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These alleles are also linked to red hair, freckling, and sun sensitivity, all of which are known melanoma phenotypic risk factors. Here we report that in melanomas and for somatic C&gt;T mutations, a signature linked to sun exposure, the expected single-nucleotide variant count associated with the presence of an\n                    <jats:italic>R<\/jats:italic>\n                    allele is estimated to be 42% (95% CI, 15\u201376%) higher than that among persons without an\n                    <jats:italic>R<\/jats:italic>\n                    allele. This figure is comparable to the expected mutational burden associated with an additional 21 years of age. We also find significant and similar enrichment of non-C&gt;T mutation classes supporting a role for additional mutagenic processes in melanoma development in individuals carrying\n                    <jats:italic>R<\/jats:italic>\n                    alleles.\n                  <\/jats:p>","DOI":"10.1038\/ncomms12064","type":"journal-article","created":{"date-parts":[[2016,7,12]],"date-time":"2016-07-12T10:55:02Z","timestamp":1468320902000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":117,"title":["Germline MC1R status influences somatic mutation burden in melanoma"],"prefix":"10.1038","volume":"7","author":[{"given":"Carla Daniela","family":"Robles-Espinoza","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola D.","family":"Roberts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuyang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5561-485X","authenticated-orcid":false,"given":"Finbarr P.","family":"Leacy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludmil B.","family":"Alexandrov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3833-0537","authenticated-orcid":false,"given":"Natapol","family":"Pornputtapong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth","family":"Halaban","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Krauthammer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rutao","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8752-8785","authenticated-orcid":false,"given":"D.","family":"Timothy Bishop","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Adams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,7,12]]},"reference":[{"key":"BFncomms12064_CR1","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1111\/pcmr.12257","volume":"27","author":"JC Garc\u00eda-Borr\u00f3n","year":"2014","unstructured":"Garc\u00eda-Borr\u00f3n, J. 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