroblasts. Nature 476, 224\u2013227 (2011).","journal-title":"Nature"},{"key":"BFncomms10100_CR11","doi-asserted-by":"publisher","first-page":"10343","DOI":"10.1073\/pnas.1105135108","volume":"108","author":"U Pfisterer","year":"2011","unstructured":"Pfisterer, U. et al. Direct conversion of human fibroblasts to dopaminergic neurons. Proc. Natl Acad. Sci. USA 108, 10343\u201310348 (2011).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFncomms10100_CR12","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1016\/j.stem.2011.09.011","volume":"9","author":"J Kim","year":"2011","unstructured":"Kim, J. et al. Functional integration of dopaminergic neurons directly converted from mouse fibroblasts. Cell Stem Cell 9, 413\u2013419 (2011).","journal-title":"Cell Stem Cell"},{"key":"BFncomms10100_CR13","doi-asserted-by":"publisher","first-page":"1035","DOI":"10.1038\/nature08797","volume":"463","author":"T Vierbuchen","year":"2010","unstructured":"Vierbuchen, T. et al. Direct conversion of fibroblasts to functional neurons by defined factors. Nature 463, 1035\u20131041 (2010).","journal-title":"Nature"},{"key":"BFncomms10100_CR14","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1016\/j.cell.2010.07.002","volume":"142","author":"M Ieda","year":"2010","unstructured":"Ieda, M. et al. Direct reprogramming of fibroblasts into functional cardiomyocytes by defined factors. Cell 142, 375\u2013386 (2010).","journal-title":"Cell"},{"key":"BFncomms10100_CR15","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1038\/nature10263","volume":"475","author":"S Sekiya","year":"2011","unstructured":"Sekiya, S. & Suzuki, A. Direct conversion of mouse fibroblasts to hepatocyte-like cells by defined factors. Nature 475, 390\u2013393 (2011).","journal-title":"Nature"},{"key":"BFncomms10100_CR16","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1038\/nature09591","volume":"468","author":"E Szabo","year":"2010","unstructured":"Szabo, E. et al. Direct conversion of human fibroblasts to multilineage blood progenitors. Nature 468, 521\u2013526 (2010).","journal-title":"Nature"},{"key":"BFncomms10100_CR17","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1016\/j.molcel.2012.09.008","volume":"47","author":"T Vierbuchen","year":"2012","unstructured":"Vierbuchen, T. & Wernig, M. Molecular roadblocks for cellular reprogramming. Mol. Cell 47, 827\u2013838 (2012).","journal-title":"Mol. Cell"},{"key":"BFncomms10100_CR18","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1242\/dev.127.4.693","volume":"127","author":"MH Farah","year":"2000","unstructured":"Farah, M. H. et al. Generation of neurons by transient expression of neural bHLH proteins in mammalian cells. Development 127, 693\u2013702 (2000).","journal-title":"Development"},{"key":"BFncomms10100_CR19","doi-asserted-by":"publisher","first-page":"2436","DOI":"10.1101\/gad.179184.111","volume":"25","author":"H Wu","year":"2011","unstructured":"Wu, H. & Zhang, Y. Mechanisms and functions of Tet protein-mediated 5-methylcytosine oxidation. Genes Dev. 25, 2436\u20132452 (2011).","journal-title":"Genes Dev."},{"key":"BFncomms10100_CR20","doi-asserted-by":"publisher","first-page":"929","DOI":"10.1126\/science.1169786","volume":"324","author":"S Kriaucionis","year":"2009","unstructured":"Kriaucionis, S. & Heintz, N. The nuclear DNA base 5-hydroxymethylcytosine is present in Purkinje neurons and the brain. Science 324, 929\u2013930 (2009).","journal-title":"Science"},{"key":"BFncomms10100_CR21","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1016\/j.stem.2013.02.005","volume":"12","author":"Y Gao","year":"2013","unstructured":"Gao, Y. et al. Replacement of Oct4 by Tet1 during iPSC induction reveals an important role of DNA methylation and hydroxymethylation in reprogramming. Cell Stem Cell 12, 453\u2013469 (2013).","journal-title":"Cell Stem Cell"},{"key":"BFncomms10100_CR22","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1038\/nature06534","volume":"451","author":"IH Park","year":"2008","unstructured":"Park, I. H. et al. Reprogramming of human somatic cells to pluripotency with defined factors. Nature 451, 141\u2013146 (2008).","journal-title":"Nature"},{"key":"BFncomms10100_CR23","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1038\/nature10323","volume":"476","author":"AS Yoo","year":"2011","unstructured":"Yoo, A. S. et al. MicroRNA-mediated conversion of human fibroblasts to neurons. Nature 476, 228\u2013231 (2011).","journal-title":"Nature"},{"key":"BFncomms10100_CR24","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/j.stem.2011.07.002","volume":"9","author":"R Ambasudhan","year":"2011","unstructured":"Ambasudhan, R. et al. Direct reprogramming of adult human fibroblasts to functional neurons under defined conditions. Cell Stem Cell 9, 113\u2013118 (2011).","journal-title":"Cell Stem Cell"},{"key":"BFncomms10100_CR25","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1038\/ncomms1669","volume":"3","author":"H Jiang","year":"2012","unstructured":"Jiang, H. et al. Parkin controls dopamine utilization in human midbrain dopaminergic neurons derived from induced pluripotent stem cells. Nat. Commun. 3, 668 (2012).","journal-title":"Nat. Commun."},{"key":"BFncomms10100_CR26","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1002\/cyto.a.20022","volume":"58","author":"E Meijering","year":"2004","unstructured":"Meijering, E. et al. Design and validation of a tool for neurite tracing and analysis in fluorescence microscopy images. Cytometry A 58, 167\u2013176 (2004).","journal-title":"Cytometry A"},{"key":"BFncomms10100_CR27","doi-asserted-by":"publisher","first-page":"844","DOI":"10.1126\/science.1092472","volume":"303","author":"LT Vassilev","year":"2004","unstructured":"Vassilev, L. T. et al. In vivo activation of the p53 pathway by small-molecule antagonists of MDM2. Science 303, 844\u2013848 (2004).","journal-title":"Science"},{"key":"BFncomms10100_CR28","doi-asserted-by":"publisher","first-page":"1237","DOI":"10.1016\/0092-8674(92)90644-R","volume":"69","author":"J Momand","year":"1992","unstructured":"Momand, J., Zambetti, G. P., Olson, D. C., George, D. & Levine, A. J. The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation. Cell 69, 1237\u20131245 (1992).","journal-title":"Cell"},{"key":"BFncomms10100_CR29","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1038\/nrc2723","volume":"9","author":"AJ Levine","year":"2009","unstructured":"Levine, A. J. & Oren, M. The first 30 years of p53: growing ever more complex. Nat. Rev. Cancer 9, 749\u2013758 (2009).","journal-title":"Nat. Rev. Cancer"},{"key":"BFncomms10100_CR30","doi-asserted-by":"publisher","first-page":"2430","DOI":"10.1128\/MCB.26.6.2430-2440.2006","volume":"26","author":"A Jarviluoma","year":"2006","unstructured":"Jarviluoma, A. et al. Phosphorylation of the cyclin-dependent kinase inhibitor p21Cip1 on serine 130 is essential for viral cyclin-mediated bypass of a p21Cip1-imposed G1 arrest. Mol. Cell Biol. 26, 2430\u20132440 (2006).","journal-title":"Mol. Cell Biol."},{"key":"BFncomms10100_CR31","first-page":"6170","volume":"61","author":"ME Lane","year":"2001","unstructured":"Lane, M. E. et al. A novel cdk2-selective inhibitor, SU9516, induces apoptosis in colon carcinoma cells. Cancer Res. 61, 6170\u20136177 (2001).","journal-title":"Cancer Res."},{"key":"BFncomms10100_CR32","doi-asserted-by":"publisher","first-page":"8023","DOI":"10.1074\/jbc.M900301200","volume":"284","author":"CC Thoreen","year":"2009","unstructured":"Thoreen, C. C. et al. An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1. J. Biol. Chem. 284, 8023\u20138032 (2009).","journal-title":"J. Biol. Chem."},{"key":"BFncomms10100_CR33","doi-asserted-by":"publisher","first-page":"1172","DOI":"10.1126\/science.1187532","volume":"328","author":"RJ Dowling","year":"2010","unstructured":"Dowling, R. J. et al. mTORC1-mediated cell proliferation, but not cell growth, controlled by the 4E-BPs. Science 328, 1172\u20131176 (2010).","journal-title":"Science"},{"key":"BFncomms10100_CR34","doi-asserted-by":"publisher","first-page":"e83","DOI":"10.1371\/journal.pbio.0040083","volume":"4","author":"HA Coller","year":"2006","unstructured":"Coller, H. A., Sang, L. & Roberts, J. M. A new description of cellular quiescence. PLoS Biol. 4, e83 (2006).","journal-title":"PLoS Biol."