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Many bacteria in turn possess pathways that provide protection against these compounds. In\n                    <jats:italic>Escherichia coli<\/jats:italic>\n                    and related bacteria, the PhoQ\/PhoP signalling system is a key regulator of this antimicrobial peptide defence. Here we show that treating\n                    <jats:italic>E. coli<\/jats:italic>\n                    with sublethal concentrations of antimicrobial peptides causes cells to filament, and that this division block is controlled by the PhoQ\/PhoP system. The filamentation results from increased expression of QueE, an enzyme that is part of a tRNA modification pathway but that, as we show here, also affects cell division. We also find that a functional YFP\u2013QueE fusion localizes to the division septum in filamentous cells, suggesting QueE blocks septation through interaction with the divisome. Regulation of septation by PhoQ\/PhoP may protect cells from antimicrobial peptide-induced stress or other conditions associated with high-level stimulation of this signalling system.\n                  <\/jats:p>","DOI":"10.1038\/ncomms12340","type":"journal-article","created":{"date-parts":[[2016,7,29]],"date-time":"2016-07-29T05:47:13Z","timestamp":1469771233000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":73,"title":["Antimicrobial peptides trigger a division block in Escherichia coli through stimulation of a signalling system"],"prefix":"10.1038","volume":"7","author":[{"given":"Srujana S.","family":"Yadavalli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5105-0265","authenticated-orcid":false,"given":"Jeffrey N.","family":"Carey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel S.","family":"Leibman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annie I.","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew M.","family":"Stern","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuela","family":"Roggiani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew M.","family":"Lippa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Goulian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,7,29]]},"reference":[{"key":"BFncomms12340_CR1","doi-asserted-by":"publisher","first-page":"1059","DOI":"10.1126\/science.2646710","volume":"243","author":"PI Fields","year":"1989","unstructured":"Fields, P. 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