{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T20:40:13Z","timestamp":1792183213872,"version":"4.4.0"},"reference-count":55,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2016,11,28]],"date-time":"2016-11-28T00:00:00Z","timestamp":1480291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2016,11,28]],"date-time":"2016-11-28T00:00:00Z","timestamp":1480291200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nat Commun"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Dysregulated energetic metabolism has been recently identified as a hallmark of cancer. Although mutations in metabolic enzymes hardwire metabolism to tumourigenesis, they are relatively infrequent in ovarian cancer. More often, cancer metabolism is re-engineered by altered abundance and activity of the metabolic enzymes. Here we identify ubiquitin-specific peptidase 13 (USP13) as a master regulator that drives ovarian cancer metabolism. USP13 specifically deubiquitinates and thus upregulates ATP citrate lyase and oxoglutarate dehydrogenase, two key enzymes that determine mitochondrial respiration, glutaminolysis and fatty acid synthesis. The\n                    <jats:italic>USP13<\/jats:italic>\n                    gene is co-amplified with\n                    <jats:italic>PIK3CA<\/jats:italic>\n                    in 29.3% of high-grade serous ovarian cancers and its overexpression is significantly associated with poor clinical outcome. Inhibiting USP13 remarkably suppresses ovarian tumour progression and sensitizes tumour cells to the treatment of PI3K\/AKT inhibitor. Our results reveal an important metabolism-centric role of USP13, which may lead to potential therapeutics targeting USP13 in ovarian cancers.\n                  <\/jats:p>","DOI":"10.1038\/ncomms13525","type":"journal-article","created":{"date-parts":[[2016,11,28]],"date-time":"2016-11-28T05:57:58Z","timestamp":1480312678000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":116,"title":["Amplification of USP13 drives ovarian cancer metabolism"],"prefix":"10.1038","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9200-7207","authenticated-orcid":false,"given":"Cecil","family":"Han","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lifeng","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun Ho","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joelle","family":"Baddour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhinav","family":"Achreja","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunhua","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiada","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guohui","family":"Wan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guang","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinna","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepak","family":"Nagrath","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiongbin","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,11,28]]},"reference":[{"key":"BFncomms13525_CR1","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1038\/ncb3124","volume":"17","author":"LK Boroughs","year":"2015","unstructured":"Boroughs, L. K. & DeBerardinis, R. J. Metabolic pathways promoting cancer cell survival and growth. Nat. Cell Biol. 17, 351\u2013359 (2015).","journal-title":"Nat. Cell Biol."},{"key":"BFncomms13525_CR2","doi-asserted-by":"publisher","first-page":"3648","DOI":"10.1172\/JCI72391","volume":"123","author":"MG Vander Heiden","year":"2013","unstructured":"Vander Heiden, M. G. Exploiting tumor metabolism: challenges for clinical translation. J. Clin. Invest. 123, 3648\u20133651 (2013).","journal-title":"J. Clin. Invest."},{"key":"BFncomms13525_CR3","doi-asserted-by":"publisher","first-page":"1029","DOI":"10.1126\/science.1160809","volume":"324","author":"MG Vander Heiden","year":"2009","unstructured":"Vander Heiden, M. G., Cantley, L. C. & Thompson, C. B. Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science 324, 1029\u20131033 (2009).","journal-title":"Science"},{"key":"BFncomms13525_CR4","doi-asserted-by":"publisher","first-page":"728","DOI":"10.1002\/msb.20134892","volume":"10","author":"L Yang","year":"2014","unstructured":"Yang, L. et al. Metabolic shifts toward glutamine regulate tumor growth, invasion and bioenergetics in ovarian cancer. Mol. Syst. Biol. 10, 728 (2014).","journal-title":"Mol. Syst. Biol."},{"key":"BFncomms13525_CR5","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1038\/nature10350","volume":"476","author":"R Possemato","year":"2011","unstructured":"Possemato, R. et al. Functional genomics reveal that the serine synthesis pathway is essential in breast cancer. Nature 476, 346\u2013350 (2011).","journal-title":"Nature"},{"key":"BFncomms13525_CR6","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.cmet.2007.10.002","volume":"7","author":"RJ DeBerardinis","year":"2008","unstructured":"DeBerardinis, R. J., Lum, J. J., Hatzivassiliou, G. & Thompson, C. B. The biology of cancer: metabolic reprogramming fuels cell growth and proliferation. Cell Metab. 7, 11\u201320 (2008).","journal-title":"Cell Metab."},{"key":"BFncomms13525_CR7","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1016\/j.cell.2011.02.013","volume":"144","author":"D Hanahan","year":"2011","unstructured":"Hanahan, D. & Weinberg, R. A. Hallmarks of cancer: the next generation. Cell 144, 646\u2013674 (2011).","journal-title":"Cell"},{"key":"BFncomms13525_CR8","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s40170-015-0128-2","volume":"3","author":"CS Ahn","year":"2015","unstructured":"Ahn, C. S. & Metallo, C. M. Mitochondria as biosynthetic factories for cancer proliferation. Cancer Metab. 3, 1 (2015).","journal-title":"Cancer Metab."},{"key":"BFncomms13525_CR9","doi-asserted-by":"publisher","first-page":"656","DOI":"10.1016\/j.cell.2012.01.058","volume":"149","author":"HQ Ying","year":"2012","unstructured":"Ying, H. Q. et al. Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism. Cell 149, 656\u2013670 (2012).","journal-title":"Cell"},{"key":"BFncomms13525_CR10","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1038\/nature12040","volume":"496","author":"J Son","year":"2013","unstructured":"Son, J. et al. Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway. Nature 496, 101\u2013105 (2013).","journal-title":"Nature"},{"key":"BFncomms13525_CR11","doi-asserted-by":"publisher","first-page":"30409","DOI":"10.1074\/jbc.R200006200","volume":"277","author":"OE Owen","year":"2002","unstructured":"Owen, O. E., Kalhan, S. C. & Hanson, R. W. The key role of anaplerosis and cataplerosis for citric acid cycle function. J. Biol. Chem. 277, 30409\u201330412 (2002).","journal-title":"J. Biol. Chem."},{"key":"BFncomms13525_CR12","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1016\/j.cmet.2011.12.009","volume":"15","author":"A Le","year":"2012","unstructured":"Le, A. et al. Glucose-independent glutamine metabolism via TCA cycling for proliferation and survival in B cells. Cell Metab. 15, 110\u2013121 (2012).","journal-title":"Cell Metab."},{"key":"BFncomms13525_CR13","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1186\/2049-3002-2-4","volume":"2","author":"SD Stuart","year":"2014","unstructured":"Stuart, S. D. et al. A strategically designed small molecule attacks alpha-ketoglutarate dehydrogenase in tumor cells through a redox process. Cancer Metab. 2, 4 (2014).","journal-title":"Cancer Metab."