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We examined whether genetic variants affect body shape as a composite phenotype that is represented by a combination of anthropometric traits. We developed an approach that calculates averaged PCs (AvPCs) representing body shape derived from six anthropometric traits (body mass index, height, weight, waist and hip circumference, waist-to-hip ratio). The first four AvPCs explain &gt;99% of the variability, are heritable, and associate with cardiometabolic outcomes. We performed genome-wide association analyses for each body shape composite phenotype across 65 studies and meta-analysed summary statistics. We identify six novel loci: <jats:italic>LEMD2<\/jats:italic> and <jats:italic>CD47<\/jats:italic> for AvPC1, <jats:italic>RPS6KA5<\/jats:italic>\/<jats:italic>C14orf159<\/jats:italic> and <jats:italic>GANAB<\/jats:italic> for AvPC3, and <jats:italic>ARL15<\/jats:italic> and <jats:italic>ANP32<\/jats:italic> for AvPC4. 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