{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T01:57:38Z","timestamp":1791597458932,"version":"4.3.4"},"reference-count":69,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2015,1,22]],"date-time":"2015-01-22T00:00:00Z","timestamp":1421884800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2015,1,22]],"date-time":"2015-01-22T00:00:00Z","timestamp":1421884800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nat Commun"],"DOI":"10.1038\/ncomms7051","type":"journal-article","created":{"date-parts":[[2015,1,22]],"date-time":"2015-01-22T07:09:07Z","timestamp":1421910547000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":305,"title":["The epigenetic modifier EZH2 controls melanoma growth and metastasis through silencing of distinct tumour suppressors"],"prefix":"10.1038","volume":"6","author":[{"given":"Daniel","family":"Zingg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julien","family":"Debbache","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon M.","family":"Schaefer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eylul","family":"Tuncer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra C.","family":"Frommel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phil","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Arenas-Ramirez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Haeusel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yudong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Bonalli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael T.","family":"McCabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caretha L.","family":"Creasy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitchell P.","family":"Levesque","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Onur","family":"Boyman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffaella","family":"Santoro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Shakhova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reinhard","family":"Dummer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lukas","family":"Sommer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,1,22]]},"reference":[{"key":"BFncomms7051_CR1","doi-asserted-by":"publisher","first-page":"9","DOI":"10.3322\/caac.21208","volume":"64","author":"R Siegel","year":"2014","unstructured":"Siegel, R., Ma, J., Zou, Z. & Jemal, A. Cancer statistics, 2014. CA Cancer J. Clin. 64, 9\u201329 (2014).","journal-title":"CA Cancer J. Clin."},{"key":"BFncomms7051_CR2","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1111\/pcmr.12172","volume":"27","author":"RR Braeuer","year":"2014","unstructured":"Braeuer, R. R. et al. Why is melanoma so metastatic? Pigment Cell Melanoma Res. 27, 19\u201336 (2014).","journal-title":"Pigment Cell Melanoma Res."},{"key":"BFncomms7051_CR3","doi-asserted-by":"publisher","first-page":"1401","DOI":"10.1038\/nm.3392","volume":"19","author":"P Lito","year":"2013","unstructured":"Lito, P., Rosen, N. & Solit, D. B. Tumor adaptation and resistance to RAF inhibitors. Nat. Med. 19, 1401\u20131409 (2013).","journal-title":"Nat. Med."},{"key":"BFncomms7051_CR4","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1126\/scisignal.2004815","volume":"7","author":"B Sanchez-Laorden","year":"2014","unstructured":"Sanchez-Laorden, B. et al. BRAF inhibitors induce metastasis in RAS mutant or inhibitor-resistant melanoma cells by reactivating MEK and ERK signaling. Sci. Signal. 7, 1\u201312 (2014).","journal-title":"Sci. Signal."},{"key":"BFncomms7051_CR5","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1097\/CCO.0000000000000046","volume":"26","author":"O Shakhova","year":"2014","unstructured":"Shakhova, O. Neural crest stem cells in melanoma development. Curr. Opin. Oncol. 26, 215\u2013221 (2014).","journal-title":"Curr. Opin. Oncol."