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We previously showed that disruption of the <jats:italic>Speg<\/jats:italic> gene locus in mice leads to a dilated cardiomyopathy with immature-appearing cardiomyocytes. Here we show that cardiomyopathy of <jats:italic>Speg<\/jats:italic><jats:sup><jats:italic>\u2212\/\u2212<\/jats:italic><\/jats:sup> mice arises as a consequence of defects in cardiac progenitor cell (CPC) function, and that neonatal cardiac dysfunction can be rescued by <jats:italic>in utero<\/jats:italic> injections of wild-type CPCs into <jats:italic>Speg<\/jats:italic><jats:sup><jats:italic>\u2212\/\u2212<\/jats:italic><\/jats:sup> foetal hearts. CPCs harvested from <jats:italic>Speg<\/jats:italic><jats:sup><jats:italic>\u2212\/\u2212<\/jats:italic><\/jats:sup> mice display defects in clone formation, growth and differentiation into cardiomyocytes <jats:italic>in vitro<\/jats:italic>, which are associated with cardiac dysfunction <jats:italic>in vivo<\/jats:italic>. <jats:italic>In utero<\/jats:italic> administration of wild-type CPCs into the hearts of <jats:italic>Speg<\/jats:italic><jats:sup><jats:italic>\u2212\/\u2212<\/jats:italic><\/jats:sup> mice results in CPC engraftment, differentiation and myocardial maturation, which rescues <jats:italic>Speg<\/jats:italic><jats:sup><jats:italic>\u2212\/\u2212<\/jats:italic><\/jats:sup> mice from neonatal heart failure and increases the number of live births by fivefold. We propose that <jats:italic>in utero<\/jats:italic> administration of CPCs may have future implications for treatment of neonatal heart diseases.<\/jats:p>","DOI":"10.1038\/ncomms9825","type":"journal-article","created":{"date-parts":[[2015,11,23]],"date-time":"2015-11-23T10:00:32Z","timestamp":1448272832000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Rescue of neonatal cardiac dysfunction in mice by administration of cardiac progenitor cells in utero"],"prefix":"10.1038","volume":"6","author":[{"given":"Xiaoli","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean R. 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