{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T16:56:05Z","timestamp":1792601765401,"version":"4.5.0"},"reference-count":59,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2013,4,23]],"date-time":"2013-04-23T00:00:00Z","timestamp":1366675200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2013,4,23]],"date-time":"2013-04-23T00:00:00Z","timestamp":1366675200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nat Commun"],"DOI":"10.1038\/ncomms2774","type":"journal-article","created":{"date-parts":[[2013,4,23]],"date-time":"2013-04-23T05:52:34Z","timestamp":1366696354000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":140,"title":["Control of lung vascular permeability and endotoxin-induced pulmonary oedema by changes in extracellular matrix mechanics"],"prefix":"10.1038","volume":"4","author":[{"given":"Akiko","family":"Mammoto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadanori","family":"Mammoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathumai","family":"Kanapathipillai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chong","family":"Wing Yung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristopher","family":"Lofgren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elaine P.S.","family":"Gee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald E.","family":"Ingber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,4,23]]},"reference":[{"key":"BFncomms2774_CR1","doi-asserted-by":"publisher","first-page":"2053","DOI":"10.1007\/s00018-007-7008-z","volume":"64","author":"BA Bryan","year":"2007","unstructured":"Bryan, B. A. & D'Amore, P. A. What tangled webs they weave: Rho-GTPase control of angiogenesis. Cell. Mol. Life Sci. 64, 2053\u20132065 (2007).","journal-title":"Cell. Mol. Life Sci."},{"key":"BFncomms2774_CR2","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1083\/jcb.200609008","volume":"176","author":"AW Orr","year":"2007","unstructured":"Orr, A. W. et al. Matrix-specific p21-activated kinase activation regulates vascular permeability in atherogenesis. J. Cell. Biol. 176, 719\u2013727 (2007).","journal-title":"J. Cell. Biol."},{"key":"BFncomms2774_CR3","doi-asserted-by":"publisher","first-page":"23910","DOI":"10.1074\/jbc.M702169200","volume":"282","author":"T Mammoto","year":"2007","unstructured":"Mammoto, T. et al. Angiopoietin-1 requires p190RhoGAP to protect against vascular leakage in vivo. J. Biol. Chem. 282, 23910\u201323918 (2007).","journal-title":"J. Biol. Chem."},{"key":"BFncomms2774_CR4","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1016\/j.ccr.2005.02.007","volume":"7","author":"R Satchi-Fainaro","year":"2005","unstructured":"Satchi-Fainaro, R. et al. Inhibition of vessel permeability by TNP-470 and its polymer conjugate, caplostatin. Cancer Cell 7, 251\u2013261 (2005).","journal-title":"Cancer Cell"},{"key":"BFncomms2774_CR5","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1165\/rcmb.F305","volume":"33","author":"MA Matthay","year":"2005","unstructured":"Matthay, M. A. & Zimmerman, G. A. Acute lung injury and the acute respiratory distress syndrome: four decades of inquiry into pathogenesis and rational management. Am. J. Respir. Cell Mol. Biol. 33, 319\u2013327 (2005).","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"BFncomms2774_CR6","doi-asserted-by":"publisher","first-page":"1121","DOI":"10.1164\/rccm.201001-0024WS","volume":"181","author":"RG Spragg","year":"2010","unstructured":"Spragg, R. G. et al. Beyond mortality: future clinical research in acute lung injury. Am. J. Respir. Crit. Care. Med. 181, 1121\u20131127 (2010).","journal-title":"Am. J. Respir. Crit. Care. Med."