},{"key":"BFncomms7051_CR6","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.ydbio.2011.12.041","volume":"366","author":"E Theveneau","year":"2012","unstructured":"Theveneau, E. & Mayor, R. Neural crest delamination and migration: from epithelium-to-mesenchyme transition to collective cell migration. Dev. Biol. 366, 34\u201354 (2012).","journal-title":"Dev. Biol."},{"key":"BFncomms7051_CR7","doi-asserted-by":"publisher","first-page":"1559","DOI":"10.1126\/science.1203543","volume":"331","author":"CL Chaffer","year":"2011","unstructured":"Chaffer, C. L. & Weinberg, R. A. A perspective on cancer cell metastasis. Science 331, 1559\u20131564 (2011).","journal-title":"Science"},{"key":"BFncomms7051_CR8","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.ydbio.2012.02.035","volume":"366","author":"E Dupin","year":"2012","unstructured":"Dupin, E. & Sommer, L. Neural crest progenitors and stem cells: from early development to adulthood. Dev. Biol. 366, 83\u201395 (2012).","journal-title":"Dev. Biol."},{"key":"BFncomms7051_CR9","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1016\/j.cell.2012.06.024","volume":"150","author":"E Hodis","year":"2012","unstructured":"Hodis, E. et al. A landscape of driver mutations in melanoma. Cell 150, 251\u2013263 (2012).","journal-title":"Cell"},{"key":"BFncomms7051_CR10","doi-asserted-by":"publisher","first-page":"1006","DOI":"10.1038\/ng.2359","volume":"44","author":"M Krauthammer","year":"2012","unstructured":"Krauthammer, M. et al. Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma. Nat. Genet. 44, 1006\u20131014 (2012).","journal-title":"Nat. Genet."},{"key":"BFncomms7051_CR11","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1016\/j.stem.2009.01.017","volume":"4","author":"S Fuchs","year":"2009","unstructured":"Fuchs, S. et al. Stage-specific control of neural crest stem cell proliferation by the small rho GTPases Cdc42 and Rac1. Cell Stem Cell 4, 236\u2013247 (2009).","journal-title":"Cell Stem Cell"},{"key":"BFncomms7051_CR12","doi-asserted-by":"crossref","first-page":"3949","DOI":"10.1242\/dev.128.20.3949","volume":"128","author":"C Paratore","year":"2001","unstructured":"Paratore, C., Goerich, D. E., Suter, U., Wegner, M. & Sommer, L. Survival and glial fate acquisition of neural crest cells are regulated by an interplay between the transcription factor Sox10 and extrinsic combinatorial signaling. Development 128, 3949\u20133961 (2001).","journal-title":"Development"},{"key":"BFncomms7051_CR13","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/S0896-6273(03)00163-6","volume":"38","author":"J Kim","year":"2003","unstructured":"Kim, J., Lo, L., Dormand, E. & Anderson, D. J. SOX10 maintains multipotency and inhibits neuronal differentiation of neural crest stem cells. Neuron 38, 17\u201331 (2003).","journal-title":"Neuron"},{"key":"BFncomms7051_CR14","doi-asserted-by":"publisher","first-page":"882","DOI":"10.1038\/ncb2535","volume":"14","author":"O Shakhova","year":"2012","unstructured":"Shakhova, O. et al. Sox10 promotes the formation and maintenance of giant congenital naevi and melanoma. Nat. Cell Biol. 14, 882\u2013890 (2012).","journal-title":"Nat. Cell Biol."},{"key":"BFncomms7051_CR15","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1038\/nature05918","volume":"447","author":"W Reik","year":"2007","unstructured":"Reik, W. Stability and flexibility of epigenetic gene regulation in mammalian development. Nature 447, 425\u2013432 (2007).","journal-title":"Nature"},{"key":"BFncomms7051_CR16","doi-asserted-by":"publisher","first-page":"1148","DOI":"10.1056\/NEJMra072067","volume":"358","author":"M Esteller","year":"2008","unstructured":"Esteller, M. Epigenetics in cancer. N. Engl. J. Med. 358, 1148\u20131159 (2008).","journal-title":"N. Engl. J. Med."