{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,9]],"date-time":"2026-11-09T23:29:19Z","timestamp":1794266959929,"version":"4.9.0"},"reference-count":46,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2012,9,25]],"date-time":"2012-09-25T00:00:00Z","timestamp":1348531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/3.0\/"},{"start":{"date-parts":[[2012,9,25]],"date-time":"2012-09-25T00:00:00Z","timestamp":1348531200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/3.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nat Commun"],"DOI":"10.1038\/ncomms2090","type":"journal-article","created":{"date-parts":[[2012,9,25]],"date-time":"2012-09-25T09:56:15Z","timestamp":1348566975000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":561,"title":["The miRNA-212\/132 family regulates both cardiac hypertrophy and cardiomyocyte autophagy"],"prefix":"10.1038","volume":"3","author":[{"given":"Ahmet","family":"Ucar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shashi K.","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Fiedler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erdem","family":"Erikci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michal","family":"Kardasinski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandor","family":"Batkai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seema","family":"Dangwal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Regalla","family":"Kumarswamy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Bang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelika","family":"Holzmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janet","family":"Remke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimiliano","family":"Caprio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Jentzsch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Engelhardt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine","family":"Geisendorf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"Glas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas G.","family":"Hofmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Nessling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karsten","family":"Richter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Schiffer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucie","family":"Carrier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. Christian","family":"Napp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johann","family":"Bauersachs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamal","family":"Chowdhury","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Thum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2012,9,25]]},"reference":[{"key":"BFncomms2090_CR1","doi-asserted-by":"publisher","first-page":"1370","DOI":"10.1056\/NEJMra072139","volume":"358","author":"JA Hill","year":"2008","unstructured":"Hill, J. A. & Olson, E. N. Cardiac plasticity. N. Engl. J. Med. 358, 1370\u20131380 (2008).","journal-title":"N. Engl. J. Med."},{"key":"BFncomms2090_CR2","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/S1937-6448(10)84003-1","volume":"284","author":"SP Barry","year":"2010","unstructured":"Barry, S. P. & Townsend, P. A. What causes a broken heart-molecular insights into heart failure. Int. Rev. Cell Mol. Biol. 284, 113\u2013179 (2010).","journal-title":"Int. Rev. Cell Mol. Biol."},{"key":"BFncomms2090_CR3","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1146\/annurev-physiol-021909-135931","volume":"72","author":"SM Ronnebaum","year":"2010","unstructured":"Ronnebaum, S. M. & Patterson, C. The FoxO family in cardiac function and dysfunction. Annu. Rev. Physiol. 72, 81\u201394 (2010).","journal-title":"Annu. Rev. Physiol."},{"key":"BFncomms2090_CR4","doi-asserted-by":"publisher","first-page":"1159","DOI":"10.1161\/CIRCULATIONAHA.106.637124","volume":"114","author":"YG Ni","year":"2006","unstructured":"Ni, Y. G. et al. Foxo transcription factors blunt cardiac hypertrophy by inhibiting calcineurin signaling. Circulation 114, 1159\u20131168 (2006).","journal-title":"Circulation"},{"key":"BFncomms2090_CR5","first-page":"267","volume":"346","author":"DJ Glas","year":"2010","unstructured":"Glas, D. J. PI3 kinase regulation of skeletal muscle hypertrophy and atrophy. Curr. Top. Microbiol. Immunol. 