{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T12:26:52Z","timestamp":1784636812206,"version":"3.55.0"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2017,1,24]],"date-time":"2017-01-24T00:00:00Z","timestamp":1485216000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2017,1,24]],"date-time":"2017-01-24T00:00:00Z","timestamp":1485216000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nat Commun"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Ischaemic heart disease limits oxygen and metabolic substrate availability to the heart, resulting in tissue death. Here, we demonstrate that the AMP-activated protein kinase (AMPK)-related protein Snf1-related kinase (SNRK) decreases cardiac metabolic substrate usage and mitochondrial uncoupling, and protects against ischaemia\/reperfusion. Hearts from transgenic mice overexpressing SNRK have decreased glucose and palmitate metabolism and oxygen consumption, but maintained power and function. They also exhibit decreased uncoupling protein 3 (UCP3) and mitochondrial uncoupling. Conversely,<jats:italic>Snrk<\/jats:italic>knockout mouse hearts have increased glucose and palmitate oxidation and UCP3. SNRK knockdown in cardiac cells decreases mitochondrial efficiency, which is abolished with UCP3 knockdown. We show that Tribbles homologue 3 (Trib3) binds to SNRK, and downregulates UCP3 through PPAR\u03b1. Finally, SNRK is increased in cardiomyopathy patients, and SNRK reduces infarct size after ischaemia\/reperfusion. SNRK also decreases cardiac cell death in a UCP3-dependent manner. Our results suggest that SNRK improves cardiac mitochondrial efficiency and ischaemic protection.<\/jats:p>","DOI":"10.1038\/ncomms14095","type":"journal-article","created":{"date-parts":[[2017,1,24]],"date-time":"2017-01-24T10:39:38Z","timestamp":1485254378000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Snf1-related kinase improves cardiac mitochondrial efficiency and decreases mitochondrial uncoupling"],"prefix":"10.1038","volume":"8","author":[{"given":"Amy K.","family":"Rines","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsiang-Chun","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongxue","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuya","family":"Sato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arineh","family":"Khechaduri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidemichi","family":"Kouzu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason","family":"Shapiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Shang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael A.","family":"Burke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eltyeb","family":"Abdelwahid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinghang","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunlei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tenley A.","family":"Rawlings","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary D.","family":"Lopaschuk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul T.","family":"Schumacker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. Dale","family":"Abel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hossein","family":"Ardehali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,1,24]]},"reference":[{"key":"BFncomms14095_CR1","doi-asserted-by":"publisher","first-page":"634","DOI":"10.1016\/j.ehj.2004.02.018","volume":"25","author":"L Lee","year":"2004","unstructured":"Lee, L., Horowitz, J. & Frenneaux, M. Metabolic manipulation in ischaemic heart disease, a novel approach to treatment. Eur. Heart. J. 25, 634\u2013641 (2004).","journal-title":"Eur. Heart. J."},{"key":"BFncomms14095_CR2","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1177\/0091270010396042","volume":"52","author":"BS Kalra","year":"2012","unstructured":"Kalra, B. S. & Roy, V. Efficacy of metabolic modulators in ischaemic heart disease: an overview. J. Clin. Pharmacol. 52, 292\u2013305 (2012).","journal-title":"J. Clin. Pharmacol."