{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T15:10:42Z","timestamp":1791558642144,"version":"4.3.4"},"reference-count":48,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2017,6,9]],"date-time":"2017-06-09T00:00:00Z","timestamp":1496966400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2017,6,9]],"date-time":"2017-06-09T00:00:00Z","timestamp":1496966400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nat Commun"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Previous genome-wide association studies (GWAS) have identified six risk loci for renal cell carcinoma (RCC). We conducted a meta-analysis of two new scans of 5,198 cases and 7,331 controls together with four existing scans, totalling 10,784 cases and 20,406 controls of European ancestry. Twenty-four loci were tested in an additional 3,182 cases and 6,301 controls. We confirm the six known RCC risk loci and identify seven new loci at 1p32.3 (rs4381241, <jats:italic>P<\/jats:italic>=3.1 \u00d7 10<jats:sup>\u221210<\/jats:sup>), 3p22.1 (rs67311347, <jats:italic>P<\/jats:italic>=2.5 \u00d7 10<jats:sup>\u22128<\/jats:sup>), 3q26.2 (rs10936602, <jats:italic>P<\/jats:italic>=8.8 \u00d7 10<jats:sup>\u22129<\/jats:sup>), 8p21.3 (rs2241261, <jats:italic>P<\/jats:italic>=5.8 \u00d7 10<jats:sup>\u22129<\/jats:sup>), 10q24.33-q25.1 (rs11813268, <jats:italic>P<\/jats:italic>=3.9 \u00d7 10<jats:sup>\u22128<\/jats:sup>), 11q22.3 (rs74911261, <jats:italic>P<\/jats:italic>=2.1 \u00d7 10<jats:sup>\u221210<\/jats:sup>) and 14q24.2 (rs4903064, <jats:italic>P<\/jats:italic>=2.2 \u00d7 10<jats:sup>\u221224<\/jats:sup>). Expression quantitative trait analyses suggest plausible candidate genes at these regions that may contribute to RCC susceptibility.<\/jats:p>","DOI":"10.1038\/ncomms15724","type":"journal-article","created":{"date-parts":[[2017,6,9]],"date-time":"2017-06-09T15:26:28Z","timestamp":1497021988000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":115,"title":["Genome-wide association study identifies multiple risk loci for renal cell carcinoma"],"prefix":"10.1038","volume":"8","author":[{"given":"Ghislaine","family":"Scelo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark P.","family":"Purdue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin M.","family":"Brown","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mattias","family":"Johansson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaoming","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeanette E.","family":"Eckel-Passow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanqing","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan N.","family":"Hofmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiyeon","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthieu","family":"Foll","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerie","family":"Gaborieau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6538-9705","authenticated-orcid":false,"given":"Mitchell J.","family":"Machiela","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leandro M.","family":"Colli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua N.","family":"Sampson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Behnoush","family":"Abedi-Ardekani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celine","family":"Besse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helene","family":"Blanche","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Boland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurie","family":"Burdette","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amelie","family":"Chabrier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geoffroy","family":"Durand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florence","family":"Le Calvez-Kelm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Egor","family":"Prokhortchouk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nivonirina","family":"Robinot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantin G.","family":"Skryabin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdalena B.","family":"Wozniak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meredith","family":"Yeager","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gordana","family":"Basta-Jovanovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zoran","family":"Dzamic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lenka","family":"Foretova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivana","family":"Holcatova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladimir","family":"Janout","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dana","family":"Mates","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anush","family":"Mukeriya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Rascu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Zaridze","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladimir","family":"Bencko