},{"key":"BFncomms7051_CR17","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1038\/nature09784","volume":"469","author":"R Margueron","year":"2011","unstructured":"Margueron, R. & Reinberg, D. The Polycomb complex PRC2 and its mark in life. Nature 469, 343\u2013349 (2011).","journal-title":"Nature"},{"key":"BFncomms7051_CR18","doi-asserted-by":"publisher","first-page":"e00005","DOI":"10.7554\/eLife.00005","volume":"1","author":"C Ciferri","year":"2012","unstructured":"Ciferri, C. et al. Molecular architecture of human polycomb repressive complex 2. Elife 1, e00005 (2012).","journal-title":"Elife"},{"key":"BFncomms7051_CR19","doi-asserted-by":"publisher","first-page":"600","DOI":"10.1016\/j.neuron.2009.08.021","volume":"63","author":"Y Hirabayashi","year":"2009","unstructured":"Hirabayashi, Y. et al. Polycomb limits the neurogenic competence of neural precursor cells to promote astrogenic fate transition. Neuron 63, 600\u2013613 (2009).","journal-title":"Neuron"},{"key":"BFncomms7051_CR20","doi-asserted-by":"publisher","first-page":"2170","DOI":"10.1182\/blood-2005-09-3585","volume":"107","author":"LM Kamminga","year":"2006","unstructured":"Kamminga, L. M. et al. The Polycomb group gene Ezh2 prevents hematopoietic stem cell exhaustion. Blood 107, 2170\u20132179 (2006).","journal-title":"Blood"},{"key":"BFncomms7051_CR21","doi-asserted-by":"publisher","first-page":"867","DOI":"10.1242\/dev.094342","volume":"141","author":"D Schwarz","year":"2014","unstructured":"Schwarz, D. et al. Ezh2 is required for neural crest-derived cartilage and bone formation. Development 141, 867\u2013877 (2014).","journal-title":"Development"},{"key":"BFncomms7051_CR22","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1016\/j.stem.2010.08.002","volume":"7","author":"M Sauvageau","year":"2010","unstructured":"Sauvageau, M. & Sauvageau, G. Polycomb group proteins: multi-faceted regulators of somatic stem cells and cancer. Cell Stem Cell 7, 299\u2013313 (2010).","journal-title":"Cell Stem Cell"},{"key":"BFncomms7051_CR23","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1200\/JCO.2005.01.5180","volume":"24","author":"IM Bachmann","year":"2006","unstructured":"Bachmann, I. M. et al. EZH2 expression is associated with high proliferation rate and aggressive tumor subgroups in cutaneous melanoma and cancers of the endometrium, prostate, and breast. J. Clin. Oncol. 24, 268\u2013273 (2006).","journal-title":"J. Clin. Oncol."},{"key":"BFncomms7051_CR24","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1111\/j.1600-0560.2006.00678.x","volume":"34","author":"JB McHugh","year":"2007","unstructured":"McHugh, J. B., Fullen, D. R., Ma, L., Kleer, C. G. & Su, L. D. Expression of polycomb group protein EZH2 in nevi and melanoma. J. Cutan. Pathol. 34, 597\u2013600 (2007).","journal-title":"J. Cutan. Pathol."},{"key":"BFncomms7051_CR25","doi-asserted-by":"publisher","first-page":"1246","DOI":"10.2353\/ajpath.2009.090042","volume":"175","author":"X Li","year":"2009","unstructured":"Li, X. et al. Targeted overexpression of EZH2 in the mammary gland disrupts ductal morphogenesis and causes epithelial hyperplasia. Am. J. Pathol. 175, 1246\u20131254 (2009).","journal-title":"Am. J. Pathol."},{"key":"BFncomms7051_CR26","doi-asserted-by":"publisher","first-page":"3098","DOI":"10.1073\/pnas.1308953111","volume":"111","author":"ME Gonzalez","year":"2014","unstructured":"Gonzalez, M. E. et al. EZH2 expands breast stem cells through activation of NOTCH1 signaling. Proc. Natl Acad. Sci. USA 111, 3098\u20133103 (2014).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFncomms7051_CR27","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1016\/j.ccr.2013.04.011","volume":"23","author":"W B\u00e9guelin","year":"2013","unstructured":"B\u00e9guelin, W. et al. EZH2 is required for germinal center formation and somatic EZH2 mutations promote lymphoid transformation. Cancer Cell 23, 677\u2013692 (2013).","journal-title":"Cancer Cell"},{"key":"BFncomms7051_CR28","doi-asserted-by":"publisher","first-page":"418","DOI":"10.1158\/1541-7786.MCR-10-0511","volume":"9","author":"T Fan","year":"2011","unstructured":"Fan, T. et al. EZH2-dependent suppression of a cellular senescence phenotype in melanoma cells by inhibition of p21\/CDKN1A expression. Mol. Cancer Res. 9, 418\u2013429 (2011).","journal-title":"Mol. Cancer Res."