{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T05:26:50Z","timestamp":1790659610342,"version":"4.1.0"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2015,4,13]],"date-time":"2015-04-13T00:00:00Z","timestamp":1428883200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2015,4,13]],"date-time":"2015-04-13T00:00:00Z","timestamp":1428883200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nat Commun"],"DOI":"10.1038\/ncomms7763","type":"journal-article","created":{"date-parts":[[2015,4,13]],"date-time":"2015-04-13T10:23:29Z","timestamp":1428920609000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":119,"title":["A fungal protease allergen provokes airway hyper-responsiveness in asthma"],"prefix":"10.1038","volume":"6","author":[{"given":"Nariman A.","family":"Balenga","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Klichinsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihui","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eunice C.","family":"Chan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Jude","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Laviolette","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Reynold A.","family":"Panettieri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirk M.","family":"Druey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,4,13]]},"reference":[{"key":"BFncomms7763_CR1","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.pupt.2012.08.009","volume":"26","author":"AR West","year":"2013","unstructured":"West, A. R. et al. Airway contractility and remodelling: links to asthma symptoms. Pulm. Pharmacol. Ther. 26, 3\u201312 (2013) .","journal-title":"Pulm. Pharmacol. Ther."},{"key":"BFncomms7763_CR2","doi-asserted-by":"publisher","first-page":"1026","DOI":"10.1378\/chest.12-3073","volume":"144","author":"N Hirota","year":"2013","unstructured":"Hirota, N. & Martin, J. G. Mechanisms of airway remodelling. Chest 144, 1026\u20131032 (2013) .","journal-title":"Chest"},{"key":"BFncomms7763_CR3","doi-asserted-by":"publisher","first-page":"L912","DOI":"10.1152\/ajplung.00259.2013","volume":"305","author":"YS Prakash","year":"2013","unstructured":"Prakash, Y. S. Airway smooth muscle in airway reactivity and remodelling: what have we learned? Am. J. Physiol. Lung Cell Mol. Physiol. 305, L912\u2013L933 (2013) .","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"key":"BFncomms7763_CR4","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1016\/j.pupt.2012.02.001","volume":"25","author":"CJ Reddel","year":"2012","unstructured":"Reddel, C. J., Weiss, A. S. & Burgess, J. K. Elastin in asthma. Pulm. Pharmacol. Ther. 25, 144\u2013153 (2012) .","journal-title":"Pulm. Pharmacol. Ther."},{"key":"BFncomms7763_CR5","doi-asserted-by":"publisher","first-page":"1297","DOI":"10.1038\/nm.3321","volume":"19","author":"LA Albacker","year":"2013","unstructured":"Albacker, L. A. et al. Invariant natural killer T cells recognize a fungal glycosphingolipid that can induce airway hyperreactivity. Nat. Med. 19, 1297\u20131304 (2013) .","journal-title":"Nat. Med."},{"key":"BFncomms7763_CR6","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1016\/j.jaci.2014.01.019","volume":"134","author":"NA Balenga","year":"2014","unstructured":"Balenga, N. A., Jester, W., Jiang, M., Panettieri, R. A. Jr & Druey, K. M. Loss of regulator of G protein signalling 5 promotes airway hyperresponsiveness in the absence of allergic inflammation. J. Allergy Clin. Immunol. 134, 451\u2013459 (2014) .","journal-title":"J. Allergy Clin. Immunol."},{"key":"BFncomms7763_CR7","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1038\/ni.3049","volume":"16","author":"BN Lambrecht","year":"2014","unstructured":"Lambrecht, B. N. & Hammad, H. The immunology of asthma. Nat. Immunol. 16, 45\u201356 (2014) .","journal-title":"Nat. Immunol."