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cezary","family":"Cybulski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleonora","family":"Fabianova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viorel","family":"Jinga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jolanta","family":"Lissowska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Lubinski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Navratilova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Rudnai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neonila","family":"Szeszenia-Dabrowska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"Benhamou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geraldine","family":"Cancel-Tassin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Cussenot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Baglietto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heiner","family":"Boeing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kay-Tee","family":"Khaw","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabete","family":"Weiderpass","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Borje","family":"Ljungberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raviprakash T.","family":"Sitaram","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fiona","family":"Bruinsma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan J.","family":"Jordan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianluca","family":"Severi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingrid","family":"Winship","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristian","family":"Hveem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars J.","family":"Vatten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tony","family":"Fletcher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kvetoslava","family":"Koppova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0118-0341","authenticated-orcid":false,"given":"Susanna C.","family":"Larsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7387-6845","authenticated-orcid":false,"given":"Alicja","family":"Wolk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosamonde E.","family":"Banks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter J.","family":"Selby","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas F.","family":"Easton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8494-732X","authenticated-orcid":false,"given":"Paul","family":"Pharoah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriella","family":"Andreotti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura E. Beane","family":"Freeman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stella","family":"Koutros","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Demetrius","family":"Albanes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satu","family":"M\u00e4nnist\u00f6","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Weinstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter E.","family":"Clark","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4318-6119","authenticated-orcid":false,"given":"Todd L.","family":"Edwards","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Loren","family":"Lipworth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan M.","family":"Gapstur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria L.","family":"Stevens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hallie","family":"Carol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew L.","family":"Freedman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark M.","family":"Pomerantz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eunyoung","family":"Cho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Kraft","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark A.","family":"Preston","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn M.","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Michael Gaziano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Howard D.","family":"Sesso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda","family":"Black","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neal D.","family":"Freedman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Yi","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John G.","family":"Anema","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard J.","family":"Kahnoski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian R.","family":"Lane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabrina L.","family":"Noyes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Petillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin Tean","family":"Teh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrike","family":"Peters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"White","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Garnet