},{"key":"BFncomms14095_CR3","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1038\/nrm3311","volume":"13","author":"DG Hardie","year":"2012","unstructured":"Hardie, D. G., Ross, F. A. & Hawley, S. A. AMPK: a nutrient and energy sensor that maintains energy homeostasis. Nat. Rev. Mol. Cell Biol. 13, 251\u2013262 (2012).","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"BFncomms14095_CR4","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/S0378-1119(02)00829-6","volume":"294","author":"N Kertesz","year":"2002","unstructured":"Kertesz, N., Samson, J., Debacker, C., Wu, H. & Labastie, M. C. Cloning and characterization of human and mouse SNRK sucrose non-fermenting protein (SNF-1)-related kinases. Gene 294, 13\u201324 (2002).","journal-title":"Gene"},{"key":"BFncomms14095_CR5","doi-asserted-by":"publisher","first-page":"736","DOI":"10.1111\/j.1432-1033.1996.00736.x","volume":"235","author":"W Becker","year":"1996","unstructured":"Becker, W., Heukelbach, J., Kentrup, H. & Joost, H. G. Molecular cloning and characterization of a novel mammalian protein kinase harboring a homology domain that defines a subfamily of serine\/threonine kinases. Eur. J. Biochem. 235, 736\u2013743 (1996).","journal-title":"Eur. J. Biochem."},{"key":"BFncomms14095_CR6","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1016\/S0006-8993(00)02548-8","volume":"873","author":"K Yoshida","year":"2000","unstructured":"Yoshida, K., Yamada, M., Nishio, C., Konishi, A. & Hatanaka, H. SNRK, a member of the SNF1 family, is related to low K(+)-induced apoptosis of cultured rat cerebellar granule neurons. Brain Res. 873, 274\u2013282 (2000).","journal-title":"Brain Res."},{"key":"BFncomms14095_CR7","doi-asserted-by":"publisher","first-page":"1417","DOI":"10.1016\/j.febslet.2005.01.042","volume":"579","author":"M Jaleel","year":"2005","unstructured":"Jaleel, M. et al. Identification of the sucrose non-fermenting related kinase SNRK, as a novel LKB1 substrate. FEBS Lett. 579, 1417\u20131423 (2005).","journal-title":"FEBS Lett."},{"key":"BFncomms14095_CR8","doi-asserted-by":"publisher","first-page":"833","DOI":"10.1038\/sj.emboj.7600110","volume":"23","author":"JM Lizcano","year":"2004","unstructured":"Lizcano, J. M. et al. LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK\/PAR-1. EMBO. J. 23, 833\u2013843 (2004).","journal-title":"EMBO. J."},{"key":"BFncomms14095_CR9","doi-asserted-by":"publisher","first-page":"2396","DOI":"10.2337\/db12-1081","volume":"62","author":"Y Li","year":"2013","unstructured":"Li, Y. et al. Identification of sucrose non-fermenting-related kinase (SNRK) as a suppressor of adipocyte inflammation. Diabetes 62, 2396\u20132409 (2013).","journal-title":"Diabetes"},{"key":"BFncomms14095_CR10","doi-asserted-by":"publisher","first-page":"1192","DOI":"10.1182\/blood-2008-06-162156","volume":"113","author":"CZ Chun","year":"2009","unstructured":"Chun, C. Z. et al. Snrk-1 is involved in multiple steps of angioblast development and acts via notch signaling pathway in artery-vein specification in vertebrates. Blood 113, 1192\u20131199 (2009).","journal-title":"Blood"},{"key":"BFncomms14095_CR11","doi-asserted-by":"publisher","first-page":"4685","DOI":"10.1096\/fj.12-212282","volume":"26","author":"AK Rines","year":"2012","unstructured":"Rines, A. K., Burke, M. A., Fernandez, R. P., Volpert, O. V. & Ardehali, H. Snf1-related kinase inhibits colon cancer cell proliferation through calcyclin-binding protein-dependent reduction of beta-catenin. FASEB J. 26, 4685\u20134695 (2012).","journal-title":"FASEB J."},{"key":"BFncomms14095_CR12","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1242\/bio.20149811","volume":"4","author":"SM Cossette","year":"2014","unstructured":"Cossette, S. M. et al. Sucrose non-fermenting related kinase enzyme is essential for cardiac metabolism. Biol. Open 4, 48\u201361 (2014).","journal-title":"Biol. Open"},{"key":"BFncomms14095_CR13","doi-asserted-by":"publisher","first-page":"474","DOI":"10.1161\/01.RES.0000258446.23525.37","volume":"100","author":"M Arad","year":"2007","unstructured":"Arad, M., Seidman, C. E. & Seidman, J. G. AMP-activated protein kinase in the heart: role during health and disease. Circ. Res. 100, 474\u2013488 (2007).","journal-title":"Circ. Res."},{"key":"BFncomms14095_CR14","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1002\/aja.1002000204","volume":"200","author":"WK Jones","year":"1994","unstructured":"Jones, W. K., Sanchez, A. & Robbins, J. Murine pulmonary myocardium: developmental analysis of cardiac gene expression. Dev. Dyn. 200, 117\u2013128 (1994).","journal-title":"Dev. Dyn."