},{"key":"BFncomms7763_CR8","doi-asserted-by":"publisher","first-page":"792","DOI":"10.1126\/science.1240342","volume":"341","author":"VO Millien","year":"2013","unstructured":"Millien, V. O. et al. Cleavage of fibrinogen by proteinases elicits allergic responses through Toll-like receptor 4. Science 341, 792\u2013796 (2013) .","journal-title":"Science"},{"key":"BFncomms7763_CR9","doi-asserted-by":"publisher","first-page":"5237","DOI":"10.4049\/jimmunol.178.8.5237","volume":"178","author":"LL Chiu","year":"2007","unstructured":"Chiu, L. L., Perng, D. W., Yu, C. H., Su, S. N. & Chow, L. P. Mold allergen, pen C 13, induces IL-8 expression in human airway epithelial cells by activating protease-activated receptor 1 and 2. J. Immunol. 178, 5237\u20135244 (2007) .","journal-title":"J. Immunol."},{"key":"BFncomms7763_CR10","doi-asserted-by":"publisher","first-page":"26667","DOI":"10.1074\/jbc.M110.193987","volume":"286","author":"JC Chen","year":"2011","unstructured":"Chen, J. C. et al. The protease allergen Pen c 13 induces allergic airway inflammation and changes in epithelial barrier integrity and function in a murine model. J. Biol. Chem. 286, 26667\u201326679 (2011) .","journal-title":"J. Biol. Chem."},{"key":"BFncomms7763_CR11","doi-asserted-by":"publisher","first-page":"e71278","DOI":"10.1371\/journal.pone.0071278","volume":"8","author":"MS Leino","year":"2013","unstructured":"Leino, M. S. et al. Barrier disrupting effects of alternaria alternata extract on bronchial epithelium from asthmatic donors. PLoS ONE 8, e71278 (2013) .","journal-title":"PLoS ONE"},{"key":"BFncomms7763_CR12","doi-asserted-by":"publisher","first-page":"5904","DOI":"10.4049\/jimmunol.169.10.5904","volume":"169","author":"F Kheradmand","year":"2002","unstructured":"Kheradmand, F. et al. A protease-activated pathway underlying Th cell type 2 activation and allergic lung disease. J. Immunol. 169, 5904\u20135911 (2002) .","journal-title":"J. Immunol."},{"key":"BFncomms7763_CR13","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1128\/iai.62.3.936-942.1994","volume":"62","author":"M Moser","year":"1994","unstructured":"Moser, M., Menz, G., Blaser, K. & Crameri, R. Recombinant expression and antigenic properties of a 32-kilodalton extracellular alkaline protease, representing a possible virulence factor from Aspergillus fumigatus. Infect. Immun. 62, 936\u2013942 (1994) .","journal-title":"Infect. Immun."},{"key":"BFncomms7763_CR14","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1016\/S0966-842X(01)02104-7","volume":"9","author":"JP Latge","year":"2001","unstructured":"Latge, J. P. The pathobiology of Aspergillus fumigatus. Trends Microbiol. 9, 382\u2013389 (2001) .","journal-title":"Trends Microbiol."},{"key":"BFncomms7763_CR15","doi-asserted-by":"publisher","first-page":"1185","DOI":"10.1067\/mai.2000.106210","volume":"105","author":"HF Kauffman","year":"2000","unstructured":"Kauffman, H. F., Tomee, J. F., van de Riet, M. A., Timmerman, A. J. & Borger, P. Protease-dependent activation of epithelial cells by fungal allergens leads to morphologic changes and cytokine production. J. Allergy Clin. Immunol. 105, 1185\u20131193 (2000) .","journal-title":"J. Allergy Clin. Immunol."},{"key":"BFncomms7763_CR16","doi-asserted-by":"publisher","first-page":"L1405","DOI":"10.1152\/ajplung.00331.2006","volume":"292","author":"BG Dekkers","year":"2007","unstructured":"Dekkers, B. G., Schaafsma, D., Nelemans, S. A., Zaagsma, J. & Meurs, H. Extracellular matrix proteins differentially regulate airway smooth muscle phenotype and function. Am. J. Physiol. Lung Cell Mol. Physiol. 292, L1405\u2013L1413 (2007) .","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"key":"BFncomms7763_CR17","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1002\/jcp.1041380114","volume":"138","author":"SG Kremer","year":"1989","unstructured":"Kremer, S. G., Breuer, W. V. & Skorecki, K. L. Vasoconstrictor hormones depolarize renal glomerular mesangial cells by activating chloride channels. J. Cell. Physiol. 