L.","family":"Anderson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juhua","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Buring","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I-Min","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wong-Ho","family":"Chow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lee E.","family":"Moore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Wood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy","family":"Eisen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Henrion","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Larkin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Poulami","family":"Barman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bradley C.","family":"Leibovich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toni K.","family":"Choueiri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Mark Lathrop","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathaniel","family":"Rothman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Francois","family":"Deleuze","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James D.","family":"McKay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander S.","family":"Parker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xifeng","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard S.","family":"Houlston","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Brennan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen J.","family":"Chanock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,6,9]]},"reference":[{"key":"BFncomms15724_CR1","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.eururo.2014.10.002","volume":"67","author":"A Znaor","year":"2015","unstructured":"Znaor, A., Lortet-Tieulent, J., Laversanne, M., Jemal, A. & Bray, F. International variations and trends in renal cell carcinoma incidence and mortality. Eur. Urol. 67, 519\u2013530 (2015).","journal-title":"Eur. Urol."},{"key":"BFncomms15724_CR2","doi-asserted-by":"crossref","first-page":"6871","DOI":"10.1158\/0008-5472.CAN-05-4556","volume":"66","author":"E Gormally","year":"2006","unstructured":"Gormally, E. et al. TP53 and KRAS2 mutations in plasma DNA of healthy subjects and subsequent cancer occurrence: a prospective study. Cancer Res. 66, 6871\u20136876 (2006).","journal-title":"Cancer Res."},{"key":"BFncomms15724_CR3","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1097\/00000478-200305000-00005","volume":"27","author":"JC Cheville","year":"2003","unstructured":"Cheville, J. C., Lohse, C. M., Zincke, H., Weaver, A. L. & Blute, M. L. Comparisons of outcome and prognostic features among histologic subtypes of renal cell carcinoma. Am. J. Surg. Pathol. 27, 612\u2013624 (2003).","journal-title":"Am. J. Surg. Pathol."},{"key":"BFncomms15724_CR4","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1001\/jama.2015.17703","volume":"315","author":"LA Mucci","year":"2016","unstructured":"Mucci, L. A. et al. Familial risk and heritability of cancer among twins in Nordic countries. JAMA 315, 68\u201376 (2016).","journal-title":"JAMA"},{"key":"BFncomms15724_CR5","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1053\/j.ackd.2013.10.001","volume":"21","author":"NB Haas","year":"2014","unstructured":"Haas, N. B. & Nathanson, K. L. Hereditary kidney cancer syndromes. Adv. Chronic Kidney Dis. 21, 81\u201390 (2014).","journal-title":"Adv. Chronic Kidney Dis."},{"key":"BFncomms15724_CR6","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1038\/nrurol.2010.47","volume":"7","author":"WM Linehan","year":"2010","unstructured":"Linehan, W. M., Srinivasan, R. & Schmidt, L. S. The genetic basis of kidney cancer: a metabolic disease. Nat. Rev. Urol. 7, 277\u2013285 (2010).","journal-title":"Nat. Rev. Urol."},{"key":"BFncomms15724_CR7","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1158\/1055-9965.EPI-06-0963","volume":"16","author":"RJ Hung","year":"2007","unstructured":"Hung, R. J. et al. Family history and the risk of kidney cancer: a multicenter case-control study in Central Europe. Cancer Epidemiol. Biomark. Prev. 16, 1287\u20131290 (2007).","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"key":"BFncomms15724_CR8","doi-asserted-by":"crossref","first-page":"1676","DOI":"10.1038\/sj.bjc.6605680","volume":"102","author":"S Karami","year":"2010","unstructured":"Karami, S. et al. Family history of cancer and renal cell cancer risk in Caucasians and African Americans. Br. J. Cancer 102, 1676\u20131680 (2010).","journal-title":"Br. J. Cancer"},{"key":"BFncomms15724_CR9","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1038\/ng.723","volume":"43","author":"MP Purdue","year":"2011","unstructured":"Purdue, M. P. et al. Genome-wide association study of renal cell carcinoma identifies two susceptibility loci on 2p21 and 11q13.3. Nat. Genet. 43, 60\u201365 (2011).","journal-title":"Nat. Genet."