{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T11:13:17Z","timestamp":1791112397160,"version":"4.1.0"},"reference-count":70,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2014,8,1]],"date-time":"2014-08-01T00:00:00Z","timestamp":1406851200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2014,8,1]],"date-time":"2014-08-01T00:00:00Z","timestamp":1406851200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nat Commun"],"DOI":"10.1038\/ncomms5563","type":"journal-article","created":{"date-parts":[[2014,8,1]],"date-time":"2014-08-01T08:42:43Z","timestamp":1406882563000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":117,"title":["Selective suppression of excessive GluN2C expression rescues early epilepsy in a tuberous sclerosis murine model"],"prefix":"10.1038","volume":"5","author":[{"given":"N.","family":"Lozovaya","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Gataullina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Tsintsadze","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Tsintsadze","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Pallesi-Pocachard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Minlebaev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N. A.","family":"Goriounova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Buhler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Watrin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Shityakov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. J.","family":"Becker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Bordey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Milh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Scavarda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Bulteau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Dorfmuller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.","family":"Delalande","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Represa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Cardoso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.","family":"Dulac","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Ben-Ari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Burnashev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,8,1]]},"reference":[{"key":"BFncomms5563_CR1","unstructured":"Curatolo, P. inSclerosis Complex From Basic Science To Clinical Phenotypes (I.C.N. AssociationMac Keith Press (2003)."},{"key":"BFncomms5563_CR2","doi-asserted-by":"publisher","first-page":"444","DOI":"10.1002\/ana.21331","volume":"63","author":"LH Zeng","year":"2008","unstructured":"Zeng, L. H., Xu, L., Gutmann, D. H. & Wong, M. Rapamycin prevents epilepsy in a mouse model of tuberous sclerosis complex. Ann. Neurol. 63, 444\u2013453 (2008).","journal-title":"Ann. Neurol."},{"key":"BFncomms5563_CR3","doi-asserted-by":"publisher","first-page":"5422","DOI":"10.1523\/JNEUROSCI.0955-08.2008","volume":"28","author":"L Meikle","year":"2008","unstructured":"Meikle, L. et al. Response of a neuronal model of tuberous sclerosis to mammalian target of rapamycin (mTOR) inhibitors: effects on mTORC1 and Akt signaling lead to improved survival and function. J. Neurosci. 28, 5422\u20135432 (2008).","journal-title":"J. Neurosci."},{"key":"BFncomms5563_CR4","doi-asserted-by":"publisher","first-page":"843","DOI":"10.1038\/nm1788","volume":"14","author":"D Ehninger","year":"2008","unstructured":"Ehninger, D. et al. Reversal of learning deficits in a Tsc2+\/- mouse model of tuberous sclerosis. Nat. Med. 14, 843\u2013848 (2008).","journal-title":"Nat. Med."