{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T17:20:21Z","timestamp":1780680021223,"version":"3.54.1"},"reference-count":54,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2004,12,1]],"date-time":"2004-12-01T00:00:00Z","timestamp":1101859200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nat Rev Cardiol"],"published-print":{"date-parts":[[2004,12]]},"DOI":"10.1038\/ncpcardio0047","type":"journal-article","created":{"date-parts":[[2004,11,24]],"date-time":"2004-11-24T02:47:00Z","timestamp":1101264420000},"page":"96-102","source":"Crossref","is-referenced-by-count":69,"title":["Ischemic preconditioning and preinfarction angina in the clinical arena"],"prefix":"10.1038","volume":"1","author":[{"given":"Shereif H","family":"Rezkalla","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert A","family":"Kloner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"BFncpcardio0047_CR1","doi-asserted-by":"publisher","first-page":"1133","DOI":"10.1016\/0735-1097(94)90880-X","volume":"24","author":"RA Kloner","year":"1994","unstructured":"Kloner RA and Yellon D (1994) Does ischemic preconditioning occur in patients? J Am Coll Cardiol 24: 1133\u20131142","journal-title":"J Am Coll Cardiol"},{"key":"BFncpcardio0047_CR2","doi-asserted-by":"publisher","first-page":"934","DOI":"10.1016\/S0140-6736(80)92101-7","volume":"2","author":"MD Jaffe","year":"1980","unstructured":"Jaffe MD and Quinn NK (1980) Warm-up phenomenon in angina pectoris. Lancet 2: 934\u2013936","journal-title":"Lancet"},{"key":"BFncpcardio0047_CR3","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1007\/BF01908148","volume":"79","author":"R Lange","year":"1984","unstructured":"Lange R et al. (1984) Effects of recurrent ischemia on myocardial high energy phosphate content in canine hearts. Basic Res Cardiol 79: 469\u2013478","journal-title":"Basic Res Cardiol"},{"key":"BFncpcardio0047_CR4","doi-asserted-by":"publisher","first-page":"1124","DOI":"10.1161\/01.CIR.74.5.1124","volume":"74","author":"CE Murry","year":"1986","unstructured":"Murry CE et al. (1986) Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium. Circulation 74: 1124\u20131136","journal-title":"Circulation"},{"key":"BFncpcardio0047_CR5","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1016\/S0033-0620(98)80002-9","volume":"40","author":"K Przyklenk","year":"1998","unstructured":"Przyklenk K and Kloner RA (1998) Ischemic preconditioning: exploring the paradox. Prog Cardiovasc Dis 40: 517\u2013547","journal-title":"Prog Cardiovasc Dis"},{"key":"BFncpcardio0047_CR6","doi-asserted-by":"publisher","first-page":"972","DOI":"10.1161\/01.RES.87.11.972","volume":"87","author":"R Bolli","year":"2000","unstructured":"Bolli R (2000) The late phase of preconditioning. Circ Res 87: 972\u2013983","journal-title":"Circ Res"},{"key":"BFncpcardio0047_CR7","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1016\/S0735-1097(98)00559-2","volume":"33","author":"A Takaoka","year":"1999","unstructured":"Takaoka A et al. (1999) Renal ischemia\/reperfusion remotely improves myocardial energy metabolism during myocardial ischemia via adenosine receptors in rabbits: effects of \u201cremote preconditioning\u201d. J Am Coll Cardiol 33: 556\u2013564","journal-title":"J Am Coll Cardiol"},{"key":"BFncpcardio0047_CR8","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1161\/01.CIR.44.5.755","volume":"44","author":"NO Fowler","year":"1971","unstructured":"Fowler NO (1971) \u201cPreinfarctional\u201d angina. A need for an objective definition and for a controlled clinical trial of its management. Circulation 44: 755\u2013758","journal-title":"Circulation"},{"key":"BFncpcardio0047_CR9","doi-asserted-by":"publisher","first-page":"2981","DOI":"10.1161\/hc4801.100038","volume":"104","author":"RA Kloner","year":"2001","unstructured":"Kloner RA and Jennings RB (2001) Consequences of brief ischemia: stunning, preconditioning, and their clinical implications: part 1. Circulation 104: 2981\u20132989","journal-title":"Circulation"},{"key":"BFncpcardio0047_CR10","doi-asserted-by":"publisher","first-page":"3158","DOI":"10.1161\/hc5001.100039","volume":"104","author":"RA Kloner","year":"2001","unstructured":"Kloner RA and Jennings RB (2001) Consequences of brief ischemia: stunning, preconditioning, and their clinical implications: part 2. Circulation 104: 3158\u20133167","journal-title":"Circulation"},{"key":"BFncpcardio0047_CR11","doi-asserted-by":"publisher","first-page":"998","DOI":"10.1016\/S0735-1097(03)00909-4","volume":"42","author":"WK Laskey","year":"1994","unstructured":"Laskey WK and Beach D (1994) Frequency and clinical