{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T02:21:48Z","timestamp":1785378108978,"version":"3.55.0"},"reference-count":49,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2013,2,26]],"date-time":"2013-02-26T00:00:00Z","timestamp":1361836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2013,2,26]],"date-time":"2013-02-26T00:00:00Z","timestamp":1361836800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nat Commun"],"DOI":"10.1038\/ncomms2526","type":"journal-article","created":{"date-parts":[[2013,2,26]],"date-time":"2013-02-26T10:19:52Z","timestamp":1361873992000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":62,"title":["Loss of TRPM2 function protects against irradiation-induced salivary gland dysfunction"],"prefix":"10.1038","volume":"4","author":[{"given":"Xibao","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Cotrim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leyla","family":"Teos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changyu","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Swaim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Mitchell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuo","family":"Mori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Indu","family":"Ambudkar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,2,26]]},"reference":[{"key":"BFncomms2526_CR1","doi-asserted-by":"publisher","first-page":"2525","DOI":"10.1002\/cncr.22302","volume":"107","author":"P Dirix","year":"2006","unstructured":"Dirix, P., Nuyts, S. & Van den Bogaert, W. . Radiation-induced xerostomia in patients with head and neck cancer: a literature review. Cancer 107, 2525\u20132534 (2006) .","journal-title":"Cancer"},{"key":"BFncomms2526_CR2","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1016\/S0167-8140(01)00427-3","volume":"61","author":"FR Burlage","year":"2001","unstructured":"Burlage, F. R., Coppes, R. P., Meertens, H., Stokman, M. A. & Vissink, A. . Parotid and submandibular\/sublingual salivary flow during high dose radiotherapy. Radiot. Oncol. 61, 271\u2013274 (2001) .","journal-title":"Radiot. Oncol."},{"key":"BFncomms2526_CR3","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1177\/154411130301400305","volume":"14","author":"A Vissink","year":"2003","unstructured":"Vissink, A., Jansma, J., Spijkervet, F. K., Burlage, F. R. & Coppes, R. P. . Oral sequelae of head and neck radiotherapy. Cri. Rev. Oral Biol. Med. 14, 199\u2013212 (2003) .","journal-title":"Cri. Rev. Oral Biol. Med."},{"key":"BFncomms2526_CR4","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1016\/j.ijrobp.2007.04.021","volume":"69","author":"AP Jellema","year":"2007","unstructured":"Jellema, A. P., Slotman, B. J., Doornaert, P., Leemans, C. R. & Langendijk, J. A. . Impact of radiation-induced xerostomia on quality of life after primary radiotherapy among patients with head and neck cancer. Int. J. Radiat. Onco. Biol. Phys. 69, 751\u2013760 (2007) .","journal-title":"Int. J. Radiat. Onco. Biol. Phys."},{"key":"BFncomms2526_CR5","doi-asserted-by":"publisher","first-page":"3770","DOI":"10.1200\/JCO.2007.14.6647","volume":"26","author":"JA Langendijk","year":"2008","unstructured":"Langendijk, J. A. et al. Impact of late treatment-related toxicity on quality of life among patients with head and neck cancer treated with radiotherapy. J. Clin. Oncol. 26, 3770\u20133776 (2008) .","journal-title":"J. Clin. Oncol."