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Previous genome-wide association studies (GWASs) have identified many genetic loci associated with raised serum urate concentrations. However, hyperuricemia alone is not sufficient for the development of gout arthritis. Here we conduct a multistage GWAS in Han Chinese using 4,275 male gout patients and 6,272 normal male controls (1,255 cases and 1,848 controls were genome-wide genotyped), with an additional 1,644 hyperuricemic controls. We discover three new risk loci, 17q23.2 (rs11653176, <jats:italic>P<\/jats:italic>=1.36 \u00d7 10<jats:sup>\u221213<\/jats:sup>, <jats:italic>BCAS3<\/jats:italic>), 9p24.2 (rs12236871, <jats:italic>P<\/jats:italic>=1.48 \u00d7 10<jats:sup>\u221210<\/jats:sup>, <jats:italic>RFX3<\/jats:italic>) and 11p15.5 (rs179785, <jats:italic>P<\/jats:italic>=1.28 \u00d7 10<jats:sup>\u22128<\/jats:sup>, <jats:italic>KCNQ1<\/jats:italic>), which contain inflammatory candidate genes. Our results suggest that these loci are most likely related to the progression from hyperuricemia to inflammatory gout, which will provide new insights into the pathogenesis of gout arthritis.<\/jats:p>","DOI":"10.1038\/ncomms8041","type":"journal-article","created":{"date-parts":[[2015,5,13]],"date-time":"2015-05-13T10:19:47Z","timestamp":1431512387000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":90,"title":["Genome-wide association analysis identifies three new risk loci for gout arthritis in Han 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