{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T22:33:58Z","timestamp":1781822038348,"version":"3.54.5"},"reference-count":65,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2017,1,10]],"date-time":"2017-01-10T00:00:00Z","timestamp":1484006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2017,1,10]],"date-time":"2017-01-10T00:00:00Z","timestamp":1484006400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nat Commun"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Ischaemic acute kidney injury (AKI), an inflammatory disease process, often progresses to chronic kidney disease (CKD), with no available effective prophylaxis. This is in part due to lack of clinically relevant CKD models in non-human primates. Here we demonstrate that inhibition of the archetypal innate immune receptor CD11b\/CD18 prevents progression of AKI to CKD in cynomolgus monkeys. Severe ischaemia-reperfusion injury of the right kidney, with subsequent periods of the left ureter ligation, causes irreversible right kidney failure 3, 6 or 9 months after AKI. Moreover, prophylactic inactivation of CD11b\/CD18, using the orthosteric CD11b\/CD18 inhibitor mAb107, improves microvascular perfusion and histopathology, reduces intrarenal pro-inflammatory mediators and salvages kidney function long term. These studies reveal an important early role of CD11b<jats:sup>+<\/jats:sup> leukocytes in post-ischaemic kidney fibrosis and failure, and suggest a potential early therapeutic intervention to mitigate progression of ischaemic AKI to CKD in humans.<\/jats:p>","DOI":"10.1038\/ncomms13899","type":"journal-article","created":{"date-parts":[[2017,1,10]],"date-time":"2017-01-10T10:34:59Z","timestamp":1484044499000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Prophylactic orthosteric inhibition of leukocyte integrin CD11b\/CD18 prevents long-term fibrotic kidney failure in cynomolgus monkeys"],"prefix":"10.1038","volume":"8","author":[{"given":"Abbas","family":"Dehnadi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Benedict Cosimi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rex","family":"Neal Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangen","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 L.","family":"Alonso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terry K.","family":"Means","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Amin","family":"Arnaout","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,1,10]]},"reference":[{"key":"BFncomms13899_CR1","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1681\/ASN.2015030261","volume":"27","author":"H Rabb","year":"2016","unstructured":"Rabb, H. et al. Inflammation in AKI: current understanding, key questions, and knowledge gaps. J. Am. Soc. Nephrol. 27, 371\u2013379 (2016).","journal-title":"J. Am. Soc. Nephrol."},{"key":"BFncomms13899_CR2","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1016\/S0140-6736(13)60647-9","volume":"382","author":"NH Lameire","year":"2013","unstructured":"Lameire, N. H. et al. Acute kidney injury: an increasing global concern. Lancet 382, 170\u2013179 (2013).","journal-title":"Lancet"},{"key":"BFncomms13899_CR3","doi-asserted-by":"publisher","first-page":"3365","DOI":"10.1681\/ASN.2004090740","volume":"16","author":"GM Chertow","year":"2005","unstructured":"Chertow, G. M., Burdick, E., Honour, M., Bonventre, J. V. & Bates, D. W. Acute kidney injury, mortality, length of stay, and costs in hospitalized patients. J. Am. Soc. Nephrol. 