},{"key":"BFncomms13525_CR14","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1016\/j.molcel.2012.05.043","volume":"47","author":"RV Duran","year":"2012","unstructured":"Duran, R. V. et al. Glutaminolysis activates Rag-mTORC1 signaling. Mol. Cell 47, 349\u2013358 (2012).","journal-title":"Mol. Cell"},{"key":"BFncomms13525_CR15","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1016\/j.cmet.2013.11.022","volume":"19","author":"RC Sun","year":"2014","unstructured":"Sun, R. C. & Denko, N. C. Hypoxic regulation of glutamine metabolism through HIF1 and SIAH2 supports lipid synthesis that is necessary for tumor growth. Cell Metab. 19, 285\u2013292 (2014).","journal-title":"Cell Metab."},{"key":"BFncomms13525_CR16","doi-asserted-by":"publisher","first-page":"18782","DOI":"10.1073\/pnas.0810199105","volume":"105","author":"DR Wise","year":"2008","unstructured":"Wise, D. R. et al. Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction. Proc. Natl Acad. Sci. USA 105, 18782\u201318787 (2008).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFncomms13525_CR17","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1038\/nature10602","volume":"481","author":"CM Metallo","year":"2012","unstructured":"Metallo, C. M. et al. Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia. Nature 481, 380\u2013384 (2012).","journal-title":"Nature"},{"key":"BFncomms13525_CR18","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1038\/nature10642","volume":"481","author":"AR Mullen","year":"2012","unstructured":"Mullen, A. R. et al. Reductive carboxylation supports growth in tumour cells with defective mitochondria. Nature 481, 385\u2013388 (2012).","journal-title":"Nature"},{"key":"BFncomms13525_CR19","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1016\/j.cmet.2013.02.002","volume":"17","author":"PA Gameiro","year":"2013","unstructured":"Gameiro, P. A. et al. In vivo HIF-mediated reductive carboxylation is regulated by citrate levels and sensitizes VHL-deficient cells to glutamine deprivation. Cell Metab. 17, 372\u2013385 (2013).","journal-title":"Cell Metab."},{"key":"BFncomms13525_CR20","first-page":"111","volume":"1825","author":"P Icard","year":"2012","unstructured":"Icard, P., Poulain, L. & Lincet, H. Understanding the central role of citrate in the metabolism of cancer cells. Biochim. Biophys. Acta 1825, 111\u2013116 (2012).","journal-title":"Biochim. Biophys. Acta"},{"key":"BFncomms13525_CR21","doi-asserted-by":"publisher","first-page":"3709","DOI":"10.1158\/0008-5472.CAN-11-4112","volume":"72","author":"N Zaidi","year":"2012","unstructured":"Zaidi, N., Swinnen, J. V. & Smans, K. ATP-citrate lyase: a key player in cancer metabolism. Cancer Res. 72, 3709\u20133714 (2012).","journal-title":"Cancer Res."},{"key":"BFncomms13525_CR22","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.bbrc.2012.04.144","volume":"422","author":"M Chypre","year":"2012","unstructured":"Chypre, M., Zaidi, N. & Smans, K. ATP-citrate lyase: a mini-review. Biochem. Biophys. Res. Commun. 422, 1\u20134 (2012).","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"BFncomms13525_CR23","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1016\/j.ccr.2005.09.008","volume":"8","author":"G Hatzivassiliou","year":"2005","unstructured":"Hatzivassiliou, G. et al. ATP citrate lyase inhibition can suppress tumor cell growth. Cancer Cell 8, 311\u2013321 (2005).","journal-title":"Cancer Cell"},{"key":"BFncomms13525_CR24","unstructured":"Koike, M. & Koike, K. Structure, assembly and function of mammalian alpha-keto acid dehydrogenase complexes. Adv. Biophys. 187\u2013227 (1976)."},{"key":"BFncomms13525_CR25","doi-asserted-by":"crossref","first-page":"8971","DOI":"10.1016\/S0021-9258(19)38795-2","volume":"265","author":"LJ Reed","year":"1990","unstructured":"Reed, L. J. & Hackert, M. L. Structure-function relationships in dihydrolipoamide acyltransferases. J. Biol. Chem. 265, 8971\u20138974 (1990).","journal-title":"J. Biol. Chem."},{"key":"BFncomms13525_CR26","doi-asserted-by":"publisher","first-page":"8788","DOI":"10.1073\/pnas.1003428107","volume":"107","author":"F Weinberg","year":"2010","unstructured":"Weinberg, F. et al. Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity. Proc. Natl Acad. Sci. USA 107, 8788\u20138793 (2010).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFncomms13525_CR27","doi-asserted-by":"publisher","first-page":"414","DOI":"10.1016\/j.molcel.2014.09.025","volume":"56","author":"C Yang","year":"2014","unstructured":"Yang, C. et al. Glutamine oxidation maintains the TCA cycle and cell survival during impaired mitochondrial pyruvate transport. Mol. Cell 56, 414\u2013424 (2014).","journal-title":"Mol. Cell"},{"key":"BFncomms13525_CR28","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/S0925-4439(02)00222-3","volume":"1637","author":"HM Huang","year":"2003","unstructured":"Huang, H. M., Zhang, H., Xu, H. & Gibson, G. E. Inhibition of the alpha-ketoglutarate dehydrogenase complex alters mitochondrial function and cellular calcium regulation. Biochim. Biophys. Acta 1637, 119\u2013126 (2003).","journal-title":"Biochim. Biophys. Acta"},{"key":"BFncomms13525_CR29","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1038\/ng.2847","volume":"46","author":"EA Bard-Chapeau","year":"2014","unstructured":"Bard-Chapeau, E. A. et al. Transposon mutagenesis identifies genes driving hepatocellular carcinoma in a chronic hepatitis B mouse model. Nat. Genet. 46, 24\u201332 (2014).","journal-title":"Nat. Genet."},{"key":"BFncomms13525_CR30","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1007\/s00726-012-1392-x","volume":"44","author":"WL Araujo","year":"2013","unstructured":"Araujo, W. L. et al. On the role of the mitochondrial 2-oxoglutarate dehydrogenase complex in amino acid metabolism. Amino Acids 44, 683\u2013700 (2013).","journal-title":"Amino Acids"},{"key":"BFncomms13525_CR31","doi-asserted-by":"publisher","first-page":"1679","DOI":"10.1016\/j.celrep.2014.04.037","volume":"7","author":"AR Mullen","year":"2014","unstructured":"Mullen, A. R. et al. Oxidation of alpha-ketoglutarate is required for reductive carboxylation in cancer cells with mitochondrial defects. Cell Rep. 7, 1679\u20131690 (2014).","journal-title":"Cell Rep."},{"key":"BFncomms13525_CR32","doi-asserted-by":"publisher","first-page":"5","DOI":"10.3322\/caac.21254","volume":"65","author":"RL Siegel","year":"2015","unstructured":"Siegel, R. L., Miller, K. D. & Jemal, A. Cancer statistics, 2015. CA Cancer J. Clin. 65, 5\u201329 (2015).","journal-title":"CA Cancer J. Clin."},{"key":"BFncomms13525_CR33","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1038\/nature14410","volume":"521","author":"AM Patch","year":"2015","unstructured":"Patch, A. M. et al. Whole-genome characterization of chemoresistant ovarian cancer. Nature 521, 489\u2013494 (2015).","journal-title":"Nature"},{"key":"BFncomms13525_CR34","doi-asserted-by":"crossref","unstructured":"Cancer Genome Atlas Research Network. Integrated genomic analyses of ovarian carcinoma. Nature 474, 609\u2013615 (2011).","DOI":"10.1038\/nature10166"},{"key":"BFncomms13525_CR35","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1158\/2159-8290.CD-11-0170","volume":"2","author":"AJ Hanrahan","year":"2012","unstructured":"Hanrahan, A. J. et al. Genomic complexity and AKT dependence in serous ovarian cancer. Cancer Dis. 2, 56\u201367 (2012).","journal-title":"Cancer Dis."},{"key":"BFncomms13525_CR36","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1016\/j.cell.2009.04.042","volume":"138","author":"ME Sowa","year":"2009","unstructured":"Sowa, M. E., Bennett, E. J., Gygi, S. P. & Harper, J. W. Defining the human deubiquitinating enzyme interaction landscape. Cell 138, 389\u2013403 (2009).","journal-title":"Cell"},{"key":"BFncomms13525_CR37","doi-asserted-by":"publisher","first-page":"2126","DOI":"10.1038\/ncomms3126","volume":"4","author":"S Domcke","year":"2013","unstructured":"Domcke, S., Sinha, R., Levine, D. A., Sander, C. & Schultz, N. Evaluating cell lines as tumour models by comparison of genomic profiles. Nat. Commun. 