{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T01:47:00Z","timestamp":1791942420160,"version":"4.3.4"},"reference-count":46,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2014,7,9]],"date-time":"2014-07-09T00:00:00Z","timestamp":1404864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2014,7,9]],"date-time":"2014-07-09T00:00:00Z","timestamp":1404864000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nat Commun"],"DOI":"10.1038\/ncomms5366","type":"journal-article","created":{"date-parts":[[2014,7,9]],"date-time":"2014-07-09T12:40:20Z","timestamp":1404909620000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":111,"title":["G1-arrested newborn cells are the predominant infectious form of the pathogen Brucella abortus"],"prefix":"10.1038","volume":"5","author":[{"given":"Micha\u00ebl","family":"Deghelt","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Mullier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Fran\u00e7ois","family":"Sternon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nayla","family":"Francis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00e9raldine","family":"Laloux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Delphine","family":"Dotreppe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Van der Henst","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Jacobs-Wagner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Jacques","family":"Letesson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"De Bolle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,7,9]]},"reference":[{"key":"BFncomms5366_CR1","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1016\/j.mib.2004.12.007","volume":"8","author":"SP Salcedo","year":"2005","unstructured":"Salcedo, S. P. & Holden, D. W. Bacterial interactions with the eukaryotic secretory pathway. Curr. Opin. Microbiol. 8, 92\u201398 (2005).","journal-title":"Curr. Opin. Microbiol."},{"key":"BFncomms5366_CR2","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1007\/0-387-30745-1_17","volume":"5","author":"E Moreno","year":"2006","unstructured":"Moreno, E. & Moriyon, I. Prokaryotes 5, 315\u2013456Springer (2006).","journal-title":"Prokaryotes"},{"key":"BFncomms5366_CR3","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1046\/j.1462-5822.2001.00102.x","volume":"3","author":"DJ Comerci","year":"2001","unstructured":"Comerci, D. J., Martinez-Lorenzo, M. J., Sieira, R., Gorvel, J. P. & Ugalde, R. A. Essential role of the VirB machinery in the maturation of the Brucella abortus-containing vacuole. Cell. Microbiol. 3, 159\u2013168 (2001).","journal-title":"Cell. Microbiol."},{"key":"BFncomms5366_CR4","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1084\/jem.20030088","volume":"198","author":"J Celli","year":"2003","unstructured":"Celli, J. et al. Brucella evades macrophage killing via VirB-dependent sustained interactions with the endoplasmic reticulum. J. Exp. Med. 198, 545\u2013556 (2003).","journal-title":"J. Exp. Med."},{"key":"BFncomms5366_CR5","doi-asserted-by":"crossref","first-page":"5711","DOI":"10.1128\/IAI.66.12.5711-5724.1998","volume":"66","author":"J Pizarro-Cerda","year":"1998","unstructured":"Pizarro-Cerda, J. et al. Brucella abortus transits through the autophagic pathway and replicates in the endoplasmic reticulum of nonprofessional phagocytes. Infect. Immun. 66, 5711\u20135724 (1998).","journal-title":"Infect. Immun."},{"key":"BFncomms5366_CR6","doi-asserted-by":"publisher","first-page":"678","DOI":"10.1111\/j.1600-0854.2008.00718.x","volume":"9","author":"T Starr","year":"2008","unstructured":"Starr, T., Ng, T. W., Wehrly, T. D., Knodler, L. A. & Celli, J. Brucella intracellular replication requires trafficking through the late endosomal\/lysosomal compartment. Traffic 9, 678\u2013694 (2008).","journal-title":"Traffic"},{"key":"BFncomms5366_CR7","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1016\/S0966-842X(01)02135-7","volume":"9","author":"YV Brun","year":"2001","unstructured":"Brun, Y. V. Global analysis of a bacterial cell cycle: tracking down necessary functions and their regulators. Trends Microbiol. 