{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T04:45:34Z","timestamp":1791348334937,"version":"4.3.1"},"reference-count":59,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2012,1,3]],"date-time":"2012-01-03T00:00:00Z","timestamp":1325548800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/3.0\/"},{"start":{"date-parts":[[2012,1,3]],"date-time":"2012-01-03T00:00:00Z","timestamp":1325548800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/3.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nat Commun"],"DOI":"10.1038\/ncomms1612","type":"journal-article","created":{"date-parts":[[2012,1,3]],"date-time":"2012-01-03T03:59:37Z","timestamp":1325563177000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":134,"title":["Existence of long-lasting experience-dependent plasticity in endocrine cell networks"],"prefix":"10.1038","volume":"3","author":[{"given":"David J.","family":"Hodson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Schaeffer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Roman\u00f2","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Fontanaud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chrystel","family":"Lafont","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerome","family":"Birkenstock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Molino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen","family":"Christian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joe","family":"Lockey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle","family":"Carmignac","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Fernandez-Fuente","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Le Tissier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrice","family":"Mollard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2012,1,3]]},"reference":[{"key":"BFncomms1612_CR1","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1146\/annurev.immunol.20.100101.151926","volume":"20","author":"J Sprent","year":"2002","unstructured":"Sprent, J. & Surh, C. D. T cell memory. Annu. Rev. Immunol. 20, 551\u2013579 (2002).","journal-title":"Annu. Rev. Immunol."},{"key":"BFncomms1612_CR2","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1038\/nature07665","volume":"457","author":"JC Sun","year":"2009","unstructured":"Sun, J. C., Beilke, J. N. & Lanier, L. L. Adaptive immune features of natural killer cells. Nature 457, 557\u2013561 (2009).","journal-title":"Nature"},{"key":"BFncomms1612_CR3","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1038\/361031a0","volume":"361","author":"TV Bliss","year":"1993","unstructured":"Bliss, T. V. & Collingridge, G. L. A synaptic model of memory: long-term potentiation in the hippocampus. Nature 361, 31\u201339 (1993).","journal-title":"Nature"},{"key":"BFncomms1612_CR4","doi-asserted-by":"publisher","first-page":"782","DOI":"10.1038\/nature03012","volume":"431","author":"DB Chklovskii","year":"2004","unstructured":"Chklovskii, D. B., Mel, B. W. & Svoboda, K. Cortical rewiring and information storage. Nature 431, 782\u2013788 (2004).","journal-title":"Nature"},{"key":"BFncomms1612_CR5","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1038\/nrn2963","volume":"12","author":"RL Redondo","year":"2011","unstructured":"Redondo, R. L. & Morris, R. G. Making memories last: the synaptic tagging and capture hypothesis. Nat. Rev. Neurosci. 12, 17\u201330 (2011).","journal-title":"Nat. Rev. Neurosci."},{"key":"BFncomms1612_CR6","doi-asserted-by":"publisher","first-page":"1339","DOI":"10.1016\/S0092-8674(00)81828-0","volume":"87","author":"TJ McHugh","year":"1996","unstructured":"McHugh, T. J., Blum, K. I., Tsien, J. Z., Tonegawa, S. & Wilson, M. A. Impaired hippocampal representation of space in CA1-specific NMDAR1 knockout mice. Cell 87, 1339\u20131349 (1996).","journal-title":"Cell"},{"key":"BFncomms1612_CR7","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1038\/43432","volume":"401","author":"YP Tang","year":"1999","unstructured":"Tang, Y. P. et al. Genetic enhancement of learning and memory in mice. Nature 401, 63\u201369 (1999).","journal-title":"Nature"},{"key":"BFncomms1612_CR8","doi-asserted-by":"publisher","first-page":"16880","DOI":"10.1073\/pnas.0508202102","volume":"102","author":"X Bonnefont","year":"2005","unstructured":"Bonnefont, X. et al. Revealing the large-scale network organization of growth hormone-secreting cells. Proc. Natl Acad. Sci. USA 102, 16880\u201316885 (2005).