},{"key":"BFncomms2526_CR6","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1080\/095530000138763","volume":"76","author":"LJW Zeilstra","year":"2000","unstructured":"Zeilstra, L. J. W. et al. Radiation induced cell loss in rat submandibulargland and its relation to gland function. Int. J. Radiat. Biol. 76, 419\u2013429 (2000) .","journal-title":"Int. J. Radiat. Biol."},{"key":"BFncomms2526_CR7","doi-asserted-by":"publisher","first-page":"1187","DOI":"10.1016\/j.ijrobp.2004.12.051","volume":"62","author":"AW Konings","year":"2005","unstructured":"Konings, A. W., Coppes, R. P. & Vissink, A. . On the mechanism of salivary gland radiosensitivity. Int. J. Radiat. Onco. Biol. Phys. 62, 1187\u20131194 (2005) .","journal-title":"Int. J. Radiat. Onco. Biol. Phys."},{"key":"BFncomms2526_CR8","doi-asserted-by":"publisher","first-page":"1090","DOI":"10.1016\/j.ijrobp.2004.12.035","volume":"62","author":"AW Konings","year":"2005","unstructured":"Konings, A. W. et al. Volume effects and region-dependent radiosensitivity of the parotid gland. Int. J. Radiat. Onco. Biol. Phys. 62, 1090\u20131095 (2005) .","journal-title":"Int. J. Radiat. Onco. Biol. Phys."},{"key":"BFncomms2526_CR9","doi-asserted-by":"publisher","first-page":"1539","DOI":"10.1002\/1097-0142(19910315)67:6<1539::AID-CNCR2820670613>3.0.CO;2-Q","volume":"67","author":"LC Stephens","year":"1991","unstructured":"Stephens, L. C., Schultheiss, T. E., Price, R. E., Ang, K. K. & Peters, L. J. . Radiation apoptosis of serous acinar cells of salivary and lacrimal glands. Cancer 67, 1539\u20131543 (1991) .","journal-title":"Cancer"},{"key":"BFncomms2526_CR10","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1080\/09553009214550911","volume":"61","author":"A Vissink","year":"1992","unstructured":"Vissink, A., Down, J. D. & Konings, A. W. . Contrasting dose-rate effects of gamma-irradiation on rat salivary gland function. Int. J. Radiat. Biol. 61, 275\u2013282 (1992) .","journal-title":"Int. J. Radiat. Biol."},{"key":"BFncomms2526_CR11","doi-asserted-by":"publisher","first-page":"983","DOI":"10.1016\/j.ijrobp.2010.06.052","volume":"78","author":"A Vissink","year":"2010","unstructured":"Vissink, A. et al. Clinical management of salivary gland hypofunction and xerostomia in head-and-neck cancer patients: successes and barriers. Int. J. Radiat. Onco. Biol. Phys. 78, 983\u2013991 (2010) .","journal-title":"Int. J. Radiat. Onco. Biol. Phys."},{"key":"BFncomms2526_CR12","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1111\/j.1601-0825.2010.01715.x","volume":"17","author":"S Osailan","year":"2011","unstructured":"Osailan, S., Pramanik, R., Shirodaria, S., Challacombe, S. J. & Proctor, G. B. . Investigating the relationship between hyposalivation and mucosal wetness. Oral Dis. 17, 109\u2013114 (2011) .","journal-title":"Oral Dis."},{"key":"BFncomms2526_CR13","doi-asserted-by":"publisher","first-page":"18S","DOI":"10.14219\/jada.archive.2008.0351","volume":"139","author":"C Dawes","year":"2008","unstructured":"Dawes, C. . Salivary flow patterns and the health of hard and soft oral tissues. J. Am. Dent. Assoc. 139, (Suppl): 18S\u201324S (2008) .","journal-title":"J. Am. Dent. Assoc."},{"key":"BFncomms2526_CR14","doi-asserted-by":"publisher","first-page":"1039","DOI":"10.1007\/s00520-010-0827-8","volume":"18","author":"SB Jensen","year":"2010","unstructured":"Jensen, S. B. et al. A systematic review of salivary gland hypofunction and xerostomia induced by cancer therapies: prevalence, severity and impact on quality of life. Support Care Cancer 18, 1039\u20131060 (2010) .","journal-title":"Support Care Cancer"},{"key":"BFncomms2526_CR15","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1016\/S0003-9969(97)00045-9","volume":"42","author":"R Sas","year":"1997","unstructured":"Sas, R. & Dawes, C. . The intra-oral distribution of unstimulated and chewing-gum-stimulated parotid saliva. Arch. Oral Biol. 42, 469\u2013474 (1997) .","journal-title":"Arch. Oral Biol."