138, 97\u2013105 (1989) .","journal-title":"J. Cell. Physiol."},{"key":"BFncomms7763_CR18","first-page":"1173","volume":"102","author":"G Pelaia","year":"2008","unstructured":"Pelaia, G. et al. Molecular mechanisms underlying airway smooth muscle contraction and proliferation: implications for asthma. J. Cell. Physiol. 102, 1173\u20131181 (2008) .","journal-title":"J. Cell. Physiol."},{"key":"BFncomms7763_CR19","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1513\/pats.200705-054VS","volume":"5","author":"RB Penn","year":"2008","unstructured":"Penn, R. B. & Benovic, J. L. Regulation of heterotrimeric G protein signalling in airway smooth muscle. Proc. Am. Thorac. Soc. 5, 47\u201357 (2008) .","journal-title":"Proc. Am. Thorac. Soc."},{"key":"BFncomms7763_CR20","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1513\/pats.200704-048VS","volume":"5","author":"W Zhang","year":"2008","unstructured":"Zhang, W. & Gunst, S. J. Interactions of airway smooth muscle cells with their tissue matrix: implications for contraction. Proc. Am. Thorac. Soc. 5, 32\u201339 (2008) .","journal-title":"Proc. Am. Thorac. Soc."},{"key":"BFncomms7763_CR21","doi-asserted-by":"publisher","first-page":"C576","DOI":"10.1152\/ajpcell.00253.2008","volume":"295","author":"SJ Gunst","year":"2008","unstructured":"Gunst, S. J. & Zhang, W. Actin cytoskeletal dynamics in smooth muscle: a new paradigm for the regulation of smooth muscle contraction. Am. J. Physiol. Cell Physiol. 295, C576\u2013C587 (2008) .","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"BFncomms7763_CR22","doi-asserted-by":"publisher","first-page":"2916","DOI":"10.1172\/JCI60387","volume":"122","author":"C Chen","year":"2012","unstructured":"Chen, C. et al. Integrin alpha9beta1 in airway smooth muscle suppresses exaggerated airway narrowing. J. Clin. Invest. 122, 2916\u20132927 (2012) .","journal-title":"J. Clin. Invest."},{"key":"BFncomms7763_CR23","doi-asserted-by":"publisher","first-page":"233","DOI":"10.3109\/01902149809041532","volume":"24","author":"P Iadarola","year":"1998","unstructured":"Iadarola, P. et al. Lung injury and degradation of extracellular matrix components by Aspergillus fumigatus serine proteinase. Exp. Lung Res. 24, 233\u2013251 (1998) .","journal-title":"Exp. Lung Res."},{"key":"BFncomms7763_CR24","doi-asserted-by":"publisher","first-page":"1318","DOI":"10.1038\/sj.bjp.0705883","volume":"142","author":"SR Elshaw","year":"2004","unstructured":"Elshaw, S. R. et al. Matrix metalloproteinase expression and activity in human airway smooth muscle cells. Br. J. Pharmacol. 142, 1318\u20131324 (2004) .","journal-title":"Br. J. Pharmacol."},{"key":"BFncomms7763_CR25","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1186\/1465-9921-6-148","volume":"6","author":"S Xie","year":"2005","unstructured":"Xie, S. et al. Induction and regulation of matrix metalloproteinase-12 in human airway smooth muscle cells. Respir. Res. 6, 148 (2005) .","journal-title":"Respir. Res."},{"key":"BFncomms7763_CR26","doi-asserted-by":"publisher","first-page":"482","DOI":"10.1165\/ajrcmb.15.4.8879182","volume":"15","author":"A Altraja","year":"1996","unstructured":"Altraja, A. et al. Expression of laminins in the airways in various types of asthmatic patients: a morphometric study. Am. J. Respir. Cell Mol. Biol. 15, 482\u2013488 (1996) .","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"BFncomms7763_CR27","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1165\/ajrcmb.23.3.3990","volume":"23","author":"SJ Hirst","year":"2000","unstructured":"Hirst, S. J., Twort, C. H. & Lee, T. H. Differential effects of extracellular matrix proteins on human airway smooth muscle cell proliferation and phenotype. Am. J. Respir. Cell Mol. Biol. 23, 335\u2013344 (2000) .","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"BFncomms7763_CR28","doi-asserted-by":"publisher","first-page":"520","DOI":"10.1016\/S0140-6736(89)90067-6","volume":"1","author":"WR Roche","year":"1989","unstructured":"Roche, W. R., Beasley, R., Williams, J. H. & Holgate, S. T. Subepithelial fibrosis in the bronchi of asthmatics. Lancet 1, 520\u2013524 (1989) .","journal-title":"Lancet"},{"key":"BFncomms7763_CR29","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1513\/pats.200704-050VS","volume":"5","author":"MJ Sanderson","year":"2008","unstructured":"Sanderson, M. J., Delmotte, P., Bai, Y. & Perez-Zogbhi, J. F. Regulation of airway smooth muscle cell contractility by Ca2+ signalling and sensitivity. Proc. Am. Thorac. Soc. 5, 23\u201331 (2008) .","journal-title":"Proc. Am. Thorac. Soc."},{"key":"BFncomms7763_CR30","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1085\/jgp.200409216","volume":"125","author":"JF Perez","year":"2005","unstructured":"Perez, J. F. & Sanderson, M. J. The frequency of calcium oscillations induced by 5-HT, ACH, and KCl determine the contraction of smooth muscle cells of intrapulmonary bronchioles. J. Gen. Physiol. 125, 535\u2013553 (2005) .","journal-title":"J. Gen. Physiol."},{"key":"BFncomms7763_CR31","doi-asserted-by":"publisher","first-page":"60","DOI":"10.3109\/15412555.2013.764403","volume":"10","author":"RA Sandhaus","year":"2013","unstructured":"Sandhaus, R. A. & Turino, G. Neutrophil elastase-mediated lung disease. COPD 10, (Suppl 1): 60\u201363 (2013) .","journal-title":"COPD"},{"key":"BFncomms7763_CR32","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1183\/09031936.00025907","volume":"30","author":"MA Khan","year":"2007","unstructured":"Khan, M. A., Kianpour, S., Stampfli, M. R. & Janssen, L. J. Kinetics of in vitro bronchoconstriction in an elastolytic mouse model of emphysema. Eur. Respir. J. 30, 691\u2013700 (2007) .","journal-title":"Eur. Respir. J."},{"key":"BFncomms7763_CR33","doi-asserted-by":"publisher","first-page":"1549","DOI":"10.1164\/ajrccm\/140.6.1549","volume":"140","author":"SY Qian","year":"1989","unstructured":"Qian, S. Y. & Mitzner, W. In vivo and in vitro lung reactivity in elastase-induced emphysema in hamsters. Am. Rev. Respir. Dis. 140, 1549\u20131555 (1989) .","journal-title":"Am. Rev. Respir. Dis."},{"key":"BFncomms7763_CR34","doi-asserted-by":"publisher","first-page":"660","DOI":"10.1073\/pnas.1216673110","volume":"110","author":"M Kudo","year":"2013","unstructured":"Kudo, M. et al. Mfge8 suppresses airway hyperresponsiveness in asthma by regulating smooth muscle contraction. Proc. Natl Acad. Sci. USA 110, 660\u2013665 (2013) .","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFncomms7763_CR35","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1124\/jpet.113.203042","volume":"346","author":"BG Dekkers","year":"2013","unstructured":"Dekkers, B. G. et al. Focal adhesion kinase regulates collagen I-induced airway smooth muscle phenotype switching. J. Pharmacol. Exp. Ther. 346, 86\u201395 (2013) .","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"BFncomms7763_CR36","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1159\/000065882","volume":"129","author":"VP Kurup","year":"2002","unstructured":"Kurup, V. P. et al. Alkaline serine proteinase from Aspergillus fumigatus has synergistic effects on Asp-f-2-induced immune response in mice. Int. Arch. Allergy Immunol. 129, 129\u2013137 (2002) .","journal-title":"Int. Arch. Allergy Immunol."},{"key":"BFncomms7763_CR37","doi-asserted-by":"publisher","first-page":"999","DOI":"10.4049\/jimmunol.1002257","volume":"187","author":"T Oguma","year":"2011","unstructured":"Oguma, T. et al. Induction of mucin and MUC5AC expression by the protease activity of Aspergillus fumigatus in airway epithelial cells. J. Immunol. 187, 999\u20131005 (2011) .","journal-title":"J. Immunol."