16, 3365\u20133370 (2005).","journal-title":"J. Am. Soc. Nephrol."},{"key":"BFncomms13899_CR4","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1038\/ki.2011.379","volume":"81","author":"SG Coca","year":"2012","unstructured":"Coca, S. G., Singanamala, S. & Parikh, C. R. Chronic kidney disease after acute kidney injury: a systematic review and meta-analysis. Kidney Int. 81, 442\u2013448 (2012).","journal-title":"Kidney Int."},{"key":"BFncomms13899_CR5","doi-asserted-by":"publisher","first-page":"967","DOI":"10.1681\/ASN.2012030222","volume":"23","author":"CYYes Hsu","year":"2012","unstructured":"Hsu, C. Y. Yes AKI truly leads to CKD. J. Am. Soc. Nephrol. 23, 967\u2013969 (2012).","journal-title":"J. Am. Soc. Nephrol."},{"key":"BFncomms13899_CR6","doi-asserted-by":"publisher","first-page":"979","DOI":"10.1681\/ASN.2011121185","volume":"23","author":"DE Rifkin","year":"2012","unstructured":"Rifkin, D. E., Coca, S. G. & Kalantar-Zadeh, K. Does AKI truly lead to CKD? J. Am. Soc. Nephrol. 23, 979\u2013984 (2012).","journal-title":"J. Am. Soc. Nephrol."},{"key":"BFncomms13899_CR7","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1681\/ASN.2011070680","volume":"23","author":"PJ Nelson","year":"2012","unstructured":"Nelson, P. J. et al. The renal mononuclear phagocytic system. J. Am. Soc. Nephrol. 23, 194\u2013203 (2012).","journal-title":"J. Am. Soc. Nephrol."},{"key":"BFncomms13899_CR8","doi-asserted-by":"publisher","first-page":"1391","DOI":"10.1038\/nm.2507","volume":"17","author":"HK Eltzschig","year":"2011","unstructured":"Eltzschig, H. K. & Eckle, T. Ischemia and reperfusion--from mechanism to translation. Nat. Med. 17, 1391\u20131401 (2011).","journal-title":"Nat. Med."},{"key":"BFncomms13899_CR9","doi-asserted-by":"publisher","first-page":"1028","DOI":"10.1038\/nm.2807","volume":"18","author":"TA Wynn","year":"2012","unstructured":"Wynn, T. A. & Ramalingam, T. R. Mechanisms of fibrosis: therapeutic translation for fibrotic disease. Nat. Med. 18, 1028\u20131040 (2012).","journal-title":"Nat. Med."},{"key":"BFncomms13899_CR10","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1681\/ASN.2014111138","volume":"27","author":"M Clements","year":"2016","unstructured":"Clements, M. et al. Differential Ly6C expression after renal ischemia-reperfusion identifies unique macrophage populations. J. Am. Soc. Nephrol. 27, 159\u2013170 (2016).","journal-title":"J. Am. Soc. Nephrol."},{"key":"BFncomms13899_CR11","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.immuni.2014.06.008","volume":"41","author":"PJ Murray","year":"2014","unstructured":"Murray, P. J. et al. Macrophage activation and polarization: nomenclature and experimental guidelines. Immunity 41, 14\u201320 (2014).","journal-title":"Immunity"},{"key":"BFncomms13899_CR12","doi-asserted-by":"publisher","first-page":"1859","DOI":"10.2215\/CJN.01170215","volume":"10","author":"J Cerda","year":"2015","unstructured":"Cerda, J. et al. Promoting kidney function recovery in patients with AKI requiring RRT. Clin. J. Am. Soc. Nephrol. 10, 1859\u20131867 (2015).","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"BFncomms13899_CR13","doi-asserted-by":"publisher","first-page":"842","DOI":"10.2215\/CJN.12801211","volume":"7","author":"BA Molitoris","year":"2012","unstructured":"Molitoris, B. A., Okusa, M. D., Palevsky, P. M., Kimmel, P. L. & Star, R. A. Designing clinical trials in acute kidney injury. Clin. J. Am. Soc. Nephrol. 