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Myofibroblasts remain a poorly defined cell type in terms of their origins and functional effects\n                    <jats:italic>in vivo<\/jats:italic>\n                    . Here we generate\n                    <jats:italic>Postn<\/jats:italic>\n                    (periostin) gene-targeted mice containing a tamoxifen-inducible Cre for cellular lineage-tracing analysis. This\n                    <jats:italic>Postn<\/jats:italic>\n                    allele identifies essentially all myofibroblasts within the heart and multiple other tissues. Lineage tracing with four additional Cre-expressing mouse lines shows that periostin-expressing myofibroblasts in the heart derive from tissue-resident fibroblasts of the Tcf21 lineage, but not endothelial, immune\/myeloid or smooth muscle cells. Deletion of periostin\n                    <jats:sup>+<\/jats:sup>\n                    myofibroblasts reduces collagen production and scar formation after MI. Periostin-traced myofibroblasts also revert back to a less-activated state upon injury resolution. Our results define the myofibroblast as a periostin-expressing cell type necessary for adaptive healing and fibrosis in the heart, which arises from Tcf21\n                    <jats:sup>+<\/jats:sup>\n                    tissue-resident fibroblasts.\n                  <\/jats:p>","DOI":"10.1038\/ncomms12260","type":"journal-article","created":{"date-parts":[[2016,7,22]],"date-time":"2016-07-22T09:53:57Z","timestamp":1469181237000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":905,"title":["Genetic lineage tracing defines myofibroblast origin and function in the injured heart"],"prefix":"10.1038","volume":"7","author":[{"given":"Onur","family":"Kanisicak","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hadi","family":"Khalil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malina J.","family":"Ivey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason","family":"Karch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bryan D.","family":"Maliken","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert N.","family":"Correll","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew J.","family":"Brody","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suh-Chin","family":"J. 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