},{"key":"BFncomms5563_CR5","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1016\/S0140-6736(08)61279-9","volume":"372","author":"P Curatolo","year":"2008","unstructured":"Curatolo, P., Bombardieri, R. & Jozwiak, S. Tuberous sclerosis. Lancet 372, 657\u2013668 (2008).","journal-title":"Lancet"},{"key":"BFncomms5563_CR6","first-page":"1639","volume":"151","author":"EP Henske","year":"1997","unstructured":"Henske, E. P. et al. Loss of tuberin in both subependymal giant cell astrocytomas and angiomyolipomas supports a two-hit model for the pathogenesis of tuberous sclerosis tumors. Am. J. Pathol. 151, 1639\u20131647 (1997).","journal-title":"Am. J. Pathol."},{"key":"BFncomms5563_CR7","doi-asserted-by":"publisher","first-page":"1096","DOI":"10.1111\/j.1750-3639.2010.00416.x","volume":"20","author":"W Qin","year":"2010","unstructured":"Qin, W. et al. Analysis of TSC cortical tubers by deep sequencing of TSC1, TSC2 and KRAS demonstrates that small second-hit mutations in these genes are rare events. Brain Pathol. 20, 1096\u20131105 (2010).","journal-title":"Brain Pathol."},{"key":"BFncomms5563_CR8","doi-asserted-by":"publisher","first-page":"1716","DOI":"10.1212\/WNL.0b013e3181e04325","volume":"74","author":"PB Crino","year":"2010","unstructured":"Crino, P. B., Aronica, E., Baltuch, G. & Nathanson, K. L. Biallelic TSC gene inactivation in tuberous sclerosis complex. Neurology 74, 1716\u20131723 (2010).","journal-title":"Neurology"},{"key":"BFncomms5563_CR9","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1097\/01.wco.0000218225.50807.12","volume":"19","author":"P Curatolo","year":"2006","unstructured":"Curatolo, P., Bombardieri, R. & Cerminara, C. Current management for epilepsy in tuberous sclerosis complex. Curr. Opin. Neurol. 19, 119\u2013123 (2006).","journal-title":"Curr. Opin. Neurol."},{"key":"BFncomms5563_CR10","doi-asserted-by":"publisher","first-page":"1477","DOI":"10.1111\/j.1528-1167.2007.01117.x","volume":"48","author":"FE Jansen","year":"2007","unstructured":"Jansen, F. E., van Huffelen, A. C., Algra, A. & van Nieuwenhuizen, O. Epilepsy surgery in tuberous sclerosis: a systematic review. Epilepsia 48, 1477\u20131484 (2007).","journal-title":"Epilepsia"},{"key":"BFncomms5563_CR11","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1016\/j.yebeh.2013.02.018","volume":"27","author":"WE Wu","year":"2013","unstructured":"Wu, W. E. et al. Brain MR spectroscopic abnormalities in \u2018MRI-negative\u2019 tuberous sclerosis complex patients. Epilepsy Behav. 27, 319\u2013325 (2013).","journal-title":"Epilepsy Behav."},{"key":"BFncomms5563_CR12","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1111\/j.1528-1167.2008.01814.x","volume":"50","author":"P Major","year":"2009","unstructured":"Major, P. et al. Are cortical tubers epileptogenic? Evidence from electrocorticography. Epilepsia 50, 147\u2013154 (2009).","journal-title":"Epilepsia"},{"key":"BFncomms5563_CR13","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1177\/0883073808325659","volume":"24","author":"R Kaufmann","year":"2009","unstructured":"Kaufmann, R., Kornreich, L. & Goldberg-Stern, H. Unusual clinical presentation of tuberless tuberous sclerosis complex. J. Child. Neurol. 24, 361\u2013364 (2009).","journal-title":"J. Child. Neurol."},{"key":"BFncomms5563_CR14","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1111\/j.1528-1157.1990.tb05516.x","volume":"31","author":"R Cusmai","year":"1990","unstructured":"Cusmai, R., Chiron, C., Curatolo, P., Dulac, O. & Tran-Dinh, S. Topographic comparative study of magnetic resonance imaging and electroencephalography in 34 children with tuberous sclerosis. Epilepsia 31, 747\u2013755 (1990).","journal-title":"Epilepsia"},{"key":"BFncomms5563_CR15","doi-asserted-by":"publisher","first-page":"1596","DOI":"10.1172\/JCI44909","volume":"121","author":"DM Feliciano","year":"2011","unstructured":"Feliciano, D. M., Su, T., Lopez, J., Platel, J. C. & Bordey, A. Single-cell Tsc1 knockout during corticogenesis generates tuber-like lesions and reduces seizure threshold in mice. J. Clin. Invest. 