346, 267\u2013278 (2010).","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"BFncomms2090_CR6","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1146\/annurev-physiol-021909-135757","volume":"72","author":"RA Gottlieb","year":"2010","unstructured":"Gottlieb, R. A. & Mentzer, R. M. Autophagy during cardiac stress: joys and frustrations of autophagy. Annu. Rev. Physiol. 72, 45\u201359 (2010).","journal-title":"Annu. Rev. Physiol."},{"key":"BFncomms2090_CR7","doi-asserted-by":"publisher","first-page":"1295","DOI":"10.1016\/j.bbamcr.2010.11.017","volume":"1813","author":"RA Gottlieb","year":"2011","unstructured":"Gottlieb, R. A. & Gustafsson, A. B. Mitochondrial turnover in the heart. Biochim. Biophys. Acta. 1813, 1295\u20131301 (2011).","journal-title":"Biochim. Biophys. Acta."},{"key":"BFncomms2090_CR8","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1038\/nm1574","volume":"13","author":"A Nakai","year":"2007","unstructured":"Nakai, A. et al. The role of autophagy in cardiomyocytes in the basal state and in response to hemodynamic stress. Nat. Med. 13, 619\u2013624 (2007).","journal-title":"Nat. Med."},{"key":"BFncomms2090_CR9","doi-asserted-by":"publisher","first-page":"4123","DOI":"10.1073\/pnas.1015081108","volume":"108","author":"DJ Cao","year":"2011","unstructured":"Cao, D. J. et al. Histone deacetylase (HDAC) inhibitors attenuate cardiac hypertrophy by suppressing autophagy. Proc. Natl Acad. Sci. USA 108, 4123\u20134128 (2011).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFncomms2090_CR10","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1101\/gad.1399806","volume":"20","author":"MA Valencia-Sanchez","year":"2006","unstructured":"Valencia-Sanchez, M. A., Liu, J., Hannon, G. J. & Parker, G. Control of translation and mRNA degradation by miRNAs and siRNAs. Genes Dev. 20, 515\u2013524 (2006).","journal-title":"Genes Dev."},{"key":"BFncomms2090_CR11","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1016\/j.cell.2009.01.002","volume":"136","author":"DP Bartel","year":"2009","unstructured":"Bartel, D. P. MicroRNAs: target recognition and regulatory functions. Cell 136, 215\u2013233 (2009).","journal-title":"Cell"},{"key":"BFncomms2090_CR12","doi-asserted-by":"publisher","first-page":"2111","DOI":"10.1073\/pnas.0710228105","volume":"105","author":"JF Chen","year":"2008","unstructured":"Chen, J. F. et al. Targeted deletion of Dicer in the heart leads to dilated cardiomyopathy and heart failure. Proc. Natl Acad. Sci. USA 105, 2111\u20132116 (2008).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFncomms2090_CR13","doi-asserted-by":"publisher","first-page":"1567","DOI":"10.1161\/CIRCULATIONAHA.108.769984","volume":"118","author":"PA da Costa Martins","year":"2008","unstructured":"da Costa Martins, P. A. et al. Conditional dicer gene deletion in the postnatal myocardium provokes spontaneous cardiac remodeling. Circulation 118, 1567\u20131576 (2008).","journal-title":"Circulation"},{"key":"BFncomms2090_CR14","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1161\/CIRCRESAHA.109.200451","volume":"105","author":"PK Rao","year":"2009","unstructured":"Rao, P. K. et al. Loss of cardiac microRNA-mediated regulation leads to dilated cardiomyopathy and heart failure. Circ. Res. 105, 585\u2013594 (2009).","journal-title":"Circ. Res."},{"key":"BFncomms2090_CR15","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1126\/science.1139089","volume":"316","author":"E van Rooij","year":"2007","unstructured":"van Rooij, E. et al. Control of stress-dependent cardiac growth and gene expression by a microRNA. Science 316, 575\u2013579 (2007).","journal-title":"Science"},{"key":"BFncomms2090_CR16","doi-asserted-by":"publisher","first-page":"662","DOI":"10.1016\/j.devcel.2009.10.013","volume":"17","author":"E van Rooij","year":"2009","unstructured":"van Rooij, E. et al. A family of microRNAs encoded by myosin genes governs myosin expression and muscle performance. Dev. Cell. 17, 662\u2013673 (2009).","journal-title":"Dev. Cell."