9, 405\u2013407 (2001).","journal-title":"Trends Microbiol."},{"key":"BFncomms5366_CR8","doi-asserted-by":"publisher","first-page":"945","DOI":"10.1046\/j.1365-2958.2002.02777.x","volume":"43","author":"AF Bellefontaine","year":"2002","unstructured":"Bellefontaine, A. F. et al. Plasticity of a transcriptional regulation network among alpha-proteobacteria is supported by the identification of CtrA targets in Brucella abortus. Mol. Microbiol. 43, 945\u2013960 (2002).","journal-title":"Mol. Microbiol."},{"key":"BFncomms5366_CR9","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1016\/j.tim.2004.06.002","volume":"12","author":"R Hallez","year":"2004","unstructured":"Hallez, R., Bellefontaine, A. F., Letesson, J. J. & De Bolle, X. Morphological and functional asymmetry in alpha-proteobacteria. Trends Microbiol. 12, 361\u2013365 (2004).","journal-title":"Trends Microbiol."},{"key":"BFncomms5366_CR10","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/S0092-8674(00)80995-2","volume":"84","author":"KC Quon","year":"1996","unstructured":"Quon, K. C., Marczynski, G. T. & Shapiro, L. Cell cycle control by an essential bacterial two-component signal transduction protein. Cell 84, 83\u201393 (1996).","journal-title":"Cell"},{"key":"BFncomms5366_CR11","doi-asserted-by":"publisher","first-page":"933","DOI":"10.1038\/nrmicro1044","volume":"2","author":"J Batut","year":"2004","unstructured":"Batut, J., Andersson, S. G. & O'Callaghan, D. The evolution of chronic infection strategies in the alpha-proteobacteria. Nat. Rev. Microbiol. 2, 933\u2013945 (2004).","journal-title":"Nat. Rev. Microbiol."},{"key":"BFncomms5366_CR12","doi-asserted-by":"publisher","first-page":"1697","DOI":"10.1073\/pnas.1114476109","volume":"109","author":"PJ Brown","year":"2012","unstructured":"Brown, P. J. et al. Polar growth in the Alphaproteobacterial order Rhizobiales. Proc. Natl Acad. Sci. USA 109, 1697\u20131701 (2012).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFncomms5366_CR13","doi-asserted-by":"publisher","first-page":"8353","DOI":"10.1128\/IAI.73.12.8353-8361.2005","volume":"73","author":"PS Chain","year":"2005","unstructured":"Chain, P. S. et al. Whole-genome analyses of speciation events in pathogenic Brucellae. Infect. Immun. 73, 8353\u20138361 (2005).","journal-title":"Infect. Immun."},{"key":"BFncomms5366_CR14","doi-asserted-by":"publisher","first-page":"3384","DOI":"10.1128\/JB.185.11.3384-3391.2003","volume":"185","author":"LS Kahng","year":"2003","unstructured":"Kahng, L. S. & Shapiro, L. Polar localization of replicon origins in the multipartite genomes of Agrobacterium tumefaciens and Sinorhizobium meliloti. J. Bacteriol. 185, 3384\u20133391 (2003).","journal-title":"J. Bacteriol."},{"key":"BFncomms5366_CR15","doi-asserted-by":"publisher","first-page":"8693","DOI":"10.1128\/JB.01239-07","volume":"189","author":"J Livny","year":"2007","unstructured":"Livny, J., Yamaichi, Y. & Waldor, M. K. Distribution of centromere-like parS sites in bacteria: insights from comparative genomics. J. Bacteriol. 189, 8693\u20138703 (2007).","journal-title":"J. Bacteriol."},{"key":"BFncomms5366_CR16","first-page":"675","volume":"88","author":"DA Mohl","year":"1997","unstructured":"Mohl, D. A. & Gober, J. W. Cell cycle-dependent polar localization of chromosome partitioning proteins in Caulobacter crescentus. Cell 88, 675\u2013684 (1997).","journal-title":"Cell"},{"key":"BFncomms5366_CR17","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/j.tim.2009.12.010","volume":"18","author":"PW Harrison","year":"2010","unstructured":"Harrison, P. W., Lower, R. P., Kim, N. K. & Young, J. P. Introducing the bacterial \u2018chromid\u2019: not a chromosome, not a plasmid. Trends Microbiol. 18, 141\u2013148 (2010).","journal-title":"Trends Microbiol."},{"key":"BFncomms5366_CR18","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1038\/nrmicro2882","volume":"10","author":"UM Pinto","year":"2012","unstructured":"Pinto, U. M., Pappas, K. M. & Winans, S. C. The ABCs of plasmid replication and segregation. Nat. Rev. Microbiol. 