{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T19:15:00Z","timestamp":1790709300987,"version":"4.1.0"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2016,6,20]],"date-time":"2016-06-20T00:00:00Z","timestamp":1466380800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2016,6,20]],"date-time":"2016-06-20T00:00:00Z","timestamp":1466380800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nat Commun"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The recognition and translation of mammalian mitochondrial mRNAs are poorly understood. To gain further insights into these processes <jats:italic>in vivo,<\/jats:italic> we characterized mice with a missense mutation that causes loss of the translational activator of cytochrome oxidase subunit I (TACO1). We report that TACO1 is not required for embryonic survival, although the mutant mice have substantially reduced COXI protein, causing an isolated complex IV deficiency. We show that TACO1 specifically binds the <jats:italic>mt-Co1<\/jats:italic> mRNA and is required for translation of COXI through its association with the mitochondrial ribosome. We determined the atomic structure of TACO1, revealing three domains in the shape of a hook with a tunnel between domains 1 and 3. Mutations in the positively charged domain 1 reduce RNA binding by TACO1. The <jats:italic>Taco1<\/jats:italic> mutant mice develop a late-onset visual impairment, motor dysfunction and cardiac hypertrophy and thus provide a useful model for future treatment trials for mitochondrial disease.<\/jats:p>","DOI":"10.1038\/ncomms11884","type":"journal-article","created":{"date-parts":[[2016,6,20]],"date-time":"2016-06-20T09:15:20Z","timestamp":1466414120000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":104,"title":["Loss of the RNA-binding protein TACO1 causes late-onset mitochondrial dysfunction in mice"],"prefix":"10.1038","volume":"7","author":[{"given":"Tara R.","family":"Richman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Sp\u00e5hr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith A.","family":"Ermer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan M. K.","family":"Davies","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helena M.","family":"Viola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristyn A.","family":"Bates","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Papadimitriou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Livia C.","family":"Hool","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Rodger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nils-G\u00f6ran","family":"Larsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"Rackham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandra","family":"Filipovska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,6,20]]},"reference":[{"key":"BFncomms11884_CR1","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1016\/j.cmet.2014.07.001","volume":"20","author":"BM Hallberg","year":"2014","unstructured":"Hallberg, B. M. & Larsson, N.-G. Making proteins in the powerhouse. Cell Metab. 20, 226\u2013240 (2014).","journal-title":"Cell Metab."},{"key":"BFncomms11884_CR2","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1091\/mbc.e06-09-0803","volume":"18","author":"A Zambrano","year":"2007","unstructured":"Zambrano, A. et al. Aberrant translation of cytochrome c oxidase subunit 1 mRNA species in the absence of Mss51p in the yeast Saccharomyces cerevisiae. Mol. Biol. Cell 18, 523\u2013535 (2007).","journal-title":"Mol. Biol. Cell"},{"key":"BFncomms11884_CR3","doi-asserted-by":"publisher","first-page":"1130","DOI":"10.1007\/BF01952112","volume":"52","author":"T Fox","year":"1996","unstructured":"Fox, T. Translational control of endogenous and recoded nuclear genes in yeast mitochondria: regulation and membrane targeting. Experientia 52, 1130\u20131135 (1996).","journal-title":"Experientia"},{"key":"BFncomms11884_CR4","doi-asserted-by":"publisher","first-page":"652","DOI":"10.1016\/j.mib.2013.07.011","volume":"16","author":"ID Small","year":"2013","unstructured":"Small, I. D., Rackham, O. & Filipovska, A. Organelle transcriptomes: products of a deconstructed genome. Curr. Opin. Microbiol. 