},{"key":"BFncomms2090_CR17","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1016\/j.cell.2007.03.030","volume":"129","author":"Y Zhao","year":"2007","unstructured":"Zhao, Y. et al. Dysregulation of cardiogenesis, cardiac conduction, and cell cycle in mice lacking miRNA-1-2. Cell 129, 303\u2013317 (2007).","journal-title":"Cell"},{"key":"BFncomms2090_CR18","doi-asserted-by":"publisher","first-page":"875","DOI":"10.1016\/j.cell.2008.02.019","volume":"132","author":"A Ventura","year":"2008","unstructured":"Ventura, A. et al. Targeted deletion reveals essential and overlapping functions of the miR-17 through 92 family of miRNA clusters. Cell 132, 875\u2013886 (2008).","journal-title":"Cell"},{"key":"BFncomms2090_CR19","doi-asserted-by":"publisher","first-page":"3242","DOI":"10.1101\/gad.1738708","volume":"22","author":"N Liu","year":"2008","unstructured":"Liu, N. et al. MicroRNA-133 regulates cardiomyocyte proliferation and suppresses smooth muscle gene expression in the heart. Genes Dev. 22, 3242\u20133254 (2008).","journal-title":"Genes Dev."},{"key":"BFncomms2090_CR20","doi-asserted-by":"publisher","first-page":"2772","DOI":"10.1172\/JCI36154","volume":"119","author":"TE Callis","year":"2009","unstructured":"Callis, T. E. et al. MicroRNA-208a is a regulator of cardiac hypertrophy and conduction in mice. J. Clin. Invest. 119, 2772\u20132786 (2009).","journal-title":"J. Clin. Invest."},{"key":"BFncomms2090_CR21","doi-asserted-by":"publisher","first-page":"1220","DOI":"10.1038\/ncb2126","volume":"12","author":"PA da Costa Martins","year":"2010","unstructured":"da Costa Martins, P. A. et al. MicroRNA-199b targets the nuclear kinase Dyrk1a in an auto-amplification loop promoting calcineurin\/NFAT signalling. Nat. Cell Biol. 12, 1220\u20131227 (2010).","journal-title":"Nat. Cell Biol."},{"key":"BFncomms2090_CR22","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1161\/CIRCULATIONAHA.107.687947","volume":"116","author":"T Thum","year":"2007","unstructured":"Thum, T. et al. MicroRNAs in the human heart: a clue to fetal gene reprogramming in heart failure. Circulation 116, 258\u2013267 (2007).","journal-title":"Circulation"},{"key":"BFncomms2090_CR23","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1161\/CIRCRESAHA.110.228676","volume":"109","author":"J Bauersachs","year":"2011","unstructured":"Bauersachs, J. & Thum, T. Biogenesis and regulation of cardiovascular microRNAs. Circ. Res. 109, 334\u2013347 (2011).","journal-title":"Circ. Res."},{"key":"BFncomms2090_CR24","doi-asserted-by":"publisher","first-page":"980","DOI":"10.1038\/nature07511","volume":"456","author":"T Thum","year":"2008","unstructured":"Thum, T. et al. MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts. Nature 456, 980\u2013984 (2008).","journal-title":"Nature"},{"key":"BFncomms2090_CR25","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.yjmcc.2011.07.010","volume":"52","author":"C Jentzsch","year":"2011","unstructured":"Jentzsch, C. et al. A phenotypic screen to identify hypertrophy-modulating microRNAs in primary cardiomyocytes. J. Mol. Cell. Cardiol. 52, 13\u201320 (2011).","journal-title":"J. Mol. Cell. Cardiol."},{"key":"BFncomms2090_CR26","doi-asserted-by":"publisher","first-page":"1101","DOI":"10.1038\/ng.709","volume":"42","author":"A Ucar","year":"2010","unstructured":"Ucar, A. et al. mir-212 and miR-132 are required for epithelial stromal interactions necessary for mouse mammary gland development. Nat. Genet. 42, 1101\u20131008 (2010).","journal-title":"Nat. Genet."