},{"key":"BFncomms2774_CR7","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1007\/s10456-008-9099-z","volume":"11","author":"JA Nagy","year":"2008","unstructured":"Nagy, J. A., Benjamin, L., Zeng, H., Dvorak, A. M. & Dvorak, H. F. Vascular permeability, vascular hyperpermeability and angiogenesis. Angiogenesis 11, 109\u2013119 (2008).","journal-title":"Angiogenesis"},{"key":"BFncomms2774_CR8","doi-asserted-by":"publisher","first-page":"574","DOI":"10.1165\/rcmb.2002-0075OC","volume":"28","author":"I Petrache","year":"2003","unstructured":"Petrache, I., Birukova, A., Ramirez, S. I., Garcia, J. G. & Verin, A. D. The role of the microtubules in tumor necrosis factor-alpha-induced endothelial cell permeability. Am. J. Respir. Cell. Mol. Biol. 28, 574\u2013581 (2003).","journal-title":"Am. J. Respir. Cell. Mol. Biol."},{"key":"BFncomms2774_CR9","doi-asserted-by":"publisher","first-page":"4031","DOI":"10.1016\/j.febslet.2005.06.018","volume":"579","author":"AA Birukova","year":"2005","unstructured":"Birukova, A. A., Adyshev, D., Gorshkov, B., Birukov, K. G. & Verin, A. D. ALK5 and Smad4 are involved in TGF-beta1-induced pulmonary endothelial permeability. FEBS Lett. 579, 4031\u20134037 (2005).","journal-title":"FEBS Lett."},{"key":"BFncomms2774_CR10","doi-asserted-by":"publisher","first-page":"3728","DOI":"10.1096\/fj.08-110494","volume":"22","author":"O Fainaru","year":"2008","unstructured":"Fainaru, O. et al. Doxycycline induces membrane expression of VE-cadherin on endothelial cells and prevents vascular hyperpermeability. Faseb J. 22, 3728\u20133735 (2008).","journal-title":"Faseb J."},{"key":"BFncomms2774_CR11","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1111\/j.1440-1843.2007.01193.x","volume":"13","author":"H Koh","year":"2008","unstructured":"Koh, H. et al. Vascular endothelial growth factor in epithelial lining fluid of patients with acute respiratory distress syndrome. Respirology 13, 281\u2013284 (2008).","journal-title":"Respirology"},{"key":"BFncomms2774_CR12","doi-asserted-by":"publisher","first-page":"1605","DOI":"10.1152\/japplphysiol.00202.2004","volume":"97","author":"M Mura","year":"2004","unstructured":"Mura, M., dos Santos, C. C., Stewart, D. & Liu, M. Vascular endothelial growth factor and related molecules in acute lung injury. J. Appl. Physiol. 97, 1605\u20131617 (2004).","journal-title":"J. Appl. Physiol."},{"key":"BFncomms2774_CR13","doi-asserted-by":"publisher","first-page":"891","DOI":"10.1016\/j.cell.2009.10.027","volume":"139","author":"KR Levental","year":"2009","unstructured":"Levental, K. R. et al. Matrix crosslinking forces tumor progression by enhancing integrin signaling. Cell 139, 891\u2013906 (2009).","journal-title":"Cell"},{"key":"BFncomms2774_CR14","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1016\/j.ccr.2005.08.010","volume":"8","author":"MJ Paszek","year":"2005","unstructured":"Paszek, M. J. et al. Tensional homeostasis and the malignant phenotype. Cancer Cell 8, 241\u2013254 (2005).","journal-title":"Cancer Cell"},{"key":"BFncomms2774_CR15","doi-asserted-by":"publisher","first-page":"1103","DOI":"10.1038\/nature07765","volume":"457","author":"A Mammoto","year":"2009","unstructured":"Mammoto, A. et al. A mechanosensitive transcriptional mechanism that controls angiogenesis. Nature 457, 1103\u20131108 (2009).","journal-title":"Nature"},{"key":"BFncomms2774_CR16","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1016\/j.cell.2006.06.044","volume":"126","author":"AJ Engler","year":"2006","unstructured":"Engler, A. J., Sen, S., Sweeney, H. L. & Discher, D. E. Matrix elasticity directs stem cell lineage specification. Cell 126, 677\u2013689 (2006).","journal-title":"Cell"},{"key":"BFncomms2774_CR17","doi-asserted-by":"publisher","first-page":"11305","DOI":"10.1073\/pnas.0800835105","volume":"105","author":"K Ghosh","year":"2008","unstructured":"Ghosh, K. et al. Tumor-derived endothelial cells exhibit aberrant Rho-mediated mechanosensing and abnormal angiogenesis in vitro. Proc. Natl Acad. Sci. USA 105, 11305\u201311310 (2008).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFncomms2774_CR18","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1083\/jcb.201004082","volume":"190","author":"F Liu","year":"2010","unstructured":"Liu, F. et al. Feedback amplification of fibrosis through matrix stiffening and COX-2 suppression. J. Cell. Biol. 190, 693\u2013706 (2010).","journal-title":"J. Cell. Biol."},{"key":"BFncomms2774_CR19","doi-asserted-by":"publisher","first-page":"R103","DOI":"10.1186\/cc6983","volume":"12","author":"LF Li","year":"2008","unstructured":"Li, L. F., Liao, S. K., Huang, C. C., Hung, M. J. & Quinn, D. A. Serine\/threonine kinase-protein kinase B and extracellular signal-regulated kinase regulate ventilator-induced pulmonary fibrosis after bleomycin-induced acute lung injury: a prospective, controlled animal experiment. Crit. Care 12, R103 (2008).","journal-title":"Crit. Care"},{"key":"BFncomms2774_CR20","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1126\/scitranslmed.3002761","volume":"3","author":"J Huynh","year":"2011","unstructured":"Huynh, J. et al. Age-related intimal stiffening enhances endothelial permeability and leukocyte transmigration. Sci. Transl. Med. 3, 112\u2013122 (2011).","journal-title":"Sci. Transl. Med."},{"key":"BFncomms2774_CR21","doi-asserted-by":"publisher","first-page":"2304","DOI":"10.1007\/s00018-006-6149-9","volume":"63","author":"HA Lucero","year":"2006","unstructured":"Lucero, H. A. & Kagan, H. M. Lysyl oxidase: an oxidative enzyme and effector of cell function. Cell. Mol. Life Sci. 63, 2304\u20132316 (2006).","journal-title":"Cell. Mol. Life Sci."},{"key":"BFncomms2774_CR22","doi-asserted-by":"publisher","first-page":"2721","DOI":"10.2741\/2879","volume":"13","author":"JF Alcudia","year":"2008","unstructured":"Alcudia, J. F. et al. Lysyl oxidase and endothelial dysfunction: mechanisms of lysyl oxidase down-regulation by pro-inflammatory cytokines. Front Biosci. 13, 2721\u20132727 (2008).","journal-title":"Front Biosci."},{"key":"BFncomms2774_CR23","doi-asserted-by":"publisher","first-page":"758","DOI":"10.1016\/j.devcel.2011.07.006","volume":"21","author":"T Mammoto","year":"2011","unstructured":"Mammoto, T. et al. Mechanochemical control of mesenchymal condensation and embryonic tooth organ formation. Dev. Cell. 21, 758\u2013769 (2011).","journal-title":"Dev. Cell."},{"key":"BFncomms2774_CR24","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1038\/laban0511-155","volume":"40","author":"T Yardeni","year":"2011","unstructured":"Yardeni, T., Eckhaus, M., Morris, H. D., Huizing, M. & Hoogstraten-Miller, S. Retro-orbital injections in mice. Lab. Anim. (NY) 40, 155\u2013160 (2011).","journal-title":"Lab. Anim. (NY)"},{"key":"BFncomms2774_CR25","first-page":"3675","volume":"27","author":"TW Gilbert","year":"2006","unstructured":"Gilbert, T. W., Sellaro, T. L. & Badylak, S. F. Decellularization of tissues and organs. Biomaterials 27, 3675\u20133683 (2006).","journal-title":"Biomaterials"},{"key":"BFncomms2774_CR26","doi-asserted-by":"publisher","first-page":"2581","DOI":"10.1089\/ten.tea.2009.0659","volume":"16","author":"AP Price","year":"2010","unstructured":"Price, A. P., England, K. A., Matson, A. M., Blazar, B. R. & Panoskaltsis-Mortari, A. Development of a decellularized lung bioreactor system for bioengineering the lung: the matrix reloaded. Tissue Eng. Part. A 16, 2581\u20132591 (2010).","journal-title":"Tissue Eng. Part. A"},{"key":"BFncomms2774_CR27","doi-asserted-by":"publisher","first-page":"3713","DOI":"10.1172\/JCI40053","volume":"119","author":"K Atabai","year":"2009","unstructured":"Atabai, K. et al. Mfge8 diminishes the severity of tissue fibrosis in mice by binding and targeting collagen for uptake by macrophages. J. Clin. Invest. 119, 3713\u20133722 (2009).","journal-title":"J. Clin. Invest."},{"key":"BFncomms2774_CR28","doi-asserted-by":"publisher","first-page":"1044","DOI":"10.2527\/1990.6841044x","volume":"68","author":"LF Miller","year":"1990","unstructured":"Miller, L. F., Judge, M. D. & Schanbacher, B. D. Intramuscular collagen and serum hydroxyproline as related to implanted testosterone, dihydrotestosterone and estradiol-17 beta in growing wethers. J. Anim. Sci. 68, 1044\u20131048 (1990).","journal-title":"J. Anim. Sci."},{"key":"BFncomms2774_CR29","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1679\/aohc1950.41.267","volume":"41","author":"LC Junqueira","year":"1978","unstructured":"Junqueira, L. C., Cossermelli, W. & Brentani, R. Differential staining of collagens type I, II and III by Sirius Red and polarization microscopy. Arch. Histol. Jpn 41, 267\u2013274 (1978).","journal-title":"Arch. Histol. Jpn"},{"key":"BFncomms2774_CR30","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1007\/BF01002772","volume":"11","author":"LC Junqueira","year":"1979","unstructured":"Junqueira, L. C., Bignolas, G. & Brentani, R. R. Picrosirius staining plus polarization microscopy, a specific method for collagen detection in tissue sections. Histochem. J. 11, 447\u2013455 (1979).","journal-title":"Histochem. J."},{"key":"BFncomms2774_CR31","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1152\/japplphysiol.00590.2004","volume":"98","author":"S Ito","year":"2005","unstructured":"Ito, S. et al. Mechanics, nonlinearity, and failure strength of lung tissue in a mouse model of emphysema: possible role of collagen remodeling. J. Appl. Physiol. 98, 503\u2013511 (2005).","journal-title":"J. Appl. Physiol."},{"key":"BFncomms2774_CR32","doi-asserted-by":"publisher","first-page":"L306","DOI":"10.1152\/ajplung.2001.280.2.L306","volume":"280","author":"R Al Jamal","year":"2001","unstructured":"Al Jamal, R., Roughley, P. J. & Ludwig, M. S. Effect of glycosaminoglycan degradation on lung tissue viscoelasticity. Am .J. Physiol. Lung Cell. Mol. Physiol. 280, L306\u2013L315 (2001).","journal-title":"Am .J. Physiol. Lung Cell. Mol. Physiol."},{"key":"BFncomms2774_CR33","doi-asserted-by":"publisher","first-page":"1009","DOI":"10.1038\/nm.2208","volume":"16","author":"V Barry-Hamilton","year":"2010","unstructured":"Barry-Hamilton, V. et al. Allosteric inhibition of lysyl oxidase-like-2 impedes the development of a pathologic microenvironment. Nat. Med. 16, 1009\u20131017 (2010).","journal-title":"Nat. Med."},{"key":"BFncomms2774_CR34","doi-asserted-by":"publisher","first-page":"20964","DOI":"10.1074\/jbc.M109.094136","volume":"285","author":"HM Rodriguez","year":"2010","unstructured":"Rodriguez, H. M. et al. Modulation of lysyl oxidase-like 2 enzymatic activity by an allosteric antibody inhibitor. J. Biol. Chem. 285, 20964\u201320974 (2010).","journal-title":"J. Biol. Chem."