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFncomms1612_CR9","doi-asserted-by":"publisher","first-page":"21878","DOI":"10.1073\/pnas.1010849107","volume":"107","author":"C Sanchez-Cardenas","year":"2010","unstructured":"Sanchez-Cardenas, C. et al. Pituitary growth hormone network responses are sexually dimorphic and regulated by gonadal steroids in adulthood. Proc. Natl Acad. Sci. USA 107, 21878\u201321883 (2010).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFncomms1612_CR10","doi-asserted-by":"publisher","first-page":"12515","DOI":"10.1073\/pnas.1105929108","volume":"108","author":"L Budry","year":"2011","unstructured":"Budry, L. et al. Related pituitary cell lineages develop into interdigitated 3D cell networks. Proc. Natl Acad. Sci. USA 108, 12515\u201312520 (2011).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFncomms1612_CR11","doi-asserted-by":"publisher","first-page":"4789","DOI":"10.1210\/en.2011-1430","volume":"152","author":"M Schaeffer","year":"2011","unstructured":"Schaeffer, M. et al. Influence of estrogens on GH-cell network dynamics in females: A live in Situ imaging approach. Endocrinology 152, 4789\u20134799 (2011).","journal-title":"Endocrinology"},{"key":"BFncomms1612_CR12","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1038\/nature00822","volume":"418","author":"M Ludwig","year":"2002","unstructured":"Ludwig, M. et al. Intracellular calcium stores regulate activity-dependent neuropeptide release from dendrites. Nature 418, 85\u201389 (2002).","journal-title":"Nature"},{"key":"BFncomms1612_CR13","doi-asserted-by":"publisher","first-page":"13773","DOI":"10.1073\/pnas.0503610102","volume":"102","author":"N Kashtan","year":"2005","unstructured":"Kashtan, N. & Alon, U. Spontaneous evolution of modularity and network motifs. Proc. Natl Acad. Sci. USA 102, 13773\u201313778 (2005).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFncomms1612_CR14","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1038\/nrn1607","volume":"6","author":"PW Frankland","year":"2005","unstructured":"Frankland, P. W. & Bontempi, B. The organization of recent and remote memories. Nat. Rev. Neurosci. 6, 119\u2013130 (2005).","journal-title":"Nat. Rev. Neurosci."},{"key":"BFncomms1612_CR15","doi-asserted-by":"publisher","first-page":"1523","DOI":"10.1152\/physrev.2000.80.4.1523","volume":"80","author":"ME Freeman","year":"2000","unstructured":"Freeman, M. E., Kanyicska, S., Lerant, A. & Nagy, G. Prolactin: structure, function, and regulation of secretion. Physiol. Rev. 80, 1523\u20131631 (2000).","journal-title":"Physiol. Rev."},{"key":"BFncomms1612_CR16","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1126\/science.1076647","volume":"299","author":"T Shingo","year":"2003","unstructured":"Shingo, T. et al. Pregnancy-stimulated neurogenesis in the adult female forebrain mediated by prolactin. Science 299, 117\u2013120 (2003).","journal-title":"Science"},{"key":"BFncomms1612_CR17","doi-asserted-by":"publisher","first-page":"3805","DOI":"10.1210\/en.2009-1385","volume":"151","author":"CM Larsen","year":"2010","unstructured":"Larsen, C. M. & Grattan, D. R. Prolactin-induced mitogenesis in the subventricular zone of the maternal brain during early pregnancy is essential for normal postpartum behavioral responses in the mother. Endocrinology 151, 3805\u20133814 (2010).","journal-title":"Endocrinology"},{"key":"BFncomms1612_CR18","doi-asserted-by":"publisher","first-page":"782","DOI":"10.1126\/science.3969568","volume":"227","author":"RS Bridges","year":"1985","unstructured":"Bridges, R. S., DiBiase, R., Loundes, D. D. & Doherty, P. C. Prolactin stimulation of maternal behavior in female rats. Science 227, 782\u2013784 (1985).","journal-title":"Science"},{"key":"BFncomms1612_CR19","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1016\/S0896-6273(00)80993-9","volume":"20","author":"TH Schwartz","year":"1998","unstructured":"Schwartz, T. H. et al. Networks of coactive neurons in developing layer 1. Neuron 20, 541\u2013552 (1998).","journal-title":"Neuron"},{"key":"BFncomms1612_CR20","doi-asserted-by":"publisher","first-page":"3619","DOI":"10.1073\/pnas.97.7.3619","volume":"97","author":"ZA Peterlin","year":"2000","unstructured":"Peterlin, Z. A., Kozloski, J., Mao, B. Q., Tsiola, A. & Yuste, R. Optical probing of neuronal circuits with calcium indicators. Proc. Natl Acad. Sci. USA 97, 3619\u20133624 (2000).