121, 1596\u20131607 (2011).","journal-title":"J. Clin. Invest."},{"key":"BFncomms5563_CR16","doi-asserted-by":"publisher","first-page":"5546","DOI":"10.1523\/JNEUROSCI.5540-06.2007","volume":"27","author":"L Meikle","year":"2007","unstructured":"Meikle, L. et al. A mouse model of tuberous sclerosis: neuronal loss of Tsc1 causes dysplastic and ectopic neurons, reduced myelination, seizure activity, and limited survival. J. Neurosci. 27, 5546\u20135558 (2007).","journal-title":"J. Neurosci."},{"key":"BFncomms5563_CR17","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1002\/ana.10283","volume":"52","author":"EJ Uhlmann","year":"2002","unstructured":"Uhlmann, E. J. et al. Astrocyte-specific TSC1 conditional knockout mice exhibit abnormal neuronal organization and seizures. Ann. Neurol. 52, 285\u2013296 (2002).","journal-title":"Ann. Neurol."},{"key":"BFncomms5563_CR18","doi-asserted-by":"publisher","first-page":"1252","DOI":"10.1093\/hmg\/ddp025","volume":"18","author":"SW Way","year":"2009","unstructured":"Way, S. W. et al. Loss of Tsc2 in radial glia models the brain pathology of tuberous sclerosis complex in the mouse. Hum. Mol. Genet. 18, 1252\u20131265 (2009).","journal-title":"Hum. Mol. Genet."},{"key":"BFncomms5563_CR19","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1016\/j.nbd.2011.07.018","volume":"45","author":"I Chevere-Torres","year":"2011","unstructured":"Chevere-Torres, I., Maki, J. M., Santini, E. & Klann, E. Impaired social interactions and motor learning skills in tuberous sclerosis complex model mice expressing a dominant\/negative form of tuberin. Neurobiol. Dis. 45, 156\u2013164 (2011).","journal-title":"Neurobiol. Dis."},{"key":"BFncomms5563_CR20","doi-asserted-by":"publisher","first-page":"648","DOI":"10.1002\/ana.21317","volume":"62","author":"SM Goorden","year":"2007","unstructured":"Goorden, S. M., van Woerden, G. M., van der Weerd, L., Cheadle, J. P. & Elgersma, Y. Cognitive deficits in Tsc1+\/- mice in the absence of cerebral lesions and seizures. Ann. Neurol. 62, 648\u2013655 (2007).","journal-title":"Ann. Neurol."},{"key":"BFncomms5563_CR21","doi-asserted-by":"publisher","first-page":"510","DOI":"10.1016\/j.neuron.2013.03.017","volume":"78","author":"HS Bateup","year":"2013","unstructured":"Bateup, H. S. et al. Excitatory\/Inhibitory synaptic imbalance leads to hippocampal hyperexcitability in mouse models of tuberous sclerosis. Neuron 78, 510\u2013522 (2013).","journal-title":"Neuron"},{"key":"BFncomms5563_CR22","doi-asserted-by":"publisher","first-page":"1727","DOI":"10.1038\/nn1566","volume":"8","author":"SF Tavazoie","year":"2005","unstructured":"Tavazoie, S. F., Alvarez, V. A., Ridenour, D. A., Kwiatkowski, D. J. & Sabatini, B. L. Regulation of neuronal morphology and function by the tumor suppressors Tsc1 and Tsc2. Nat. Neurosci. 8, 1727\u20131734 (2005).","journal-title":"Nat. Neurosci."},{"key":"BFncomms5563_CR23","doi-asserted-by":"publisher","first-page":"1051","DOI":"10.1016\/S0306-4522(99)00392-9","volume":"94","author":"K Zilles","year":"1999","unstructured":"Zilles, K., Qu, M. S., Kohling, R. & Speckmann, E. J. Ionotropic glutamate and GABA receptors in human epileptic neocortical tissue: quantitative in vitro receptor autoradiography. Neuroscience 94, 1051\u20131061 (1999).","journal-title":"Neuroscience"},{"key":"BFncomms5563_CR24","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1002\/1531-8249(200101)49:1<67::AID-ANA10>3.0.CO;2-L","volume":"49","author":"R White","year":"2001","unstructured":"White, R. et al. Selective alterations in glutamate and GABA receptor subunit mRNA expression in dysplastic neurons and giant cells of cortical tubers. Ann. Neurol. 