},{"key":"BFncomms7763_CR38","doi-asserted-by":"publisher","first-page":"1267","DOI":"10.1086\/315027","volume":"180","author":"P Borger","year":"1999","unstructured":"Borger, P. et al. Proteases from Aspergillus fumigatus induce interleukin (IL)-6 and IL-8 production in airway epithelial cell lines by transcriptional mechanisms. J. Infect. Dis. 180, 1267\u20131274 (1999) .","journal-title":"J. Infect. Dis."},{"key":"BFncomms7763_CR39","doi-asserted-by":"publisher","first-page":"1965","DOI":"10.1086\/420850","volume":"189","author":"TV Kogan","year":"2004","unstructured":"Kogan, T. V., Jadoun, J., Mittelman, L., Hirschberg, K. & Osherov, N. Involvement of secreted Aspergillus fumigatus proteases in disruption of the actin fiber cytoskeleton and loss of focal adhesion sites in infected A549 lung pneumocytes. J. Infect. Dis. 189, 1965\u20131973 (2004) .","journal-title":"J. Infect. Dis."},{"key":"BFncomms7763_CR40","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1016\/j.jaci.2014.04.028","volume":"134","author":"PC Porter","year":"2014","unstructured":"Porter, P. C. et al. Airway surface mycosis in chronic TH2-associated airway disease. J. Allergy Clin. Immunol. 134, 325\u2013331 (2014) .","journal-title":"J. Allergy Clin. Immunol."},{"key":"BFncomms7763_CR41","doi-asserted-by":"publisher","first-page":"2109","DOI":"10.1164\/ajrccm.151.6.7767565","volume":"151","author":"HF Kauffman","year":"1995","unstructured":"Kauffman, H. F., Tomee, J. F., van der Werf, T. S., de Monchy, J. G. & Koeter, G. K. Review of fungus-induced asthmatic reactions. Am. J. Respir. Crit. Care Med. 151, 2109\u20132115 (1995) .","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"BFncomms7763_CR42","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1183\/09031936.00068010","volume":"38","author":"N Miglino","year":"2011","unstructured":"Miglino, N., Roth, M., Tamm, M. & Borger, P. House dust mite extract downregulates C\/EBPalpha in asthmatic bronchial smooth muscle cells. Eur. Respir. J. 38, 50\u201358 (2011) .","journal-title":"Eur. Respir. J."},{"key":"BFncomms7763_CR43","doi-asserted-by":"publisher","first-page":"710","DOI":"10.1016\/j.pupt.2013.07.003","volume":"26","author":"SE Wenzel","year":"2013","unstructured":"Wenzel, S. E. Complex phenotypes in asthma: current definitions. Pulm. Pharmacol. Ther. 26, 710\u2013715 (2013) .","journal-title":"Pulm. Pharmacol. Ther."},{"key":"BFncomms7763_CR44","doi-asserted-by":"publisher","first-page":"1362","DOI":"10.1016\/j.acra.2005.08.027","volume":"12","author":"A Haczku","year":"2005","unstructured":"Haczku, A. et al. Hyperpolarized 3He MRI in asthma measurements of regional ventilation following allergic sensitization and challenge in mice--preliminary results. Acad. Radiol. 12, 1362\u20131370 (2005) .","journal-title":"Acad. Radiol."}],"container-title":["Nature Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/ncomms7763.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/ncomms7763","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/ncomms7763.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,5]],"date-time":"2023-01-05T11:50:47Z","timestamp":1672919447000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/ncomms7763"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4,13]]},"references-count":44,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2015,11,3]]}},"alternative-id":["BFncomms7763"],"URL":"https:\/\/doi.org\/10.1038\/ncomms7763","relation":{},"ISSN":["2041-1723"],"issn-type":[{"value":"2041-1723","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,4,13]]},"assertion":[{"value":"23 April 2014","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 February 2015","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 April 2015","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing financial interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"6763"}}