{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T12:19:02Z","timestamp":1789647542721,"version":"4.0.0"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2013,2,19]],"date-time":"2013-02-19T00:00:00Z","timestamp":1361232000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2013,2,19]],"date-time":"2013-02-19T00:00:00Z","timestamp":1361232000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nat Commun"],"DOI":"10.1038\/ncomms2493","type":"journal-article","created":{"date-parts":[[2013,2,19]],"date-time":"2013-02-19T12:27:05Z","timestamp":1361276825000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":173,"title":["Parasympathetic stimulation improves epithelial organ regeneration"],"prefix":"10.1038","volume":"4","author":[{"given":"Sarah M.","family":"Knox","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle M. A.","family":"Lombaert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Candace L.","family":"Haddox","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaun R.","family":"Abrams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Cotrim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian J.","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew P.","family":"Hoffman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,2,19]]},"reference":[{"key":"BFncomms2493_CR1","doi-asserted-by":"publisher","first-page":"re8","DOI":"10.1126\/scisignal.3145re8","volume":"3","author":"A Bergmann","year":"2010","unstructured":"Bergmann A. & Steller H. . Apoptosis, stem cells, and tissue regeneration. Sci. Signal 3, re8 (2010) .","journal-title":"Sci. Signal"},{"key":"BFncomms2493_CR2","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1083\/jcb.201105099","volume":"196","author":"RS King","year":"2012","unstructured":"King R. S. & Newmark P. A. . Beyond the cell: the cell biology of regeneration. J. Cell. Biol. 196, 553\u2013562 (2012) .","journal-title":"J. Cell. Biol."},{"key":"BFncomms2493_CR3","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1002\/ar.b.20079","volume":"287","author":"BM Carlson","year":"2005","unstructured":"Carlson B. M. . Some principles of regeneration in mammalian systems. Anat. Rec. B New. Anat. 287, 4\u201313 (2005) .","journal-title":"Anat. Rec. B New. Anat."},{"key":"BFncomms2493_CR4","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.autneu.2006.10.006","volume":"133","author":"GB Proctor","year":"2007","unstructured":"Proctor G. B. & Carpenter G. H. . Regulation of salivary gland function by autonomic nerves. Auton. Neurosci. 133, 3\u201318 (2007) .","journal-title":"Auton. Neurosci."},{"key":"BFncomms2493_CR5","first-page":"361","volume":"24","author":"Y Tatsuishi","year":"2009","unstructured":"Tatsuishi Y. et al. Human salivary gland stem\/progenitor cells remain dormant even after irradiation. Int. J. Mol. Med. 24, 361\u2013366 (2009) .","journal-title":"Int. J. Mol. Med."},{"key":"BFncomms2493_CR6","doi-asserted-by":"publisher","first-page":"2595","DOI":"10.1634\/stemcells.2007-1034","volume":"26","author":"IM Lombaert","year":"2008","unstructured":"Lombaert I. M., Brunsting J. F., Wierenga P. K., Kampinga H. H., de Haan G. & Coppes R. P. . Keratinocyte growth factor prevents radiation damage to salivary glands by expansion of the stem\/progenitor pool. Stem Cells 26, 2595\u20132601 (2008) .","journal-title":"Stem Cells"},{"key":"BFncomms2493_CR7","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1111\/j.1601-0825.2010.01723.x","volume":"17","author":"RP Coppes","year":"2011","unstructured":"Coppes R. P. & Stokman M. A. . Stem cells and the repair of radiation-induced salivary gland damage. Oral Dis. 17, 143\u2013153 (2011) .","journal-title":"Oral Dis."},{"key":"BFncomms2493_CR8","doi-asserted-by":"publisher","first-page":"983","DOI":"10.1016\/j.ijrobp.2010.06.052","volume":"78","author":"A Vissink","year":"2010","unstructured":"Vissink A. et al. Clinical management of salivary gland hypofunction and xerostomia in head-and-neck cancer patients: successes and barriers. Int. J. Radiat. Oncol. Biol. Phys. 78, 983\u2013991 (2010) .","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"BFncomms2493_CR9","doi-asserted-by":"publisher","first-page":"1645","DOI":"10.1126\/science.1192046","volume":"329","author":"SM Knox","year":"2010","unstructured":"Knox S. M., Lombaert I. M., Reed X., Vitale-Cross L., Gutkind J. S. & Hoffman M. P. . Parasympathetic innervation maintains epithelial progenitor cells during salivary organogenesis. Science 329, 1645\u20131647 (2010) .","journal-title":"Science"},{"key":"BFncomms2493_CR10","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1016\/0012-1606(75)90137-2","volume":"43","author":"MD Coughlin","year":"1975","unstructured":"Coughlin M. D. . Target organ stimulation of parasympathetic nerve growth in the developing mouse submandibular gland. Dev. Biol. 43, 140\u2013158 (1975) .","journal-title":"Dev. Biol."