10, 755\u2013765 (2012).","journal-title":"Nat. Rev. Microbiol."},{"key":"BFncomms5366_CR19","doi-asserted-by":"publisher","first-page":"3269","DOI":"10.1101\/gad.1496506","volume":"20","author":"MA Fogel","year":"2006","unstructured":"Fogel, M. A. & Waldor, M. K. A dynamic, mitotic-like mechanism for bacterial chromosome segregation. Genes Dev. 20, 3269\u20133282 (2006).","journal-title":"Genes Dev."},{"key":"BFncomms5366_CR20","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/j.cell.2006.05.038","volume":"126","author":"M Thanbichler","year":"2006","unstructured":"Thanbichler, M. & Shapiro, L. MipZ, a spatial regulator coordinating chromosome segregation with cell division in Caulobacter. Cell 126, 147\u2013162 (2006).","journal-title":"Cell"},{"key":"BFncomms5366_CR21","doi-asserted-by":"publisher","first-page":"2201","DOI":"10.1101\/gr.2456204","volume":"14","author":"A Dricot","year":"2004","unstructured":"Dricot, A. et al. Generation of the Brucella melitensis ORFeome version 1.1. Genome Res. 14, 2201\u20132206 (2004).","journal-title":"Genome Res."},{"key":"BFncomms5366_CR22","doi-asserted-by":"publisher","first-page":"998","DOI":"10.1016\/j.micinf.2013.10.008","volume":"15","author":"C Van der Henst","year":"2013","unstructured":"Van der Henst, C., de Barsy, M., Zorreguieta, A., Letesson, J. J. & De Bolle, X. The Brucella pathogens are polarized bacteria. Microbes Infect. 15, 998\u20131004 (2013).","journal-title":"Microbes Infect."},{"key":"BFncomms5366_CR23","doi-asserted-by":"publisher","first-page":"9257","DOI":"10.1073\/pnas.0402606101","volume":"101","author":"PH Viollier","year":"2004","unstructured":"Viollier, P. H. et al. Rapid and sequential movement of individual chromosomal loci to specific subcellular locations during bacterial DNA replication. Proc. Natl Acad. Sci. USA 101, 9257\u20139262 (2004).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFncomms5366_CR24","doi-asserted-by":"publisher","first-page":"985","DOI":"10.1046\/j.1365-2958.2002.03234.x","volume":"46","author":"Y Li","year":"2002","unstructured":"Li, Y., Sergueev, K. & Austin, S. The segregation of the Escherichia coli origin and terminus of replication. Mol. Microbiol. 46, 985\u2013996 (2002).","journal-title":"Mol. Microbiol."},{"key":"BFncomms5366_CR25","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1111\/j.1365-2958.2006.05346.x","volume":"62","author":"HJ Nielsen","year":"2006","unstructured":"Nielsen, H. J., Ottesen, J. R., Youngren, B., Austin, S. J. & Hansen, F. G. The Escherichia coli chromosome is organized with the left and right chromosome arms in separate cell halves. Mol. Microbiol. 62, 331\u2013338 (2006).","journal-title":"Mol. Microbiol."},{"key":"BFncomms5366_CR26","doi-asserted-by":"publisher","first-page":"1444","DOI":"10.1038\/sj.emboj.7601577","volume":"26","author":"R Hallez","year":"2007","unstructured":"Hallez, R. et al. The asymmetric distribution of the essential histidine kinase PdhS indicates a differentiation event in Brucella abortus. EMBO J. 26, 1444\u20131455 (2007).","journal-title":"EMBO J."},{"key":"BFncomms5366_CR27","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1111\/j.1365-2958.2004.04379.x","volume":"55","author":"MA Fogel","year":"2005","unstructured":"Fogel, M. A. & Waldor, M. K. Distinct segregation dynamics of the two Vibrio cholerae chromosomes. Mol. Microbiol. 55, 125\u2013136 (2005).","journal-title":"Mol. Microbiol."},{"key":"BFncomms5366_CR28","doi-asserted-by":"publisher","first-page":"10661","DOI":"10.1073\/pnas.96.19.10661","volume":"96","author":"RB Jensen","year":"1999","unstructured":"Jensen, R. B. & Shapiro, L. The Caulobacter crescentus smc gene is required for cell cycle progression and chromosome segregation. Proc. Natl Acad. Sci. USA 96, 10661\u201310666 (1999).