},{"key":"BFncomms7051_CR29","doi-asserted-by":"publisher","first-page":"768","DOI":"10.1038\/jid.2012.357","volume":"133","author":"C Luo","year":"2012","unstructured":"Luo, C. et al. MiR-137 inhibits the invasion of melanoma cells through downregulation of multiple oncogenic target genes. J. Invest. Dermatol. 133, 768\u2013775 (2012).","journal-title":"J. Invest. Dermatol."},{"key":"BFncomms7051_CR30","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1016\/j.canlet.2013.08.021","volume":"341","author":"C Luo","year":"2013","unstructured":"Luo, C. et al. MiR-101 inhibits melanoma cell invasion and proliferation by targeting MITF and EZH2. Cancer Lett. 341, 240\u2013247 (2013).","journal-title":"Cancer Lett."},{"key":"BFncomms7051_CR31","doi-asserted-by":"publisher","first-page":"e1003644","DOI":"10.1371\/journal.pgen.1003644","volume":"9","author":"ML Harris","year":"2013","unstructured":"Harris, M. L. et al. A dual role for SOX10 in the maintenance of the postnatal melanocyte lineage and the differentiation of melanocyte stem cell progenitors. PLoS Genet. 9, e1003644 (2013).","journal-title":"PLoS Genet."},{"key":"BFncomms7051_CR32","doi-asserted-by":"publisher","first-page":"976","DOI":"10.1097\/00000478-199808000-00007","volume":"22","author":"KJ Busam","year":"1998","unstructured":"Busam, K. J. et al. Expression of melan-A (MART1) in benign melanocytic nevi and primary cutaneous malignant melanoma. Am. J. Surg. Pathol. 22, 976\u2013982 (1998).","journal-title":"Am. J. Surg. Pathol."},{"key":"BFncomms7051_CR33","first-page":"195","volume":"123","author":"AM Gown","year":"1986","unstructured":"Gown, A. M., Vogel, A. M., Hoak, D., Gough, F. & McNutt, M. A. Monoclonal antibodies specific for melanocytic tumors distinguish subpopulations of melanocytes. Am. J. Pathol. 123, 195\u2013203 (1986).","journal-title":"Am. J. Pathol."},{"key":"BFncomms7051_CR34","doi-asserted-by":"publisher","first-page":"4005","DOI":"10.1158\/0008-5472.CAN-04-2970","volume":"65","author":"J Ackermann","year":"2005","unstructured":"Ackermann, J. et al. Metastasizing melanoma formation caused by expression of activated N-RasQ61K on an INK4a-deficient background. Cancer Res. 65, 4005\u20134011 (2005).","journal-title":"Cancer Res."},{"key":"BFncomms7051_CR35","doi-asserted-by":"publisher","first-page":"854","DOI":"10.1038\/416854a","volume":"416","author":"EK Nishimura","year":"2002","unstructured":"Nishimura, E. K. et al. Dominant role of the niche in melanocyte stem-cell fate determination. Nature 416, 854\u2013860 (2002).","journal-title":"Nature"},{"key":"BFncomms7051_CR36","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1007\/s12185-012-1181-z","volume":"96","author":"YR Chung","year":"2012","unstructured":"Chung, Y. R., Schatoff, E. & Abdel-Wahab, O. Epigenetic alterations in hematopoietic malignancies. Int. J. Hematol. 96, 413\u2013427 (2012).","journal-title":"Int. J. Hematol."},{"key":"BFncomms7051_CR37","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1038\/nature12477","volume":"500","author":"LB Alexandrov","year":"2013","unstructured":"Alexandrov, L. B. et al. Signatures of mutational processes in human cancer. Nature 500, 415\u2013421 (2013).","journal-title":"Nature"},{"key":"BFncomms7051_CR38","doi-asserted-by":"publisher","first-page":"2989","DOI":"10.1073\/pnas.1116418109","volume":"109","author":"MT McCabe","year":"2012","unstructured":"McCabe, M. T. et al. Mutation of A677 in histone methyltransferase EZH2 in human B-cell lymphoma promotes hypertrimethylation of histone H3 on lysine 27 (H3K27). Proc. Natl Acad. Sci. USA 109, 2989\u20132994 (2012).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFncomms7051_CR39","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1002\/dvg.20205","volume":"44","author":"M Bosenberg","year":"2006","unstructured":"Bosenberg, M. et al. Characterization of melanocyte-specific inducible Cre recombinase transgenic mice. Genesis 44, 262\u2013267 (2006).","journal-title":"Genesis"},{"key":"BFncomms7051_CR40","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1038\/5007","volume":"21","author":"P Soriano","year":"1999","unstructured":"Soriano, P. Generalized lacZ expression with the ROSA26 Cre reporter strain. Nat. Genet. 