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We show that mTOR signalling is dysregulated during early postnatal development in the cerebral cortex of germ-line heterozygous\n                    <jats:italic>Pten<\/jats:italic>\n                    mutant mice (\n                    <jats:italic>Pten<\/jats:italic>\n                    <jats:sup>\n                      <jats:italic>+\/\u2212<\/jats:italic>\n                    <\/jats:sup>\n                    ), which model macrocephaly\/autism syndrome. The basolateral amygdala (BLA) receives input from subcortical-projecting neurons in the medial prefrontal cortex (mPFC). Analysis of mPFC to BLA axonal projections reveals that\n                    <jats:italic>Pten<\/jats:italic>\n                    <jats:sup>\n                      <jats:italic>+\/\u2212<\/jats:italic>\n                    <\/jats:sup>\n                    mice exhibit increased axonal branching and connectivity, which is accompanied by increased activity in the BLA in response to social stimuli and social behavioural deficits. The latter two phenotypes can be suppressed by pharmacological inhibition of S6K1 during early postnatal life or by reducing the activity of mPFC\u2013BLA circuitry in adulthood. These findings identify a mechanism of altered connectivity that has potential relevance to the pathophysiology of macrocephaly\/autism syndrome and autism spectrum disorders featuring dysregulated mTOR signalling.\n                  <\/jats:p>","DOI":"10.1038\/ncomms13421","type":"journal-article","created":{"date-parts":[[2016,11,15]],"date-time":"2016-11-15T05:08:26Z","timestamp":1479186506000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":122,"title":["Hyperconnectivity of prefrontal cortex to amygdala projections in a mouse model of macrocephaly\/autism syndrome"],"prefix":"10.1038","volume":"7","author":[{"given":"Wen-Chin","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youjun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damon T.","family":"Page","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,11,15]]},"reference":[{"key":"BFncomms13421_CR1","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1016\/j.cell.2012.03.017","volume":"149","author":"M Laplante","year":"2012","unstructured":"Laplante, M. & Sabatini, D. 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