},{"key":"BFncomms2090_CR27","doi-asserted-by":"publisher","first-page":"563","DOI":"10.4161\/cc.10.4.14737","volume":"10","author":"A Ucar","year":"2011","unstructured":"Ucar, A., Vafaizadeh, V., Chowdhury, K. & Groner, B. MicroRNA-dependent regulation of the microenvironment and the epithelial stromal cell interactions in the mouse mammary gland. Cell Cycle 10, 563\u2013565 (2011).","journal-title":"Cell Cycle"},{"key":"BFncomms2090_CR28","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1016\/S0092-8674(04)00400-3","volume":"117","author":"M Sandri","year":"2004","unstructured":"Sandri, M. et al. Foxo transcription factors induce the atrophy related ubiquitin ligase atrogin-1 and cause skeletal muscle atrophy. Cell 117, 399\u2013412 (2004).","journal-title":"Cell"},{"key":"BFncomms2090_CR29","doi-asserted-by":"publisher","first-page":"1058","DOI":"10.1172\/JCI200422220","volume":"114","author":"HH Li","year":"2004","unstructured":"Li, H. H. et al. Atrogin-1\/muscle atrophy F-box inhibits calcineurin-dependent cardiac hypertrophy by participating in an SCF ubiquitin ligase complex. J. Clin. Invest. 114, 1058\u20131071 (2004).","journal-title":"J. Clin. Invest."},{"key":"BFncomms2090_CR30","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/S1050-1738(02)00188-3","volume":"13","author":"BA Rothermel","year":"2003","unstructured":"Rothermel, B. A., Vega, R. B. & Williams, R. S. The role of modulatory calcineurin-interacting proteins in calcineurin signaling. Trends Cardiovasc. Med. 13, 15\u201321 (2003).","journal-title":"Trends Cardiovasc. Med."},{"key":"BFncomms2090_CR31","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1016\/S1097-2765(00)00053-8","volume":"6","author":"H Okamura","year":"2000","unstructured":"Okamura, H. et al. Concerted dephosphorylation of the transcription factor NFAT1 induces a conformational switch that regulates transcriptional activity. Mol. Cell. 6, 539\u2013550 (2000).","journal-title":"Mol. Cell."},{"key":"BFncomms2090_CR32","doi-asserted-by":"publisher","first-page":"28319","DOI":"10.1074\/jbc.M109.024406","volume":"284","author":"A Sengupta","year":"2009","unstructured":"Sengupta, A., Molkentin, J. D. & Yutzey, K. E. FoxO transcription factors promote autophagy in cardiomyocytes. J. Biol. Chem. 284, 28319\u201328331 (2009).","journal-title":"J. Biol. Chem."},{"key":"BFncomms2090_CR33","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1007\/s12265-010-9200-z","volume":"3","author":"A Ferdous","year":"2010","unstructured":"Ferdous, A., Battiprolu, P. K., Ni, Y. G., Rothermel, B. A. & Hill, J. A. FoxO, autophagy, and cardiac remodeling. J. Cardiovasc. Transl. Res. 3, 355\u2013364 (2010).","journal-title":"J. Cardiovasc. Transl. Res."},{"key":"BFncomms2090_CR34","doi-asserted-by":"publisher","first-page":"29776","DOI":"10.1074\/jbc.M603783200","volume":"281","author":"A Hamacher-Brady","year":"2006","unstructured":"Hamacher-Brady, A., Brady, N. R. & Gottlieb, R. A. Enhancing macroautophagy protects against ischemia\/reperfusion injury in cardiac myocytes. J. Biol. Chem. 281, 29776\u201329787 (2006).","journal-title":"J. Biol. Chem."},{"key":"BFncomms2090_CR35","doi-asserted-by":"publisher","first-page":"8529","DOI":"10.1038\/sj.onc.1207197","volume":"22","author":"T Aki","year":"2003","unstructured":"Aki, T., Yamaguchi, K., Fujimiya, T. & Mizukami, Y. Phosphoinositide 3-kinase accelerates autophagic cell death during glucose deprivation in the rat cardiomyocyte-derived cell line H9c2. Oncogene 22, 8529\u20138535 (2003).","journal-title":"Oncogene"},{"key":"BFncomms2090_CR36","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/S0076-6879(08)03609-4","volume":"452","author":"E Shvets","year":"2009","unstructured":"Shvets, E. & Elazar, Z. Flow cytometric analysis of autophagy in living mammalian cells. Methods Enzymol. 452, 131\u2013141 (2009).","journal-title":"Methods Enzymol."},{"key":"BFncomms2090_CR37","doi-asserted-by":"publisher","first-page":"1149","DOI":"10.1016\/j.cell.2007.10.035","volume":"131","author":"M Komatsu","year":"2007","unstructured":"Komatsu, M. et al. Homeostatic levels of p62control cytoplasmic inclusion body formation in autophagy-deficient mice. Cell 131, 1149\u20131163 (2007).","journal-title":"Cell"},{"key":"BFncomms2090_CR38","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1093\/cvr\/cvr073","volume":"91","author":"H Kanamori","year":"2011","unstructured":"Kanamori, H. et al. The role of autophagy emerging in postinfarction cardiac remodelling. Cardiovasc. Res. 91, 330\u2013339 (2011).","journal-title":"Cardiovasc. Res."