},{"key":"BFncomms2526_CR16","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1038\/ni0612-621e","volume":"13","author":"A Di","year":"2012","unstructured":"Di, A. et al. The redox-sensitive cation channel TRPM2 modulates phagocyte ROS production and inflammation. Nat. Immunol. 13, 621 (2012) .","journal-title":"Nat. Immunol."},{"key":"BFncomms2526_CR17","doi-asserted-by":"publisher","first-page":"1515","DOI":"10.1113\/jphysiol.2010.201855","volume":"589","author":"A Sumoza-Toledo","year":"2011","unstructured":"Sumoza-Toledo, A. & Penner, R. . TRPM2: a multifunctional ion channel for calcium signalling. J. Physiol. 589, 1515\u20131525 (2011) .","journal-title":"J. Physiol."},{"key":"BFncomms2526_CR18","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1160\/TH08-10-0641","volume":"101","author":"CM Hecquet","year":"2009","unstructured":"Hecquet, C. M. & Malik, A. B. . Role of H(2)O(2)-activated TRPM2 calcium channel in oxidant-induced endothelial injury. Thromb. Haemost. 101, 619\u2013625 (2009) .","journal-title":"Thromb. Haemost."},{"key":"BFncomms2526_CR19","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1016\/j.ceca.2011.04.006","volume":"50","author":"N Takahashi","year":"2011","unstructured":"Takahashi, N., Kozai, D., Kobayashi, R., Ebert, M. & Mori, Y. . Roles of TRPM2 in oxidative stress. Cell Calcium 50, 279\u2013287 (2011) .","journal-title":"Cell Calcium"},{"key":"BFncomms2526_CR20","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1007\/s12185-012-1008-y","volume":"95","author":"Y Masuda","year":"2012","unstructured":"Masuda, Y. & Kamiya, K. . Molecular nature of radiation injury and DNA repair disorders associated with radiosensitivity. Int. J. Hematol. 95, 239\u2013245 (2012) .","journal-title":"Int. J. Hematol."},{"key":"BFncomms2526_CR21","doi-asserted-by":"publisher","first-page":"1455","DOI":"10.1007\/s00018-010-0533-1","volume":"68","author":"C Blenn","year":"2011","unstructured":"Blenn, C., Wyrsch, P., Bader, J., Bollhalder, M. & Althaus, F. R. . Poly(ADP-ribose)glycohydrolase is an upstream regulator of Ca2+ fluxes in oxidative cell death. Cell Mol. life Sci. 68, 1455\u20131466 (2011) .","journal-title":"Cell Mol. life Sci."},{"key":"BFncomms2526_CR22","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/j.ejphar.2006.08.007","volume":"548","author":"MM Khattab","year":"2006","unstructured":"Khattab, M. M. . TEMPOL, a membrane-permeable radical scavenger, attenuates peroxynitrite- and superoxide anion-enhanced carrageenan-induced paw edema and hyperalgesia: a key role for superoxide anion. Eur. J. Pharmacol. 548, 167\u2013173 (2006) .","journal-title":"Eur. J. Pharmacol."},{"key":"BFncomms2526_CR23","first-page":"1750","volume":"52","author":"SM Hahn","year":"1992","unstructured":"Hahn, S. M. et al. Tempol, a stable free radical, is a novel murine radiation protector. Cancer Res. 52, 1750\u20131753 (1992) .","journal-title":"Cancer Res."},{"key":"BFncomms2526_CR24","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/0003-9861(91)90442-L","volume":"289","author":"JB Mitchell","year":"1991","unstructured":"Mitchell, J. B. et al. Inhibition of oxygen-dependent radiation-induced damage by the nitroxide superoxide dismutase mimic, tempol. Arch. Bioche. Biophy. 