16, 652\u2013658 (2013).","journal-title":"Curr. Opin. Microbiol."},{"key":"BFncomms11884_CR5","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1126\/science.aaa1193","volume":"348","author":"A Amunts","year":"2015","unstructured":"Amunts, A., Brown, A., Toots, J., Scheres, S. & Ramakrishnan, V. The structure of the human mitochondrial ribosome. Science 348, 95\u201398 (2015).","journal-title":"Science"},{"key":"BFncomms11884_CR6","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1126\/science.aaa3872","volume":"348","author":"BJ Greber","year":"2015","unstructured":"Greber, B. J. et al. The complete structure of the 55S mammalian mitochondrial ribosome. Science 348, 303\u2013308 (2015).","journal-title":"Science"},{"key":"BFncomms11884_CR7","doi-asserted-by":"publisher","first-page":"1198","DOI":"10.1016\/j.bbabio.2011.06.010","volume":"1807","author":"A R\u00f6tig","year":"2011","unstructured":"R\u00f6tig, A. Human diseases with impaired mitochondrial protein synthesis. Biochim. Biophys. Acta 1807, 1198\u20131205 (2011).","journal-title":"Biochim. Biophys. Acta"},{"key":"BFncomms11884_CR8","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1038\/nature11707","volume":"491","author":"SB Vafai","year":"2012","unstructured":"Vafai, S. B. & Mootha, V. K. Mitochondrial disorders as windows into an ancient organelle. Nature 491, 374\u2013383 (2012).","journal-title":"Nature"},{"key":"BFncomms11884_CR9","doi-asserted-by":"publisher","first-page":"833","DOI":"10.1038\/ng.390","volume":"41","author":"W Weraarpachai","year":"2009","unstructured":"Weraarpachai, W. et al. Mutation in TACO1, encoding a translational activator of COX I, results in cytochrome c oxidase deficiency and late-onset Leigh syndrome. Nat. Genet. 41, 833\u2013837 (2009).","journal-title":"Nat. Genet."},{"key":"BFncomms11884_CR10","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1136\/jnnp.14.3.216","volume":"14","author":"DD Leigh","year":"1951","unstructured":"Leigh, D. D. Subacute necrotizing encephalomyelopathy in an infant. J. Neurol. Neurosurg. Psychiatry 14, 216\u2013221 (1951).","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"BFncomms11884_CR11","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1038\/emboj.2012.300","volume":"32","author":"F Distelmaier","year":"2012","unstructured":"Distelmaier, F., Smeitink, J. A., Willems, P. H. & Koopman, W. J. H. OXPHOS mutations and neurodegeneration. EMBO J. 32, 9\u201329 (2012).","journal-title":"EMBO J."},{"key":"BFncomms11884_CR12","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1016\/j.bbadis.2009.07.013","volume":"1802","author":"F Diaz","year":"2010","unstructured":"Diaz, F. Biochim Biophys Acta 1802, 100\u2013110 (2010).","journal-title":"Biochim Biophys Acta"},{"key":"BFncomms11884_CR13","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1007\/978-1-4614-3573-0_14","volume":"748","author":"S Dimauro","year":"2012","unstructured":"Dimauro, S., Tanji, K. & Schon, E. A. The many clinical faces of cytochrome c oxidase deficiency. Adv. Exp. Med. Biol. 748, 341\u2013357 (2012).","journal-title":"Adv. Exp. Med. Biol."},{"key":"BFncomms11884_CR14","doi-asserted-by":"publisher","first-page":"720","DOI":"10.1016\/j.nmd.2010.06.017","volume":"20","author":"J Seeger","year":"2010","unstructured":"Seeger, J. et al. Clinical and neuropathological findings in patients with TACO1 mutations. Neuromuscul. Disord. 20, 720\u2013724 (2010).","journal-title":"Neuromuscul. Disord."},{"key":"BFncomms11884_CR15","doi-asserted-by":"publisher","first-page":"120061","DOI":"10.1098\/rsob.120061","volume":"2","author":"TD Andrews","year":"2012","unstructured":"Andrews, T. D. et al. Massively parallel sequencing of the mouse exome to accurately identify rare, induced mutations: an immediate source for thousands of new mouse models. Open Biol. 2, 120061 (2012).","journal-title":"Open Biol."