{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T20:47:05Z","timestamp":1788468425921,"version":"build-2803163510"},"reference-count":42,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2014,6,17]],"date-time":"2014-06-17T00:00:00Z","timestamp":1402963200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2014,6,17]],"date-time":"2014-06-17T00:00:00Z","timestamp":1402963200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nat Commun"],"DOI":"10.1038\/ncomms5108","type":"journal-article","created":{"date-parts":[[2014,6,17]],"date-time":"2014-06-17T14:57:00Z","timestamp":1403017020000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":52,"title":["Diminished hERG K+ channel activity facilitates strong human labour contractions but is dysregulated in obese women"],"prefix":"10.1038","volume":"5","author":[{"given":"Helena C.","family":"Parkington","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janet","family":"Stevenson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary A.","family":"Tonta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Paul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trent","family":"Butler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaushik","family":"Maiti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eng-Cheng","family":"Chan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Penelope M.","family":"Sheehan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaun P.","family":"Brennecke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harold A.","family":"Coleman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,6,17]]},"reference":[{"key":"BFncomms5108_CR1","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1056\/NEJMra061360","volume":"356","author":"R Smith","year":"2007","unstructured":"Smith, R. Parturition. N. Engl. J. Med. 356, 271\u2013283 (2007).","journal-title":"N. Engl. J. Med."},{"key":"BFncomms5108_CR2","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1196\/annals.1389.038","volume":"1101","author":"RC Young","year":"2007","unstructured":"Young, R. C. Myocytes, myometrium, and uterine contractions. Ann. N. Y. Acad. Sci. 1101, 72\u201384 (2007).","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"BFncomms5108_CR3","doi-asserted-by":"publisher","first-page":"1445","DOI":"10.1016\/S0002-9378(99)70390-X","volume":"181","author":"HC Parkington","year":"1999","unstructured":"Parkington, H. C., Tonta, M. A., Brennecke, S. P. & Coleman, H. A. Contractile activity, membrane potential, and cytoplasmic calcium in human uterine smooth muscle in the third trimester of pregnancy and during labor. Am. J. Obstet. Gynecol. 181, 1445\u20131451 (1999).","journal-title":"Am. J. Obstet. Gynecol."},{"key":"BFncomms5108_CR4","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1196\/annals.1389.031","volume":"1101","author":"A Shmygol","year":"2007","unstructured":"Shmygol, A., Blanks, A. M., Bru-Mercier, G., Gullam, J. E. & Thornton, S. Control of uterine Ca2+ by membrane voltage: toward understanding the excitation-contraction coupling in human myometrium. Ann. N. Y. Acad. Sci. 1101, 97\u2013109 (2007).","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"BFncomms5108_CR5","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1038\/nature04710","volume":"440","author":"MC Sanguinetti","year":"2006","unstructured":"Sanguinetti, M. C. & Tristani-Firouzi, M. hERG potassium channels and cardiac arrhythmia. Nature 440, 463\u2013469 (2006).","journal-title":"Nature"},{"key":"BFncomms5108_CR6","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/S0092-8674(00)80728-X","volume":"97","author":"GW Abbott","year":"1999","unstructured":"Abbott, G. W. et al. MiRP1 forms IKr potassium channels with HERG and is associated with cardiac arrhythmia. Cell 97, 175\u2013187 (1999).","journal-title":"Cell"},{"key":"BFncomms5108_CR7","doi-asserted-by":"publisher","first-page":"1783","DOI":"10.1161\/01.CIR.0000124225.43852.50","volume":"109","author":"M