49, 67\u201378 (2001).","journal-title":"Ann. Neurol."},{"key":"BFncomms5563_CR25","doi-asserted-by":"publisher","first-page":"454","DOI":"10.1002\/ana.21342","volume":"63","author":"DM Talos","year":"2008","unstructured":"Talos, D. M., Kwiatkowski, D. J., Cordero, K., Black, P. M. & Jensen, F. E. Cell-specific alterations of glutamate receptor expression in tuberous sclerosis complex cortical tubers. Ann. Neurol. 63, 454\u2013465 (2008).","journal-title":"Ann. Neurol."},{"key":"BFncomms5563_CR26","doi-asserted-by":"publisher","first-page":"906","DOI":"10.1212\/WNL.56.7.906","volume":"56","author":"PB Crino","year":"2001","unstructured":"Crino, P. B., Duhaime, A. C., Baltuch, G. & White, R. Differential expression of glutamate and GABA-A receptor subunit mRNA in cortical dysplasia. Neurology 56, 906\u2013913 (2001).","journal-title":"Neurology"},{"key":"BFncomms5563_CR27","doi-asserted-by":"publisher","first-page":"24","DOI":"10.3389\/fnana.2012.00024","volume":"6","author":"D Feldmeyer","year":"2012","unstructured":"Feldmeyer, D. Excitatory neuronal connectivity in the barrel cortex. Front. Neuroanat. 6, 24 (2012).","journal-title":"Front. Neuroanat."},{"key":"BFncomms5563_CR28","doi-asserted-by":"publisher","first-page":"9885","DOI":"10.1523\/JNEUROSCI.22-22-09885.2002","volume":"22","author":"M Beierlein","year":"2002","unstructured":"Beierlein, M., Fall, C. P., Rinzel, J. & Yuste, R. Thalamocortical bursts trigger recurrent activity in neocortical networks: layer 4 as a frequency-dependent gate. J. Neurosci. 22, 9885\u20139894 (2002).","journal-title":"J. Neurosci."},{"key":"BFncomms5563_CR29","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1111\/j.1469-7793.1999.00169.x","volume":"521","author":"D Feldmeyer","year":"1999","unstructured":"Feldmeyer, D., Egger, V., Lubke, J. & Sakmann, B. Reliable synaptic connections between pairs of excitatory layer 4 neurones within a single \u2018barrel\u2019 of developing rat somatosensory cortex. J. Physiol. 521, (Pt 1): 169\u2013190 (1999).","journal-title":"J. Physiol."},{"key":"BFncomms5563_CR30","doi-asserted-by":"publisher","first-page":"708","DOI":"10.1523\/JNEUROSCI.4409-05.2006","volume":"26","author":"AM Binshtok","year":"2006","unstructured":"Binshtok, A. M., Fleidervish, I. A., Sprengel, R. & Gutnick, M. J. NMDA receptors in layer 4 spiny stellate cells of the mouse barrel cortex contain the NR2C subunit. J. Neurosci. 26, 708\u2013715 (2006).","journal-title":"J. Neurosci."},{"key":"BFncomms5563_CR31","doi-asserted-by":"publisher","first-page":"1055","DOI":"10.1016\/S0896-6273(00)80623-6","volume":"21","author":"IA Fleidervish","year":"1998","unstructured":"Fleidervish, I. A., Binshtok, A. M. & Gutnick, M. J. Functionally distinct NMDA receptors mediate horizontal connectivity within layer 4 of mouse barrel cortex. Neuron 21, 1055\u20131065 (1998).","journal-title":"Neuron"},{"key":"BFncomms5563_CR32","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1016\/j.neuron.2008.12.020","volume":"61","author":"S Lefort","year":"2009","unstructured":"Lefort, S., Tomm, C., Floyd Sarria, J. C. & Petersen, C. C. The excitatory neuronal network of the C2 barrel column in mouse primary somatosensory cortex. Neuron 61, 301\u2013316 (2009).","journal-title":"Neuron"},{"key":"BFncomms5563_CR33","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1016\/0896-6273(94)90210-0","volume":"12","author":"H Monyer","year":"1994","unstructured":"Monyer, H., Burnashev, N., Laurie, D. J., Sakmann, B. & Seeburg, P. H. Developmental and regional expression in the rat brain and functional properties of four NMDA receptors. Neuron 12, 529\u2013540 (1994).","journal-title":"Neuron"},{"key":"BFncomms5563_CR34","doi-asserted-by":"publisher","first-page":"618","DOI":"10.1124\/jpet.109.156752","volume":"331","author":"BM