},{"key":"BFncomms2774_CR35","doi-asserted-by":"crossref","first-page":"7831","DOI":"10.1016\/S0021-9258(18)36022-8","volume":"254","author":"PC Trackman","year":"1979","unstructured":"Trackman, P. C. & Kagan, H. M. Nonpeptidyl amine inhibitors are substrates of lysyl oxidase. J. Biol. Chem. 254, 7831\u20137836 (1979).","journal-title":"J. Biol. Chem."},{"key":"BFncomms2774_CR36","doi-asserted-by":"publisher","first-page":"3213","DOI":"10.1021\/nl301206p","volume":"12","author":"M Kanapathipillai","year":"2012","unstructured":"Kanapathipillai, M. et al. Inhibition of mammary tumor growth using lysyl oxidase-targeting nanoparticles to modify extracellular matrix. Nano. Lett. 12, 3213\u20133217 (2012).","journal-title":"Nano. Lett."},{"key":"BFncomms2774_CR37","doi-asserted-by":"publisher","first-page":"1222","DOI":"10.1038\/nature04695","volume":"440","author":"JT Erler","year":"2006","unstructured":"Erler, J. T. et al. Lysyl oxidase is essential for hypoxia-induced metastasis. Nature 440, 1222\u20131226 (2006).","journal-title":"Nature"},{"key":"BFncomms2774_CR38","doi-asserted-by":"publisher","first-page":"L379","DOI":"10.1152\/ajplung.00010.2008","volume":"295","author":"G Matute-Bello","year":"2008","unstructured":"Matute-Bello, G., Frevert, C. W. & Martin, T. R. Animal models of acute lung injury. Am. J. Physiol. Lung. Cell. Mol. Physiol. 295, L379\u2013L399 (2008).","journal-title":"Am. J. Physiol. Lung. Cell. Mol. Physiol."},{"key":"BFncomms2774_CR39","doi-asserted-by":"publisher","first-page":"1239","DOI":"10.1164\/rccm.200902-0215OC","volume":"180","author":"A Kumarasamy","year":"2009","unstructured":"Kumarasamy, A. et al. Lysyl oxidase activity is dysregulated during impaired alveolarization of mouse and human lungs. Am. J. Respir. Crit. Care Med. 180, 1239\u20131252 (2009).","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"BFncomms2774_CR40","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1093\/cvr\/cvn102","volume":"79","author":"C Rodriguez","year":"2008","unstructured":"Rodriguez, C. et al. Regulation of lysyl oxidase in vascular cells: lysyl oxidase as a new player in cardiovascular diseases. Cardiovasc. Res. 79, 7\u201313 (2008).","journal-title":"Cardiovasc. Res."},{"key":"BFncomms2774_CR41","doi-asserted-by":"publisher","first-page":"2503","DOI":"10.1161\/01.CIR.0000038109.84500.1E","volume":"106","author":"JM Maki","year":"2002","unstructured":"Maki, J. M. et al. Inactivation of the lysyl oxidase gene Lox leads to aortic aneurysms, cardiovascular dysfunction, and perinatal death in mice. Circulation 106, 2503\u20132509 (2002).","journal-title":"Circulation"},{"key":"BFncomms2774_CR42","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1007\/s10237-002-0009-9","volume":"1","author":"D Stamenovic","year":"2002","unstructured":"Stamenovic, D. & Ingber, D. E. Models of cytoskeletal mechanics of adherent cells. Biomech. Model Mechanobiol. 1, 95\u2013108 (2002).","journal-title":"Biomech. Model Mechanobiol."},{"key":"BFncomms2774_CR43","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1038\/nrm1357","volume":"5","author":"E Dejana","year":"2004","unstructured":"Dejana, E. Endothelial cell-cell junctions: happy together. Nat. Rev. Mol. Cell Biol. 5, 261\u2013270 (2004).","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"BFncomms2774_CR44","doi-asserted-by":"publisher","first-page":"1195","DOI":"10.1242\/jcs.067009","volume":"124","author":"PP Provenzano","year":"2011","unstructured":"Provenzano, P. P. & Keely, P. J. Mechanical signaling through the cytoskeleton regulates cell proliferation by coordinated focal adhesion and Rho GTPase signaling. J. Cell. Sci. 124, 1195\u20131205 (2011).","journal-title":"J. Cell. Sci."