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Since the majority of the bones, cartilage and connective tissues that comprise the head and face are derived from a multipotent migratory progenitor cell population called the neural crest, craniofacial disorders are typically attributed to defects in neural crest cell development. Treacher Collins syndrome (TCS) is a disorder of craniofacial development and although TCS arises primarily through autosomal dominant mutations in\n                    <jats:italic>TCOF1<\/jats:italic>\n                    , no clear genotype\u2013phenotype correlation has been documented. Here we show that\n                    <jats:italic>Tcof1<\/jats:italic>\n                    haploinsufficiency results in oxidative stress-induced DNA damage and neuroepithelial cell death. Consistent with this discovery, maternal treatment with antioxidants minimizes cell death in the neuroepithelium and substantially ameliorates or prevents the pathogenesis of craniofacial anomalies in\n                    <jats:italic>Tcof1<\/jats:italic>\n                    <jats:sup>+\/\u2212<\/jats:sup>\n                    mice. Thus maternal antioxidant dietary supplementation may provide an avenue for protection against the pathogenesis of TCS and similar neurocristopathies.\n                  <\/jats:p>","DOI":"10.1038\/ncomms10328","type":"journal-article","created":{"date-parts":[[2016,1,21]],"date-time":"2016-01-21T06:22:57Z","timestamp":1453357377000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":105,"title":["Prevention of Treacher Collins syndrome craniofacial anomalies in mouse models via maternal antioxidant supplementation"],"prefix":"10.1038","volume":"7","author":[{"given":"Daisuke","family":"Sakai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jill","family":"Dixon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annita","family":"Achilleos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Dixon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul A.","family":"Trainor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,1,21]]},"reference":[{"key":"BFncomms10328_CR1","doi-asserted-by":"crossref","unstructured":"Le Douarin, N. 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