Costa","year":"2009","unstructured":"Costa, B. M. et al. N-methyl-D-aspartate (NMDA) receptor NR2 subunit selectivity of a series of novel piperazine-2,3-dicarboxylate derivatives: preferential blockade of extrasynaptic NMDA receptors in the rat hippocampal CA3-CA1 synapse. J. Pharmacol. Exp. Ther. 331, 618\u2013626 (2009).","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"BFncomms5563_CR35","doi-asserted-by":"publisher","first-page":"782","DOI":"10.1124\/mol.111.073239","volume":"80","author":"TM Acker","year":"2011","unstructured":"Acker, T. M. et al. Mechanism for noncompetitive inhibition by novel GluN2C\/D N-methyl-D-aspartate receptor subunit-selective modulators. Mol. Pharmacol. 80, 782\u2013795 (2011).","journal-title":"Mol. Pharmacol."},{"key":"BFncomms5563_CR36","doi-asserted-by":"publisher","first-page":"544","DOI":"10.1016\/S1525-1578(10)60586-7","volume":"7","author":"T Ichikawa","year":"2005","unstructured":"Ichikawa, T. et al. A case of solitary subependymal giant cell astrocytoma: two somatic hits of TSC2 in the tumor, without evidence of somatic mosaicism. J. Mol. Diagn. 7, 544\u2013549 (2005).","journal-title":"J. Mol. Diagn."},{"key":"BFncomms5563_CR37","doi-asserted-by":"publisher","first-page":"e6755","DOI":"10.1371\/journal.pone.0006755","volume":"4","author":"T Hakami","year":"2009","unstructured":"Hakami, T. et al. NMDA receptor hypofunction leads to generalized and persistent aberrant gamma oscillations independent of hyperlocomotion and the state of consciousness. PLoS ONE 4, e6755 (2009).","journal-title":"PLoS ONE"},{"key":"BFncomms5563_CR38","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1002\/ana.20211","volume":"56","author":"M Baybis","year":"2004","unstructured":"Baybis, M. et al. mTOR cascade activation distinguishes tubers from focal cortical dysplasia. Ann. Neurol. 56, 478\u2013487 (2004).","journal-title":"Ann. Neurol."},{"key":"BFncomms5563_CR39","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1002\/ana.10251","volume":"52","author":"AJ Becker","year":"2002","unstructured":"Becker, A. J. et al. Focal cortical dysplasia of Taylor's balloon cell type: mutational analysis of the TSC1 gene indicates a pathogenic relationship to tuberous sclerosis. Ann. Neurol. 52, 29\u201337 (2002).","journal-title":"Ann. Neurol."},{"key":"BFncomms5563_CR40","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1002\/ana.20949","volume":"60","author":"MC Ljungberg","year":"2006","unstructured":"Ljungberg, M. C. et al. Activation of mammalian target of rapamycin in cytomegalic neurons of human cortical dysplasia. Ann. Neurol. 60, 420\u2013429 (2006).","journal-title":"Ann. Neurol."},{"key":"BFncomms5563_CR41","doi-asserted-by":"publisher","first-page":"510","DOI":"10.1002\/ana.20234","volume":"56","author":"H Miyata","year":"2004","unstructured":"Miyata, H., Chiang, A. C. & Vinters, H. V. Insulin signaling pathways in cortical dysplasia and TSC-tubers: tissue microarray analysis. Ann. Neurol. 56, 510\u2013519 (2004).","journal-title":"Ann. Neurol."},{"key":"BFncomms5563_CR42","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/j.expneurol.2011.10.002","volume":"244","author":"M Wong","year":"2013","unstructured":"Wong, M. Mammalian target of rapamycin (mTOR) activation in focal cortical dysplasia and related focal cortical malformations. Exp. Neurol. 244, 22\u201326 (2013).","journal-title":"Exp. Neurol."},{"key":"BFncomms5563_CR43","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1111\/j.0013-9580.2005.66104.x","volume":"46","author":"RS Fisher","year":"2005","unstructured":"Fisher, R. S. et al. Epileptic seizures and epilepsy: definitions proposed by the International League Against Epilepsy (ILAE) and the International Bureau for Epilepsy (IBE). Epilepsia 46, 470\u2013472 (2005).","journal-title":"Epilepsia"},{"key":"BFncomms5563_CR44","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1038\/nn.2477","volume":"13","author":"D Nie","year":"2010","unstructured":"Nie, D. et al. Tsc2-Rheb signaling regulates EphA-mediated axon guidance. Nat. Neurosci. 