7, 842\u2013843 (2012).","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"BFncomms13899_CR14","doi-asserted-by":"publisher","first-page":"2731","DOI":"10.4049\/jimmunol.172.5.2731","volume":"172","author":"J Mestas","year":"2004","unstructured":"Mestas, J. & Hughes, C. C. Of mice and not men: differences between mouse and human immunology. J. Immunol. 172, 2731\u20132738 (2004).","journal-title":"J. Immunol."},{"key":"BFncomms13899_CR15","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.ddmod.2014.06.003","volume":"11","author":"BJ Lim","year":"2014","unstructured":"Lim, B. J., Yang, H. C. & Fogo, A. B. Animal models of regression\/progression of kidney disease. Drug Discov. Today Dis. Models 11, 45\u201351 (2014).","journal-title":"Drug Discov. Today Dis. Models"},{"key":"BFncomms13899_CR16","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1182\/blood.V75.5.1037.1037","volume":"75","author":"MA Arnaout","year":"1990","unstructured":"Arnaout, M. A. Structure and function of the leukocyte adhesion molecules CD11\/CD18. Blood 75, 1037\u20131050 (1990).","journal-title":"Blood"},{"key":"BFncomms13899_CR17","doi-asserted-by":"publisher","first-page":"1853","DOI":"10.1084\/jem.186.11.1853","volume":"186","author":"T Tang","year":"1997","unstructured":"Tang, T. et al. A role for Mac-1 (CDIIb\/CD18) in immune complex-stimulated neutrophil function in vivo: mac-1 deficiency abrogates sustained Fcgamma receptor-dependent neutrophil adhesion and complement-dependent proteinuria in acute glomerulonephritis. J. Exp. Med. 186, 1853\u20131863 (1997).","journal-title":"J. Exp. Med."},{"key":"BFncomms13899_CR18","doi-asserted-by":"publisher","first-page":"1173","DOI":"10.1002\/1521-4141(200104)31:4<1173::AID-IMMU1173>3.0.CO;2-9","volume":"31","author":"C Wagner","year":"2001","unstructured":"Wagner, C. et al. The complement receptor 3, CR3 (CD11b\/CD18), on T lymphocytes: activation-dependent up-regulation and regulatory function. Eur. J. Immunol. 31, 1173\u20131180 (2001).","journal-title":"Eur. J. Immunol."},{"key":"BFncomms13899_CR19","doi-asserted-by":"publisher","first-page":"939","DOI":"10.1189\/jlb.0506353","volume":"80","author":"KK Lahmers","year":"2006","unstructured":"Lahmers, K. K. et al. Comparative gene expression by WC1+ gammadelta and CD4+ alphabeta T lymphocytes, which respond to Anaplasma marginale, demonstrates higher expression of chemokines and other myeloid cell-associated genes by WC1+ gammadelta T cells. J. Leukoc. Biol. 80, 939\u2013952 (2006).","journal-title":"J. Leukoc. Biol."},{"key":"BFncomms13899_CR20","doi-asserted-by":"publisher","first-page":"e7475","DOI":"10.1371\/journal.pone.0007475","volume":"4","author":"D Pilling","year":"2009","unstructured":"Pilling, D., Fan, T., Huang, D., Kaul, B. & Gomer, R. H. Identification of markers that distinguish monocyte-derived fibrocytes from monocytes, macrophages, and fibroblasts. PLoS ONE 4, e7475 (2009).","journal-title":"PLoS ONE"},{"key":"BFncomms13899_CR21","doi-asserted-by":"publisher","first-page":"115","DOI":"10.4049\/jimmunol.1202136","volume":"190","author":"H Zhou","year":"2013","unstructured":"Zhou, H. et al. CD11b\/CD18 (Mac-1) is a novel surface receptor for extracellular double-stranded RNA to mediate cellular inflammatory responses. J. Immunol. 190, 115\u2013125 (2013).","journal-title":"J. Immunol."