},{"key":"BFncomms10100_CR35","doi-asserted-by":"publisher","first-page":"1095","DOI":"10.1126\/science.1155998","volume":"321","author":"L Sang","year":"2008","unstructured":"Sang, L., Coller, H. A. & Roberts, J. M. Control of the reversibility of cellular quiescence by the transcriptional repressor HES1. Science 321, 1095\u20131100 (2008).","journal-title":"Science"},{"key":"BFncomms10100_CR36","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1038\/nbt1310","volume":"25","author":"K Watanabe","year":"2007","unstructured":"Watanabe, K. et al. A ROCK inhibitor permits survival of dissociated human embryonic stem cells. Nat. Biotechnol. 25, 681\u2013686 (2007).","journal-title":"Nat. Biotechnol."},{"key":"BFncomms10100_CR37","doi-asserted-by":"publisher","first-page":"8299","DOI":"10.1073\/pnas.1014041108","volume":"108","author":"W Li","year":"2011","unstructured":"Li, W. et al. Rapid induction and long-term self-renewal of primitive neural precursors from human embryonic stem cells by small molecule inhibitors. Proc. Natl Acad. Sci. USA 108, 8299\u20138304 (2011).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFncomms10100_CR38","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.stem.2009.12.001","volume":"6","author":"MA Esteban","year":"2010","unstructured":"Esteban, M. A. et al. Vitamin C enhances the generation of mouse and human induced pluripotent stem cells. Cell Stem Cell 6, 71\u201379 (2010).","journal-title":"Cell Stem Cell"},{"key":"BFncomms10100_CR39","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1007\/s12015-010-9138-1","volume":"6","author":"DS Kim","year":"2010","unstructured":"Kim, D. S. et al. Robust enhancement of neural differentiation from human ES and iPS cells regardless of their innate difference in differentiation propensity. Stem Cell Rev. 6, 270\u2013281 (2010).","journal-title":"Stem Cell Rev."},{"key":"BFncomms10100_CR40","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1038\/nbt.1529","volume":"27","author":"SM Chambers","year":"2009","unstructured":"Chambers, S. M. et al. Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling. Nat. Biotechnol. 27, 275\u2013280 (2009).","journal-title":"Nat. Biotechnol."},{"key":"BFncomms10100_CR41","doi-asserted-by":"publisher","first-page":"1229","DOI":"10.1038\/nprot.2011.380","volume":"6","author":"SR Stacpoole","year":"2011","unstructured":"Stacpoole, S. R. et al. Efficient derivation of NPCs, spinal motor neurons and midbrain dopaminergic neurons from hESCs at 3% oxygen. Nat. Protoc. 6, 1229\u20131240 (2011).","journal-title":"Nat. Protoc."},{"key":"BFncomms10100_CR42","doi-asserted-by":"publisher","first-page":"10269","DOI":"10.1073\/pnas.1834070100","volume":"100","author":"YC Yang","year":"2003","unstructured":"Yang, Y. C. et al. Hierarchical model of gene regulation by transforming growth factor beta. Proc. Natl Acad. Sci. USA 100, 10269\u201310274 (2003).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFncomms10100_CR43","doi-asserted-by":"publisher","first-page":"2120","DOI":"10.1634\/stemcells.2005-0514","volume":"24","author":"E Roussa","year":"2006","unstructured":"Roussa, E. et al. Transforming growth factor beta is required for differentiation of mouse mesencephalic progenitors into dopaminergic neurons in vitro and in vivo: ectopic induction in dorsal mesencephalon. Stem Cells 24, 2120\u20132129 (2006).","journal-title":"Stem Cells"},{"key":"BFncomms10100_CR44","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.ydbio.2013.01.012","volume":"376","author":"J Cai","year":"2013","unstructured":"Cai, J. et al. BMP and TGF-beta pathway mediators are critical upstream regulators of Wnt signaling during midbrain dopamine differentiation in human pluripotent stem cells. Dev. Biol. 376, 62\u201373 (2013).","journal-title":"Dev. Biol."},{"key":"BFncomms10100_CR45","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1038\/nature02006","volume":"425","author":"R Derynck","year":"2003","unstructured":"Derynck, R. & Zhang, Y. E. Smad-dependent and Smad-independent pathways in TGF-beta family signalling. Nature 425, 577\u2013584 (2003).","journal-title":"Nature"},{"key":"BFncomms10100_CR46","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1124\/mol.62.1.65","volume":"62","author":"GJ Inman","year":"2002","unstructured":"Inman, G. J. et al. SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7. Mol. Pharmacol. 