},{"key":"BFncomms15724_CR10","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1093\/hmg\/ddr479","volume":"21","author":"X Wu","year":"2012","unstructured":"Wu, X. et al. A genome-wide association study identifies a novel susceptibility locus for renal cell carcinoma on 12p11.23. Hum. Mol. Genet. 21, 456\u2013462 (2012).","journal-title":"Hum. Mol. Genet."},{"key":"BFncomms15724_CR11","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1093\/hmg\/dds489","volume":"22","author":"M Henrion","year":"2013","unstructured":"Henrion, M. et al. Common variation at 2q22.3 (ZEB2) influences the risk of renal cancer. Hum. Mol. Genet. 22, 825\u2013831 (2013).","journal-title":"Hum. Mol. Genet."},{"key":"BFncomms15724_CR12","doi-asserted-by":"crossref","first-page":"2776","DOI":"10.1038\/ncomms3776","volume":"4","author":"J Gudmundsson","year":"2013","unstructured":"Gudmundsson, J. et al. A common variant at 8q24.21 is associated with renal cell cancer. Nat. Commun. 4, 2776 (2013).","journal-title":"Nat. Commun."},{"key":"BFncomms15724_CR13","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1038\/ng.2204","volume":"44","author":"J Schodel","year":"2012","unstructured":"Schodel, J. et al. Common genetic variants at the 11q13.3 renal cancer susceptibility locus influence binding of HIF to an enhancer of cyclin D1 expression. Nat. Genet. 44, 420\u2013425 (2012).","journal-title":"Nat. Genet."},{"key":"BFncomms15724_CR14","doi-asserted-by":"crossref","first-page":"12098","DOI":"10.1038\/ncomms12098","volume":"7","author":"P Bigot","year":"2016","unstructured":"Bigot, P. et al. Functional characterization of the 12p12.1 renal cancer-susceptibility locus implicates BHLHE41. Nat. Commun. 7, 12098 (2016).","journal-title":"Nat. Commun."},{"key":"BFncomms15724_CR15","doi-asserted-by":"crossref","first-page":"e0122589","DOI":"10.1371\/journal.pone.0122589","volume":"10","author":"MY Henrion","year":"2015","unstructured":"Henrion, M. Y. et al. Common variation at 1q24.1 (ALDH9A1) is a potential risk factor for renal cancer. PLoS ONE 10, e0122589 (2015).","journal-title":"PLoS ONE"},{"key":"BFncomms15724_CR16","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1093\/hmg\/ddr551","volume":"21","author":"SS Han","year":"2012","unstructured":"Han, S. S. et al. The chromosome 2p21 region harbors a complex genetic architecture for association with risk for renal cell carcinoma. Hum. Mol. Genet. 21, 1190\u20131200 (2012).","journal-title":"Hum. Mol. Genet."},{"key":"BFncomms15724_CR17","doi-asserted-by":"crossref","first-page":"3555","DOI":"10.1093\/bioinformatics\/btv402","volume":"31","author":"MJ Machiela","year":"2015","unstructured":"Machiela, M. J. & Chanock, S. J. LDlink: a web-based application for exploring population-specific haplotype structure and linking correlated alleles of possible functional variants. Bioinformatics 31, 3555\u20133557 (2015).","journal-title":"Bioinformatics"},{"key":"BFncomms15724_CR18","doi-asserted-by":"crossref","first-page":"D877","DOI":"10.1093\/nar\/gkv1340","volume":"44","author":"LD Ward","year":"2016","unstructured":"Ward, L. D. & Kellis, M. HaploReg v4: systematic mining of putative causal variants, cell types, regulators and target genes for human complex traits and disease. Nucleic Acids Res. 44, D877\u2013D881 (2016).","journal-title":"Nucleic Acids Res."},{"key":"BFncomms15724_CR19","doi-asserted-by":"crossref","first-page":"1790","DOI":"10.1101\/gr.137323.112","volume":"22","author":"AP Boyle","year":"2012","unstructured":"Boyle, A. P. et al. Annotation of functional variation in personal genomes using RegulomeDB. Genome Res. 22, 1790\u20131797 (2012).","journal-title":"Genome Res."},{"key":"BFncomms15724_CR20","doi-asserted-by":"crossref","unstructured":"Cancer Genome Atlas Research Network. Comprehensive molecular characterization of clear cell renal cell carcinoma. Nature 499, 43\u201349 (2013).","DOI":"10.1038\/nature12222"},{"key":"BFncomms15724_CR21","doi-asserted-by":"crossref","first-page":"e57886","DOI":"10.1371\/journal.pone.0057886","volume":"8","author":"MB Wozniak","year":"2013","unstructured":"Wozniak, M. B. et al. Integrative genome-wide gene expression profiling of clear cell renal cell carcinoma in Czech Republic and in the United States. PLoS ONE 8, e57886 (2013).","journal-title":"PLoS ONE"},{"key":"BFncomms15724_CR22","unstructured":"Roadmap Epigenomics Consortium. et al. Integrative analysis of 111 reference human epigenomes. Nature 518, 317\u2013330 (2015)."},{"key":"BFncomms15724_CR23","doi-asserted-by":"crossref","first-page":"5135","DOI":"10.1038\/ncomms6135","volume":"5","author":"G Scelo","year":"2014","unstructured":"Scelo, G. et al. Variation in genomic landscape of clear cell renal cell carcinoma across Europe. Nat. Commun. 5, 5135 (2014).","journal-title":"Nat. Commun."},{"key":"BFncomms15724_CR24","doi-asserted-by":"crossref","first-page":"1968","DOI":"10.1200\/JCO.2012.45.2003","volume":"32","author":"J Brugarolas","year":"2014","unstructured":"Brugarolas, J. Molecular genetics of clear-cell renal cell carcinoma. J. Clin. Oncol. 