},{"key":"BFncomms14095_CR15","doi-asserted-by":"publisher","first-page":"2033","DOI":"10.1096\/fj.00-0828fje","volume":"15","author":"C Garcia-Martinez","year":"2001","unstructured":"Garcia-Martinez, C. et al. Overexpression of UCP3 in cultured human muscle lowers mitochondrial membrane potential, raises ATP\/ADP ratio, and favors fatty acid vs. glucose oxidation. FASEB J. 15, 2033\u20132035 (2001).","journal-title":"FASEB J."},{"key":"BFncomms14095_CR16","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1074\/jbc.273.1.5","volume":"273","author":"O Boss","year":"1998","unstructured":"Boss, O. et al. Uncoupling protein-3 expression in rodent skeletal muscle is modulated by food intake but not by changes in environmental temperature. J. Biol. Chem. 273, 5\u20138 (1998).","journal-title":"J. Biol. Chem."},{"key":"BFncomms14095_CR17","doi-asserted-by":"publisher","first-page":"833","DOI":"10.1096\/fj.00-0351com","volume":"15","author":"ME Young","year":"2001","unstructured":"Young, M. E. et al. Uncoupling protein 3 transcription is regulated by peroxisome proliferator-activated receptor (alpha) in the adult rodent heart. FASEB J. 15, 833\u2013845 (2001).","journal-title":"FASEB J."},{"key":"BFncomms14095_CR18","doi-asserted-by":"publisher","first-page":"23410","DOI":"10.1074\/jbc.M801236200","volume":"283","author":"Z Lu","year":"2008","unstructured":"Lu, Z. & Sack, M. N. ATF-1 is a hypoxia-responsive transcriptional activator of skeletal muscle mitochondrial-uncoupling protein 3. J. Biol. Chem. 283, 23410\u201323418 (2008).","journal-title":"J. Biol. Chem."},{"key":"BFncomms14095_CR19","doi-asserted-by":"publisher","first-page":"1574","DOI":"10.1126\/science.1079817","volume":"300","author":"K Du","year":"2003","unstructured":"Du, K., Herzig, S., Kulkarni, R. N. & Montminy, M. TRB3: a tribbles homolog that inhibits Akt\/PKB activation by insulin in liver. Science 300, 1574\u20131577 (2003).","journal-title":"Science"},{"key":"BFncomms14095_CR20","doi-asserted-by":"publisher","first-page":"530","DOI":"10.1038\/nm1044","volume":"10","author":"SH Koo","year":"2004","unstructured":"Koo, S. H. et al. PGC-1 promotes insulin resistance in liver through PPAR-alpha-dependent induction of TRB-3. Nat. Med. 10, 530\u2013534 (2004).","journal-title":"Nat. Med."},{"key":"BFncomms14095_CR21","doi-asserted-by":"publisher","first-page":"R925","DOI":"10.1152\/ajpregu.00027.2014","volume":"306","author":"D An","year":"2014","unstructured":"An, D. et al. Overexpression of TRB3 in muscle alters muscle fiber type and improves exercise capacity in mice. Am. J. Physiol. Regul. Integr. Comp. Physiol. 306, R925\u2013R933 (2014).","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"BFncomms14095_CR22","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1038\/217078a0","volume":"217","author":"DR Challoner","year":"1968","unstructured":"Challoner, D. R. Respiration in myocardium. Nature 217, 78\u201379 (1968).","journal-title":"Nature"},{"key":"BFncomms14095_CR23","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1023\/A:1027327015957","volume":"17","author":"DF Rolfe","year":"1997","unstructured":"Rolfe, D. F. & Brand, M. D. The physiological significance of mitochondrial proton leak in animal cells and tissues. Biosci. Rep. 17, 9\u201316 (1997).","journal-title":"Biosci. Rep."},{"key":"BFncomms14095_CR24","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1042\/BJ20051927","volume":"395","author":"SM Nadtochiy","year":"2006","unstructured":"Nadtochiy, S. M., Tompkins, A. J. & Brookes, P. S. Different mechanisms of mitochondrial proton leak in ischaemia\/reperfusion injury and preconditioning: implications for pathology and cardioprotection. Biochem. J. 395, 611\u2013618 (2006).","journal-title":"Biochem. J."},{"key":"BFncomms14095_CR25","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1016\/j.physbeh.2007.11.039","volume":"94","author":"M Nabben","year":"2008","unstructured":"Nabben, M. & Hoeks, J. Mitochondrial uncoupling protein 3 and its role in cardiac- and skeletal muscle metabolism. Physiol. Behav. 94, 259\u2013269 (2008).","journal-title":"Physiol. Behav."},{"key":"BFncomms14095_CR26","doi-asserted-by":"publisher","first-page":"2457","DOI":"10.2337\/db07-0481","volume":"56","author":"S Boudina","year":"2007","unstructured":"Boudina, S. et al. Mitochondrial energetics in the heart in obesity-related diabetes: direct evidence for increased uncoupled respiration and activation of uncoupling proteins. Diabetes 56, 2457\u20132466 (2007).","journal-title":"Diabetes"},{"key":"BFncomms14095_CR27","doi-asserted-by":"publisher","first-page":"e000086","DOI":"10.1161\/JAHA.113.000086","volume":"2","author":"C Perrino","year":"2013","unstructured":"Perrino, C. et al. Genetic deletion of uncoupling protein 3 exaggerates apoptotic cell death in the ischaemic heart leading to heart failure. J. Am. Heart Assoc. 