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Studies on mesenchymal stromal\/stem cells (MSCs) have mainly focused on bone marrow. Here we show that lineage tracing of\n                    <jats:italic>Gdf5<\/jats:italic>\n                    -expressing joint interzone cells identifies in adult mouse synovium an MSC population largely negative for the skeletal stem cell markers\n                    <jats:italic>Nestin<\/jats:italic>\n                    -GFP, Leptin receptor and Gremlin1. Following cartilage injury,\n                    <jats:italic>Gdf5<\/jats:italic>\n                    -lineage cells underpin synovial hyperplasia through proliferation, are recruited to a\n                    <jats:italic>Nestin<\/jats:italic>\n                    -GFP\n                    <jats:sup>high<\/jats:sup>\n                    perivascular population, and contribute to cartilage repair. The transcriptional co-factor Yap is upregulated after injury, and its conditional ablation in\n                    <jats:italic>Gdf5<\/jats:italic>\n                    -lineage cells prevents synovial lining hyperplasia and decreases contribution of\n                    <jats:italic>Gdf5<\/jats:italic>\n                    -lineage cells to cartilage repair. Cultured\n                    <jats:italic>Gdf5<\/jats:italic>\n                    -lineage cells exhibit progenitor activity for stable chondrocytes and are able to self-organize three-dimensionally to form a synovial lining-like layer. Finally, human synovial MSCs transduced with\n                    <jats:italic>Bmp7<\/jats:italic>\n                    display morphogenetic properties by patterning a joint-like organ\n                    <jats:italic>in vivo<\/jats:italic>\n                    . Our findings further the understanding of the skeletal stem\/progenitor cells in adult life.\n                  <\/jats:p>","DOI":"10.1038\/ncomms15040","type":"journal-article","created":{"date-parts":[[2017,5,16]],"date-time":"2017-05-16T05:45:07Z","timestamp":1494913507000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":179,"title":["Joint morphogenetic cells in the adult mammalian synovium"],"prefix":"10.1038","volume":"8","author":[{"given":"Anke J.","family":"Roelofs","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janja","family":"Zupan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna H. 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