32, 1968\u20131976 (2014).","journal-title":"J. Clin. Oncol."},{"key":"BFncomms15724_CR25","doi-asserted-by":"crossref","first-page":"30701","DOI":"10.1074\/jbc.M112.353524","volume":"287","author":"L Zhang","year":"2012","unstructured":"Zhang, L. et al. Fas-associated factor 1 is a scaffold protein that promotes beta-transducin repeat-containing protein (beta-TrCP)-mediated beta-catenin ubiquitination and degradation. J. Biol. Chem. 287, 30701\u201330710 (2012).","journal-title":"J. Biol. Chem."},{"key":"BFncomms15724_CR26","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/j.biocel.2008.09.024","volume":"41","author":"WM Linehan","year":"2009","unstructured":"Linehan, W. M., Rubin, J. S. & Bottaro, D. P. VHL loss of function and its impact on oncogenic signaling networks in clear cell renal cell carcinoma. Int. J. Biochem. Cell Biol. 41, 753\u2013756 (2009).","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"BFncomms15724_CR27","unstructured":"DIAbetes Genetics Replication And Meta-analysis (DIAGRAM) Consortium. et al. Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility. Nat. Genet. 46, 234\u2013244 (2014)."},{"key":"BFncomms15724_CR28","doi-asserted-by":"crossref","first-page":"e0120890","DOI":"10.1371\/journal.pone.0120890","volume":"10","author":"MN Harder","year":"2015","unstructured":"Harder, M. N. et al. The type 2 diabetes risk allele of TMEM154-rs6813195 associates with decreased beta cell function in a study of 6,486 Danes. PLoS ONE 10, e0120890 (2015).","journal-title":"PLoS ONE"},{"key":"BFncomms15724_CR29","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1172\/JCI29900","volume":"118","author":"N Finnberg","year":"2008","unstructured":"Finnberg, N., Klein-Szanto, A. J. & El-Deiry, W. S. TRAIL-R deficiency in mice promotes susceptibility to chronic inflammation and tumorigenesis. J. Clin. Invest. 118, 111\u2013123 (2008).","journal-title":"J. Clin. Invest."},{"key":"BFncomms15724_CR30","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1038\/nprot.2009.86","volume":"4","author":"P Kumar","year":"2009","unstructured":"Kumar, P., Henikoff, S. & Ng, P. C. Predicting the effects of coding non-synonymous variants on protein function using the SIFT algorithm. Nat. Protoc. 4, 1073\u20131081 (2009).","journal-title":"Nat. Protoc."},{"key":"BFncomms15724_CR31","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1038\/nmeth0410-248","volume":"7","author":"IA Adzhubei","year":"2010","unstructured":"Adzhubei, I. A. et al. A method and server for predicting damaging missense mutations. Nat. Methods 7, 248\u2013249 (2010).","journal-title":"Nat. Methods"},{"key":"BFncomms15724_CR32","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1200\/JCO.2014.56.5101","volume":"33","author":"F Suarez","year":"2015","unstructured":"Suarez, F. et al. Incidence, presentation, and prognosis of malignancies in ataxia-telangiectasia: a report from the French national registry of primary immune deficiencies. J. Clin. Oncol. 33, 202\u2013208 (2015).","journal-title":"J. Clin. Oncol."},{"key":"BFncomms15724_CR33","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1097\/GIM.0b013e3181f415b5","volume":"12","author":"SA Savage","year":"2010","unstructured":"Savage, S. A. & Bertuch, A. A. The genetics and clinical manifestations of telomere biology disorders. Genet. Med. 12, 753\u2013764 (2010).","journal-title":"Genet. Med."},{"key":"BFncomms15724_CR34","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1038\/ng.2528","volume":"45","author":"V Codd","year":"2013","unstructured":"Codd, V. et al. Identification of seven loci affecting mean telomere length and their association with disease. Nat. Genet. 45, 422\u2013427 (2013).","journal-title":"Nat. Genet."},{"key":"BFncomms15724_CR35","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1038\/ng.2733","volume":"45","author":"D Chubb","year":"2013","unstructured":"Chubb, D. et al. Common variation at 3q26.2, 6p21.33, 17p11.2 and 22q13.1 influences multiple myeloma risk. Nat. Genet. 45, 1221\u20131225 (2013).","journal-title":"Nat. Genet."},{"key":"BFncomms15724_CR36","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1038\/ng.2843","volume":"46","author":"HE Speedy","year":"2014","unstructured":"Speedy, H. E. et al. A genome-wide association study identifies multiple susceptibility loci for chronic lymphocytic leukemia. Nat. Genet. 46, 56\u201360 (2014).","journal-title":"Nat. Genet."},{"key":"BFncomms15724_CR37","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1093\/hmg\/ddt519","volume":"23","author":"JD Figueroa","year":"2014","unstructured":"Figueroa, J. D. et al. Genome-wide association study identifies multiple loci associated with bladder cancer risk. Hum. Mol. Genet. 23, 1387\u20131398 (2014).","journal-title":"Hum. Mol. Genet."},{"key":"BFncomms15724_CR38","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1038\/ng.670","volume":"42","author":"RS Houlston","year":"2010","unstructured":"Houlston, R. S. et al. Meta-analysis of three genome-wide association studies identifies susceptibility loci for colorectal cancer at 1q41, 3q26.2, 12q13.13 and 20q13.33. Nat. Genet. 