289, 62\u201370 (1991) .","journal-title":"Arch. Bioche. Biophy."},{"key":"BFncomms2526_CR25","doi-asserted-by":"publisher","first-page":"1114","DOI":"10.1038\/jcbfm.2008.10","volume":"28","author":"Y Deng-Bryant","year":"2008","unstructured":"Deng-Bryant, Y., Singh, I. N., Carrico, K. M. & Hall, E. D. . Neuroprotective effects of tempol, a catalytic scavenger of peroxynitrite-derived free radicals, in a mouse traumatic brain injury model. J. Cereb. Blood Flow Metab. 28, 1114\u20131126 (2008) .","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"BFncomms2526_CR26","doi-asserted-by":"publisher","first-page":"604","DOI":"10.1080\/10715760902977432","volume":"43","author":"Y Xiong","year":"2009","unstructured":"Xiong, Y., Singh, I. N. & Hall, E. D. . Tempol protection of spinal cord mitochondria from peroxynitrite-induced oxidative damage. Free Rad. Res. 43, 604\u2013612 (2009) .","journal-title":"Free Rad. Res."},{"key":"BFncomms2526_CR27","doi-asserted-by":"publisher","first-page":"147","DOI":"10.3109\/10715762.2011.645207","volume":"46","author":"T Yoshida","year":"2012","unstructured":"Yoshida, T., Goto, S., Kawakatsu, M., Urata, Y. & Li, T. S. . Mitochondrial dysfunction, a probable cause of persistent oxidative stress after exposure to ionizing radiation. Free Rad. Res. 46, 147\u2013153 (2012) .","journal-title":"Free Rad. Res."},{"key":"BFncomms2526_CR28","doi-asserted-by":"publisher","first-page":"8","DOI":"10.2174\/1874210601206010008","volume":"6","author":"C De la Cal","year":"2012","unstructured":"De la Cal, C. et al. Radiation produces irreversible chronic dysfunction in the submandibular glands of the rat. Open Dent. J. 6, 8\u201313 (2012) .","journal-title":"Open Dent. J."},{"key":"BFncomms2526_CR29","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1016\/0167-5699(95)80029-8","volume":"16","author":"F Lund","year":"1995","unstructured":"Lund, F., Solvason, N., Grimaldi, J. C., Parkhouse, R. M. & Howard, M. . Murine CD38: an immunoregulatory ectoenzyme. Immunol. Today 16, 469\u2013473 (1995) .","journal-title":"Immunol. Today"},{"key":"BFncomms2526_CR30","doi-asserted-by":"publisher","first-page":"328","DOI":"10.2119\/2006-00099.Lund","volume":"12","author":"FE Lund","year":"2006","unstructured":"Lund, F. E. . Signaling properties of CD38 in the mouse immune system: enzyme-dependent and -independent roles in immunity. Mol. Med. 12, 328\u2013333 (2006) .","journal-title":"Mol. Med."},{"key":"BFncomms2526_CR31","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1111\/j.1600-065X.1998.tb01573.x","volume":"161","author":"FE Lund","year":"1998","unstructured":"Lund, F. E. et al. CD38: a new paradigm in lymphocyte activation and signal transduction. Immunol. Rev. 161, 79\u201393 (1998) .","journal-title":"Immunol. Rev."},{"key":"BFncomms2526_CR32","doi-asserted-by":"publisher","first-page":"334","DOI":"10.2119\/2006-00094.Malavasi","volume":"12","author":"F Malavasi","year":"2006","unstructured":"Malavasi, F. et al. CD38 and CD157 as receptors of the immune system: a bridge between innate and adaptive immunity. Mol. Med. 12, 334\u2013341 (2006) .","journal-title":"Mol. Med."},{"key":"BFncomms2526_CR33","doi-asserted-by":"publisher","first-page":"672","DOI":"10.1096\/fj.08-123265","volume":"23","author":"P Caiafa","year":"2009","unstructured":"Caiafa, P., Guastafierro, T. & Zampieri, M. . Epigenetics: poly(ADP-ribosyl)ation of PARP-1 regulates genomic methylation patterns. FASEB J. 23, 672\u2013678 (2009) .","journal-title":"FASEB J."