2, e000086 (2013).","journal-title":"J. Am. Heart Assoc."},{"key":"BFncomms14095_CR28","doi-asserted-by":"publisher","first-page":"H1192","DOI":"10.1152\/ajpheart.00592.2012","volume":"304","author":"C Ozcan","year":"2013","unstructured":"Ozcan, C., Palmeri, M., Horvath, T. L., Russell, K. S. & Russell, R. R. 3rd Role of uncoupling protein 3 in ischaemia-reperfusion injury, arrhythmias, and preconditioning. Am. J. Physiol. Heart. Circ. Physiol. 304, H1192\u2013H1200 (2013).","journal-title":"Am. J. Physiol. Heart. Circ. Physiol."},{"key":"BFncomms14095_CR29","doi-asserted-by":"publisher","first-page":"3260","DOI":"10.2337\/db12-0063","volume":"61","author":"S Boudina","year":"2012","unstructured":"Boudina, S. et al. UCP3 regulates cardiac efficiency and mitochondrial coupling in high fat-fed mice but not in leptin-deficient mice. Diabetes 61, 3260\u20133269 (2012).","journal-title":"Diabetes"},{"key":"BFncomms14095_CR30","doi-asserted-by":"publisher","first-page":"H161","DOI":"10.1152\/ajpheart.01065.2004","volume":"291","author":"C Loichot","year":"2006","unstructured":"Loichot, C. et al. Deletion of peroxisome proliferator-activated receptor-alpha induces an alteration of cardiac functions. Am. J. Physiol. Heart Circ. Physiol. 291, H161\u2013H166 (2006).","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"BFncomms14095_CR31","doi-asserted-by":"publisher","first-page":"2924","DOI":"10.2337\/db08-0079","volume":"57","author":"H Bugger","year":"2008","unstructured":"Bugger, H. et al. Type 1 diabetic akita mouse hearts are insulin sensitive but manifest structurally abnormal mitochondria that remain coupled despite increased uncoupling protein 3. Diabetes 57, 2924\u20132932 (2008).","journal-title":"Diabetes"},{"key":"BFncomms14095_CR32","doi-asserted-by":"publisher","first-page":"660","DOI":"10.1161\/01.CIR.101.6.660","volume":"101","author":"Y Fujio","year":"2000","unstructured":"Fujio, Y., Nguyen, T., Wencker, D., Kitsis, R. N. & Walsh, K. Akt promotes survival of cardiomyocytes in vitro and protects against ischemia-reperfusion injury in mouse heart. Circulation 101, 660\u2013667 (2000).","journal-title":"Circulation"},{"key":"BFncomms14095_CR33","doi-asserted-by":"publisher","first-page":"8217","DOI":"10.1128\/MCB.00979-06","volume":"26","author":"HJ Koh","year":"2006","unstructured":"Koh, H. J. et al. Skeletal muscle-selective knockout of LKB1 increases insulin sensitivity, improves glucose homeostasis, and decreases TRB3. Mol. Cell Biol. 26, 8217\u20138227 (2006).","journal-title":"Mol. Cell Biol."},{"key":"BFncomms14095_CR34","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1002\/emmm.201200240","volume":"4","author":"R Wu","year":"2012","unstructured":"Wu, R. et al. Hexokinase II knockdown results in exaggerated cardiac hypertrophy via increased ROS production. EMBO Mol. Med. 4, 633\u2013646 (2012).","journal-title":"EMBO Mol. Med."},{"key":"BFncomms14095_CR35","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1172\/JCI0213946","volume":"109","author":"DD Belke","year":"2002","unstructured":"Belke, D. D. et al. Insulin signaling coordinately regulates cardiac size, metabolism, and contractile protein isoform expression. J. Clin. Invest. 109, 629\u2013639 (2002).","journal-title":"J. Clin. Invest."},{"key":"BFncomms14095_CR36","doi-asserted-by":"publisher","first-page":"806","DOI":"10.1161\/CIRCULATIONAHA.110.003418","volume":"124","author":"M Liesa","year":"2011","unstructured":"Liesa, M. et al. Mitochondrial transporter ATP binding cassette mitochondrial erythroid is a novel gene required for cardiac recovery after ischemia\/reperfusion. Circulation 124, 806\u2013813 (2011).","journal-title":"Circulation"},{"key":"BFncomms14095_CR37","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1016\/S0022-3565(24)38044-9","volume":"288","author":"GW Wang","year":"1999","unstructured":"Wang, G. W. & Kang, Y. J. Inhibition of doxorubicin toxicity in cultured neonatal mouse cardiomyocytes with elevated metallothionein levels. J. Pharmacol. Exp. Ther. 288, 938\u2013944 (1999).","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"BFncomms14095_CR38","doi-asserted-by":"publisher","first-page":"3320","DOI":"10.1074\/jbc.273.6.3320","volume":"273","author":"GR Budinger","year":"1998","unstructured":"Budinger, G. R., Duranteau, J., Chandel, N. S. & Schumacker, P. T. Hibernation during hypoxia in cardiomyocytes. Role of mitochondria as the O2 sensor. J. Biol. Chem. 273, 3320\u20133326 (1998).","journal-title":"J. Biol. Chem."