},{"key":"BFncomms11884_CR16","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1046\/j.1432-1327.1998.2540389.x","volume":"254","author":"L Nijtmans","year":"1998","unstructured":"Nijtmans, L., Taanman, J., Muijsers, A., Speijer, D. & Van den Bogert, C. Assembly of cytochrome-c oxidase in cultured human cells. Eur. J. Biochem. 254, 389\u2013394 (1998).","journal-title":"Eur. J. Biochem."},{"key":"BFncomms11884_CR17","doi-asserted-by":"publisher","first-page":"2780","DOI":"10.1093\/bioinformatics\/btn507","volume":"24","author":"L Holm","year":"2008","unstructured":"Holm, L., K\u00e4\u00e4ri\u00e4inen, S., Rosenstr\u00f6m, P. & Schenkel, A. Searching protein structure databases with DaliLite v.3. Bioinformatics 24, 2780\u20132781 (2008).","journal-title":"Bioinformatics"},{"key":"BFncomms11884_CR18","doi-asserted-by":"publisher","first-page":"2124","DOI":"10.1002\/prot.24841","volume":"83","author":"MC Franklin","year":"2015","unstructured":"Franklin, M. C. et al. Structural genomics for drug design against the pathogen Coxiella burnetii. Proteins 83, 2124\u20132136 (2015).","journal-title":"Proteins"},{"key":"BFncomms11884_CR19","doi-asserted-by":"publisher","first-page":"7980","DOI":"10.1073\/pnas.132241399","volume":"99","author":"DH Shin","year":"2002","unstructured":"Shin, D. H., Yokota, H., Kim, R. & Kim, S.-H. Crystal structure of conserved hypothetical protein Aq1575 from Aquifex aeolicus. Proc. Natl Acad. Sci. USA 99, 7980\u20137985 (2002).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFncomms11884_CR20","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1016\/j.bbamcr.2012.03.007","volume":"1833","author":"JM Herrmann","year":"2013","unstructured":"Herrmann, J. M., Woellhaf, M. W. & Bonnefoy, N. Control of protein synthesis in yeast mitochondria: The concept of translational activators. Biochim. Biophys. Acta 1833, 286\u2013294 (2013).","journal-title":"Biochim. Biophys. Acta"},{"key":"BFncomms11884_CR21","doi-asserted-by":"publisher","first-page":"16305","DOI":"10.1074\/jbc.M513805200","volume":"281","author":"S Duvezin-Caubet","year":"2006","unstructured":"Duvezin-Caubet, S. et al. A \u2018petite obligate\u2019 mutant of Saccharomyces cerevisiae: functional mtDNA is lethal in cells lacking the delta subunit of mitochondrial F1-ATPase. J. Biol. Chem. 281, 16305\u201316313 (2006).","journal-title":"J. Biol. Chem."},{"key":"BFncomms11884_CR22","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1016\/j.cell.2011.06.051","volume":"146","author":"TR Mercer","year":"2011","unstructured":"Mercer, T. R. et al. The human mitochondrial transcriptome. Cell 146, 645\u2013658 (2011).","journal-title":"Cell"},{"key":"BFncomms11884_CR23","doi-asserted-by":"publisher","first-page":"8033","DOI":"10.1093\/nar\/gks506","volume":"40","author":"T Chujo","year":"2012","unstructured":"Chujo, T. et al. LRPPRC\/SLIRP suppresses PNPase-mediated mRNA decay and promotes polyadenylation in human mitochondria. Nucleic Acids Res. 40, 8033\u20138047 (2012).","journal-title":"Nucleic Acids Res."},{"key":"BFncomms11884_CR24","doi-asserted-by":"publisher","first-page":"937","DOI":"10.1017\/S1355838201010299","volume":"7","author":"T Jiang","year":"2001","unstructured":"Jiang, T., Guerrier-Takada, C. & Altman, S. Protein-RNA interactions in the subunits of human nuclear RNase P. RNA 7, 937\u2013941 (2001).","journal-title":"RNA"},{"key":"BFncomms11884_CR25","doi-asserted-by":"publisher","first-page":"S20","DOI":"10.1186\/1752-0509-6-S1-S20","volume":"6","author":"Y Zhang","year":"2012","unstructured":"Zhang, Y., Lin, J. & Gao, Y. In silico identification of a multi-functional regulatory protein involved in Holliday junction resolution in bacteria. BMC Syst. Biol. 6, S20\u2013S20 (2012).","journal-title":"BMC Syst. Biol."},{"key":"BFncomms11884_CR26","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1093\/hmg\/ddp477","volume":"19","author":"H Yang","year":"2009","unstructured":"Yang, H. et al. Analysis of mouse models of cytochrome c oxidase deficiency owing to mutations in Sco2. Hum. Mol. Genet. 