significance of ischemic preconditioning during percutaneous coronary intervention. J Am Coll Cardiol 42: 998\u20131003","journal-title":"J Am Coll Cardiol"},{"key":"BFncpcardio0047_CR12","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1161\/01.CIR.91.1.37","volume":"91","author":"RA Kloner","year":"1995","unstructured":"Kloner RA et al. (1995) Previous angina alters in-hospital outcome in TIMI 4. A clinical correlate to preconditioning? Circulation 91: 37\u201345","journal-title":"Circulation"},{"key":"BFncpcardio0047_CR13","doi-asserted-by":"publisher","first-page":"1042","DOI":"10.1161\/01.CIR.97.11.1042","volume":"97","author":"RA Kloner","year":"1998","unstructured":"Kloner RA et al. (1998) Prospective temporal analysis of the onset of preinfarction angina versus outcome: an ancillary study in TIMI-9B. Circulation 97: 1042\u20131045","journal-title":"Circulation"},{"key":"BFncpcardio0047_CR14","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1161\/01.CIR.91.2.291","volume":"91","author":"F Ottani","year":"1995","unstructured":"Ottani F et al. (1995) Prodromal angina limits infarct size. A role for ischemic preconditioning. Circulation 91: 291\u2013297","journal-title":"Circulation"},{"key":"BFncpcardio0047_CR15","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1016\/0735-1097(95)80002-X","volume":"26","author":"T Anzai","year":"1995","unstructured":"Anzai T et al. (1995) Preinfarction angina as a major predictor of left ventricular function and long-term prognosis after a first Q wave myocardial infarction. J Am Coll Cardiol 26: 319\u2013327","journal-title":"J Am Coll Cardiol"},{"key":"BFncpcardio0047_CR16","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0002-9149(00)01262-5","volume":"87","author":"R Zahn","year":"2001","unstructured":"Zahn R et al. (2001) Effect of preinfarction angina pectoris on outcome in patients with acute myocardial infarction treated with primary angioplasty (results from the Myocardial Infarction Registry [MIR]). Am J Cardiol 87: 1\u20136","journal-title":"Am J Cardiol"},{"key":"BFncpcardio0047_CR17","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1002\/clc.4960220911","volume":"22","author":"M Fujita","year":"1999","unstructured":"Fujita M et al. (1999) Determinants of collateral development in patients with acute myocardial infarction. Clin Cardiol 22: 595\u2013599","journal-title":"Clin Cardiol"},{"key":"BFncpcardio0047_CR18","doi-asserted-by":"publisher","first-page":"512","DOI":"10.1016\/S0735-1097(97)00521-4","volume":"31","author":"N Perez-Castellano","year":"1998","unstructured":"Perez-Castellano N et al. (1998) Influence of collateral circulation on in-hospital death from anterior acute myocardial infarction. J Am Coll Cardiol 31: 512\u2013518","journal-title":"J Am Coll Cardiol"},{"key":"BFncpcardio0047_CR19","first-page":"830","volume":"41","author":"H Yamagishi","year":"2000","unstructured":"Yamagishi H et al. (2000) Effects of preinfarction angina on myocardial injury in patients with acute myocardial infarction: a study with resting 123I-BMIPP and 201T1 myocardial SPECT. J Nucl Med 41: 830\u2013836","journal-title":"J Nucl Med"},{"key":"BFncpcardio0047_CR20","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1056\/NEJM199601043340102","volume":"334","author":"F Andreotti","year":"1996","unstructured":"Andreotti F et al. (1996) Preinfarction angina as a predictor of more rapid coronary thrombolysis in patients with acute myocardial infarction. N Engl J Med 334: 7\u201312","journal-title":"N Engl J Med"},{"key":"BFncpcardio0047_CR21","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1056\/NEJM199607043350116","volume":"335","author":"RQ Migrino","year":"1996","unstructured":"Migrino RQ et al. (1996) Preinfarction angina. N Engl J Med 335: 59\u201361","journal-title":"N Engl J Med"},{"key":"BFncpcardio0047_CR22","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1161\/01.RES.0000117583.66950.43","volume":"94","author":"B O'Rourke","year":"2004","unstructured":"O'Rourke B (2004) Evidence for mitochondrial K+ channels and their role in cardioprotection. Circ Res 94: 420\u2013432","journal-title":"Circ Res"},{"key":"BFncpcardio0047_CR23","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1053\/euhj.1997.0748","volume":"19","author":"C Napoli","year":"1998","unstructured":"Napoli C et al. (1998) New-onset angina preceding acute myocardial infarction is associated with improved contractile recovery after thrombolysis. Eur Heart J 19: 411\u2013419","journal-title":"Eur Heart J"},{"key":"BFncpcardio0047_CR24","doi-asserted-by":"publisher","first-page":"1966","DOI":"10.1016\/S0735-1097(99)00462-3","volume":"34","author":"T