4, 2126 (2013).","journal-title":"Nat. Commun."},{"key":"BFncomms13525_CR38","doi-asserted-by":"publisher","first-page":"414","DOI":"10.1038\/ncomms1421","volume":"2","author":"X Zhao","year":"2011","unstructured":"Zhao, X., Fiske, B., Kawakami, A., Li, J. & Fisher, D. E. Regulation of MITF stability by the USP13 deubiquitinase. Nat. Commun. 2, 414 (2011).","journal-title":"Nat. Commun."},{"key":"BFncomms13525_CR39","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1038\/38664","volume":"389","author":"M Grunstein","year":"1997","unstructured":"Grunstein, M. Histone acetylation in chromatin structure and transcription. Nature 389, 349\u2013352 (1997).","journal-title":"Nature"},{"key":"BFncomms13525_CR40","doi-asserted-by":"publisher","first-page":"1076","DOI":"10.1126\/science.1164097","volume":"324","author":"KE Wellen","year":"2009","unstructured":"Wellen, K. E. et al. ATP-citrate lyase links cellular metabolism to histone acetylation. Science 324, 1076\u20131080 (2009).","journal-title":"Science"},{"key":"BFncomms13525_CR41","doi-asserted-by":"publisher","first-page":"1486","DOI":"10.1038\/ncb2874","volume":"15","author":"J Zhang","year":"2013","unstructured":"Zhang, J. et al. Deubiquitylation and stabilization of PTEN by USP13. Nat. Cell Biol. 15, 1486\u20131494 (2013).","journal-title":"Nat. Cell Biol."},{"key":"BFncomms13525_CR42","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1038\/nsmb.2792","volume":"21","author":"F Mattiroli","year":"2014","unstructured":"Mattiroli, F. & Sixma, T. K. Lysine-targeting specificity in ubiquitin and ubiquitin-like modification pathways. Nat. Struct. Mol. Biol. 21, 308\u2013316 (2014).","journal-title":"Nat. Struct. Mol. Biol."},{"key":"BFncomms13525_CR43","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1016\/j.cell.2015.07.017","volume":"162","author":"LB Sullivan","year":"2015","unstructured":"Sullivan, L. B. et al. Supporting aspartate biosynthesis is an essential function of respiration in proliferating cells. Cell 162, 552\u2013563 (2015).","journal-title":"Cell"},{"key":"BFncomms13525_CR44","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1016\/j.cell.2015.07.016","volume":"162","author":"K Birsoy","year":"2015","unstructured":"Birsoy, K. et al. An essential role of the mitochondrial electron transport chain in cell proliferation is to enable aspartate synthesis. Cell 162, 540\u2013551 (2015).","journal-title":"Cell"},{"key":"BFncomms13525_CR45","doi-asserted-by":"publisher","first-page":"1317","DOI":"10.1038\/ncb3233","volume":"17","author":"S Cardaci","year":"2015","unstructured":"Cardaci, S. et al. Pyruvate carboxylation enables growth of SDH-deficient cells by supporting aspartate biosynthesis. Nat. Cell Biol. 17, 1317\u20131326 (2015).","journal-title":"Nat. Cell Biol."},{"key":"BFncomms13525_CR46","doi-asserted-by":"publisher","first-page":"2236","DOI":"10.1038\/ncomms3236","volume":"4","author":"SM Fendt","year":"2013","unstructured":"Fendt, S. M. et al. Reductive glutamine metabolism is a function of the alpha-ketoglutarate to citrate ratio in cells. Nat. Commun. 4, 2236 (2013).","journal-title":"Nat. Commun."},{"key":"BFncomms13525_CR47","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1186\/2049-3002-2-23","volume":"2","author":"JJ Kamphorst","year":"2014","unstructured":"Kamphorst, J. J., Chung, M. K., Fan, J. & Rabinowitz, J. D. Quantitative analysis of acetyl-CoA production in hypoxic cancer cells reveals substantial contribution from acetate. Cancer Metab. 2, 23 (2014).","journal-title":"Cancer Metab."