21, 70\u201371 (1999).","journal-title":"Nat. Genet."},{"key":"BFncomms7051_CR41","doi-asserted-by":"publisher","first-page":"941","DOI":"10.1016\/j.cell.2011.05.004","volume":"145","author":"P Rabbani","year":"2011","unstructured":"Rabbani, P. et al. Coordinated activation of Wnt in epithelial and melanocyte stem cells initiates pigmented hair regeneration. Cell 145, 941\u2013955 (2011).","journal-title":"Cell"},{"key":"BFncomms7051_CR42","doi-asserted-by":"publisher","first-page":"1329","DOI":"10.1016\/0092-8674(90)90696-C","volume":"61","author":"G Cotsarelis","year":"1990","unstructured":"Cotsarelis, G., Sun, T. T. & Lavker, R. M. Label-retaining cells reside in the bulge area of pilosebaceous unit: implications for follicular stem cells, hair cycle, and skin carcinogenesis. Cell 61, 1329\u20131337 (1990).","journal-title":"Cell"},{"key":"BFncomms7051_CR43","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1111\/j.1755-148X.2010.00823.x","volume":"24","author":"MC Zipser","year":"2011","unstructured":"Zipser, M. C. et al. A proliferative melanoma cell phenotype is responsive to RAF\/MEK inhibition independent of BRAF mutation status. Pigment Cell Melanoma Res. 24, 326\u2013333 (2011).","journal-title":"Pigment Cell Melanoma Res."},{"key":"BFncomms7051_CR44","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1111\/j.1600-0749.2007.00378.x","volume":"20","author":"C Gaggioli","year":"2007","unstructured":"Gaggioli, C. & Sahai, E. Melanoma invasion\u2014current knowledge and future directions. Pigment Cell Res. 20, 161\u2013172 (2007).","journal-title":"Pigment Cell Res."},{"key":"BFncomms7051_CR45","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/j.ccr.2013.05.009","volume":"24","author":"M S\u00e1ez-Ayala","year":"2013","unstructured":"S\u00e1ez-Ayala, M. et al. Directed phenotype switching as an effective antimelanoma strategy. Cancer Cell 24, 105\u2013119 (2013).","journal-title":"Cancer Cell"},{"key":"BFncomms7051_CR46","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1016\/j.ccr.2013.08.018","volume":"24","author":"J Caramel","year":"2013","unstructured":"Caramel, J. et al. A switch in the expression of embryonic EMT-inducers drives the development of malignant melanoma. Cancer Cell 24, 466\u2013480 (2013).","journal-title":"Cancer Cell"},{"key":"BFncomms7051_CR47","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1038\/ni876","volume":"4","author":"I-H Su","year":"2003","unstructured":"Su, I.-H. et al. Ezh2 controls B cell development through histone H3 methylation and Igh rearrangement. Nat. Immunol. 4, 124\u2013131 (2003).","journal-title":"Nat. Immunol."},{"key":"BFncomms7051_CR48","doi-asserted-by":"publisher","first-page":"5009","DOI":"10.1172\/JCI70626","volume":"123","author":"M Caganova","year":"2013","unstructured":"Caganova, M. et al. Germinal center dysregulation by histone methyltransferase EZH2 promotes lymphomagenesis. J. Clin. Invest. 123, 5009\u20135022 (2013).","journal-title":"J. Clin. Invest."},{"key":"BFncomms7051_CR49","doi-asserted-by":"publisher","first-page":"1107","DOI":"10.1182\/blood-2011-11-394932","volume":"120","author":"S Tanaka","year":"2012","unstructured":"Tanaka, S. et al. Ezh2 augments leukemogenicity by reinforcing differentiation blockage in acute myeloid leukemia. Blood 120, 1107\u20131117 (2012).","journal-title":"Blood"},{"key":"BFncomms7051_CR50","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1038\/nm.2100","volume":"16","author":"J Min","year":"2010","unstructured":"Min, J. et al. An oncogene-tumor suppressor cascade drives metastatic prostate cancer by coordinately activating Ras and nuclear factor-kappaB. Nat. Med. 16, 286\u2013294 (2010).","journal-title":"Nat. Med."