Jiang","year":"2004","unstructured":"Jiang, M. et al. KCNE2 protein is expressed in ventricles of different species, and changes in its expression contribute to electrical remodeling in diseased hearts. Circulation 109, 1783\u20131788 (2004).","journal-title":"Circulation"},{"key":"BFncomms5108_CR8","doi-asserted-by":"publisher","first-page":"2313","DOI":"10.1113\/jphysiol.2009.171272","volume":"587","author":"IA Greenwood","year":"2009","unstructured":"Greenwood, I. A., Yeung, S. Y., Tribe, R. M. & Ohya, S. Loss of functional K+ channels encoded by ether-a-go-go-related genes in mouse myometrium prior to labour onset. J. Physiol. 587, 2313\u20132326 (2009).","journal-title":"J. Physiol."},{"key":"BFncomms5108_CR9","doi-asserted-by":"publisher","first-page":"C1284","DOI":"10.1152\/ajpcell.1999.277.6.C1284","volume":"277","author":"HI Akbarali","year":"1999","unstructured":"Akbarali, H. I., Thatte, H., He, X. D., Giles, W. R. & Goyal, R. K. Role of HERG-like K+ currents in opossum esophageal circular smooth muscle. Am. J. Physiol. Cell Physiol. 277, C1284\u2013C1290 (1999).","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"BFncomms5108_CR10","doi-asserted-by":"publisher","first-page":"G883","DOI":"10.1152\/ajpgi.00394.2002","volume":"284","author":"AM Farrelly","year":"2003","unstructured":"Farrelly, A. M. et al. Expression and function of KCNH2 (HERG) in the human jejunum. Am. J. Physiol. Gastrointest. Liver Physiol. 284, G883\u2013G895 (2003).","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"BFncomms5108_CR11","doi-asserted-by":"publisher","first-page":"R895","DOI":"10.1152\/ajpregu.00521.2007","volume":"294","author":"M Mewe","year":"2008","unstructured":"Mewe, M. et al. Erg K+ channels modulate contractile activity in the bovine epididymal duct. Am. J. Physiol. Regul. Integr. Comp. Physiol. 294, R895\u2013R904 (2008).","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"BFncomms5108_CR12","doi-asserted-by":"publisher","first-page":"G277","DOI":"10.1152\/ajpgi.00200.2001","volume":"282","author":"S Ohya","year":"2002","unstructured":"Ohya, S., Asakura, K., Muraki, K., Watanabe, M. & Imaizumi, Y. Molecular and functional characterization of ERG, KCNQ, and KCNE subtypes in rat stomach smooth muscle. Am. J. Physiol. Gastrointest. Liver Physiol. 282, G277\u2013G287 (2002).","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"BFncomms5108_CR13","doi-asserted-by":"publisher","first-page":"C866","DOI":"10.1152\/ajpcell.00099.2002","volume":"283","author":"S Ohya","year":"2002","unstructured":"Ohya, S., Horowitz, B. & Greenwood, I. A. Functional and molecular identification of ERG channels in murine portal vein myocytes. Am. J. Physiol. Cell Physiol. 283, C866\u2013C877 (2002).","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"BFncomms5108_CR14","doi-asserted-by":"publisher","first-page":"G392","DOI":"10.1152\/ajpgi.00325.2002","volume":"284","author":"E Parr","year":"2003","unstructured":"Parr, E., Pozo, M. J., Horowitz, B., Nelson, M. T. & Mawe, G. M. ERG K+ channels modulate the electrical and contractile activities of gallbladder smooth muscle. Am. J. Physiol. Gastrointest. Liver Physiol. 284, G392\u2013G398 (2003).","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"BFncomms5108_CR15","doi-asserted-by":"publisher","first-page":"2503","DOI":"10.1074\/jbc.M208525200","volume":"278","author":"F Shoeb","year":"2003","unstructured":"Shoeb, F., Malykhina, A. P. & Akbarali, H. I. Cloning and functional characterization of the smooth muscle ether-a-go-go-related gene K+ channel. Potential role of a conserved amino acid substitution in the S4 region. J. Biol. Chem. 278, 2503\u20132514 (2003).","journal-title":"J. Biol. Chem."},{"key":"BFncomms5108_CR16","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1177\/1933719107306229","volume":"14","author":"Z Jie","year":"2007","unstructured":"Jie, Z., Kendrick, A., Quenby, S. & Wray, S. Contractility and calcium signaling of human myometrium are profoundly affected by cholesterol manipulation: implications for labor? Reprod. Sci. 14, 456\u2013466 (2007).","journal-title":"Reprod. Sci."