},{"key":"BFncomms2774_CR45","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1097\/MOH.0b013e3282fa7445","volume":"15","author":"A Mammoto","year":"2008","unstructured":"Mammoto, A., Mammoto, T. & Ingber, D. E. Rho signaling and mechanical control of vascular development. Curr. Opin. Hematol. 15, 228\u2013234 (2008).","journal-title":"Curr. Opin. Hematol."},{"key":"BFncomms2774_CR46","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1242\/jcs.03353","volume":"120","author":"A Mammoto","year":"2007","unstructured":"Mammoto, A., Huang, S. & Ingber, D. E. Filamin links cell shape and cytoskeletal structure to Rho regulation by controlling accumulation of p190RhoGAP in lipid rafts. J. Cell. Sci. 120, 456\u2013467 (2007).","journal-title":"J. Cell. Sci."},{"key":"BFncomms2774_CR47","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1242\/jcs.114.7.1343","volume":"114","author":"B Wojciak-Stothard","year":"2001","unstructured":"Wojciak-Stothard, B., Potempa, S., Eichholtz, T. & Ridley, A. J. Rho and Rac but not Cdc42 regulate endothelial cell permeability. J. Cell. Sci. 114, 1343\u20131355 (2001).","journal-title":"J. Cell. Sci."},{"key":"BFncomms2774_CR48","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1593\/neo.101086","volume":"13","author":"MA Taylor","year":"2011","unstructured":"Taylor, M. A., Amin, J. D., Kirschmann, D. A. & Schiemann, W. P. Lysyl oxidase contributes to mechanotransduction-mediated regulation of transforming growth factor-beta signaling in breast cancer cells. Neoplasia 13, 406\u2013418 (2011).","journal-title":"Neoplasia"},{"key":"BFncomms2774_CR49","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1016\/j.atherosclerosis.2009.07.036","volume":"208","author":"M Onoda","year":"2010","unstructured":"Onoda, M. et al. Lysyl oxidase resolves inflammation by reducing monocyte chemoattractant protein-1 in abdominal aortic aneurysm. Atherosclerosis 208, 366\u2013369 (2010).","journal-title":"Atherosclerosis"},{"key":"BFncomms2774_CR50","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/1755-1536-2-7","volume":"2","author":"CZ Chen","year":"2009","unstructured":"Chen, C. Z. & Raghunath, M. Focus on collagen: in vitro systems to study fibrogenesis and antifibrosis state of the art. Fibrogenesis Tissue Repair 2, 7 (2009).","journal-title":"Fibrogenesis Tissue Repair"},{"key":"BFncomms2774_CR51","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/S0021-9150(98)00130-0","volume":"140","author":"A Bruel","year":"1998","unstructured":"Bruel, A., Ortoft, G. & Oxlund, H. Inhibition of cross-links in collagen is associated with reduced stiffness of the aorta in young rats. Atherosclerosis 140, 135\u2013145 (1998).","journal-title":"Atherosclerosis"},{"key":"BFncomms2774_CR52","doi-asserted-by":"publisher","first-page":"1365","DOI":"10.1161\/01.ATV.0000033935.66786.DE","volume":"22","author":"RA Bank","year":"2002","unstructured":"Bank, R. A. & van Hinsbergh, V. W. Lysyl oxidase: new looks on LOX. Arterioscler. Thromb. Vasc. Biol. 22, 1365\u20131366 (2002).","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"BFncomms2774_CR53","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1007\/978-1-60761-500-2_10","volume":"661","author":"CM Hecquet","year":"2010","unstructured":"Hecquet, C. M., Ahmmed, G. U. & Malik, A. B. TRPM2 channel regulates endothelial barrier function. Adv. Exp. Med. Biol. 661, 155\u2013167 (2010).","journal-title":"Adv. Exp. Med. Biol."