},{"key":"BFncomms2090_CR39","doi-asserted-by":"publisher","first-page":"1287","DOI":"10.1016\/j.febslet.2010.01.017","volume":"584","author":"CH Jung","year":"2010","unstructured":"Jung, C. H., Ro, S. H., Cao, J., Otto, N. M. & Kim, D. H. mTOR regulation of autophagy. FEBS Lett. 584, 1287\u20131295 (2010).","journal-title":"FEBS Lett."},{"key":"BFncomms2090_CR40","doi-asserted-by":"publisher","first-page":"600","DOI":"10.4161\/auto.6.5.11947","volume":"6","author":"M Taneike","year":"2010","unstructured":"Taneike, M. et al. Inhibition of autophagy in the heart induces age-related cardiomyopathy. Autophagy 6, 600\u2013606 (2010).","journal-title":"Autophagy"},{"key":"BFncomms2090_CR41","doi-asserted-by":"publisher","first-page":"1067","DOI":"10.1093\/eurheartj\/ehs043","volume":"33","author":"R Kumarswamy","year":"2012","unstructured":"Kumarswamy, R. et al. SERCA2a gene therapy restores microRNA-1 expression in heart failure via an Akt\/FoxO3A-dependent pathway. Eur. Heart J. 33, 1067\u20131075 (2012).","journal-title":"Eur. Heart J."},{"key":"BFncomms2090_CR42","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1161\/01.RES.0000260203.55077.61","volume":"100","author":"S Merkle","year":"2007","unstructured":"Merkle, S. et al. A role for caspase-1 in heart failure. Circ. Res. 100, 645\u2013653 (2007).","journal-title":"Circ. Res."},{"key":"BFncomms2090_CR43","doi-asserted-by":"publisher","first-page":"8277","DOI":"10.1073\/pnas.88.18.8277","volume":"88","author":"HA Rockman","year":"1991","unstructured":"Rockman, H. A. et al. Segregation of atrial-specific and inducible expression of an atrial natriuretic factor transgene in an in vivo murine model of cardiac hypertrophy. Proc. Natl Acad. Sci. USA 88, 8277\u20138281 (1991).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFncomms2090_CR44","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1038\/nature04303","volume":"438","author":"J Krutzfeldt","year":"2005","unstructured":"Krutzfeldt, J. et al. Silencing of microRNAs in vivo with 'antagomirs'. Nature 438, 685\u2013689 (2005).","journal-title":"Nature"},{"key":"BFncomms2090_CR45","doi-asserted-by":"publisher","first-page":"1705","DOI":"10.2353\/ajpath.2009.080875","volume":"174","author":"H Kanamori","year":"2009","unstructured":"Kanamori, H. et al. Functional significance and morphological characterization of starvation-induced autophagy in the adult heart. Am. J. Pathol. 174, 1705\u20131714 (2009).","journal-title":"Am. J. Pathol."},{"key":"BFncomms2090_CR46","first-page":"319","volume":"49","author":"MH Ullman-Cullere","year":"1999","unstructured":"Ullman-Cullere, M. H. & Foltz, C. J. Body condition scoring: a rapid and accurate method for assessing health status in mice. Lab. Anim. Sci. 49, 319\u2013323 (1999).","journal-title":"Lab. Anim. Sci."}],"container-title":["Nature Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/ncomms2090","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/ncomms2090.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/ncomms2090.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,6]],"date-time":"2023-01-06T00:24:01Z","timestamp":1672964641000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/ncomms2090"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,9,25]]},"references-count":46,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2012,1]]}},"alternative-id":["BFncomms2090"],"URL":"https:\/\/doi.org\/10.1038\/ncomms2090","relation":{},"ISSN":["2041-1723"],"issn-type":[{"value":"2041-1723","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,9,25]]},"assertion":[{"value":"14 June 2012","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 August 2012","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 September 2012","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"A.U., S.K.G., K.C. and T.T. are co-inventors on a patent entitled 'Inhibition of microRNA-212\/132 as a therapeutical approach for the treatment and prevention of hypertrophy and autophagy associated heart diseases.' The remaining authors declare no competing financial interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"1078"}}