},{"key":"BFncomms2526_CR34","doi-asserted-by":"publisher","first-page":"263","DOI":"10.2741\/3244","volume":"14","author":"E Esposito","year":"2009","unstructured":"Esposito, E. & Cuzzocrea, S. . Superoxide, NO, peroxynitrite and PARP in circulatory shock and inflammation. Front Biosci. 14, 263\u2013296 (2009) .","journal-title":"Front Biosci."},{"key":"BFncomms2526_CR35","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1007\/s12253-010-9266-6","volume":"16","author":"NJ Fauzee","year":"2010","unstructured":"Fauzee, N. J., Pan, J. & Wang, Y. L. . PARP and PARG inhibitors\u2013new therapeutic targets in cancer treatment. Pathol. Oncol. Res. 16, 469\u2013478 (2010) .","journal-title":"Pathol. Oncol. Res."},{"key":"BFncomms2526_CR36","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1016\/j.radonc.2011.05.085","volume":"99","author":"LS Nanduri","year":"2011","unstructured":"Nanduri, L. S. et al. Regeneration of irradiated salivary glands with stem cell marker expressing cells. Radiother. Oncol. 99, 367\u2013372 (2011) .","journal-title":"Radiother. Oncol."},{"key":"BFncomms2526_CR37","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1634\/theoncologist.2009-S104","volume":"15","author":"D Citrin","year":"2010","unstructured":"Citrin, D. et al. Radioprotectors and mitigators of radiation-induced normal tissue injury. Oncologist 15, 360\u2013371 (2010) .","journal-title":"Oncologist"},{"key":"BFncomms2526_CR38","doi-asserted-by":"publisher","first-page":"1632","DOI":"10.1016\/j.freeradbiomed.2007.02.030","volume":"42","author":"BP Soule","year":"2007","unstructured":"Soule, B. P. et al. The chemistry and biology of nitroxide compounds. Free Radic. Biol. Med. 42, 1632\u20131650 (2007) .","journal-title":"Free Radic. Biol. Med."},{"key":"BFncomms2526_CR39","doi-asserted-by":"publisher","first-page":"1179","DOI":"10.2174\/092986707780597998","volume":"14","author":"R Aguilar-Quesada","year":"2007","unstructured":"Aguilar-Quesada, R. et al. Modulation of transcription by PARP-1: consequences in carcinogenesis and inflammation. Curr. Med. Chem. 14, 1179\u20131187 (2007) .","journal-title":"Curr. Med. Chem."},{"key":"BFncomms2526_CR40","doi-asserted-by":"publisher","first-page":"3033","DOI":"10.1158\/1078-0432.CCR-06-2872","volume":"13","author":"JM Albert","year":"2007","unstructured":"Albert, J. M. et al. Inhibition of poly(ADP-ribose) polymerase enhances cell death and improves tumor growth delay in irradiated lung cancer models. Clin. Cancer Res. 13, 3033\u20133042 (2007) .","journal-title":"Clin. Cancer Res."},{"key":"BFncomms2526_CR41","doi-asserted-by":"publisher","first-page":"2728","DOI":"10.1158\/1078-0432.CCR-06-3039","volume":"13","author":"CK Donawho","year":"2007","unstructured":"Donawho, C. K. et al. ABT-888, an orally active poly(ADP-ribose) polymerase inhibitor that potentiates DNA-damaging agents in preclinical tumor models. Clin. Cancer Res. 13, 2728\u20132737 (2007) .","journal-title":"Clin. Cancer Res."},{"key":"BFncomms2526_CR42","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1158\/1535-7163.MCT-05-0418","volume":"5","author":"G Noel","year":"2006","unstructured":"Noel, G. et al. Radiosensitization by the poly(ADP-ribose) polymerase inhibitor 4-amino-1,8-naphthalimide is specific of the S phase of the cell cycle and involves arrest of DNA synthesis. Mol. Cancer Ther. 5, 564\u2013574 (2006) .","journal-title":"Mol. Cancer Ther."