},{"key":"BFncomms13899_CR22","doi-asserted-by":"publisher","first-page":"2478","DOI":"10.1182\/blood.V97.8.2478","volume":"97","author":"AB van Spriel","year":"2001","unstructured":"van Spriel, A. B. et al. Mac-1 (CD11b\/CD18) is essential for Fc receptor-mediated neutrophil cytotoxicity and immunologic synapse formation. Blood 97, 2478\u20132486 (2001).","journal-title":"Blood"},{"key":"BFncomms13899_CR23","doi-asserted-by":"publisher","first-page":"3039","DOI":"10.1038\/ncomms4039","volume":"5","author":"GS Ling","year":"2014","unstructured":"Ling, G. S. et al. Integrin CD11b positively regulates TLR4-induced signalling pathways in dendritic cells but not in macrophages. Nat. Commun. 5, 3039 (2014).","journal-title":"Nat. Commun."},{"key":"BFncomms13899_CR24","doi-asserted-by":"publisher","first-page":"2847","DOI":"10.1172\/JCI31008","volume":"117","author":"H Wu","year":"2007","unstructured":"Wu, H. et al. TLR4 activation mediates kidney ischemia\/reperfusion injury. J. Clin. Invest. 117, 2847\u20132859 (2007).","journal-title":"J. Clin. Invest."},{"key":"BFncomms13899_CR25","doi-asserted-by":"publisher","first-page":"5ra13","DOI":"10.1126\/scitranslmed.3000111","volume":"1","author":"AP Castano","year":"2009","unstructured":"Castano, A. P. et al. Serum amyloid P inhibits fibrosis through Fc gamma R-dependent monocyte-macrophage regulation in vivo. Sci. Transl. Med. 1, 5ra13 (2009).","journal-title":"Sci. Transl. Med."},{"key":"BFncomms13899_CR26","doi-asserted-by":"publisher","first-page":"1219","DOI":"10.4049\/jimmunol.168.3.1219","volume":"168","author":"R Li","year":"2002","unstructured":"Li, R. et al. Characterization of a conformationally sensitive murine monoclonal antibody directed to the metal ion-dependent adhesion site face of integrin CD11b. J. Immunol. 168, 1219\u20131225 (2002).","journal-title":"J. Immunol."},{"key":"BFncomms13899_CR27","doi-asserted-by":"publisher","first-page":"6393","DOI":"10.4049\/jimmunol.1102394","volume":"187","author":"B Mahalingam","year":"2011","unstructured":"Mahalingam, B. et al. Stable coordination of the inhibitory Ca2+ ion at the metal ion-dependent adhesion site in integrin CD11b\/CD18 by an antibody-derived ligand aspartate: implications for integrin regulation and structure-based drug design. J. Immunol. 187, 6393\u20136401 (2011).","journal-title":"J. Immunol."},{"key":"BFncomms13899_CR28","doi-asserted-by":"publisher","first-page":"804","DOI":"10.1038\/nrd3266","volume":"9","author":"D Cox","year":"2010","unstructured":"Cox, D., Brennan, M. & Moran, N. Integrins as therapeutic targets: lessons and opportunities. Nat. Rev. Drug Discov. 9, 804\u2013820 (2010).","journal-title":"Nat. Rev. Drug Discov."},{"key":"BFncomms13899_CR29","doi-asserted-by":"publisher","first-page":"489","DOI":"10.3109\/08860229509037614","volume":"17","author":"CE Haug","year":"1995","unstructured":"Haug, C. E. et al. Real-time monitoring of renal function during ischemic injury in the rhesus monkey. Ren. Fail. 17, 489\u2013502 (1995).","journal-title":"Ren. Fail."},{"key":"BFncomms13899_CR30","first-page":"635","volume":"25","author":"WK Summers","year":"1971","unstructured":"Summers, W. K. & Jamison, R. L. The no reflow phenomenon in renal ischemia. Lab Invest. 25, 635\u2013643 (1971).","journal-title":"Lab Invest."},{"key":"BFncomms13899_CR31","doi-asserted-by":"publisher","first-page":"1503","DOI":"10.1681\/ASN.2006010017","volume":"17","author":"P Devarajan","year":"2006","unstructured":"Devarajan, P. Update on mechanisms of ischemic acute kidney injury. J. Am. Soc. Nephrol. 