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Here we developed an electrospun membrane biofunctionalized with a fragment of the laminin \u03b21-chain to modulate the expression of MMP2 in this context. We demonstrate that interfacing of the \u03b21-fragment with the mesothelium of the peritoneal membrane via a biomaterial abrogates the release of active MMP2 in response to transforming growth factor \u03b21 and rescues tissue integrity <jats:italic>ex vivo<\/jats:italic> and <jats:italic>in vivo<\/jats:italic> in a mouse model of peritoneal fibrosis. Importantly, our data demonstrate that the membrane inhibits MMP2 expression. Changes in the expression of epithelial-to-mesenchymal transition (EMT)-related molecules further point towards a contribution of the modulation of EMT. Biomaterial-based presentation of regulatory basement membrane signals directly addresses limitations of current therapeutic approaches by enabling a localized and specific method to counteract MMP2 release applicable to a broad range of therapeutic targets.<\/jats:p>","DOI":"10.1038\/ncomms15509","type":"journal-article","created":{"date-parts":[[2017,6,8]],"date-time":"2017-06-08T11:12:21Z","timestamp":1496920341000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Preventing tissue fibrosis by local biomaterials interfacing of specific cryptic extracellular matrix information"],"prefix":"10.1038","volume":"8","author":[{"given":"Christine-Maria","family":"Horejs","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Philippe","family":"St-Pierre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juha R. 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