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Blocking the restabilization of a memory during reconsolidation is held to result in a permanent amnesia. The targeted knockdown of either <jats:italic>Zif268<\/jats:italic> or <jats:italic>Arc<\/jats:italic> levels in the brain, and inhibition of protein synthesis, after a brief recall results in a non-recoverable retrograde amnesia, known as reconsolidation blockade. These experimental manipulations are seen as key proof for the existence of reconsolidation. However, here we demonstrate that despite disrupting the molecular correlates of reconsolidation in the hippocampus, rodents are still able to recover contextual memories. Our results challenge the view that reconsolidation is a separate memory process and instead suggest that the molecular events activated initially at recall act to constrain premature extinction.<\/jats:p>","DOI":"10.1038\/ncomms8897","type":"journal-article","created":{"date-parts":[[2015,8,4]],"date-time":"2015-08-04T09:56:48Z","timestamp":1438682208000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Rescue of long-term memory after reconsolidation blockade"],"prefix":"10.1038","volume":"6","author":[{"given":"Simon","family":"Trent","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Barnes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy","family":"Hall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerrie L.","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,8,4]]},"reference":[{"key":"BFncomms8897_CR1","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1038\/nrn2590","volume":"10","author":"K Nader","year":"2009","unstructured":"Nader, K. & Hardt, O. 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