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Although recent studies have revealed that fatty acid metabolism is involved in systemic acquired resistance, the precise function of oxylipins in plant defence remains unknown. Here we report a cotton P450 gene <jats:italic>SILENCE-INDUCED STEM NECROSIS<\/jats:italic> (<jats:italic>SSN<\/jats:italic>), RNAi suppression of which causes a lesion mimic phenotype. SSN is also involved in jasmonate metabolism and the response to wounding. Fatty acid and oxylipin metabolite analysis showed that <jats:italic>SSN<\/jats:italic> overexpression causes hyperaccumulation of hydroxide and ketodiene fatty acids and reduced levels of 18:2 fatty acids, whereas silencing causes an imbalance in <jats:italic>LOX<\/jats:italic> (lipoxygenase) expression and excessive hydroperoxide fatty acid accumulation. We also show that an unknown oxylipin-derived factor is a putative mobile signal required for systemic cell death and hypothesize that SSN acts as a valve to regulate HR on pathogen infection.<\/jats:p>","DOI":"10.1038\/ncomms6372","type":"journal-article","created":{"date-parts":[[2014,11,5]],"date-time":"2014-11-05T13:23:01Z","timestamp":1415193781000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":108,"title":["Cotton cytochrome P450 CYP82D regulates systemic cell death by modulating the octadecanoid pathway"],"prefix":"10.1038","volume":"5","author":[{"given":"Longqing","family":"Sun","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Longfu","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daojun","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling","family":"Min","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xianlong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2014,11,5]]},"reference":[{"key":"BFncomms6372_CR1","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1105\/tpc.110.082602","volume":"23","author":"BP Thomma","year":"2011","unstructured":"Thomma, B. 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