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The mechanism by which this occurs has heretofore been unknown. We show sliding of these proteins along DNA occurs on a new vehicle in molecular biology, a \u2018molecular sled\u2019 named pVIc. This 11-amino acid viral peptide binds to DNA independent of sequence. pVIc slides on DNA, exhibiting the fastest one-dimensional diffusion constant, 26\u00b11.8 \u00d7 10<jats:sup>6<\/jats:sup> (bp)<jats:sup>2<\/jats:sup>\u2009s<jats:sup>\u22121<\/jats:sup>. pVIc is a \u2018molecular sled,\u2019 because it can slide heterologous cargos along DNA, for example, a streptavidin tetramer. Similar peptides, for example, from the C terminus of \u03b2-actin or NLSIII of the p53 protein, slide along DNA. Characteristics of the \u2018molecular sled\u2019 in its milieu (virion, nucleus) have implications for how proteins in the nucleus of cells interact and imply a new form of biochemistry, one-dimensional biochemistry.<\/jats:p>","DOI":"10.1038\/ncomms10202","type":"journal-article","created":{"date-parts":[[2016,2,2]],"date-time":"2016-02-02T10:49:13Z","timestamp":1454410153000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Molecular sled is an eleven-amino acid vehicle facilitating biochemical interactions via sliding components along DNA"],"prefix":"10.1038","volume":"7","author":[{"given":"Walter F.","family":"Mangel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William J.","family":"McGrath","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kan","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vito","family":"Graziano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul C.","family":"Blainey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,2,2]]},"reference":[{"key":"BFncomms10202_CR1","doi-asserted-by":"publisher","first-page":"1778","DOI":"10.1002\/j.1460-2075.1996.tb00526.x","volume":"15","author":"J Ding","year":"1996","unstructured":"Ding, J., McGrath, W. 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