},{"key":"BFncomms2774_CR54","doi-asserted-by":"publisher","first-page":"4378","DOI":"10.1158\/1078-0432.CCR-06-2685","volume":"13","author":"TM Shieh","year":"2007","unstructured":"Shieh, T. M. et al. Association of expression aberrances and genetic polymorphisms of lysyl oxidase with areca-associated oral tumorigenesis. Clin. Cancer Res. 13, 4378\u20134385 (2007).","journal-title":"Clin. Cancer Res."},{"key":"BFncomms2774_CR55","doi-asserted-by":"publisher","first-page":"24690","DOI":"10.1074\/jbc.M412979200","volume":"280","author":"B Fogelgren","year":"2005","unstructured":"Fogelgren, B. et al. Cellular fibronectin binds to lysyl oxidase with high affinity and is critical for its proteolytic activation. J. Biol. Chem. 280, 24690\u201324697 (2005).","journal-title":"J. Biol. Chem."},{"key":"BFncomms2774_CR56","doi-asserted-by":"publisher","first-page":"C606","DOI":"10.1152\/ajpcell.00269.2001","volume":"282","author":"N Wang","year":"2002","unstructured":"Wang, N. et al. Cell prestress. I. Stiffness and prestress are closely associated in adherent contractile cells. Am. J. Physiol. Cell. Physiol. 282, C606\u2013C616 (2002).","journal-title":"Am. J. Physiol. Cell. Physiol."},{"key":"BFncomms2774_CR57","doi-asserted-by":"publisher","first-page":"2165","DOI":"10.1039\/c2lc40074j","volume":"12","author":"HJ Kim","year":"2012","unstructured":"Kim, H. J., Huh, D., Hamilton, G. & Ingber, D. E. Human gut-on-a-chip inhabited by microbial flora that experiences intestinal peristalsis-like motions and flow. Lab. Chip. 12, 2165\u20132174 (2012).","journal-title":"Lab. Chip."},{"key":"BFncomms2774_CR58","doi-asserted-by":"publisher","first-page":"S69","DOI":"10.1016\/j.ymthe.2006.08.203","volume":"13","author":"A-L Bolcato-Bellemin","year":"2006","unstructured":"Bolcato-Bellemin, A.-L., Bonnet, M.-E. & Erbache, P. In vivo delivery of DNA or siRNA formulated into nanoparticles with linear PEI. Mol. Ther. 13, S69 (2006).","journal-title":"Mol. Ther."},{"key":"BFncomms2774_CR59","doi-asserted-by":"publisher","first-page":"2972","DOI":"10.1007\/s11095-008-9693-1","volume":"25","author":"ME Bonnet","year":"2008","unstructured":"Bonnet, M. E., Erbacher, P. & Bolcato-Bellemin, A. L. Systemic delivery of DNA or siRNA mediated by linear polyethylenimine (L-PEI) does not induce an inflammatory response. Pharm. Res. 25, 2972\u20132982 (2008).","journal-title":"Pharm. Res."}],"container-title":["Nature Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/ncomms2774.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/ncomms2774","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/ncomms2774.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,5]],"date-time":"2023-01-05T20:58:32Z","timestamp":1672952312000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/ncomms2774"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,4,23]]},"references-count":59,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2013,6,26]]}},"alternative-id":["BFncomms2774"],"URL":"https:\/\/doi.org\/10.1038\/ncomms2774","relation":{},"ISSN":["2041-1723"],"issn-type":[{"value":"2041-1723","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,4,23]]},"assertion":[{"value":"25 January 2013","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 March 2013","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 April 2013","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing financial interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"1759"}}