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Subtle inter-patient genetic variation and environmental factors combine to determine variation in disease progression. A common non-synonymous polymorphism in\n                    <jats:italic>TM6SF2<\/jats:italic>\n                    (rs58542926 c.449 C&gt;T, p.Glu167Lys) was recently associated with increased hepatic triglyceride content, but whether this variant promotes clinically relevant hepatic fibrosis is unknown. Here we confirm that\n                    <jats:italic>TM6SF2<\/jats:italic>\n                    minor allele carriage is associated with NAFLD and is causally related to a previously reported chromosome 19 GWAS signal that was ascribed to the gene\n                    <jats:italic>NCAN<\/jats:italic>\n                    . Furthermore, using two histologically characterized cohorts encompassing steatosis, steatohepatitis, fibrosis and cirrhosis (combined\n                    <jats:italic>n<\/jats:italic>\n                    =1,074), we demonstrate a new association, independent of potential confounding factors (age, BMI, type 2 diabetes mellitus and\n                    <jats:italic>PNPLA3<\/jats:italic>\n                    rs738409 genotype), with advanced hepatic fibrosis\/cirrhosis. These findings establish new and important clinical relevance to\n                    <jats:italic>TM6SF2<\/jats:italic>\n                    in NAFLD.\n                  <\/jats:p>","DOI":"10.1038\/ncomms5309","type":"journal-article","created":{"date-parts":[[2014,6,30]],"date-time":"2014-06-30T10:38:10Z","timestamp":1404124690000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":544,"title":["TM6SF2 rs58542926 influences hepatic fibrosis progression in patients with non-alcoholic fatty liver disease"],"prefix":"10.1038","volume":"5","author":[{"given":"Yang-Lin","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen L.","family":"Reeves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alastair D.","family":"Burt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dina","family":"Tiniakos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart","family":"McPherson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian B. 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