{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T04:13:22Z","timestamp":1792815202575,"version":"4.5.0"},"reference-count":17,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2014,3,24]],"date-time":"2014-03-24T00:00:00Z","timestamp":1395619200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2014,3,24]],"date-time":"2014-03-24T00:00:00Z","timestamp":1395619200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nat Commun"],"DOI":"10.1038\/ncomms4469","type":"journal-article","created":{"date-parts":[[2014,3,24]],"date-time":"2014-03-24T13:29:15Z","timestamp":1395667755000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":178,"title":["Mutations in epigenetic regulators including SETD2 are gained during relapse in paediatric acute lymphoblastic leukaemia"],"prefix":"10.1038","volume":"5","author":[{"given":"Brenton G.","family":"Mar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars B.","family":"Bullinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen M.","family":"McLean","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter V.","family":"Grauman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marian H.","family":"Harris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristen","family":"Stevenson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donna S.","family":"Neuberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amit U.","family":"Sinha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen E.","family":"Sallan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lewis B.","family":"Silverman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew L.","family":"Kung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Lo Nigro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin L.","family":"Ebert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott A.","family":"Armstrong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,3,24]]},"reference":[{"key":"BFncomms4469_CR1","doi-asserted-by":"publisher","first-page":"1377","DOI":"10.1126\/science.1164266","volume":"322","author":"CG Mullighan","year":"2008","unstructured":"Mullighan, C. G. et al. Genomic analysis of the clonal origins of relapsed acute lymphoblastic leukemia. Science 322, 1377\u20131380 (2008).","journal-title":"Science"},{"key":"BFncomms4469_CR2","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1038\/nature10725","volume":"481","author":"J Zhang","year":"2012","unstructured":"Zhang, J. et al. The genetic basis of early T-cell precursor acute lymphoblastic leukaemia. Nature 481, 157\u2013163 (2012).","journal-title":"Nature"},{"key":"BFncomms4469_CR3","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1038\/ng.2532","volume":"45","author":"L Holmfeldt","year":"2013","unstructured":"Holmfeldt, L. et al. The genomic landscape of hypodiploid acute lymphoblastic leukemia. Nat. Genet. 45, 242\u2013252 (2013).","journal-title":"Nat. Genet."},{"key":"BFncomms4469_CR4","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1038\/nature09727","volume":"471","author":"CG Mullighan","year":"2011","unstructured":"Mullighan, C. G. et al. CREBBP mutations in relapsed acute lymphoblastic leukaemia. Nature 471, 235\u2013239 (2011).","journal-title":"Nature"},{"key":"BFncomms4469_CR5","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1038\/ng.2508","volume":"45","author":"K De Keersmaecker","year":"2013","unstructured":"De Keersmaecker, K. et al. Exome sequencing identifies mutation in CNOT3 and ribosomal genes RPL5 and RPL10 in T-cell acute lymphoblastic leukemia. Nat. Genet. 45, 186\u2013190 (2013).","journal-title":"Nat. Genet."},{"key":"BFncomms4469_CR6","doi-asserted-by":"publisher","first-page":"1881","DOI":"10.1038\/leu.2012.56","volume":"26","author":"B Mar","year":"2012","unstructured":"Mar, B. et al. Sequencing histone-modifying enzymes identifies UTX mutations in acute lymphoblastic leukemia. Leukemia. 26, 1881\u20131883 (2012).","journal-title":"Leukemia."},{"key":"BFncomms4469_CR7","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1038\/nature08672","volume":"463","author":"G Dalgliesh","year":"2010","unstructured":"Dalgliesh, G. et al. Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes. Nature 463, 360\u2013363 (2010).","journal-title":"Nature"},{"key":"BFncomms4469_CR8","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1038\/nm.3078","volume":"19","author":"G Tzoneva","year":"2013","unstructured":"Tzoneva, G. et al. Activating mutations in the NT5C2 nucleotidase gene drive chemotherapy resistance in relapsed ALL. Nat. Med. 19, 368\u2013371 (2013).","journal-title":"Nat. Med."