17, 1503\u20131520 (2006).","journal-title":"J. Am. Soc. Nephrol."},{"key":"BFncomms13899_CR32","doi-asserted-by":"publisher","first-page":"2296","DOI":"10.4049\/jimmunol.168.5.2296","volume":"168","author":"T Kamata","year":"2002","unstructured":"Kamata, T. et al. The role of the CPNKEKEC sequence in the \u03b22 subunit I domain in regulation of integrin \u03b1L\u03b22 (LFA-1). J. Immunol. 168, 2296\u20132301 (2002).","journal-title":"J. Immunol."},{"key":"BFncomms13899_CR33","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1056\/NEJM198203253061201","volume":"306","author":"MA Arnaout","year":"1982","unstructured":"Arnaout, M. A. et al. Deficiency of a granulocyte-membrane glycoprotein (gp150) in a boy with recurrent bacterial infections. N. Engl. J. Med. 306, 693\u2013699 (1982).","journal-title":"N. Engl. J. Med."},{"key":"BFncomms13899_CR34","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1172\/JCI106781","volume":"51","author":"J Flores","year":"1972","unstructured":"Flores, J., DiBona, D. R., Beck, C. H. & Leaf, A. The role of cell swelling in ischemic renal damage and the protective effect of hypertonic solute. J. Clin. Invest. 51, 118\u2013126 (1972).","journal-title":"J. Clin. Invest."},{"key":"BFncomms13899_CR35","doi-asserted-by":"publisher","first-page":"2279","DOI":"10.1111\/j.1600-6143.2011.03754.x","volume":"11","author":"A Siedlecki","year":"2011","unstructured":"Siedlecki, A., Irish, W. & Brennan, D. C. Delayed graft function in the kidney transplant. Am. J. Transplant. 11, 2279\u20132296 (2011).","journal-title":"Am. J. Transplant."},{"key":"BFncomms13899_CR36","doi-asserted-by":"publisher","first-page":"911","DOI":"10.1111\/j.1538-7836.2009.03360.x","volume":"7","author":"RH Aster","year":"2009","unstructured":"Aster, R. H., Curtis, B. R., McFarland, J. G. & Bougie, D. W. Drug-induced immune thrombocytopenia: pathogenesis, diagnosis, and management. J. Thromb. Haemost. 7, 911\u2013918 (2009).","journal-title":"J. Thromb. Haemost."},{"key":"BFncomms13899_CR37","first-page":"F1052","volume":"267","author":"H Rabb","year":"1994","unstructured":"Rabb, H. et al. Role of CD11a and CD11b in ischemic acute renal failure in rats. Am. J. Physiol. 267, F1052\u2013F1058 (1994).","journal-title":"Am. J. Physiol."},{"key":"BFncomms13899_CR38","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1111\/j.1432-2277.1995.tb01487.x","volume":"8","author":"M Booster","year":"1995","unstructured":"Booster, M. et al. Inhibition of CD18-dependent leukocyte adherence by mAb 6.5 E does not prevent ischemia-reperfusion injury as seen in grafted kidneys. Transpl. Int. 8, 126\u2013132 (1995).","journal-title":"Transpl. Int."},{"key":"BFncomms13899_CR39","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1006\/jsre.1999.5724","volume":"87","author":"LC Tajra","year":"1999","unstructured":"Tajra, L. C. et al. In vivo effects of monoclonal antibodies against rat \u03b22 integrins on kidney ischemia-reperfusion injury. J. Surg. Res. 87, 32\u201338 (1999).","journal-title":"J. Surg. Res."},{"key":"BFncomms13899_CR40","first-page":"509","volume":"135","author":"MA Thornton","year":"1989","unstructured":"Thornton, M. A., Winn, R., Alpers, C. E. & Zager, R. A. An evaluation of the neutrophil as a mediator of in vivo renal ischemic-reperfusion injury. Am. J. Pathol. 135, 509\u2013515 (1989).","journal-title":"Am. J. Pathol."