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Here, we carry out the largest GWAS meta-analysis of MPB to date, comprising 10,846 early-onset cases and 11,672 controls from eight independent cohorts. We identify 63 MPB-associated loci (<jats:italic>P<\/jats:italic>&lt;5 \u00d7 10<jats:sup>\u22128<\/jats:sup>, METAL) of which 23 have not been reported previously. The 63 loci explain \u223c39% of the phenotypic variance in MPB and highlight several plausible candidate genes (<jats:italic>FGF5<\/jats:italic>, <jats:italic>IRF4<\/jats:italic>, <jats:italic>DKK2<\/jats:italic>) and pathways (melatonin signalling, adipogenesis) that are likely to be implicated in the key-pathophysiological features of MPB and may represent promising targets for the development of novel therapeutic options. The data provide molecular evidence that rather than being an isolated trait, MPB shares a substantial biological basis with numerous other human phenotypes and may deserve evaluation as an early prognostic marker, for example, for prostate cancer, sudden cardiac arrest and neurodegenerative disorders.<\/jats:p>","DOI":"10.1038\/ncomms14694","type":"journal-article","created":{"date-parts":[[2017,3,8]],"date-time":"2017-03-08T10:11:31Z","timestamp":1488967891000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":96,"title":["Meta-analysis identifies novel risk loci and yields systematic insights into the biology of male-pattern baldness"],"prefix":"10.1038","volume":"8","author":[{"given":"Stefanie","family":"Heilmann-Heimbach","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Herold","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lara M.","family":"Hochfeld","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Axel M.","family":"Hillmer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dale R.","family":"Nyholt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian","family":"Hecker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asif","family":"Javed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elaine G. 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