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In two-stage meta-analyses of genome-wide association studies for three HRV traits in up to 53,174 individuals of European ancestry, we detect 17 genome-wide significant SNPs in eight loci. HRV SNPs tag non-synonymous SNPs (in\n                    <jats:italic>NDUFA11<\/jats:italic>\n                    and\n                    <jats:italic>KIAA1755<\/jats:italic>\n                    ), expression quantitative trait loci (eQTLs) (influencing\n                    <jats:italic>GNG11<\/jats:italic>\n                    ,\n                    <jats:italic>RGS6<\/jats:italic>\n                    and\n                    <jats:italic>NEO1<\/jats:italic>\n                    ), or are located in genes preferentially expressed in the sinoatrial node (\n                    <jats:italic>GNG11<\/jats:italic>\n                    ,\n                    <jats:italic>RGS6<\/jats:italic>\n                    and\n                    <jats:italic>HCN4)<\/jats:italic>\n                    . Genetic risk scores account for 0.9 to 2.6% of the HRV variance. Significant genetic correlation is found for HRV with heart rate (\u22120.74&lt;\n                    <jats:italic>r<\/jats:italic>\n                    <jats:sub>\n                      <jats:italic>g<\/jats:italic>\n                    <\/jats:sub>\n                    &lt;\u22120.55) and blood pressure (\u22120.35&lt;\n                    <jats:italic>r<\/jats:italic>\n                    <jats:sub>\n                      <jats:italic>g<\/jats:italic>\n                    <\/jats:sub>\n                    &lt;\u22120.20). These findings provide clinically relevant biological insight into heritable variation in vagal heart rhythm regulation, with a key role for genetic variants (\n                    <jats:italic>GNG11<\/jats:italic>\n                    ,\n                    <jats:italic>RGS6)<\/jats:italic>\n                    that influence G-protein heterotrimer action in GIRK-channel induced pacemaker membrane hyperpolarization.\n                  <\/jats:p>","DOI":"10.1038\/ncomms15805","type":"journal-article","created":{"date-parts":[[2017,6,14]],"date-time":"2017-06-14T09:15:09Z","timestamp":1497431709000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":110,"title":["Genetic loci associated with heart rate variability and their effects on cardiac disease risk"],"prefix":"10.1038","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5047-4077","authenticated-orcid":false,"given":"Ilja M.","family":"Nolte","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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