},{"key":"BFncomms4469_CR9","doi-asserted-by":"crossref","unstructured":"Cancer Genome Atlas Research Network. Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia. New Engl. J. Med. 368, 2059\u20132074 (2013).","DOI":"10.1056\/NEJMoa1301689"},{"key":"BFncomms4469_CR10","doi-asserted-by":"publisher","first-page":"590","DOI":"10.1016\/j.cell.2013.03.025","volume":"153","author":"F Li","year":"2013","unstructured":"Li, F. et al. The histone mark H3K36me3 regulates human dna mismatch repair through its interaction with MutSalpha. Cell 153, 590\u2013600 (2013).","journal-title":"Cell"},{"key":"BFncomms4469_CR11","doi-asserted-by":"publisher","first-page":"1298","DOI":"10.1038\/nm.2430","volume":"17","author":"B Diouf","year":"2011","unstructured":"Diouf, B. et al. Somatic deletions of genes regulating MSH2 protein stability cause DNA mismatch repair deficiency and drug resistance in human leukemia cells. Nat. Med. 17, 1298\u20131303 (2011).","journal-title":"Nat. Med."},{"key":"BFncomms4469_CR12","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1038\/nrm3274","volume":"13","author":"E Wagner","year":"2012","unstructured":"Wagner, E. & Carpenter, P. Understanding the language of Lys36 methylation at histone H3. Nat Rev Mol Cell Biol 13, 115\u2013126 (2012).","journal-title":"Nat Rev Mol Cell Biol"},{"key":"BFncomms4469_CR13","doi-asserted-by":"publisher","first-page":"1386","DOI":"10.1038\/ng.2777","volume":"45","author":"JD Jaffe","year":"2013","unstructured":"Jaffe, J. D. et al. Global chromatin profiling reveals NSD2 mutations in pediatric acute lymphoblastic leukemia. Nat. Genet. 45, 1386\u20131391 (2013).","journal-title":"Nat. Genet."},{"key":"BFncomms4469_CR14","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1038\/leu.2013.204","volume":"28","author":"J Oyer","year":"2013","unstructured":"Oyer, J. et al. Point mutation E1099K in MMSET\/NSD2 enhances its methyltranferase activity and leads to altered global chromatin methylation in lymphoid malignancies. Leukemia. 28, 198\u2013201 (2013).","journal-title":"Leukemia."},{"key":"BFncomms4469_CR15","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1038\/ng.2558","volume":"45","author":"JA Meyer","year":"2013","unstructured":"Meyer, J.A. et al. Relapse-specific mutations in NT5C2 in childhood acute lymphoblastic leukemia. Nat Genet 45, 290\u2013294 (2013).","journal-title":"Nat Genet"},{"key":"BFncomms4469_CR16","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1038\/onc.2011.267","volume":"31","author":"S Spiegel","year":"2012","unstructured":"Spiegel, S., Milstien, S. & Grant, S. Endogenous modulators and pharmacological inhibitors of histone deacetylases in cancer therapy. Oncogene 31, 537\u2013551 (2012).","journal-title":"Oncogene"},{"key":"BFncomms4469_CR17","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/j.ccr.2011.06.009","volume":"20","author":"S Daigle","year":"2011","unstructured":"Daigle, S. et al. Selective killing of mixed lineage leukemia cells by a potent small-molecule DOT1L inhibitor. Cancer Cell 20, 53\u201365 (2011).","journal-title":"Cancer Cell"}],"container-title":["Nature Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/ncomms4469.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/ncomms4469","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/ncomms4469.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,6]],"date-time":"2023-01-06T04:02:32Z","timestamp":1672977752000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/ncomms4469"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,3,24]]},"references-count":17,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2014,5,20]]}},"alternative-id":["BFncomms4469"],"URL":"https:\/\/doi.org\/10.1038\/ncomms4469","relation":{},"ISSN":["2041-1723"],"issn-type":[{"value":"2041-1723","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,3,24]]},"assertion":[{"value":"8 October 2013","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 February 2014","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 March 2014","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing financial interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"3469"}}