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After being exposed to microbial components, they migrate to secondary lymphoid organs and activate T lymphocytes. Here we show that during mouse malaria, splenic inflammatory monocytes differentiate into monocyte-derived dendritic cells (MO-DCs), which are CD11b\n                    <jats:sup>+<\/jats:sup>\n                    F4\/80\n                    <jats:sup>+<\/jats:sup>\n                    CD11c\n                    <jats:sup>+<\/jats:sup>\n                    MHCII\n                    <jats:sup>high<\/jats:sup>\n                    DC-SIGN\n                    <jats:sup>high<\/jats:sup>\n                    Ly6c\n                    <jats:sup>+<\/jats:sup>\n                    and express high levels of CCR5, CXCL9 and CXCL10 (CCR5\n                    <jats:sup>+<\/jats:sup>\n                    CXCL9\/10\n                    <jats:sup>+<\/jats:sup>\n                    MO-DCs). We propose that malaria-induced splenic MO-DCs take a reverse migratory route. After differentiation in the spleen, CCR5\n                    <jats:sup>+<\/jats:sup>\n                    CXCL9\/10\n                    <jats:sup>+<\/jats:sup>\n                    MO-DCs traffic to the brain in a CCR2-independent, CCR5-dependent manner, where they amplify the influx of CD8\n                    <jats:sup>+<\/jats:sup>\n                    T lymphocytes, leading to a lethal neuropathological syndrome.\n                  <\/jats:p>","DOI":"10.1038\/ncomms13277","type":"journal-article","created":{"date-parts":[[2016,11,3]],"date-time":"2016-11-03T05:35:56Z","timestamp":1478151356000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":59,"title":["Splenic differentiation and emergence of CCR5+CXCL9+CXCL10+ monocyte-derived dendritic cells in the brain during cerebral malaria"],"prefix":"10.1038","volume":"7","author":[{"given":"Isabella C.","family":"Hirako","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco A.","family":"Ataide","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucas","family":"Faustino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia A.","family":"Assis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth W.","family":"Sorensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2237-2262","authenticated-orcid":false,"given":"Hisashi","family":"Ueta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia M.","family":"Ara\u00fajo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo B.","family":"Menezes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9679-7912","authenticated-orcid":false,"given":"Andrew D.","family":"Luster","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo T.","family":"Gazzinelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,11,3]]},"reference":[{"key":"BFncomms13277_CR1","doi-asserted-by":"publisher","first-page":"656","DOI":"10.1126\/science.1178331","volume":"327","author":"F Geissmann","year":"2010","unstructured":"Geissmann, F. et al. 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