19, 170\u2013180 (2009).","journal-title":"Hum. Mol. Genet."},{"key":"BFncomms11884_CR27","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1093\/hmg\/ddl477","volume":"16","author":"C Dell'Agnello","year":"2007","unstructured":"Dell'Agnello, C. et al. Increased longevity and refractoriness to Ca2+-dependent neurodegeneration in Surf1 knockout mice. Hum. Mol. Genet. 16, 431\u2013444 (2007).","journal-title":"Hum. Mol. Genet."},{"key":"BFncomms11884_CR28","doi-asserted-by":"publisher","first-page":"5859","DOI":"10.1093\/nar\/gkp627","volume":"37","author":"O Rackham","year":"2009","unstructured":"Rackham, O. et al. Pentatricopeptide repeat domain protein 1 lowers the levels of mitochondrial leucine tRNAs in cells. Nucleic Acids Res. 37, 5859\u20135867 (2009).","journal-title":"Nucleic Acids Res."},{"key":"BFncomms11884_CR29","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1038\/emboj.2011.392","volume":"31","author":"B Ruzzenente","year":"2012","unstructured":"Ruzzenente, B. et al. LRPPRC is necessary for polyadenylation and coordination of translation of mitochondrial mRNAs. EMBO J. 31, 443\u2013456 (2012).","journal-title":"EMBO J."},{"key":"BFncomms11884_CR30","doi-asserted-by":"publisher","first-page":"195","DOI":"10.4161\/rna.6.2.8050","volume":"6","author":"DJ Coughlin","year":"2009","unstructured":"Coughlin, D. J., Babak, T., Nihranz, C., Hughes, T. R. & Engelke, D. R. Prediction and verification of mouse tRNA gene families. RNA Biol. 6, 195\u2013202 (2009).","journal-title":"RNA Biol."},{"key":"BFncomms11884_CR31","doi-asserted-by":"publisher","first-page":"418","DOI":"10.1038\/nprot.2006.62","volume":"1","author":"I Wittig","year":"2006","unstructured":"Wittig, I., Braun, H.-P. & Sch\u00e4gger, H. Blue native PAGE. Nat. Protoc. 1, 418\u2013428 (2006).","journal-title":"Nat. Protoc."},{"key":"BFncomms11884_CR32","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1016\/S0891-5849(01)00576-7","volume":"31","author":"SMS Davies","year":"2001","unstructured":"Davies, S. M. S., Poljak, A. A., Duncan, M. W. M., Smythe, G. A. G. & Murphy, M. P. M. Measurements of protein carbonyls, ortho- and meta-tyrosine and oxidative phosphorylation complex activity in mitochondria from young and old rats. Free Rad. Biol. Med. 31, 181\u2013190 (2001).","journal-title":"Free Rad. Biol. Med."},{"key":"BFncomms11884_CR33","doi-asserted-by":"publisher","first-page":"965","DOI":"10.1038\/nprot.2008.61","volume":"3","author":"A Kuznetsov","year":"2008","unstructured":"Kuznetsov, A. et al. Analysis of mitochondrial function in situ in permeabilized muscle fibers, tissues and cells. Nat. Protoc. 3, 965\u2013976 (2008).","journal-title":"Nat. Protoc."},{"key":"BFncomms11884_CR34","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1107\/S0021889893005588","volume":"26","author":"W Kabsch","year":"1993","unstructured":"Kabsch, W. Automatic processing of rotation diffraction data from crystals of initially unknown symmetry and cell constants. J. Appl. Crystallogr 26, 795\u2013800 (1993).","journal-title":"J. Appl. Crystallogr"},{"key":"BFncomms11884_CR35","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1107\/S0907444909052925","volume":"66","author":"PD Adams","year":"2010","unstructured":"Adams, P. D. et al. PHENIX: a comprehensive Python-based system for macromolecular structure solution. Acta Crystallogr. D Biol. Crystallogr. 66, 213\u2013221 (2010).","journal-title":"Acta Crystallogr. D Biol. Crystallogr."},{"key":"BFncomms11884_CR36","doi-asserted-by":"publisher","first-page":"1445","DOI":"10.1107\/S0907444901014007","volume":"57","author":"A Perrakis","year":"2001","unstructured":"Perrakis, A., Harkiolaki, M., Wilson, K. S. & Lamzin, V. S. ARP\/wARP and molecular replacement. Acta Crystallogr. D Biol. Crystallogr. 57, 1445\u20131450 (2001).","journal-title":"Acta Crystallogr. D Biol. Crystallogr."