42, 973\u2013977 (2010).","journal-title":"Nat. Genet."},{"key":"BFncomms15724_CR39","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1038\/ng.3004","volume":"46","author":"KM Walsh","year":"2014","unstructured":"Walsh, K. M. et al. Variants near TERT and TERC influencing telomere length are associated with high-grade glioma risk. Nat. Genet. 46, 731\u2013735 (2014).","journal-title":"Nat. Genet."},{"key":"BFncomms15724_CR40","doi-asserted-by":"crossref","first-page":"9293","DOI":"10.1073\/pnas.0911494107","volume":"107","author":"D Levy","year":"2010","unstructured":"Levy, D. et al. Genome-wide association identifies OBFC1 as a locus involved in human leukocyte telomere biology. Proc. Natl Acad. Sci. USA 107, 9293\u20139298 (2010).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFncomms15724_CR41","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1038\/ng.3373","volume":"47","author":"MH Law","year":"2015","unstructured":"Law, M. H. et al. Genome-wide meta-analysis identifies five new susceptibility loci for cutaneous malignant melanoma. Nat. Genet. 47, 987\u2013995 (2015).","journal-title":"Nat. Genet."},{"key":"BFncomms15724_CR42","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1038\/ng.2354","volume":"44","author":"B Howie","year":"2012","unstructured":"Howie, B., Fuchsberger, C., Stephens, M., Marchini, J. & Abecasis, G. R. Fast and accurate genotype imputation in genome-wide association studies through pre-phasing. Nat. Genet. 44, 955\u2013959 (2012).","journal-title":"Nat. Genet."},{"key":"BFncomms15724_CR43","doi-asserted-by":"crossref","first-page":"e1000529","DOI":"10.1371\/journal.pgen.1000529","volume":"5","author":"BN Howie","year":"2009","unstructured":"Howie, B. N., Donnelly, P. & Marchini, J. A flexible and accurate genotype imputation method for the next generation of genome-wide association studies. PLoS Genet. 5, e1000529 (2009).","journal-title":"PLoS Genet."},{"key":"BFncomms15724_CR44","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.ajhg.2011.02.002","volume":"88","author":"SH Lee","year":"2011","unstructured":"Lee, S. H., Wray, N. R., Goddard, M. E. & Visscher, P. M. Estimating missing heritability for disease from genome-wide association studies. Am. J. Hum. Genet. 88, 294\u2013305 (2011).","journal-title":"Am. J. Hum. Genet."},{"key":"BFncomms15724_CR45","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1038\/ng.608","volume":"42","author":"J Yang","year":"2010","unstructured":"Yang, J. et al. Common SNPs explain a large proportion of the heritability for human height. Nat. Genet. 42, 565\u2013569 (2010).","journal-title":"Nat. Genet."},{"key":"BFncomms15724_CR46","doi-asserted-by":"crossref","first-page":"djv279","DOI":"10.1093\/jnci\/djv279","volume":"107","author":"JN Sampson","year":"2015","unstructured":"Sampson, J. N. et al. Analysis of heritability and shared heritability based on genome-wide association studies for thirteen cancer types. J. Natl Cancer Inst. 107, djv279 (2015).","journal-title":"J. Natl Cancer Inst."},{"key":"BFncomms15724_CR47","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1093\/bioinformatics\/btn224","volume":"24","author":"P Du","year":"2008","unstructured":"Du, P., Kibbe, W. A. & Lin, S. M. lumi: a pipeline for processing Illumina microarray. Bioinformatics 24, 1547\u20131548 (2008).","journal-title":"Bioinformatics"},{"key":"BFncomms15724_CR48","first-page":"7","volume":"25","author":"H Li","year":"2009","unstructured":"Li, H. & Durbin, R. Fast and accurate short read alignment with Burrows-Wheeler transform. Bioinformatics 25, 7 (2009).","journal-title":"Bioinformatics"}],"container-title":["Nature Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/ncomms15724.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/ncomms15724","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/doifinder\/10.1038\/ncomms15724","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/www.nature.com\/articles\/ncomms15724.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,23]],"date-time":"2022-12-23T00:33:16Z","timestamp":1671755596000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/ncomms15724"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6,9]]},"references-count":48,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2017,8,11]]}},"alternative-id":["BFncomms15724"],"URL":"https:\/\/doi.org\/10.1038\/ncomms15724","relation":{},"ISSN":["2041-1723"],"issn-type":[{"value":"2041-1723","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,6,9]]},"assertion":[{"value":"14 October 2016","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 April 2017","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 June 2017","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing financial interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"15724"}}