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFncomms1612_CR21","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1038\/329719a0","volume":"329","author":"W Schlegel","year":"1987","unstructured":"Schlegel, W. et al. Oscillations of cytosolic Ca2+ in pituitary cells due to action potentials. Nature 329, 719\u2013721 (1987).","journal-title":"Nature"},{"key":"BFncomms1612_CR22","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1111\/j.1365-2826.2010.02104.x","volume":"23","author":"Z He","year":"2011","unstructured":"He, Z. et al. Continuous on-line monitoring of secretion from rodent pituitary endocrine cells using fluorescent protein surrogate markers. J. Neuroendocrinol. 23, 197\u2013207 (2011).","journal-title":"J. Neuroendocrinol."},{"key":"BFncomms1612_CR23","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1126\/science.1173299","volume":"325","author":"AL Barabasi","year":"2009","unstructured":"Barabasi, A. L. Scale-free networks: a decade and beyond. Science 325, 412\u2013413 (2009).","journal-title":"Science"},{"key":"BFncomms1612_CR24","doi-asserted-by":"publisher","first-page":"1419","DOI":"10.1126\/science.1175509","volume":"326","author":"P Bonifazi","year":"2009","unstructured":"Bonifazi, P. et al. GABAergic hub neurons orchestrate synchrony in developing hippocampal networks. Science 326, 1419\u20131424 (2009).","journal-title":"Science"},{"key":"BFncomms1612_CR25","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/0006-8993(81)90036-6","volume":"212","author":"M Selmanoff","year":"1981","unstructured":"Selmanoff, M. & Wise, P. M. Decreased dopamine turnover in the median eminence in response to suckling in the lactating rat. Brain Res. 212, 101\u2013115 (1981).","journal-title":"Brain Res."},{"key":"BFncomms1612_CR26","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1159\/000123449","volume":"36","author":"KT Demarest","year":"1983","unstructured":"Demarest, K. T., McKay, D. W., Riegle, G. D. & Moore, K. E. Biochemical indices of tuberoinfundibular dopaminergic neuronal activity during lactation: a lack of response to prolactin. Neuroendocrinology 36, 130\u2013137 (1983).","journal-title":"Neuroendocrinology"},{"key":"BFncomms1612_CR27","doi-asserted-by":"publisher","first-page":"4688","DOI":"10.1210\/en.2006-0600","volume":"147","author":"GM Anderson","year":"2006","unstructured":"Anderson, G. M., Grattan, D. R., van den Ancker, W. & Bridges, R. S. Reproductive experience increases prolactin responsiveness in the medial preoptic area and arcuate nucleus of female rats. Endocrinology 147, 4688\u20134694 (2006).","journal-title":"Endocrinology"},{"key":"BFncomms1612_CR28","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1677\/JOE-09-0414","volume":"205","author":"E Castrique","year":"2010","unstructured":"Castrique, E., Fernandez-Fuente, M., Le Tissier, P., Herman, A. & Levy, A. Use of a prolactin-Cre\/ROSA-YFP transgenic mouse provides no evidence for lactotroph transdifferentiation after weaning, or increase in lactotroph\/somatotroph proportion in lactation. J. Endocrinol. 205, 49\u201360 (2010).","journal-title":"J. Endocrinol."},{"key":"BFncomms1612_CR29","doi-asserted-by":"publisher","first-page":"10389","DOI":"10.1074\/jbc.273.17.10389","volume":"273","author":"NC Guerineau","year":"1998","unstructured":"Guerineau, N. C., Bonnefont, X., Stoeckel, L. & Mollard, P. Synchronized spontaneous Ca2+ transients in acute anterior pituitary slices. J. Biol. Chem. 273, 10389\u201310395 (1998).","journal-title":"J. Biol. Chem."