},{"key":"BFncomms2493_CR11","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1007\/978-1-4615-0717-8_2","volume":"506","author":"J Rossi","year":"2002","unstructured":"Rossi J. & Airaksinen M. S. . GDNF family signalling in exocrine tissues: distinct roles for GDNF and neurturin in parasympathetic neuron development. Adv. Exp. Med. Biol. 506, (Pt A): 19\u201326 (2002) .","journal-title":"Adv. Exp. Med. Biol."},{"key":"BFncomms2493_CR12","doi-asserted-by":"publisher","first-page":"3944","DOI":"10.1046\/j.1460-9568.2000.00292.x","volume":"12","author":"J Rossi","year":"2000","unstructured":"Rossi J., Tomac A., Saarma M. & Airaksinen M. S. . Distinct roles for GFRalpha1 and GFRalpha2 signalling in different cranial parasympathetic ganglia in vivo. Eur. J. Neurosci. 12, 3944\u20133952 (2000) .","journal-title":"Eur. J. Neurosci."},{"key":"BFncomms2493_CR13","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1016\/S0896-6273(00)81086-7","volume":"22","author":"J Rossi","year":"1999","unstructured":"Rossi J. et al. Retarded growth and deficits in the enteric and parasympathetic nervous system in mice lacking GFRa2, a functional neurturin receptor. Neuron 22, 243\u2013252 (1999) .","journal-title":"Neuron"},{"key":"BFncomms2493_CR14","doi-asserted-by":"crossref","first-page":"4877","DOI":"10.1242\/dev.127.22.4877","volume":"127","author":"H Enomoto","year":"2000","unstructured":"Enomoto H., Heuckeroth R. O., Golden J. P., Johnson E. M. & Milbrandt J. . Development of cranial parasympathetic ganglia requires sequential actions of GDNF and neurturin. Development 127, 4877\u20134889 (2000) .","journal-title":"Development"},{"key":"BFncomms2493_CR15","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1016\/S0896-6273(00)81087-9","volume":"22","author":"RO Heuckeroth","year":"1999","unstructured":"Heuckeroth R. O. et al. Gene targeting reveals a critical role for neurturin in the development and maintenance of enteric, sensory, and parasympathetic neurons. Neuron 22, 253\u2013263 (1999) .","journal-title":"Neuron"},{"key":"BFncomms2493_CR16","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1172\/JCI200317995","volume":"112","author":"J Rossi","year":"2003","unstructured":"Rossi J., Herzig K. H., Voikar V., Hiltunen P. H., Segerstrale M. & Airaksinen M. S. . Alimentary tract innervation deficits and dysfunction in mice lacking GDNF family receptor alpha2. J. Clin. Invest. 112, 707\u2013716 (2003) .","journal-title":"J. Clin. Invest."},{"key":"BFncomms2493_CR17","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1111\/j.1432-0436.2006.00088.x","volume":"74","author":"VN Patel","year":"2006","unstructured":"Patel V. N., Rebustini I. T. & Hoffman M. P. . Salivary gland branching morphogenesis. Differentiation 74, 349\u2013364 (2006) .","journal-title":"Differentiation"},{"key":"BFncomms2493_CR18","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1038\/nrn812","volume":"3","author":"MS Airaksinen","year":"2002","unstructured":"Airaksinen M. S. & Saarma M. . The GDNF family: signalling, biological functions and therapeutic value. Nat. Rev. Neurosci. 3, 383\u2013394 (2002) .","journal-title":"Nat. Rev. Neurosci."},{"key":"BFncomms2493_CR19","doi-asserted-by":"crossref","first-page":"3773","DOI":"10.1242\/dev.128.19.3773","volume":"128","author":"E Hashino","year":"2001","unstructured":"Hashino E., Shero M., Junghans D., Rohrer H., Milbrandt J. & Johnson E. M. Jr. . GDNF and neurturin are target-derived factors essential for cranial parasympathetic neuron development. Development 128, 3773\u20133782 (2001) .","journal-title":"Development"},{"key":"BFncomms2493_CR20","doi-asserted-by":"publisher","first-page":"958","DOI":"10.1097\/01.MLG.0000163340.90211.87","volume":"115","author":"CA Sullivan","year":"2005","unstructured":"Sullivan C. A., Haddad R. I., Tishler R. B., Mahadevan A. & Krane J. F. . Chemoradiation-induced cell loss in human submandibular glands. Laryngoscope 115, 958\u2013964 (2005) .","journal-title":"Laryngoscope"},{"key":"BFncomms2493_CR21","doi-asserted-by":"publisher","first-page":"13337","DOI":"10.1074\/jbc.M110.112094","volume":"285","author":"SP Soltoff","year":"2010","unstructured":"Soltoff S. P. & Hedden L. . Isoproterenol and cAMP block ERK phosphorylation and enhance [Ca2+]i increases and oxygen consumption by muscarinic receptor stimulation in rat parotid and submandibular acinar cells. J. Biol. Chem. 285, 13337\u201313348 (2010) .","journal-title":"J. Biol. Chem."