},{"key":"BFncomms5108_CR17","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1177\/1933719109349780","volume":"17","author":"CA Higgins","year":"2010","unstructured":"Higgins, C. A. et al. Maternal obesity and its relationship with spontaneous and oxytocin-induced contractility of human myometrium in vitro. Reprod. Sci. 17, 177\u2013185 (2010).","journal-title":"Reprod. Sci."},{"key":"BFncomms5108_CR18","doi-asserted-by":"publisher","first-page":"1315","DOI":"10.1097\/AOG.0b013e318217922a","volume":"117","author":"EM Fyfe","year":"2011","unstructured":"Fyfe, E. M. et al. Risk of first-stage and second-stage cesarean delivery by maternal body mass index among nulliparous women in labor at term. Obstet. Gynecol. 117, 1315\u20131322 (2011).","journal-title":"Obstet. Gynecol."},{"key":"BFncomms5108_CR19","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1124\/pr.57.4.10","volume":"57","author":"GA Gutman","year":"2005","unstructured":"Gutman, G. A. et al. International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels. Pharmacol. Rev. 57, 473\u2013508 (2005).","journal-title":"Pharmacol. Rev."},{"key":"BFncomms5108_CR20","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1085\/jgp.201210826","volume":"140","author":"V Garg","year":"2012","unstructured":"Garg, V., Sachse, F. B. & Sanguinetti, M. C. Tuning of EAG K+ channel inactivation: molecular determinants of amplification by mutations and a small molecule. J. Gen. Physiol. 140, 307\u2013324 (2012).","journal-title":"J. Gen. Physiol."},{"key":"BFncomms5108_CR21","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1111\/j.1469-7793.1999.229af.x","volume":"514","author":"HC Parkington","year":"1999","unstructured":"Parkington, H. C., Tonta, M. A., Davies, N. K., Brennecke, S. P. & Coleman, H. A. Hyperpolarization and slowing of the rate of contraction in human uterus in pregnancy by prostaglandins E2 and F2\u03b1: involvement of the Na+ pump. J. Physiol. 514, 229\u2013243 (1999).","journal-title":"J. Physiol."},{"key":"BFncomms5108_CR22","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1089\/lrb.2007.5104","volume":"5","author":"EA Beckett","year":"2007","unstructured":"Beckett, E. A., Hollywood, M. A., Thornbury, K. D. & McHale, N. G. Spontaneous electrical activity in sheep mesenteric lymphatics. Lymphat. Res. Biol. 5, 29\u201343 (2007).","journal-title":"Lymphat. Res. Biol."},{"key":"BFncomms5108_CR23","doi-asserted-by":"publisher","first-page":"1049","DOI":"10.1113\/jphysiol.2007.137034","volume":"583","author":"RJ Lang","year":"2007","unstructured":"Lang, R. J., Hashitani, H., Tonta, M. A., Parkington, H. C. & Suzuki, H. Spontaneous electrical and Ca2+ signals in typical and atypical smooth muscle cells and interstitial cell of Cajal-like cells of mouse renal pelvis. J. Physiol. 583, 1049\u20131068 (2007).","journal-title":"J. Physiol."},{"key":"BFncomms5108_CR24","doi-asserted-by":"publisher","first-page":"153","DOI":"10.2170\/jjphysiol.25.153","volume":"25","author":"T Osa","year":"1975","unstructured":"Osa, T. & Katase, T. Physiological comparison of the longitudinal and circular muscles of the pregnant rat uterus. Jpn. J. Physiol. 25, 153\u2013164 (1975).","journal-title":"Jpn. J. Physiol."},{"key":"BFncomms5108_CR25","doi-asserted-by":"publisher","first-page":"839","DOI":"10.1113\/jphysiol.2004.070615","volume":"560","author":"S Shabir","year":"2004","unstructured":"Shabir, S., Borisova, L., Wray, S. & Burdyga, T. Rho-kinase inhibition and electromechanical coupling in rat and guinea-pig ureter smooth muscle: Ca2+-dependent and -independent mechanisms. J. Physiol. 560, 839\u2013855 (2004).","journal-title":"J. Physiol."},{"key":"BFncomms5108_CR26","doi-asserted-by":"publisher","first-page":"C468","DOI":"10.1152\/ajpcell.00142.2006","volume":"292","author":"SY Yeung","year":"2007","unstructured":"Yeung, S. Y. & Greenwood, I. A. Pharmacological and biophysical isolation of K+ currents encoded by ether-a-go-go-related genes in murine hepatic portal vein smooth muscle cells. Am. J. Physiol. Cell Physiol. 