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To investigate the genetic determinants of variation in grip strength, we perform a large-scale genetic discovery analysis in a combined sample of 195,180 individuals and identify 16 loci associated with grip strength (\n                    <jats:italic>P<\/jats:italic>\n                    &lt;5 \u00d7 10\n                    <jats:sup>\u22128<\/jats:sup>\n                    ) in combined analyses. A number of these loci contain genes implicated in structure and function of skeletal muscle fibres (\n                    <jats:italic>ACTG1<\/jats:italic>\n                    ), neuronal maintenance and signal transduction (\n                    <jats:italic>PEX14, TGFA, SYT1<\/jats:italic>\n                    ), or monogenic syndromes with involvement of psychomotor impairment (\n                    <jats:italic>PEX14, LRPPRC<\/jats:italic>\n                    and\n                    <jats:italic>KANSL1<\/jats:italic>\n                    ). Mendelian randomization analyses are consistent with a causal effect of higher genetically predicted grip strength on lower fracture risk. In conclusion, our findings provide new biological insight into the mechanistic underpinnings of grip strength and the causal role of muscular strength in age-related morbidities and mortality.\n                  <\/jats:p>","DOI":"10.1038\/ncomms16015","type":"journal-article","created":{"date-parts":[[2017,7,12]],"date-time":"2017-07-12T06:20:50Z","timestamp":1499840450000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":197,"title":["Large-scale GWAS identifies multiple loci for hand grip strength providing biological insights into muscular fitness"],"prefix":"10.1038","volume":"8","author":[{"given":"Sara M.","family":"Willems","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3983-2093","authenticated-orcid":false,"given":"Daniel 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