62, 65\u201374 (2002).","journal-title":"Mol. Pharmacol."},{"key":"BFncomms10100_CR47","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1016\/j.celrep.2013.12.031","volume":"6","author":"Y Wang","year":"2014","unstructured":"Wang, Y. & Zhang, Y. Regulation of TET protein stability by calpains. Cell Rep. 6, 278\u2013284 (2014).","journal-title":"Cell Rep."},{"key":"BFncomms10100_CR48","doi-asserted-by":"publisher","first-page":"e45031","DOI":"10.1371\/journal.pone.0045031","volume":"7","author":"Y Arioka","year":"2012","unstructured":"Arioka, Y., Watanabe, A., Saito, K. & Yamada, Y. Activation-induced cytidine deaminase alters the subcellular localization of Tet family proteins. PLoS ONE 7, e45031 (2012).","journal-title":"PLoS ONE"},{"key":"BFncomms10100_CR49","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1016\/S0006-8993(98)00146-2","volume":"792","author":"M L\u2019hirondel","year":"1998","unstructured":"L\u2019hirondel, M. et al. Lack of autoreceptor-mediated inhibitory control of dopamine release in striatal synaptosomes of D2 receptor-deficient mice. Brain Res. 792, 253\u2013262 (1998).","journal-title":"Brain Res."},{"key":"BFncomms10100_CR50","doi-asserted-by":"publisher","first-page":"568","DOI":"10.1016\/j.celrep.2012.08.030","volume":"2","author":"CH Hsu","year":"2012","unstructured":"Hsu, C. H. et al. TET1 suppresses cancer invasion by activating the tissue inhibitors of metalloproteinases. Cell Rep. 2, 568\u2013579 (2012).","journal-title":"Cell Rep."},{"key":"BFncomms10100_CR51","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1038\/emboj.2012.357","volume":"32","author":"R Deplus","year":"2013","unstructured":"Deplus, R. et al. TET2 and TET3 regulate GlcNAcylation and H3K4 methylation through OGT and SET1\/COMPASS. EMBO J. 32, 645\u2013655 (2013).","journal-title":"EMBO J."},{"key":"BFncomms10100_CR52","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1038\/mp.2010.50","volume":"16","author":"EY Yuen","year":"2011","unstructured":"Yuen, E. Y. et al. Mechanisms for acute stress-induced enhancement of glutamatergic transmission and working memory. Mol. Psychiatry 16, 156\u2013170 (2011).","journal-title":"Mol. Psychiatry"}],"updated-by":[{"DOI":"10.1038\/s41467-026-77919-w","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T00:00:00Z","timestamp":1791504000000}}],"container-title":["Nature Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/ncomms10100.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/ncomms10100","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/ncomms10100.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T16:13:36Z","timestamp":1791562416000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/ncomms10100"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12,7]]},"references-count":52,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2015,12,22]]}},"alternative-id":["BFncomms10100"],"URL":"https:\/\/doi.org\/10.1038\/ncomms10100","relation":{},"ISSN":["2041-1723"],"issn-type":[{"value":"2041-1723","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,12,7]]},"assertion":[{"value":"30 April 2015","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 November 2015","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 December 2015","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 October 2026","order":5,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":6,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"A Correction to this paper has been published:","order":7,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"https:\/\/doi.org\/10.1038\/s41467-026-77919-w","URL":"https:\/\/doi.org\/10.1038\/s41467-026-77919-w","order":8,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing financial interests.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Ethics"}}],"article-number":"10100"}}