},{"key":"BFncomms1612_CR30","doi-asserted-by":"publisher","first-page":"8891","DOI":"10.1073\/pnas.151339598","volume":"98","author":"T Fauquier","year":"2001","unstructured":"Fauquier, T., Guerineau, N. C., McKinney, R. A., Bauer, K. & Mollard, P. Folliculostellate cell network: a route for long-distance communication in the anterior pituitary. Proc. Natl Acad. Sci. USA 98, 8891\u20138896 (2001).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFncomms1612_CR31","doi-asserted-by":"publisher","first-page":"4465","DOI":"10.1073\/pnas.0902599107","volume":"107","author":"C Lafont","year":"2010","unstructured":"Lafont, C. et al. Cellular in vivo imaging reveals coordinated regulation of pituitary microcirculation and GH cell network function. Proc. Natl Acad. Sci. USA 107, 4465\u20134470 (2010).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFncomms1612_CR32","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1210\/er.2010-0005","volume":"31","author":"SS Stojilkovic","year":"2010","unstructured":"Stojilkovic, S. S., Tabak, J. & Bertram, R. Ion channels and signaling in the pituitary gland. Endocr. Rev. 31, 845\u2013915 (2010).","journal-title":"Endocr. Rev."},{"key":"BFncomms1612_CR33","doi-asserted-by":"publisher","first-page":"5397","DOI":"10.1523\/JNEUROSCI.21-15-05397.2001","volume":"21","author":"AO Martin","year":"2001","unstructured":"Martin, A. O., Mathieu, M. N., Chevillard, C. & Guerineau, N. C. Gap junctions mediate electrical signaling and ensuing cytosolic Ca2+ increases between chromaffin cells in adrenal slices: a role in catecholamine release. J. Neurosci. 21, 5397\u20135405 (2001).","journal-title":"J. Neurosci."},{"key":"BFncomms1612_CR34","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1159\/000125344","volume":"51","author":"M Eriksson","year":"1990","unstructured":"Eriksson, M. & Uvnas-Moberg, K. Plasma levels of vasoactive intestinal polypeptide and oxytocin in response to suckling, electrical stimulation of the mammary nerve and oxytocin infusion in rats. Neuroendocrinology 51, 237\u2013240 (1990).","journal-title":"Neuroendocrinology"},{"key":"BFncomms1612_CR35","doi-asserted-by":"publisher","first-page":"1981","DOI":"10.1210\/endo-126-4-1981","volume":"126","author":"IE Wanke","year":"1990","unstructured":"Wanke, I. E. & Rorstad, O. P. Receptors for vasoactive intestinal peptide in rat anterior pituitary glands: localization of binding to lactotropes. Endocrinology 126, 1981\u20131988 (1990).","journal-title":"Endocrinology"},{"key":"BFncomms1612_CR36","doi-asserted-by":"publisher","first-page":"2292","DOI":"10.1210\/en.2008-1611","volume":"150","author":"JE Kennett","year":"2009","unstructured":"Kennett, J. E., Poletini, M. O., Fitch, C. A. & Freeman, M. E. Antagonism of oxytocin prevents suckling- and estradiol-induced, but not progesterone-induced, secretion of prolactin. Endocrinology 150, 2292\u20132299 (2009).","journal-title":"Endocrinology"},{"key":"BFncomms1612_CR37","doi-asserted-by":"publisher","first-page":"1113","DOI":"10.1152\/jappl.1982.52.5.1113","volume":"52","author":"FW Booth","year":"1982","unstructured":"Booth, F. W. Effect of limb immobilization on skeletal muscle. J. Appl. Physiol. 52, 1113\u20131118 (1982).","journal-title":"J. Appl. Physiol."},{"key":"BFncomms1612_CR38","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1152\/jappl.1979.47.2.435","volume":"47","author":"FW Booth","year":"1979","unstructured":"Booth, F. W. & Seider, M. J. Recovery of skeletal muscle after 3 mo of hindlimb immobilization in rats. J. Appl. Physiol. 47, 435\u2013439 (1979).","journal-title":"J. Appl. Physiol."},{"key":"BFncomms1612_CR39","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/S0079-6123(01)33012-1","volume":"133","author":"DR Grattan","year":"2001","unstructured":"Grattan, D. R. The actions of prolactin in the brain during pregnancy and lactation. Prog. Brain Res. 133, 153\u2013171 (2001).","journal-title":"Prog. Brain Res."},{"key":"BFncomms1612_CR40","doi-asserted-by":"publisher","first-page":"752","DOI":"10.1111\/j.1365-2826.2008.01736.x","volume":"20","author":"DR Grattan","year":"2008","unstructured":"Grattan, D. R. & Kokay, I. C. Prolactin: a pleiotropic neuroendocrine hormone. J. Neuroendocrinol. 20, 752\u2013763 (2008).","journal-title":"J. Neuroendocrinol."