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Thus far, cellular mechanisms promoting the emergence of resistance to multiple drug classes have not been described in this organism. Here we demonstrate that a mutator phenotype caused by a mismatch repair defect is prevalent in\n                    <jats:italic>C. glabrata<\/jats:italic>\n                    clinical isolates. Strains carrying alterations in mismatch repair gene\n                    <jats:italic>MSH2<\/jats:italic>\n                    exhibit a higher propensity to breakthrough antifungal treatment\n                    <jats:italic>in vitro<\/jats:italic>\n                    and in mouse models of colonization, and are recovered at a high rate (55% of all\n                    <jats:italic>C. glabrata<\/jats:italic>\n                    recovered) from patients. This genetic mechanism promotes the acquisition of resistance to multiple antifungals, at least partially explaining the elevated rates of triazole and multi-drug resistance associated with\n                    <jats:italic>C. glabrata<\/jats:italic>\n                    . We anticipate that identifying\n                    <jats:italic>MSH2<\/jats:italic>\n                    defects in infecting strains may influence the management of patients on antifungal drug therapy.\n                  <\/jats:p>","DOI":"10.1038\/ncomms11128","type":"journal-article","created":{"date-parts":[[2016,3,29]],"date-time":"2016-03-29T09:58:55Z","timestamp":1459245535000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":264,"title":["Prevalent mutator genotype identified in fungal pathogen Candida glabrata promotes multi-drug resistance"],"prefix":"10.1038","volume":"7","author":[{"given":"Kelley R.","family":"Healey","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanan","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Winder B.","family":"Perez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shawn R.","family":"Lockhart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jack D.","family":"Sobel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitrios","family":"Farmakiotis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitrios P.","family":"Kontoyiannis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Sanglard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saad J.","family":"Taj-Aldeen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara D.","family":"Alexander","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Jimenez-Ortigosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erika","family":"Shor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David S.","family":"Perlin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,3,29]]},"reference":[{"key":"BFncomms11128_CR1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3109\/10408410903241444","volume":"36","author":"MA Pfaller","year":"2010","unstructured":"Pfaller, M. 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This has now been corrected in the HTML; the PDF version of the paper was correct from the time of publication.","order":6,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"D.P.K. has received research support and\/or advised Merck, Pfizer, Astellas and F2G. D.S.P. has received research support and\/or advised Merck, Astellas, Cidara and Synexis. The remaining authors declare no competing financial interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"11128"}}