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Syphilis elimination will require development of an effective vaccine that has thus far remained elusive. Here we assess the vaccine potential of Tp0751, a vascular adhesin from the causative agent of syphilis,<jats:italic>Treponema pallidum<\/jats:italic>subsp.<jats:italic>pallidum<\/jats:italic>. Tp0751-immunized animals exhibit a significantly reduced bacterial organ burden upon<jats:italic>T. pallidum<\/jats:italic>challenge compared with unimmunized animals. Introduction of lymph nodes from Tp0751-immunized,<jats:italic>T. pallidum<\/jats:italic>-challenged animals to naive animals fails to induce infection, confirming sterile protection. These findings provide evidence that Tp0751 is a promising syphilis vaccine candidate.<\/jats:p>","DOI":"10.1038\/ncomms14273","type":"journal-article","created":{"date-parts":[[2017,2,1]],"date-time":"2017-02-01T13:20:33Z","timestamp":1485955233000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":82,"title":["A defined syphilis vaccine candidate inhibits dissemination of Treponema pallidum subspecies pallidum"],"prefix":"10.1038","volume":"8","author":[{"given":"Karen V.","family":"Lithgow","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Hof","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charmaine","family":"Wetherell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Drew","family":"Phillips","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Houston","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline E.","family":"Cameron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,2,1]]},"reference":[{"key":"BFncomms14273_CR1","unstructured":"World Health Organization, Department of Reproductive Health and Research. 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