13, 163\u2013172 (2010).","journal-title":"Nat. Neurosci."},{"key":"BFncomms5563_CR45","doi-asserted-by":"publisher","first-page":"1292","DOI":"10.1038\/ncomms2295","volume":"3","author":"A Sato","year":"2012","unstructured":"Sato, A. et al. Rapamycin reverses impaired social interaction in mouse models of tuberous sclerosis complex. Nat. Commun. 3, 1292 (2012).","journal-title":"Nat. Commun."},{"key":"BFncomms5563_CR46","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1111\/j.1399-0004.2008.01129.x","volume":"75","author":"EA Vail","year":"2009","unstructured":"Vail, E. A., Rakowski, S. K., Numis, A. L. & Thiele, E. A. Role of mutational analysis in diagnosis of tuberous sclerosis complex. Clin. Genet. 75, 282\u2013285 (2009).","journal-title":"Clin. Genet."},{"key":"BFncomms5563_CR47","doi-asserted-by":"publisher","first-page":"1236","DOI":"10.1111\/j.1528-1167.2009.02474.x","volume":"51","author":"CJ Chu-Shore","year":"2010","unstructured":"Chu-Shore, C. J., Major, P., Camposano, S., Muzykewicz, D. & Thiele, E. A. The natural history of epilepsy in tuberous sclerosis complex. Epilepsia 51, 1236\u20131241 (2010).","journal-title":"Epilepsia"},{"key":"BFncomms5563_CR48","doi-asserted-by":"publisher","first-page":"612","DOI":"10.1016\/j.neuron.2009.05.015","volume":"62","author":"MP Beenhakker","year":"2009","unstructured":"Beenhakker, M. P. & Huguenard, J. R. Neurons that fire together also conspire together: is normal sleep circuitry hijacked to generate epilepsy? Neuron 62, 612\u2013632 (2009).","journal-title":"Neuron"},{"key":"BFncomms5563_CR49","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1016\/j.tins.2007.05.007","volume":"30","author":"JR Huguenard","year":"2007","unstructured":"Huguenard, J. R. & McCormick, D. A. Thalamic synchrony and dynamic regulation of global forebrain oscillations. Trends Neurosci. 30, 350\u2013356 (2007).","journal-title":"Trends Neurosci."},{"key":"BFncomms5563_CR50","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1146\/annurev.neuro.20.1.185","volume":"20","author":"DA McCormick","year":"1997","unstructured":"McCormick, D. A. & Bal, T. Sleep and arousal: thalamocortical mechanisms. Annu. Rev. Neurosci. 20, 185\u2013215 (1997).","journal-title":"Annu. Rev. Neurosci."},{"key":"BFncomms5563_CR51","doi-asserted-by":"publisher","first-page":"6783","DOI":"10.1523\/JNEUROSCI.17-17-06783.1997","volume":"17","author":"A Kandel","year":"1997","unstructured":"Kandel, A. & Buzsaki, G. Cellular-synaptic generation of sleep spindles, spike-and-wave discharges, and evoked thalamocortical responses in the neocortex of the rat. J. Neurosci. 17, 6783\u20136797 (1997).","journal-title":"J. Neurosci."},{"key":"BFncomms5563_CR52","first-page":"153","volume":"42","author":"RD Traub","year":"2001","unstructured":"Traub, R. D. et al. A possible role for gap junctions in generation of very fast EEG oscillations preceding the onset of, and perhaps initiating, seizures. Epilepsia 42, 153\u2013170 (2001).","journal-title":"Epilepsia"},{"key":"BFncomms5563_CR53","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1016\/j.neuroimage.2004.11.052","volume":"25","author":"JP Lachaux","year":"2005","unstructured":"Lachaux, J. P. et al. The many faces of the gamma band response to complex visual stimuli. Neuroimage 25, 491\u2013501 (2005).","journal-title":"Neuroimage"},{"key":"BFncomms5563_CR54","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.brainres.2005.03.042","volume":"1046","author":"G Moddel","year":"2005","unstructured":"Moddel, G. et al. The NMDA receptor NR2B subunit contributes to epileptogenesis in human cortical dysplasia. Brain. Res. 1046, 10\u201323 (2005).","journal-title":"Brain. Res."