{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T22:35:48Z","timestamp":1790289348805,"version":"4.1.0"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2015,8,5]],"date-time":"2015-08-05T00:00:00Z","timestamp":1438732800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2015,8,5]],"date-time":"2015-08-05T00:00:00Z","timestamp":1438732800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nat Commun"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Dysfunctional adipose tissue represents a hallmark of type 2 diabetes and systemic insulin resistance, characterized by fibrotic deposition of collagens and increased immune cell infiltration within the depots. Here we generate an inducible model of loss of function of the protein phosphatase and tensin homologue (PTEN), a phosphatase critically involved in turning off the insulin signal transduction cascade, to assess the role of enhanced insulin signalling specifically in mature adipocytes. These mice gain more weight on chow diet and short-term as well as long-term high-fat diet exposure. Despite the increase in weight, they retain enhanced insulin sensitivity, show improvements in oral glucose tolerance tests, display reduced adipose tissue inflammation and maintain elevated adiponectin levels. These improvements also lead to reduced hepatic steatosis and enhanced hepatic insulin sensitivity. Prolonging insulin action selectively in the mature adipocyte is therefore sufficient to maintain normal systemic metabolic homeostasis.<\/jats:p>","DOI":"10.1038\/ncomms8906","type":"journal-article","created":{"date-parts":[[2015,8,5]],"date-time":"2015-08-05T05:50:01Z","timestamp":1438753801000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":104,"title":["Selective enhancement of insulin sensitivity in the mature adipocyte is sufficient for systemic metabolic improvements"],"prefix":"10.1038","volume":"6","author":[{"given":"Thomas S.","family":"Morley","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan Y.","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp E.","family":"Scherer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,8,5]]},"reference":[{"key":"BFncomms8906_CR1","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1016\/j.coph.2004.03.003","volume":"4","author":"AR Nawrocki","year":"2004","unstructured":"Nawrocki, A. R. & Scherer, P. E. The delicate balance between fat and muscle: adipokines in metabolic disease and musculoskeletal inflammation. Curr. Opin. Pharmacol. 4, 281\u2013289 (2004).","journal-title":"Curr. Opin. Pharmacol."},{"key":"BFncomms8906_CR2","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/S1534-5807(02)00199-5","volume":"3","author":"M Bluher","year":"2002","unstructured":"Bluher, M. et al. Adipose tissue selective insulin receptor knockout protects against obesity and obesity-related glucose intolerance. Dev. Cell 3, 25\u201338 (2002).","journal-title":"Dev. Cell"},{"key":"BFncomms8906_CR3","doi-asserted-by":"publisher","first-page":"967","DOI":"10.1016\/j.cmet.2014.03.018","volume":"19","author":"M Liu","year":"2014","unstructured":"Liu, M. et al. Grb10 promotes lipolysis and thermogenesis by phosphorylation-dependent feedback inhibition of mTORC1. 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Free fatty acids regulate insulin secretion from pancreatic beta cells through GPR40. Nature 422, 173\u2013176 (2003).","journal-title":"Nature"},{"key":"BFncomms8906_CR12","doi-asserted-by":"publisher","first-page":"2498","DOI":"10.1128\/MCB.25.6.2498-2510.2005","volume":"25","author":"C Kurlawalla-Martinez","year":"2005","unstructured":"Kurlawalla-Martinez, C. et al. Insulin hypersensitivity and resistance to streptozotocin-induced diabetes in mice lacking PTEN in adipose tissue. Mol. Cell Biol. 25, 2498\u20132510 (2005).","journal-title":"Mol. Cell Biol."},{"key":"BFncomms8906_CR13","doi-asserted-by":"publisher","first-page":"1054","DOI":"10.1016\/j.febslet.2010.01.061","volume":"584","author":"K Martens","year":"2010","unstructured":"Martens, K., Bottelbergs, A. & Baes, M. Ectopic recombination in the central and peripheral nervous system by aP2\/FABP4-Cre mice: implications for metabolism research. 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