},{"key":"BFncomms13899_CR41","doi-asserted-by":"publisher","first-page":"2932","DOI":"10.1182\/blood.V97.10.2932","volume":"97","author":"R Rezzonico","year":"2001","unstructured":"Rezzonico, R., Imbert, V., Chicheportiche, R. & Dayer, J. M. Ligation of CD11b and CD11c \u03b22 integrins by antibodies or soluble CD23 induces macrophage inflammatory protein 1alpha (MIP-1alpha) and MIP-1beta production in primary human monocytes through a pathway dependent on nuclear factor-kappaB. Blood 97, 2932\u20132940 (2001).","journal-title":"Blood"},{"key":"BFncomms13899_CR42","doi-asserted-by":"publisher","first-page":"2068","DOI":"10.4049\/jimmunol.173.3.2068","volume":"173","author":"Z Jakus","year":"2004","unstructured":"Jakus, Z., Berton, G., Ligeti, E., Lowell, C. A. & Mocsai, A. Responses of neutrophils to anti-integrin antibodies depends on costimulation through low affinity Fc gamma Rs: full activation requires both integrin and nonintegrin signals. J. Immunol. 173, 2068\u20132077 (2004).","journal-title":"J. Immunol."},{"key":"BFncomms13899_CR43","doi-asserted-by":"publisher","first-page":"5899","DOI":"10.4049\/jimmunol.178.9.5899","volume":"178","author":"L Li","year":"2007","unstructured":"Li, L. et al. NKT cell activation mediates neutrophil IFN-gamma production and renal ischemia-reperfusion injury. J. Immunol. 178, 5899\u20135911 (2007).","journal-title":"J. Immunol."},{"key":"BFncomms13899_CR44","doi-asserted-by":"publisher","first-page":"3315","DOI":"10.1681\/ASN.2003090757","volume":"16","author":"ML Kielar","year":"2005","unstructured":"Kielar, M. L. et al. Maladaptive role of IL-6 in ischemic acute renal failure. J. Am. Soc. Nephrol. 16, 3315\u20133325 (2005).","journal-title":"J. Am. Soc. Nephrol."},{"key":"BFncomms13899_CR45","doi-asserted-by":"publisher","first-page":"18424","DOI":"10.1038\/srep18424","volume":"6","author":"TM Yu","year":"2016","unstructured":"Yu, T. M. et al. RANTES mediates kidney ischemia reperfusion injury through a possible role of HIF-1alpha and LncRNA PRINS. Sci. Rep. 6, 18424 (2016).","journal-title":"Sci. Rep."},{"key":"BFncomms13899_CR46","doi-asserted-by":"publisher","first-page":"2331","DOI":"10.1681\/ASN.2008020170","volume":"19","author":"H Wu","year":"2008","unstructured":"Wu, H. et al. IL-18 contributes to renal damage after ischemia-reperfusion. J. Am. Soc. Nephrol. 19, 2331\u20132341 (2008).","journal-title":"J. Am. Soc. Nephrol."},{"key":"BFncomms13899_CR47","doi-asserted-by":"publisher","first-page":"1517","DOI":"10.4049\/jimmunol.170.3.1517","volume":"170","author":"JM Thurman","year":"2003","unstructured":"Thurman, J. M., Ljubanovic, D., Edelstein, C. L., Gilkeson, G. S. & Holers, V. M. Lack of a functional alternative complement pathway ameliorates ischemic acute renal failure in mice. J. Immunol. 170, 1517\u20131523 (2003).","journal-title":"J. Immunol."},{"key":"BFncomms13899_CR48","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1189\/jlb.70.2.192","volume":"70","author":"MJ Burne","year":"2001","unstructured":"Burne, M. J. et al. IL-1 and TNF independent pathways mediate ICAM-1\/VCAM-1 up-regulation in ischemia reperfusion injury. J. Leukoc. Biol. 70, 192\u2013198 (2001).","journal-title":"J. Leukoc. Biol."},{"key":"BFncomms13899_CR49","doi-asserted-by":"publisher","first-page":"1753","DOI":"10.1111\/j.1523-1755.2005.00272.x","volume":"67","author":"D Cugini","year":"2005","unstructured":"Cugini, D. et al. Inhibition of the chemokine receptor CXCR2 prevents kidney graft function deterioration due to ischemia\/reperfusion. Kidney Int. 67, 1753\u20131761 (2005).","journal-title":"Kidney Int."