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Risk of AOM is dependent on environmental and host factors, as well as a significant genetic component. We identify genome-wide significance at a locus on 6q25.3 (rs2932989, <jats:italic>P<\/jats:italic><jats:sub>meta<\/jats:sub>=2.15 \u00d7 10<jats:sup>\u221209<\/jats:sup>), and show that the associated variants are correlated with the methylation status of the <jats:italic>FNDC1<\/jats:italic> gene (cg05678571, <jats:italic>P<\/jats:italic>=1.43 \u00d7 10<jats:sup>\u221206<\/jats:sup>), and further show it is an eQTL for <jats:italic>FNDC1<\/jats:italic> (<jats:italic>P<\/jats:italic>=9.3 \u00d7 10<jats:sup>\u221205<\/jats:sup>). The mouse homologue, Fndc1, is expressed in middle ear tissue and its expression is upregulated upon lipopolysaccharide treatment. In this first GWAS of AOM and the largest OM genetic study to date, we identify the first genome-wide significant locus associated with AOM.<\/jats:p>","DOI":"10.1038\/ncomms12792","type":"journal-article","created":{"date-parts":[[2016,9,28]],"date-time":"2016-09-28T10:33:30Z","timestamp":1475058810000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Genome-wide association study for acute otitis media in children identifies FNDC1 as disease contributing gene"],"prefix":"10.1038","volume":"7","author":[{"given":"Gijs","family":"van Ingen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9","family":"Goedegebure","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rahul","family":"Pandey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun Rose","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael E.","family":"March","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent W. 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