},{"key":"BFncomms5563_CR55","doi-asserted-by":"publisher","first-page":"971","DOI":"10.1111\/j.1528-1157.2000.tb00281.x","volume":"41","author":"IM Najm","year":"2000","unstructured":"Najm, I. M. et al. Epileptogenicity correlated with increased N-methyl-D-aspartate receptor subunit NR2A\/B in human focal cortical dysplasia. Epilepsia 41, 971\u2013976 (2000).","journal-title":"Epilepsia"},{"key":"BFncomms5563_CR56","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1016\/j.yebeh.2011.07.024","volume":"22","author":"M Ghasemi","year":"2011","unstructured":"Ghasemi, M. & Schachter, S. C. The NMDA receptor complex as a therapeutic target in epilepsy: a review. Epilepsy Behav. 22, 617\u2013640 (2011).","journal-title":"Epilepsy Behav."},{"key":"BFncomms5563_CR57","doi-asserted-by":"publisher","first-page":"2846","DOI":"10.1523\/JNEUROSCI.0116-07.2007","volume":"27","author":"Y Liu","year":"2007","unstructured":"Liu, Y. et al. NMDA receptor subunits have differential roles in mediating excitotoxic neuronal death both in vitro and in vivo. J. Neurosci. 27, 2846\u20132857 (2007).","journal-title":"J. Neurosci."},{"key":"BFncomms5563_CR58","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1001\/archpsyc.59.7.663","volume":"59","author":"JH Krystal","year":"2002","unstructured":"Krystal, J. H., Anand, A. & Moghaddam, B. Effects of NMDA receptor antagonists: implications for the pathophysiology of schizophrenia. Arch. Gen. Psychiatry 59, 663\u2013664 (2002).","journal-title":"Arch. Gen. Psychiatry"},{"key":"BFncomms5563_CR59","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1038\/mp.2011.31","volume":"17","author":"M Carlen","year":"2012","unstructured":"Carlen, M. et al. A critical role for NMDA receptors in parvalbumin interneurons for gamma rhythm induction and behavior. Mol. Psychiatry 17, 537\u2013548 (2012).","journal-title":"Mol. Psychiatry"},{"key":"BFncomms5563_CR60","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1111\/j.1528-1167.2005.01013.x","volume":"46","author":"C Cepeda","year":"2005","unstructured":"Cepeda, C., Andre, V. M., Vinters, H. V., Levine, M. S. & Mathern, G. W. Are cytomegalic neurons and balloon cells generators of epileptic activity in pediatric cortical dysplasia? Epilepsia 46, (Suppl 5): 82\u201388 (2005).","journal-title":"Epilepsia"},{"key":"BFncomms5563_CR61","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1007\/s00401-007-0225-6","volume":"114","author":"E Aronica","year":"2007","unstructured":"Aronica, E., Boer, K., Baybis, M., Yu, J. & Crino, P. Co-expression of cyclin D1 and phosphorylated ribosomal S6 proteins in hemimegalencephaly. Acta Neuropathol. 114, 287\u2013293 (2007).","journal-title":"Acta Neuropathol."},{"key":"BFncomms5563_CR62","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1111\/j.1528-1167.2007.00925.x","volume":"48","author":"U Samadani","year":"2007","unstructured":"Samadani, U., Judkins, A. R., Akpalu, A., Aronica, E. & Crino, P. B. Differential cellular gene expression in ganglioglioma. Epilepsia 48, 646\u2013653 (2007).","journal-title":"Epilepsia"},{"key":"BFncomms5563_CR63","unstructured":"Wong, M. & Crino, P. B. in mTOR and Epileptogenesis in Developmental Brain Malformations 4th edn eds Noebels J.L., Avoli M., Rogawski M.A., Olsen R.W., Delgado-Escueta A.V. National Center for Biotechnology Information (2012)."},{"key":"BFncomms5563_CR64","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1002\/9780470994030.ch18","volume":"288","author":"PB Crino","year":"2007","unstructured":"Crino, P. B. Focal brain malformations: a spectrum of disorders along the mTOR cascade. Novartis Found. Symp. 288, 260\u2013272 discussion 272-81 (2007).","journal-title":"Novartis Found. Symp."