292, C468\u2013C476 (2007).","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"BFncomms5108_CR27","doi-asserted-by":"publisher","first-page":"H1244","DOI":"10.1152\/ajpheart.01252.2008","volume":"296","author":"J Chen","year":"2009","unstructured":"Chen, J. et al. PKA phosphorylation of HERG protein regulates the rate of channel synthesis. Am. J. Physiol. Heart Circ. Physiol. 296, H1244\u2013H1254 (2009).","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"BFncomms5108_CR28","doi-asserted-by":"publisher","first-page":"17244","DOI":"10.1074\/jbc.M010904200","volume":"276","author":"J Cui","year":"2001","unstructured":"Cui, J. et al. Analysis of the cyclic nucleotide binding domain of the HERG potassium channel and interactions with KCNE2. J. Biol. Chem. 276, 17244\u201317251 (2001).","journal-title":"J. Biol. Chem."},{"key":"BFncomms5108_CR29","doi-asserted-by":"publisher","first-page":"2194","DOI":"10.1210\/jc.2002-021862","volume":"88","author":"MW MacDougall","year":"2003","unstructured":"MacDougall, M. W., Europe-Finner, G. N. & Robson, S. C. Human myometrial quiescence and activation during gestation and parturition involve dramatic changes in expression and activity of particulate type II (RII alpha) protein kinase A holoenzyme. J. Clin. Endocrinol. Metab. 88, 2194\u20132205 (2003).","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"BFncomms5108_CR30","doi-asserted-by":"publisher","first-page":"578","DOI":"10.1111\/j.1471-0528.2010.02889.x","volume":"118","author":"S Arrowsmith","year":"2011","unstructured":"Arrowsmith, S., Wray, S. & Quenby, S. Maternal obesity and labour complications following induction of labour in prolonged pregnancy. BJOG 118, 578\u2013588 (2011).","journal-title":"BJOG"},{"key":"BFncomms5108_CR31","doi-asserted-by":"publisher","first-page":"184","DOI":"10.5694\/mja11.11120","volume":"196","author":"HD McIntyre","year":"2012","unstructured":"McIntyre, H. D., Gibbons, K. S., Flenady, V. J. & Callaway, L. K. Overweight and obesity in Australian mothers: epidemic or endemic? Med. J. Aust. 196, 184\u2013188 (2012).","journal-title":"Med. J. Aust."},{"key":"BFncomms5108_CR32","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/j.mce.2008.06.003","volume":"292","author":"P Kundu","year":"2008","unstructured":"Kundu, P. et al. Hormonal regulation of cardiac KCNE2 gene expression. Mol. Cell. Endocrinol. 292, 50\u201362 (2008).","journal-title":"Mol. Cell. Endocrinol."},{"key":"BFncomms5108_CR33","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1097\/00008469-200206000-00012","volume":"11","author":"J Wuu","year":"2002","unstructured":"Wuu, J. et al. Correlates of pregnancy oestrogen, progesterone and sex hormone-binding globulin in the USA and China. Eur. J. Cancer Prev. 11, 283\u2013293 (2002).","journal-title":"Eur. J. Cancer Prev."},{"key":"BFncomms5108_CR34","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1210\/jc.2012-3481","volume":"98","author":"BJ Meyer","year":"2013","unstructured":"Meyer, B. J. et al. Maternal obesity is associated with the formation of small dense LDL and hypoadiponectinemia in the third trimester. J. Clin. Endocrinol. Metab. 98, 643\u2013652 (2013).","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"BFncomms5108_CR35","doi-asserted-by":"publisher","first-page":"H2464","DOI":"10.1152\/ajpheart.00965.2011","volume":"302","author":"L Howitt","year":"2012","unstructured":"Howitt, L., Grayson, T. H., Morris, M. J., Sandow, S. L. & Murphy, T. V. Dietary obesity increases NO and inhibits BKCa-mediated, endothelium-dependent dilation in rat cremaster muscle artery: association with caveolins and caveolae. Am. J. Physiol. Heart Circ. Physiol. 