},{"key":"BFncomms13899_CR50","doi-asserted-by":"publisher","first-page":"2503","DOI":"10.1097\/01.ASN.0000089563.63641.A8","volume":"14","author":"K Furuichi","year":"2003","unstructured":"Furuichi, K. et al. CCR2 signaling contributes to ischemia-reperfusion injury in kidney. J. Am. Soc. Nephrol. 14, 2503\u20132515 (2003).","journal-title":"J. Am. Soc. Nephrol."},{"key":"BFncomms13899_CR51","doi-asserted-by":"publisher","first-page":"882","DOI":"10.1038\/ni0901-882","volume":"2","author":"F Granucci","year":"2001","unstructured":"Granucci, F. et al. Inducible IL-2 production by dendritic cells revealed by global gene expression analysis. Nat. Immunol. 2, 882\u2013888 (2001).","journal-title":"Nat. Immunol."},{"key":"BFncomms13899_CR52","doi-asserted-by":"publisher","first-page":"3983","DOI":"10.4049\/jimmunol.172.7.3983","volume":"172","author":"BH Nelson","year":"2004","unstructured":"Nelson, B. H. IL-2 regulatory T cells, and tolerance. J. Immunol. 172, 3983\u20133988 (2004).","journal-title":"J. Immunol."},{"key":"BFncomms13899_CR53","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1038\/ki.2009.259","volume":"76","author":"MT Gandolfo","year":"2009","unstructured":"Gandolfo, M. T. et al. Foxp3+ regulatory T cells participate in repair of ischemic acute kidney injury. Kidney Int. 76, 717\u2013729 (2009).","journal-title":"Kidney Int."},{"key":"BFncomms13899_CR54","doi-asserted-by":"publisher","first-page":"1744","DOI":"10.1681\/ASN.2008111160","volume":"20","author":"GR Kinsey","year":"2009","unstructured":"Kinsey, G. R. et al. Regulatory T cells suppress innate immunity in kidney ischemia-reperfusion injury. J. Am. Soc. Nephrol. 20, 1744\u20131753 (2009).","journal-title":"J. Am. Soc. Nephrol."},{"key":"BFncomms13899_CR55","doi-asserted-by":"publisher","first-page":"1320","DOI":"10.1097\/TP.0b013e3181d8e9dc","volume":"89","author":"Q Guan","year":"2010","unstructured":"Guan, Q., Nguan, C. Y. & Du, C. Expression of transforming growth factor-beta1 limits renal ischemia-reperfusion injury. Transplantation 89, 1320\u20131327 (2010).","journal-title":"Transplantation"},{"key":"BFncomms13899_CR56","doi-asserted-by":"publisher","first-page":"500","DOI":"10.2215\/CJN.07830814","volume":"10","author":"RH Thiele","year":"2015","unstructured":"Thiele, R. H., Isbell, J. M. & Rosner, M. H. AKI associated with cardiac surgery. Clin. J. Am. Soc. Nephrol. 10, 500\u2013514 (2015).","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"BFncomms13899_CR57","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1001\/archinternmed.2010.514","volume":"171","author":"A Ishani","year":"2011","unstructured":"Ishani, A. et al. The magnitude of acute serum creatinine increase after cardiac surgery and the risk of chronic kidney disease, progression of kidney disease, and death. Arch. Intern. Med. 171, 226\u2013233 (2011).","journal-title":"Arch. Intern. Med."},{"key":"BFncomms13899_CR58","doi-asserted-by":"publisher","first-page":"2444","DOI":"10.1161\/CIRCULATIONAHA.108.800011","volume":"119","author":"CE Hobson","year":"2009","unstructured":"Hobson, C. E. et al. Acute kidney injury is associated with increased long-term mortality after cardiothoracic surgery. Circulation 119, 2444\u20132453 (2009).","journal-title":"Circulation"},{"key":"BFncomms13899_CR59","doi-asserted-by":"publisher","first-page":"1039","DOI":"10.1093\/ndt\/gfn667","volume":"24","author":"SG Yarlagadda","year":"2009","unstructured":"Yarlagadda, S. G., Coca, S. G., Formica, R. N. Jr, Poggio, E. D. & Parikh, C. R. Association between delayed graft function and allograft and patient survival: a systematic review and meta-analysis. Nephrol. Dial. Transplant. 