},{"key":"BFncomms7051_CR51","doi-asserted-by":"publisher","first-page":"768","DOI":"10.1016\/j.ccr.2013.04.020","volume":"23","author":"N Tiwari","year":"2013","unstructured":"Tiwari, N. et al. Sox4 is a master regulator of epithelial-mesenchymal transition by controlling ezh2 expression and epigenetic reprogramming. Cancer Cell 23, 768\u2013783 (2013).","journal-title":"Cancer Cell"},{"key":"BFncomms7051_CR52","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/j.canlet.2012.10.009","volume":"338","author":"O Shakhova","year":"2013","unstructured":"Shakhova, O. & Sommer, L. Testing the cancer stem cell hypothesis in melanoma: the clinics will tell. Cancer Lett. 338, 74\u201381 (2013).","journal-title":"Cancer Lett."},{"key":"BFncomms7051_CR53","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1016\/j.ccr.2011.10.030","volume":"20","author":"WE Damsky","year":"2011","unstructured":"Damsky, W. E. et al. \u03b2-catenin signaling controls metastasis in Braf-activated Pten-deficient melanomas. Cancer Cell 20, 741\u2013754 (2011).","journal-title":"Cancer Cell"},{"key":"BFncomms7051_CR54","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1007\/BF01696231","volume":"71","author":"AP Stegmann","year":"1995","unstructured":"Stegmann, A. P. et al. In vitro-induced resistance to the deoxycytidine analogues cytarabine (AraC) and 5-aza-2'-deoxycytidine (DAC) in a rat model for acute myeloid leukemia is mediated by mutations in the deoxycytidine kinase (dck) gene. Ann. Hematol. 71, 41\u201347 (1995).","journal-title":"Ann. Hematol."},{"key":"BFncomms7051_CR55","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1007\/s00726-009-0408-7","volume":"38","author":"MH Park","year":"2010","unstructured":"Park, M. H., Nishimura, K., Zanelli, C. F. & Valentini, S. R. Functional significance of eIF5A and its hypusine modification in eukaryotes. Amino Acids 38, 491\u2013500 (2010).","journal-title":"Amino Acids"},{"key":"BFncomms7051_CR56","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1038\/nature11126","volume":"487","author":"C Scuoppo","year":"2012","unstructured":"Scuoppo, C. et al. A tumour suppressor network relying on the polyamine-hypusine axis. Nature 487, 244\u2013248 (2012).","journal-title":"Nature"},{"key":"BFncomms7051_CR57","doi-asserted-by":"publisher","first-page":"4801","DOI":"10.1091\/mbc.e06-04-0260","volume":"17","author":"E Efimenko","year":"2006","unstructured":"Efimenko, E. et al. Caenorhabditis elegans DYF-2, an orthologue of human WDR19, is a component of the intraflagellar transport machinery in sensory cilia. Mol. Biol. Cell 17, 4801\u20134811 (2006).","journal-title":"Mol. Biol. Cell"},{"key":"BFncomms7051_CR58","doi-asserted-by":"publisher","first-page":"1397","DOI":"10.1158\/1078-0432.CCR-07-1535","volume":"14","author":"B Lin","year":"2008","unstructured":"Lin, B. et al. WDR19 expression is increased in prostate cancer compared with normal cells, but low-intensity expression in cancers is associated with shorter time to biochemical failures and local recurrence. Clin. Cancer Res. 14, 1397\u20131406 (2008).","journal-title":"Clin. Cancer Res."},{"key":"BFncomms7051_CR59","doi-asserted-by":"publisher","first-page":"1094","DOI":"10.1016\/j.cell.2014.07.032","volume":"158","author":"YD Shaul","year":"2014","unstructured":"Shaul, Y. D. et al. Dihydropyrimidine accumulation is required for the epithelial-mesenchymal transition. Cell 158, 1094\u20131109 (2014).","journal-title":"Cell"},{"key":"BFncomms7051_CR60","doi-asserted-by":"publisher","first-page":"480","DOI":"10.1038\/nature12751","volume":"502","author":"K Helin","year":"2013","unstructured":"Helin, K. & Dhanak, D. Chromatin proteins and modifications as drug targets. Nature 502, 480\u2013488 (2013).","journal-title":"Nature"},{"key":"BFncomms7051_CR61","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/S0092-8674(00)81079-X","volume":"85","author":"M Serrano","year":"1996","unstructured":"Serrano, M. et al. Role of the INK4a locus in tumor suppression and cell mortality. Cell 85, 27\u201337 (1996).","journal-title":"Cell"},{"key":"BFncomms7051_CR62","doi-asserted-by":"publisher","first-page":"4293","DOI":"10.1093\/nar\/19.15.4293","volume":"19","author":"PW Laird","year":"1991","unstructured":"Laird, P. W. et al. Simplified mammalian DNA isolation procedure. Nucleic Acids Res. 19, 4293 (1991).","journal-title":"Nucleic Acids Res."