302, H2464\u2013H2476 (2012).","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"BFncomms5108_CR36","doi-asserted-by":"publisher","first-page":"263","DOI":"10.4161\/chan.4946","volume":"1","author":"RC Balijepalli","year":"2007","unstructured":"Balijepalli, R. C. et al. Kv11.1 (ERG1) K+ channels localize in cholesterol and sphingolipid enriched membranes and are modulated by membrane cholesterol. Channels (Austin) 1, 263\u2013272 (2007).","journal-title":"Channels (Austin)"},{"key":"BFncomms5108_CR37","doi-asserted-by":"publisher","first-page":"3169","DOI":"10.1113\/jphysiol.2010.191585","volume":"588","author":"C Dart","year":"2010","unstructured":"Dart, C. Lipid microdomains and the regulation of ion channel function. J. Physiol. 588, 3169\u20133178 (2010).","journal-title":"J. Physiol."},{"key":"BFncomms5108_CR38","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1113\/jphysiol.2005.098475","volume":"570","author":"K Noble","year":"2006","unstructured":"Noble, K., Zhang, J. & Wray, S. Lipid rafts, the sarcoplasmic reticulum and uterine calcium signalling: an integrated approach. J. Physiol. 570, 29\u201335 (2006).","journal-title":"J. Physiol."},{"key":"BFncomms5108_CR39","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1046\/j.1365-2265.1997.2441017.x","volume":"47","author":"L Hardie","year":"1997","unstructured":"Hardie, L., Trayhurn, P., Abramovich, D. & Fowler, P. Circulating leptin in women: a longitudinal study in the menstrual cycle and during pregnancy. Clin. Endocrinol. (Oxf.) 47, 101\u2013106 (1997).","journal-title":"Clin. Endocrinol. (Oxf.)"},{"key":"BFncomms5108_CR40","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1016\/j.ajog.2006.01.106","volume":"195","author":"AT Moynihan","year":"2006","unstructured":"Moynihan, A. T., Hehir, M. P., Glavey, S. V., Smith, T. J. & Morrison, J. J. Inhibitory effect of leptin on human uterine contractility in vitro. Am. J. Obstet. Gynecol. 195, 504\u2013509 (2006).","journal-title":"Am. J. Obstet. Gynecol."},{"key":"BFncomms5108_CR41","doi-asserted-by":"publisher","first-page":"359.e1","DOI":"10.1016\/j.ajog.2012.01.032","volume":"206","author":"MP Hehir","year":"2012","unstructured":"Hehir, M. P. & Morrison, J. J. The adipokine apelin and human uterine contractility. Am. J. Obstet. Gynecol. 206, 359.e1\u2013359.e5 (2012).","journal-title":"Am. J. Obstet. Gynecol."},{"key":"BFncomms5108_CR42","doi-asserted-by":"publisher","first-page":"e21542","DOI":"10.1371\/journal.pone.0021542","volume":"6","author":"J Paul","year":"2011","unstructured":"Paul, J. et al. Phasic phosphorylation of caldesmon and ERK 1\/2 during contractions in human myometrium. PLoS ONE 6, e21542 (2011).","journal-title":"PLoS ONE"}],"container-title":["Nature Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/ncomms5108.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/ncomms5108","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/ncomms5108.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,6]],"date-time":"2023-01-06T03:39:10Z","timestamp":1672976350000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/ncomms5108"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,6,17]]},"references-count":42,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2014,9,22]]}},"alternative-id":["BFncomms5108"],"URL":"https:\/\/doi.org\/10.1038\/ncomms5108","relation":{},"ISSN":["2041-1723"],"issn-type":[{"value":"2041-1723","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,6,17]]},"assertion":[{"value":"6 February 2014","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 May 2014","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 June 2014","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Roger Smith has a patent held at the University of Newcastle related to the use of hERG modulators in pregnancy: International (PCT) Patent Application No. PCT\/AU2012\/001446 'Compositions and methods for modulating uterine contractions', with a priority date of 24 November 2011. The remaining authors declare no competing financial interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"4108"}}