},{"key":"BFncomms13525_CR48","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1038\/nature11706","volume":"491","author":"A Schulze","year":"2012","unstructured":"Schulze, A. & Harris, A. L. How cancer metabolism is tuned for proliferation and vulnerable to disruption. Nature 491, 364\u2013373 (2012).","journal-title":"Nature"},{"key":"BFncomms13525_CR49","doi-asserted-by":"publisher","first-page":"992","DOI":"10.1038\/ncb3039","volume":"16","author":"VS LeBleu","year":"2014","unstructured":"LeBleu, V. S. et al. PGC-1alpha mediates mitochondrial biogenesis and oxidative phosphorylation in cancer cells to promote metastasis. Nat. Cell Biol. 16, 992\u20131003 1001\u20131015 (2014).","journal-title":"Nat. Cell Biol."},{"key":"BFncomms13525_CR50","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1016\/j.molcel.2016.02.011","volume":"61","author":"WX Zong","year":"2016","unstructured":"Zong, W. X., Rabinowitz, J. D. & White, E. Mitochondria and cancer. Mol. Cell 61, 667\u2013676 (2016).","journal-title":"Mol. Cell"},{"key":"BFncomms13525_CR51","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/j.cell.2011.08.037","volume":"147","author":"J Liu","year":"2011","unstructured":"Liu, J. et al. Beclin1 controls the levels of p53 by regulating the deubiquitination activity of USP10 and USP13. Cell 147, 223\u2013234 (2011).","journal-title":"Cell"},{"key":"BFncomms13525_CR52","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1038\/nrd4204","volume":"13","author":"DA Fruman","year":"2014","unstructured":"Fruman, D. A. & Rommel, C. PI3K and cancer: lessons, challenges and opportunities. Nat. Rev. Drug Discov. 13, 140\u2013156 (2014).","journal-title":"Nat. Rev. Drug Discov."},{"key":"BFncomms13525_CR53","doi-asserted-by":"publisher","first-page":"1447","DOI":"10.1016\/j.celrep.2014.07.058","volume":"8","author":"C Han","year":"2014","unstructured":"Han, C. et al. The RNA-binding protein DDX1 promotes primary microRNA maturation and inhibits ovarian tumor progression. Cell Rep. 8, 1447\u20131460 (2014).","journal-title":"Cell Rep."},{"key":"BFncomms13525_CR54","doi-asserted-by":"publisher","first-page":"E667","DOI":"10.1152\/ajpcell.1992.263.3.C667","volume":"263","author":"AT Kharroubi","year":"1992","unstructured":"Kharroubi, A. T., Masterson, T. M., Aldaghlas, T. A., Kennedy, K. A. & Kelleher, J. K. Isotopomer spectral analysis of triglyceride fatty acid synthesis in 3T3-L1 cells. Am. J. Physiol. 263, E667\u2013E675 (1992).","journal-title":"Am. J. Physiol."},{"key":"BFncomms13525_CR55","doi-asserted-by":"publisher","first-page":"911","DOI":"10.1139\/y59-099","volume":"37","author":"EG Bligh","year":"1959","unstructured":"Bligh, E. G. & Dyer, W. J. A rapid method of total lipid extraction and purification. Can. J. Biochem. Physiol. 37, 911\u2013917 (1959).","journal-title":"Can. J. Biochem. Physiol."}],"container-title":["Nature Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/ncomms13525.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/ncomms13525","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/ncomms13525.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,4]],"date-time":"2023-01-04T04:37:50Z","timestamp":1672807070000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/ncomms13525"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11,28]]},"references-count":55,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2016,12,23]]}},"alternative-id":["BFncomms13525"],"URL":"https:\/\/doi.org\/10.1038\/ncomms13525","relation":{},"ISSN":["2041-1723"],"issn-type":[{"value":"2041-1723","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,11,28]]},"assertion":[{"value":"10 February 2016","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 October 2016","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 November 2016","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing financial interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"13525"}}