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Here we demonstrate that connectivity in the host\u2013pathogen interactome is directly related to pathogen fitness during infection. Using <jats:italic>Y. pestis<\/jats:italic> as a model organism, we show that the centrality-lethality rule holds for pathogen fitness during infection but only when the host\u2013pathogen interactome is considered. Our results suggest that the importance of pathogen proteins during infection is directly related to their number of interactions with the host. We also show that pathogen proteins causing an extensive rewiring of the host interactome have a higher impact in pathogen fitness during infection. Hence, we conclude that hubs in the host\u2013pathogen interactome should be explored as promising targets for antimicrobial drug design.<\/jats:p>","DOI":"10.1038\/ncomms14092","type":"journal-article","created":{"date-parts":[[2017,1,16]],"date-time":"2017-01-16T10:03:27Z","timestamp":1484561007000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":68,"title":["Centrality in the host\u2013pathogen interactome is associated with pathogen fitness during infection"],"prefix":"10.1038","volume":"8","author":[{"given":"N\u00faria","family":"Crua Asensio","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabet","family":"Mu\u00f1oz Giner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia S\u00e1nchez","family":"de Groot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Torrent Burgas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,1,16]]},"reference":[{"key":"BFncomms14092_CR1","doi-asserted-by":"publisher","first-page":"4413","DOI":"10.1128\/IAI.05622-11","volume":"79","author":"H Yang","year":"2011","unstructured":"Yang, H. et al. 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