},{"key":"BFncomms1612_CR41","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1038\/45957","volume":"402","author":"CH Kinsley","year":"1999","unstructured":"Kinsley, C. H. et al. Motherhood improves learning and memory. Nature 402, 137\u2013138 (1999).","journal-title":"Nature"},{"key":"BFncomms1612_CR42","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1038\/nn1023","volume":"6","author":"K Tomizawa","year":"2003","unstructured":"Tomizawa, K. et al. Oxytocin improves long-lasting spatial memory during motherhood through MAP kinase cascade. Nat. Neurosci. 6, 384\u2013390 (2003).","journal-title":"Nat. Neurosci."},{"key":"BFncomms1612_CR43","first-page":"125","volume":"26","author":"J Townsend","year":"2005","unstructured":"Townsend, J. et al. Effects of prolactin on hypothalamic supraoptic neurones: evidence for modulation of STAT5 expression and electrical activity. Neuro. Endocrinol. Lett. 26, 125\u2013130 (2005).","journal-title":"Neuro. Endocrinol. Lett."},{"key":"BFncomms1612_CR44","doi-asserted-by":"publisher","first-page":"R1216\u2013","DOI":"10.1152\/ajpregu.00730.2005","volume":"290","author":"IC Kokay","year":"2006","unstructured":"Kokay, I. C., Bull, P. M., Davis, R. L., Ludwig, M. & Grattan, D. R. Expression of the long form of the prolactin receptor in magnocellular oxytocin neurons is associated with specific prolactin regulation of oxytocin neurons. Am. J. Physiol. Regul. Integr. Comp. Physiol. 290, R1216\u2013 R1225 (2006).","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"BFncomms1612_CR45","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1016\/j.cell.2007.02.044","volume":"129","author":"I Konstantinova","year":"2007","unstructured":"Konstantinova, I. et al. EphA-Ephrin-A-mediated beta cell communication regulates insulin secretion from pancreatic islets. Cell 129, 359\u2013370 (2007).","journal-title":"Cell"},{"key":"BFncomms1612_CR46","doi-asserted-by":"publisher","first-page":"1798","DOI":"10.2337\/diabetes.54.6.1798","volume":"54","author":"MA Ravier","year":"2005","unstructured":"Ravier, M. A. et al. Loss of connexin36 channels alters beta-cell coupling, islet synchronization of glucose-induced Ca2+ and insulin oscillations, and basal insulin release. Diabetes 54, 1798\u20131807 (2005).","journal-title":"Diabetes"},{"key":"BFncomms1612_CR47","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1007\/BF00550880","volume":"418","author":"RM Santos","year":"1991","unstructured":"Santos, R. M. et al. Widespread synchronous [Ca2+]i oscillations due to bursting electrical activity in single pancreatic islets. Pflugers Arch. 418, 417\u2013422 (1991).","journal-title":"Pflugers Arch."},{"key":"BFncomms1612_CR48","doi-asserted-by":"publisher","first-page":"818","DOI":"10.1111\/j.1471-0528.1978.tb15835.x","volume":"85","author":"FA Van Assche","year":"1978","unstructured":"Van Assche, F. A., Aerts, L. & De Prins, F. A morphological study of the endocrine pancreas in human pregnancy. Br. J. Obstet. Gynaecol. 85, 818\u2013820 (1978).","journal-title":"Br. J. Obstet. Gynaecol."},{"key":"BFncomms1612_CR49","doi-asserted-by":"publisher","first-page":"806","DOI":"10.1126\/science.1146812","volume":"318","author":"SK Karnik","year":"2007","unstructured":"Karnik, S. K. et al. Menin controls growth of pancreatic beta-cells in pregnant mice and promotes gestational diabetes mellitus. Science 318, 806\u2013809 (2007).","journal-title":"Science"},{"key":"BFncomms1612_CR50","doi-asserted-by":"publisher","first-page":"1467","DOI":"10.1210\/endo-119-4-1467","volume":"119","author":"C Orskov","year":"1986","unstructured":"Orskov, C. et al. Glucagon-like peptides GLP-1 and GLP-2, predicted products of the glucagon gene, are secreted separately from pig small intestine but not pancreas. Endocrinology 119, 1467\u20131475 (1986).","journal-title":"Endocrinology"},{"key":"BFncomms1612_CR51","doi-asserted-by":"publisher","first-page":"656","DOI":"10.1038\/45230","volume":"402","author":"M Kojima","year":"1999","unstructured":"Kojima, M. et al. Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 402, 656\u2013660 (1999).","journal-title":"Nature"},{"key":"BFncomms1612_CR52","first-page":"546","volume":"59","author":"F Feyrter","year":"1938","unstructured":"Feyrter, F. \u00dcber diffuse endokrine epitheliale Organe. Zentralblatt Innere Medizin 59, 546\u2013556 (1938).","journal-title":"Zentralblatt Innere Medizin"},{"key":"BFncomms1612_CR53","doi-asserted-by":"publisher","first-page":"4681","DOI":"10.1210\/endo.141.12.7828","volume":"141","author":"C Magoulas","year":"2000","unstructured":"Magoulas, C. et al. A secreted fluorescent reporter targeted to pituitary growth hormone cells in transgenic mice. Endocrinology 141, 4681\u20134689 (2000).","journal-title":"Endocrinology"},{"key":"BFncomms1612_CR54","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1159\/000274493","volume":"91","author":"C Sanchez-Cardenas","year":"2010","unstructured":"Sanchez-Cardenas, C. & Hernandez-Cruz, A. GnRH-Induced [Ca2+]i-signalling patterns in mouse gonadotrophs recorded from acute pituitary slices in vitro. Neuroendocrinology 91, 239\u2013255 (2010).","journal-title":"Neuroendocrinology"},{"key":"BFncomms1612_CR55","doi-asserted-by":"publisher","first-page":"2519","DOI":"10.1529\/biophysj.106.102459","volume":"93","author":"R Niesner","year":"2007","unstructured":"Niesner, R., Andresen, V., Neumann, J., Spiecker, H. & Gunzer, M. The power of single and multibeam two-photon microscopy for high-resolution and high-speed deep tissue and intravital imaging. Biophys. J. 93, 2519\u20132529 (2007).","journal-title":"Biophys. J."},{"key":"BFncomms1612_CR56","doi-asserted-by":"publisher","first-page":"720","DOI":"10.1210\/en.2002-220847","volume":"144","author":"L McGuinness","year":"2003","unstructured":"McGuinness, L. et al. Autosomal dominant growth hormone deficiency disrupts secretory vesicles in vitro and in vivo in transgenic mice. Endocrinology 144, 720\u2013731 (2003).","journal-title":"Endocrinology"},{"key":"BFncomms1612_CR57","doi-asserted-by":"publisher","first-page":"1429","DOI":"10.1172\/JCI117813","volume":"95","author":"Y Munari-Silem","year":"1995","unstructured":"Munari-Silem, Y., Lebrethon, M. C., Morand, I., Rousset, B. & Saez, J. M. Gap junction-mediated cell-to-cell communication in bovine and human adrenal cells. A process whereby cells increase their responsiveness to physiological corticotropin concentrations. J. Clin. Invest. 95, 1429\u20131439 (1995).","journal-title":"J. Clin. Invest."},{"key":"BFncomms1612_CR58","doi-asserted-by":"publisher","first-page":"990","DOI":"10.1210\/endo-127-3-990","volume":"127","author":"PM Lledo","year":"1990","unstructured":"Lledo, P. M., Legendre, P., Israel, J. M. & Vincent, J. D. Dopamine inhibits two characterized voltage-dependent calcium currents in identified rat lactotroph cells. Endocrinology 127, 990\u20131001 (1990).","journal-title":"Endocrinology"},{"key":"BFncomms1612_CR59","doi-asserted-by":"publisher","first-page":"1217","DOI":"10.1111\/j.1365-2826.2010.02052.x","volume":"22","author":"DJ Hodson","year":"2010","unstructured":"Hodson, D. J., Molino, F., Fontanaud, P., Bonnefont, X. & Mollard, P. Investigating and Modelling Pituitary Endocrine Network Function. J. Neuroendocrinol. 22, 1217\u20131225 (2010).","journal-title":"J. Neuroendocrinol."}],"container-title":["Nature Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/ncomms1612","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/ncomms1612.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/ncomms1612.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,5]],"date-time":"2023-01-05T19:49:08Z","timestamp":1672948148000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/ncomms1612"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,1,3]]},"references-count":59,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2012,1]]}},"alternative-id":["BFncomms1612"],"URL":"https:\/\/doi.org\/10.1038\/ncomms1612","relation":{},"ISSN":["2041-1723"],"issn-type":[{"value":"2041-1723","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,1,3]]},"assertion":[{"value":"3 May 2011","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 November 2011","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 January 2012","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing financial interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"605"}}