},{"key":"BFncomms2526_CR43","doi-asserted-by":"publisher","first-page":"1709","DOI":"10.1096\/fj.06-5916fje","volume":"20","author":"L Tentori","year":"2006","unstructured":"Tentori, L. et al. Inhibition of poly(ADP-ribose) polymerase prevents irinotecan-induced intestinal damage and enhances irinotecan\/temozolomide efficacy against colon carcinoma. FASEB J. 20, 1709\u20131711 (2006) .","journal-title":"FASEB J."},{"key":"BFncomms2526_CR44","doi-asserted-by":"publisher","first-page":"913","DOI":"10.1038\/nature03443","volume":"434","author":"HE Bryant","year":"2005","unstructured":"Bryant, H. E. et al. Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase. Nature 434, 913\u2013917 (2005) .","journal-title":"Nature"},{"key":"BFncomms2526_CR45","doi-asserted-by":"publisher","first-page":"917","DOI":"10.1038\/nature03445","volume":"434","author":"H Farmer","year":"2005","unstructured":"Farmer, H. et al. Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy. Nature 434, 917\u2013921 (2005) .","journal-title":"Nature"},{"key":"BFncomms2526_CR46","doi-asserted-by":"publisher","first-page":"4928","DOI":"10.1158\/1078-0432.CCR-07-0662","volume":"13","author":"AP Cotrim","year":"2007","unstructured":"Cotrim, A. P. et al. Differential radiation protection of salivary glands versus tumor by Tempol with accompanying tissue assessment of Tempol by magnetic resonance imaging. Clin. Cancer Res. 13, 4928\u20134933 (2007) .","journal-title":"Clin. Cancer Res."},{"key":"BFncomms2526_CR47","doi-asserted-by":"publisher","first-page":"738","DOI":"10.1038\/nm1758","volume":"14","author":"S Yamamoto","year":"2008","unstructured":"Yamamoto, S. et al. TRPM2-mediated Ca2+ influx induces chemokine production in monocytes that aggravates inflammatory neutrophil infiltration. Nat. Med. 14, 738\u2013747 (2008) .","journal-title":"Nat. Med."},{"key":"BFncomms2526_CR48","doi-asserted-by":"publisher","first-page":"1807","DOI":"10.1158\/1078-0432.CCR-03-0194","volume":"10","author":"JM Vitolo","year":"2004","unstructured":"Vitolo, J. M. et al. The stable nitroxide tempol facilitates salivary gland protection during head and neck irradiation in a mouse model. Clin. Cancer Res. 10, 1807\u20131812 (2004) .","journal-title":"Clin. Cancer Res."},{"key":"BFncomms2526_CR49","doi-asserted-by":"publisher","first-page":"7564","DOI":"10.1158\/1078-0432.CCR-05-0958","volume":"11","author":"AP Cotrim","year":"2005","unstructured":"Cotrim, A. P. et al. Kinetics of tempol for prevention of xerostomia following head and neck irradiation in a mouse model. Clin. Cancer Res. 11, 7564\u20137568 (2005) .","journal-title":"Clin. Cancer Res."}],"container-title":["Nature Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/ncomms2526.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/ncomms2526","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/ncomms2526.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,6]],"date-time":"2023-01-06T02:07:42Z","timestamp":1672970862000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/ncomms2526"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,2,26]]},"references-count":49,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2013,6,26]]}},"alternative-id":["BFncomms2526"],"URL":"https:\/\/doi.org\/10.1038\/ncomms2526","relation":{},"ISSN":["2041-1723"],"issn-type":[{"value":"2041-1723","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,2,26]]},"assertion":[{"value":"4 July 2012","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 January 2013","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 February 2013","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing financial interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"1515"}}