},{"key":"BFncomms14095_CR39","doi-asserted-by":"publisher","first-page":"2080","DOI":"10.1074\/jbc.M804570200","volume":"284","author":"LI Gordon","year":"2009","unstructured":"Gordon, L. I. et al. Blockade of the erbB2 receptor induces cardiomyocyte death through mitochondrial and reactive oxygen species-dependent pathways. J. Biol. Chem. 284, 2080\u20132087 (2009).","journal-title":"J. Biol. Chem."},{"key":"BFncomms14095_CR40","doi-asserted-by":"publisher","first-page":"906","DOI":"10.1161\/01.CIR.0000155609.95618.75","volume":"111","author":"RS Decker","year":"2005","unstructured":"Decker, R. S. et al. Myosin-binding protein C phosphorylation, myofibril structure, and contractile function during low-flow ischemia. Circulation 111, 906\u2013912 (2005).","journal-title":"Circulation"},{"key":"BFncomms14095_CR41","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1161\/CIRCRESAHA.110.223115","volume":"108","author":"R Wu","year":"2011","unstructured":"Wu, R. et al. Reduction in hexokinase II levels results in decreased cardiac function and altered remodeling after ischemia\/reperfusion injury. Circ. Res. 108, 60\u201369 (2011).","journal-title":"Circ. Res."},{"key":"BFncomms14095_CR42","doi-asserted-by":"publisher","first-page":"4152","DOI":"10.1073\/pnas.1119338109","volume":"109","author":"Y Ichikawa","year":"2012","unstructured":"Ichikawa, Y. et al. Disruption of ATP-binding cassette B8 in mice leads to cardiomyopathy through a decrease in mitochondrial iron export. Proc. Natl Acad. Sci. USA 109, 4152\u20134157 (2012).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFncomms14095_CR43","doi-asserted-by":"publisher","first-page":"9079","DOI":"10.1128\/MCB.24.20.9079-9091.2004","volume":"24","author":"JM Huss","year":"2004","unstructured":"Huss, J. M., Torra, I. P., Staels, B., Giguere, V. & Kelly, D. P. Estrogen-related receptor alpha directs peroxisome proliferator-activated receptor alpha signaling in the transcriptional control of energy metabolism in cardiac and skeletal muscle. Mol. Cell Biol. 24, 9079\u20139091 (2004).","journal-title":"Mol. Cell Biol."}],"updated-by":[{"DOI":"10.1038\/ncomms16155","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2017,8,30]],"date-time":"2017-08-30T00:00:00Z","timestamp":1504051200000}}],"container-title":["Nature Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/ncomms14095.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/ncomms14095","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/ncomms14095.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,14]],"date-time":"2025-06-14T19:16:28Z","timestamp":1749928588000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/ncomms14095"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1,24]]},"references-count":43,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2017,4,28]]}},"alternative-id":["BFncomms14095"],"URL":"https:\/\/doi.org\/10.1038\/ncomms14095","relation":{"correction":[{"id-type":"doi","id":"10.1038\/ncomms16155","asserted-by":"object"}]},"ISSN":["2041-1723"],"issn-type":[{"value":"2041-1723","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,1,24]]},"assertion":[{"value":"16 August 2016","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 November 2016","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 January 2017","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 August 2017","order":4,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Update","order":5,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors inadvertently omitted Eltyeb Abdelwahid, who contributed to the generation of animal models and their initial evaluation, from the author list. This has now been corrected in both the PDF and HTML versions of the Article.","order":6,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing financial interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"14095"}}