},{"key":"BFncomms5563_CR65","doi-asserted-by":"publisher","first-page":"13","DOI":"10.3389\/fphar.2012.00013","volume":"3","author":"CV Dayas","year":"2012","unstructured":"Dayas, C. V., Smith, D. W. & Dunkley, P. R. An emerging role for the Mammalian target of rapamycin in \u2018pathological\u2019 protein translation: relevance to cocaine addiction. Front. Pharmacol. 3, 13 (2012).","journal-title":"Front. Pharmacol."},{"key":"BFncomms5563_CR66","doi-asserted-by":"publisher","first-page":"973","DOI":"10.1016\/j.febslet.2011.02.001","volume":"585","author":"JM Han","year":"2011","unstructured":"Han, J. M. & Sahin, M. TSC1\/TSC2 signaling in the CNS. FEBS Lett. 585, 973\u2013980 (2011).","journal-title":"FEBS Lett."},{"key":"BFncomms5563_CR67","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1038\/nature11556","volume":"490","author":"SC Landis","year":"2012","unstructured":"Landis, S. C. et al. A call for transparent reporting to optimize the predictive value of preclinical research. Nature 490, 187\u2013191 (2012).","journal-title":"Nature"},{"key":"BFncomms5563_CR68","doi-asserted-by":"publisher","first-page":"815","DOI":"10.1021\/js980402t","volume":"88","author":"DE Clark","year":"1999","unstructured":"Clark, D. E. Rapid calculation of polar molecular surface area and its application to the prediction of transport phenomena. 2. Prediction of blood-brain barrier penetration. J. Pharm. Sci. 88, 815\u2013821 (1999).","journal-title":"J. Pharm. Sci."},{"key":"BFncomms5563_CR69","doi-asserted-by":"publisher","first-page":"S29","DOI":"10.1016\/S0928-0987(00)00162-7","volume":"11","author":"G Cruciani","year":"2000","unstructured":"Cruciani, G., Pastor, M. & Guba, W. VolSurf: a new tool for the pharmacokinetic optimization of lead compounds. Eur. J. Pharm. Sci. 11, (Suppl 2): S29\u2013S39 (2000).","journal-title":"Eur. J. Pharm. Sci."},{"key":"BFncomms5563_CR70","doi-asserted-by":"publisher","first-page":"480","DOI":"10.1093\/jnci\/89.7.480","volume":"89","author":"RL Dedrick","year":"1997","unstructured":"Dedrick, R. L. & Flessner, M. F. Pharmacokinetic problems in peritoneal drug administration: tissue penetration and surface exposure. J. Natl. Cancer. Inst. 89, 480\u2013487 (1997).","journal-title":"J. Natl. Cancer. Inst."}],"container-title":["Nature Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/ncomms5563.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/ncomms5563","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/ncomms5563.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,31]],"date-time":"2024-05-31T15:42:22Z","timestamp":1717170142000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/ncomms5563"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8,1]]},"references-count":70,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2014,12,17]]}},"alternative-id":["BFncomms5563"],"URL":"https:\/\/doi.org\/10.1038\/ncomms5563","relation":{},"ISSN":["2041-1723"],"issn-type":[{"value":"2041-1723","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,8,1]]},"assertion":[{"value":"16 April 2014","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 June 2014","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 August 2014","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"On the 22 April 2014, Inserm Transfert filed a patent entitled 'Method and pharmaceutical composition for use in the treatment of epileptic seizures' (E.U. patent deposit number PCT\/EP2014\/058143); N.B., Y.B and N.L. are identified as inventors of this patent. All other authors declare no competing financial interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"4563"}}