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFncomms5366_CR29","doi-asserted-by":"publisher","first-page":"1060","DOI":"10.1128\/JB.188.3.1060-1070.2006","volume":"188","author":"P Srivastava","year":"2006","unstructured":"Srivastava, P., Fekete, R. A. & Chattoraj, D. K. Segregation of the replication terminus of the two Vibrio cholerae chromosomes. J. Bacteriol. 188, 1060\u20131070 (2006).","journal-title":"J. Bacteriol."},{"key":"BFncomms5366_CR30","doi-asserted-by":"publisher","first-page":"3458","DOI":"10.1002\/eji.201040497","volume":"40","author":"C Archambaud","year":"2010","unstructured":"Archambaud, C. et al. Contrasting roles of macrophages and dendritic cells in controlling initial pulmonary Brucella infection. Eur. J. Immunol. 40, 3458\u20133471 (2010).","journal-title":"Eur. J. Immunol."},{"key":"BFncomms5366_CR31","doi-asserted-by":"publisher","first-page":"e1004184","DOI":"10.1371\/journal.pgen.1004184","volume":"10","author":"JH Baek","year":"2014","unstructured":"Baek, J. H. & Chattoraj, D. K. Chromosome I controls chromosome II replication in Vibrio cholerae. PLoS Genet. 10, e1004184 (2014).","journal-title":"PLoS Genet."},{"key":"BFncomms5366_CR32","doi-asserted-by":"publisher","first-page":"3124","DOI":"10.1038\/sj.emboj.7601747","volume":"26","author":"T Rasmussen","year":"2007","unstructured":"Rasmussen, T., Jensen, R. B. & Skovgaard, O. The two chromosomes of Vibrio cholerae are initiated at different time points in the cell cycle. EMBO J. 26, 3124\u20133131 (2007).","journal-title":"EMBO J."},{"key":"BFncomms5366_CR33","doi-asserted-by":"publisher","first-page":"965","DOI":"10.1111\/j.1462-5822.2012.01771.x","volume":"14","author":"DM Posadas","year":"2012","unstructured":"Posadas, D. M., Ruiz-Ranwez, V., Bonomi, H. R., Martin, F. A. & Zorreguieta, A. BmaC, a novel autotransporter of Brucella suis, is involved in bacterial adhesion to host cells. Cell. Microbiol. 14, 965\u2013982 (2012).","journal-title":"Cell. Microbiol."},{"key":"BFncomms5366_CR34","doi-asserted-by":"publisher","first-page":"996","DOI":"10.1128\/IAI.01241-12","volume":"81","author":"V Ruiz-Ranwez","year":"2013","unstructured":"Ruiz-Ranwez, V. et al. BtaE, an adhesin that belongs to the trimeric autotransporter family, is required for full virulence and defines a specific adhesive pole of Brucella suis. Infect. Immun. 81, 996\u20131007 (2013).","journal-title":"Infect. Immun."},{"key":"BFncomms5366_CR35","doi-asserted-by":"publisher","first-page":"1075","DOI":"10.1093\/infdis\/jit007","volume":"207","author":"SP Salcedo","year":"2013","unstructured":"Salcedo, S. P. et al. Pathogenic brucellae replicate in human trophoblasts. J. Infect. Dis. 207, 1075\u20131083 (2013).","journal-title":"J. Infect. Dis."},{"key":"BFncomms5366_CR36","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1007\/s00430-009-0123-8","volume":"198","author":"RM Roop 2nd","year":"2009","unstructured":"Roop, R. M. 2nd, Gaines, J. M., Anderson, E. S., Caswell, C. C. & Martin, D. W. Survival of the fittest: how Brucella strains adapt to their intracellular niche in the host. Med. Microbiol. Immunol. 198, 221\u2013238 (2009).","journal-title":"Med. Microbiol. Immunol."},{"key":"BFncomms5366_CR37","doi-asserted-by":"publisher","first-page":"1791","DOI":"10.1111\/j.1462-5822.2006.00749.x","volume":"8","author":"M Dozot","year":"2006","unstructured":"Dozot, M. et al. The stringent response mediator Rsh is required for Brucella melitensis and Brucella suis virulence, and for expression of the type IV secretion system virB. Cell. Microbiol. 8, 1791\u20131802 (2006).","journal-title":"Cell. Microbiol."},{"key":"BFncomms5366_CR38","doi-asserted-by":"publisher","first-page":"3431","DOI":"10.1101\/gad.12.21.3431","volume":"12","author":"S Dukan","year":"1998","unstructured":"Dukan, S. & Nystrom, T. Bacterial senescence: stasis results in increased and differential oxidation of cytoplasmic proteins leading to developmental induction of the heat shock regulon. Genes Dev. 12, 3431\u20133441 (1998).","journal-title":"Genes Dev."},{"key":"BFncomms5366_CR39","doi-asserted-by":"publisher","first-page":"6782","DOI":"10.1128\/jb.177.23.6782-6790.1995","volume":"177","author":"K Keyer","year":"1995","unstructured":"Keyer, K., Gort, A. S. & Imlay, J. A. Superoxide and the production of oxidative DNA damage. J. Bacteriol. 