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The mechanisms that lead to retention and accumulation of macrophages in the vascular wall remain unclear. Regulator of G-Protein Signalling-1 (RGS1) deactivates G-protein signalling, reducing the response to sustained chemokine stimulation. Here we show that\n                    <jats:italic>Rgs1<\/jats:italic>\n                    is upregulated in atherosclerotic plaque and aortic aneurysms.\n                    <jats:italic>Rgs1<\/jats:italic>\n                    reduces macrophage chemotaxis and desensitizes chemokine receptor signalling. In early atherosclerotic lesions,\n                    <jats:italic>Rgs1<\/jats:italic>\n                    regulates macrophage accumulation and is required for the formation and rupture of Angiotensin II-induced aortic aneurysms, through effects on leukocyte retention. Collectively, these data reveal a role for\n                    <jats:italic>Rgs1<\/jats:italic>\n                    in leukocyte trafficking and vascular inflammation and identify\n                    <jats:italic>Rgs1<\/jats:italic>\n                    , and inhibition of chemokine receptor signalling as potential therapeutic targets in vascular disease.\n                  <\/jats:p>","DOI":"10.1038\/ncomms7614","type":"journal-article","created":{"date-parts":[[2015,3,18]],"date-time":"2015-03-18T08:36:14Z","timestamp":1426667774000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":67,"title":["RGS1 regulates myeloid cell accumulation in atherosclerosis and aortic aneurysm rupture through altered chemokine signalling"],"prefix":"10.1038","volume":"6","author":[{"given":"Jyoti","family":"Patel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eileen","family":"McNeill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gillian","family":"Douglas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley B.","family":"Hale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"de Bono","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Regent","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asif J.","family":"Iqbal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Regan-Komito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Stylianou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David R.","family":"Greaves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith M.","family":"Channon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,3,18]]},"reference":[{"key":"BFncomms7614_CR1","doi-asserted-by":"publisher","first-page":"894","DOI":"10.1038\/29788","volume":"394","author":"L Boring","year":"1998","unstructured":"Boring, L., Gosling, J., Cleary, M. & Charo, I. 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