},{"key":"BFncomms11884_CR37","doi-asserted-by":"publisher","first-page":"2126","DOI":"10.1107\/S0907444904019158","volume":"60","author":"P Emsley","year":"2004","unstructured":"Emsley, P. & Cowtan, K. Coot: model-building tools for molecular graphics. Acta Crystallogr. D Biol. Crystallogr. 60, 2126\u20132132 (2004).","journal-title":"Acta Crystallogr. D Biol. Crystallogr."},{"key":"BFncomms11884_CR38","unstructured":"Bricogne, G. et al. Buster Version 2.10.0 Global Phasing Ltd (2011)."},{"key":"BFncomms11884_CR39","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1002\/prot.10286","volume":"50","author":"SC Lovell","year":"2003","unstructured":"Lovell, S. C. et al. Structure validation by C alpha geometry: phi,psi and C beta deviation. Proteins 50, 437\u2013450 (2003).","journal-title":"Proteins"},{"key":"BFncomms11884_CR40","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/0091-3057(80)90067-2","volume":"13","author":"JJ Crawley","year":"1980","unstructured":"Crawley, J. J. & Goodwin, F. K. F. Preliminary report of a simple animal behavior model for the anxiolytic effects of benzodiazepines. Pharmacol. Biochem. Behavior 13, 167\u2013170 (1980).","journal-title":"Pharmacol. Biochem. Behavior"},{"key":"BFncomms11884_CR41","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.visres.2004.12.015","volume":"45","author":"JJ Abdeljalil","year":"2005","unstructured":"Abdeljalil, J. J. et al. The optomotor response: a robust first-line visual screening method for mice. Vis. Res. 45, 8\u20138 (2005).","journal-title":"Vis. Res."},{"key":"BFncomms11884_CR42","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1007\/s00213-002-1009-2","volume":"161","author":"EA Del Bel","year":"2002","unstructured":"Del Bel, E. A., Souza, A. S., Guimar\u00e3es, F. S., da-Silva, C. A. & Nucci-da-Silva, L. P. Motor effects of acute and chronic inhibition of nitric oxide synthesis in mice. Psychopharmacology 161, 32\u201337 (2002).","journal-title":"Psychopharmacology"},{"key":"BFncomms11884_CR43","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1111\/j.1432-1033.1996.00779.x","volume":"241","author":"M Claros","year":"1996","unstructured":"Claros, M. & Vincens, P. Computational method to predict mitochondrially imported proteins and their targeting sequences. Eur. J. Biochem. 241, 779\u2013786 (1996).","journal-title":"Eur. J. Biochem."},{"key":"BFncomms11884_CR44","doi-asserted-by":"publisher","first-page":"W597","DOI":"10.1093\/nar\/gkt376","volume":"41","author":"H McWilliam","year":"2013","unstructured":"McWilliam, H. et al. Analysis tool web services from the EMBL-EBI. Nucleic Acids Res. 41, W597\u2013W600 (2013).","journal-title":"Nucleic Acids Res."},{"key":"BFncomms11884_CR45","first-page":"28","volume":"2","author":"TL Bailey","year":"1993","unstructured":"Bailey, T. L. & Elkan, C. Fitting a mixture model by expectation maximization to discover motifs in biopolymers. Proc. Int. Conf. Intell. Syst. Mol. Biol. 2, 28\u201336 (1993).","journal-title":"Proc. Int. Conf. Intell. Syst. Mol. Biol."}],"container-title":["Nature Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/ncomms11884.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/ncomms11884","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/ncomms11884.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,4]],"date-time":"2023-01-04T11:17:03Z","timestamp":1672831023000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/ncomms11884"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6,20]]},"references-count":45,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2016,9,1]]}},"alternative-id":["BFncomms11884"],"URL":"https:\/\/doi.org\/10.1038\/ncomms11884","relation":{},"ISSN":["2041-1723"],"issn-type":[{"value":"2041-1723","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,6,20]]},"assertion":[{"value":"21 January 2016","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 May 2016","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 June 2016","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing financial interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"11884"}}