},{"key":"BFncomms2493_CR22","doi-asserted-by":"publisher","first-page":"664","DOI":"10.1053\/jhep.2003.50371","volume":"38","author":"JA Oben","year":"2003","unstructured":"Oben J. A. et al. Sympathetic nervous system inhibition increases hepatic progenitors and reduces liver injury. Hepatology 38, 664\u2013673 (2003) .","journal-title":"Hepatology"},{"key":"BFncomms2493_CR23","doi-asserted-by":"publisher","first-page":"1041","DOI":"10.1016\/S0002-9440(10)64972-3","volume":"156","author":"NV Botchkareva","year":"2000","unstructured":"Botchkareva N. V. et al. New roles for glial cell line-derived neurotrophic factor and neurturin: involvement in hair cycle control. Am. J. Pathol. 156, 1041\u20131053 (2000) .","journal-title":"Am. J. Pathol."},{"key":"BFncomms2493_CR24","doi-asserted-by":"publisher","first-page":"1164","DOI":"10.1016\/S1474-4422(10)70254-4","volume":"9","author":"WJ Marks Jr.","year":"2010","unstructured":"Marks W. J. Jr. et al. Gene delivery of AAV2-neurturin for Parkinson's disease: a double-blind, randomised, controlled trial. Lancet Neurol. 9, 1164\u20131172 (2010) .","journal-title":"Lancet Neurol."},{"key":"BFncomms2493_CR25","first-page":"53","volume":"58","author":"A Ramirez","year":"1994","unstructured":"Ramirez A., Bravo A., Jorcano J. L. & Vidal M. . Sequences 5\u2032 of the bovine keratin 5 gene direct tissue- and cell-type-specific expression of a lacZ gene in the adult and during development. Differentiation 58, 53\u201364 (1994) .","journal-title":"Differentiation"},{"key":"BFncomms2493_CR26","doi-asserted-by":"publisher","first-page":"1223","DOI":"10.1242\/dev.01690","volume":"132","author":"Z Steinberg","year":"2005","unstructured":"Steinberg Z. et al. FGFR2b signaling regulates ex vivo submandibular gland epithelial cell proliferation and branching morphogenesis. Development 132, 1223\u20131234 (2005) .","journal-title":"Development"},{"key":"BFncomms2493_CR27","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1007\/978-1-60327-483-8_3","volume":"461","author":"I Thesleff","year":"2008","unstructured":"Thesleff I. & Sahlberg C. . Organ culture in the analysis of tissue interactions. Methods Mol. Biol. 461, 23\u201330 (2008) .","journal-title":"Methods Mol. Biol."},{"key":"BFncomms2493_CR28","doi-asserted-by":"publisher","first-page":"482","DOI":"10.1016\/j.devcel.2009.07.016","volume":"17","author":"IT Rebustini","year":"2009","unstructured":"Rebustini I. T. et al. MT2-MMP-dependent release of collagen IV NC1 domains regulates submandibular gland branching morphogenesis. Dev. Cell. 17, 482\u2013493 (2009) .","journal-title":"Dev. Cell."},{"key":"BFncomms2493_CR29","doi-asserted-by":"publisher","first-page":"9308","DOI":"10.1074\/jbc.M709995200","volume":"283","author":"VN Patel","year":"2008","unstructured":"Patel V. N. et al. Specific heparan sulfate structures modulate FGF10-mediated submandibular gland epithelial morphogenesis and differentiation. J. Biol. Chem. 283, 9308\u20139317 (2008) .","journal-title":"J. Biol. Chem."}],"container-title":["Nature Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/ncomms2493.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/ncomms2493","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/ncomms2493.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,6]],"date-time":"2023-01-06T02:10:14Z","timestamp":1672971014000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/ncomms2493"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,2,19]]},"references-count":29,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2013,6,26]]}},"alternative-id":["BFncomms2493"],"URL":"https:\/\/doi.org\/10.1038\/ncomms2493","relation":{},"ISSN":["2041-1723"],"issn-type":[{"value":"2041-1723","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,2,19]]},"assertion":[{"value":"24 October 2012","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 January 2013","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 February 2013","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing financial interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"1494"}}