177, 6782\u20136790 (1995).","journal-title":"J. Bacteriol."},{"key":"BFncomms5366_CR40","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1126\/science.1244705","volume":"343","author":"S Helaine","year":"2014","unstructured":"Helaine, S. et al. Internalization of Salmonella by macrophages induces formation of nonreplicating persisters. Science 343, 204\u2013208 (2014).","journal-title":"Science"},{"key":"BFncomms5366_CR41","doi-asserted-by":"publisher","first-page":"6867","DOI":"10.1128\/JB.00700-08","volume":"190","author":"JA Lesley","year":"2008","unstructured":"Lesley, J. A. & Shapiro, L. SpoT regulates DnaA stability and initiation of DNA replication in carbon-starved Caulobacter crescentus. J. Bacteriol. 190, 6867\u20136880 (2008).","journal-title":"J. Bacteriol."},{"key":"BFncomms5366_CR42","doi-asserted-by":"publisher","first-page":"784","DOI":"10.1038\/nbt1183-784","volume":"1","author":"R Simon","year":"1983","unstructured":"Simon, R., Priefer, U. & P\u00fchler, A. A broad host range mobilization system for in vivo genetic engineering: transposon mutagenesis in Gram negative bacteria. Nat. Biotechnol. 1, 784\u2013791 (1983).","journal-title":"Nat. Biotechnol."},{"key":"BFncomms5366_CR43","doi-asserted-by":"publisher","first-page":"1551","DOI":"10.1099\/00221287-139-7-1551","volume":"139","author":"A Cloeckaert","year":"1993","unstructured":"Cloeckaert, A., Zygmunt, M. S., Dubray, G. & Limet, J. N. Characterization of O-polysaccharide specific monoclonal antibodies derived from mice infected with the rough Brucella melitensis strain B115. J. Gen. Microbiol. 139, 1551\u20131556 (1993).","journal-title":"J. Gen. Microbiol."},{"key":"BFncomms5366_CR44","doi-asserted-by":"publisher","first-page":"612","DOI":"10.1111\/j.1365-2958.2011.07579.x","volume":"80","author":"O Sliusarenko","year":"2011","unstructured":"Sliusarenko, O., Heinritz, J., Emonet, T. & Jacobs-Wagner, C. High-throughput, subpixel precision analysis of bacterial morphogenesis and intracellular spatio-temporal dynamics. Mol. Microbiol. 80, 612\u2013627 (2011).","journal-title":"Mol. Microbiol."},{"key":"BFncomms5366_CR45","doi-asserted-by":"publisher","first-page":"3116","DOI":"10.1128\/JB.00260-12","volume":"194","author":"J Hocking","year":"2012","unstructured":"Hocking, J. et al. Osmolality-dependent relocation of penicillin-binding protein PBP2 to the division site in Caulobacter crescentus. J. Bacteriol. 194, 3116\u20133127 (2012).","journal-title":"J. Bacteriol."},{"key":"BFncomms5366_CR46","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1083\/jcb.201303036","volume":"201","author":"G Laloux","year":"2013","unstructured":"Laloux, G. & Jacobs-Wagner, C. Spatiotemporal control of PopZ localization through cell cycle-coupled multimerization. J. Cell Biol. 201, 827\u2013841 (2013).","journal-title":"J. Cell Biol."}],"container-title":["Nature Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/ncomms5366.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/ncomms5366","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/ncomms5366.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,6]],"date-time":"2023-01-06T03:33:59Z","timestamp":1672976039000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/ncomms5366"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7,9]]},"references-count":46,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2014,9,22]]}},"alternative-id":["BFncomms5366"],"URL":"https:\/\/doi.org\/10.1038\/ncomms5366","relation":{},"ISSN":["2041-1723"],"issn-type":[{"value":"2041-1723","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,7,9]]},"assertion":[{"value":"25 October 2013","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 June 2014","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 July 2014","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing financial interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"4366"}}