},{"key":"BFncomms7051_CR63","doi-asserted-by":"publisher","first-page":"414","DOI":"10.1002\/ijc.2910390324","volume":"39","author":"DC Bennett","year":"1987","unstructured":"Bennett, D. C., Cooper, P. J. & Hart, I. R. A line of non-tumorigenic mouse melanocytes, syngeneic with the B16 melanoma and requiring a tumour promoter for growth. Int. J. Cancer 39, 414\u2013418 (1987).","journal-title":"Int. J. Cancer"},{"key":"BFncomms7051_CR64","doi-asserted-by":"publisher","first-page":"R100","DOI":"10.1186\/gb-2006-7-10-r100","volume":"7","author":"AE Carpenter","year":"2006","unstructured":"Carpenter, A. E. et al. CellProfiler: image analysis software for identifying and quantifying cell phenotypes. Genome Biol. 7, R100 (2006).","journal-title":"Genome Biol."},{"key":"BFncomms7051_CR65","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1007\/978-1-62703-706-8_25","volume":"1094","author":"R Santoro","year":"2014","unstructured":"Santoro, R. Analysis of chromatin composition of repetitive sequences: the ChIP-Chop assay. Methods Mol. Biol. 1094, 319\u2013328 (2014).","journal-title":"Methods Mol. Biol."},{"key":"BFncomms7051_CR66","doi-asserted-by":"publisher","first-page":"1427","DOI":"10.1093\/bioinformatics\/18.11.1427","volume":"18","author":"L-C Li","year":"2002","unstructured":"Li, L.-C. & Dahiya, R. MethPrimer: designing primers for methylation PCRs. Bioinformatics 18, 1427\u20131431 (2002).","journal-title":"Bioinformatics"},{"key":"BFncomms7051_CR67","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1007\/0-387-29362-0_23","volume":"Vol. 5","author":"GK Smyth","year":"2005","unstructured":"Smyth, G. K. Bioinformatics and Computational Biology Solutions Using R and Bioconductor Statistics for Biology and Health Vol. 5, 397\u2013420Springer (2005).","journal-title":"Bioinformatics and Computational Biology Solutions Using R and Bioconductor"},{"key":"BFncomms7051_CR68","doi-asserted-by":"publisher","first-page":"e164","DOI":"10.1093\/nar\/gkq603","volume":"38","author":"K Wang","year":"2010","unstructured":"Wang, K., Li, M. & Hakonarson, H. ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data. Nucleic Acids Res. 38, e164 (2010).","journal-title":"Nucleic Acids Res."},{"key":"BFncomms7051_CR69","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1093\/bioinformatics\/btp616","volume":"26","author":"MD Robinson","year":"2010","unstructured":"Robinson, M. D., McCarthy, D. J. & Smyth, G. K. edgeR: a Bioconductor package for differential expression analysis of digital gene expression data. Bioinformatics 26, 139\u2013140 (2010).","journal-title":"Bioinformatics"}],"container-title":["Nature Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/ncomms7051.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/ncomms7051","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/ncomms7051.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,5]],"date-time":"2023-01-05T07:20:15Z","timestamp":1672903215000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/ncomms7051"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1,22]]},"references-count":69,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2015,5,5]]}},"alternative-id":["BFncomms7051"],"URL":"https:\/\/doi.org\/10.1038\/ncomms7051","relation":{},"ISSN":["2041-1723"],"issn-type":[{"value":"2041-1723","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,1,22]]},"assertion":[{"value":"9 May 2014","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 December 2014","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 January 2015","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing financial interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"6051"}}