24, 1039\u20131047 (2009).","journal-title":"Nephrol. Dial. Transplant."},{"key":"BFncomms13899_CR60","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1056\/NEJMoa0802289","volume":"360","author":"C Moers","year":"2009","unstructured":"Moers, C. et al. Machine perfusion or cold storage in deceased-donor kidney transplantation. N. Engl. J. Med. 360, 7\u201319 (2009).","journal-title":"N. Engl. J. Med."},{"key":"BFncomms13899_CR61","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1016\/S0828-282X(06)70925-4","volume":"22","author":"IR Bata","year":"2006","unstructured":"Bata, I. R., Gregor, R. D., Wolf, H. K. & Brownell, B. Trends in five-year survival of patients discharged after acute myocardial infarction. Can. J. Cardiol. 22, 399\u2013404 (2006).","journal-title":"Can. J. Cardiol."},{"key":"BFncomms13899_CR62","doi-asserted-by":"crossref","unstructured":"Horenstein, A. L., Durelli, I. & Malavasi, F. Purification of clinical-grade monoclonal antibodies by chromatographic methods. Methods Mol Biol. 308, 191\u2013208 (2005).","DOI":"10.1385\/1-59259-922-2:191"},{"key":"BFncomms13899_CR63","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1681\/ASN.2009091005","volume":"22","author":"AB Farris","year":"2011","unstructured":"Farris, A. B. et al. Morphometric and visual evaluation of fibrosis in renal biopsies. J. Am. Soc. Nephrol. 22, 176\u2013186 (2011).","journal-title":"J. Am. Soc. Nephrol."},{"key":"BFncomms13899_CR64","doi-asserted-by":"publisher","first-page":"1562","DOI":"10.1093\/ndt\/15.10.1562","volume":"15","author":"DK Ysebaert","year":"2000","unstructured":"Ysebaert, D. K. et al. Identification and kinetics of leukocytes after severe ischaemia\/reperfusion renal injury. Nephrol. Dial. Transplant. 15, 1562\u20131574 (2000).","journal-title":"Nephrol. Dial. Transplant."},{"key":"BFncomms13899_CR65","unstructured":"La Morte, W. W. Sample size calculations in research http:\/\/www.uml.edu\/docs\/samplesizecalcsLaMorte_tcm18-37807.doc."}],"container-title":["Nature Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/ncomms13899.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/ncomms13899","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/ncomms13899.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,23]],"date-time":"2022-12-23T00:10:26Z","timestamp":1671754226000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/ncomms13899"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1,10]]},"references-count":65,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2017,4,28]]}},"alternative-id":["BFncomms13899"],"URL":"https:\/\/doi.org\/10.1038\/ncomms13899","relation":{},"ISSN":["2041-1723"],"issn-type":[{"value":"2041-1723","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,1,10]]},"assertion":[{"value":"3 August 2016","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 November 2016","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 January 2017","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing financial interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"13899"}}