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Here we show resident F4\/80\n                    <jats:sup>hi<\/jats:sup>\n                    GATA6\n                    <jats:sup>+<\/jats:sup>\n                    macrophages are long-lived, undergo non-stochastic self-renewal and retain cells of embryonic origin for at least 4 months in mice. However, Ly6C\n                    <jats:sup>+<\/jats:sup>\n                    monocytes constitutively enter the peritoneal cavity in a CCR2-dependent manner, where they mature into short-lived F4\/80\n                    <jats:sup>lo<\/jats:sup>\n                    MHCII\n                    <jats:sup>+<\/jats:sup>\n                    cells that act, in part, as precursors of F4\/80\n                    <jats:sup>hi<\/jats:sup>\n                    GATA6\n                    <jats:sup>+<\/jats:sup>\n                    macrophages. Notably, monocyte-derived F4\/80\n                    <jats:sup>hi<\/jats:sup>\n                    macrophages eventually displace the embryonic population with age in a process that is highly gender dependent and not due to proliferative exhaustion of the incumbent embryonic population, despite the greater proliferative activity of newly recruited cells. Furthermore, although monocyte-derived cells acquire key characteristics of the embryonic population, expression of Tim4 was impaired, leading to cumulative changes in the population with age.\n                  <\/jats:p>","DOI":"10.1038\/ncomms11852","type":"journal-article","created":{"date-parts":[[2016,6,13]],"date-time":"2016-06-13T05:57:43Z","timestamp":1465797463000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":350,"title":["Long-lived self-renewing bone marrow-derived macrophages displace embryo-derived cells to inhabit adult serous cavities"],"prefix":"10.1038","volume":"7","author":[{"given":"Calum C.","family":"Bain","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine A.","family":"Hawley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah","family":"Garner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte L.","family":"Scott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anika","family":"Schridde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas J.","family":"Steers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Mack","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anagha","family":"Joshi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3525-7570","authenticated-orcid":false,"given":"Martin","family":"Guilliams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allan Mc I.","family":"Mowat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederic","family":"Geissmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen J.","family":"Jenkins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,6,13]]},"reference":[{"key":"BFncomms11852_CR1","doi-asserted-by":"publisher","first-page":"3488","DOI":"10.4049\/jimmunol.179.6.3488","volume":"179","author":"L Landsman","year":"2007","unstructured":"Landsman, L. & Jung, S. 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