Noda","year":"1999","unstructured":"Noda T et al. (1999) Evidence for the delayed effect in human ischemic preconditioning: prospective multicenter study for preconditioning in acute myocardial infarction. J Am Coll Cardiol 34: 1966\u20131974","journal-title":"J Am Coll Cardiol"},{"key":"BFncpcardio0047_CR25","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1002\/clc.4960240504","volume":"24","author":"AN Neskovic","year":"2001","unstructured":"Neskovic AN et al. (2001) Preinfarction angina prevents left ventricular remodeling in patients treated with thrombolysis for myocardial infarction. Clin Cardiol 24: 364\u2013370","journal-title":"Clin Cardiol"},{"key":"BFncpcardio0047_CR26","doi-asserted-by":"publisher","first-page":"1846","DOI":"10.1016\/S0735-1097(01)01240-2","volume":"37","author":"I Iglesias-Garriz","year":"2001","unstructured":"Iglesias-Garriz I et al. (2001) Pre-infarction angina elicits greater myocardial viability on reperfusion after myocardial infarction: a dobutamine stress echocardiographic study. J Am Coll Cardiol 37: 1846\u20131850","journal-title":"J Am Coll Cardiol"},{"key":"BFncpcardio0047_CR27","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/0002-8703(92)90915-I","volume":"124","author":"T Hirai","year":"1992","unstructured":"Hirai T et al. (1992) Significance of preinfarction angina for preservation of left ventricular function in acute myocardial infarction. Am Heart J 124: 19\u201324","journal-title":"Am Heart J"},{"key":"BFncpcardio0047_CR28","doi-asserted-by":"publisher","first-page":"656","DOI":"10.1161\/hc0502.102867","volume":"105","author":"SH Rezkalla","year":"2002","unstructured":"Rezkalla SH and Kloner RA (2002) No-reflow phenomenon. Circulation 105: 656\u2013662","journal-title":"Circulation"},{"key":"BFncpcardio0047_CR29","doi-asserted-by":"publisher","first-page":"1322","DOI":"10.1378\/chest.122.4.1322","volume":"122","author":"HK Yip","year":"2002","unstructured":"Yip HK et al. (2002) Angiographic morphologic features of infarct-related arteries and timely reperfusion in acute myocardial infarction: predictors of slow-flow and no-reflow phenomenon. Chest 122: 1322\u20131332","journal-title":"Chest"},{"key":"BFncpcardio0047_CR30","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1016\/S0167-5273(00)00340-5","volume":"75","author":"T Takahashi","year":"2000","unstructured":"Takahashi T et al. (2000) Absence of preinfarction angina is associated with a risk of no-reflow phenomenon after primary coronary angioplasty for a first anterior wall acute myocardial infarction. Int J Cardiol 75: 253\u2013260","journal-title":"Int J Cardiol"},{"key":"BFncpcardio0047_CR31","doi-asserted-by":"publisher","first-page":"796","DOI":"10.1067\/mhj.2002.123835","volume":"144","author":"P Colonna","year":"2002","unstructured":"Colonna P et al. (2002) Reduced microvascular and myocardial damage in patients with acute myocardial infarction and preinfarction angina. Am Heart J 144: 796\u2013803","journal-title":"Am Heart J"},{"key":"BFncpcardio0047_CR32","doi-asserted-by":"publisher","first-page":"2999","DOI":"10.1161\/01.CIR.0000041803.03687.7A","volume":"106","author":"P Taggart","year":"2002","unstructured":"Taggart P and Yellon DM (2002) Preconditioning and arrhythmias. Circulation 106: 2999\u20133001","journal-title":"Circulation"},{"key":"BFncpcardio0047_CR33","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1016\/0002-8703(92)90645-C","volume":"123","author":"YW Li","year":"1992","unstructured":"Li YW et al. (1992) The transient nature of the effect of ischemic preconditioning on myocardial infarct size and ventricular arrhythmia. Am Heart J 123: 346\u2013353","journal-title":"Am Heart J"},{"key":"BFncpcardio0047_CR34","doi-asserted-by":"publisher","first-page":"1369","DOI":"10.1016\/S0735-1097(01)01561-3","volume":"38","author":"PJ Gheeraert","year":"2001","unstructured":"Gheeraert PJ et al. (2001) Preinfarction angina protects against out-of-hospital ventricular fibrillation in patients with acute occlusion of the left coronary artery. J Am Coll Cardiol 38: 1369\u20131374","journal-title":"J Am Coll Cardiol"},{"key":"BFncpcardio0047_CR35","doi-asserted-by":"publisher","first-page":"1850","DOI":"10.1161\/01.CIR.94.8.1850","volume":"94","author":"V Pasceri","year":"1996","unstructured":"Pasceri V et al. (1996) Preconditioning by transient myocardial ischemia confers protection against ischemia-induced ventricular arrhythmias in variant angina. Circulation 94: 1850\u20131856","journal-title":"Circulation"},{"key":"BFncpcardio0047_CR36","doi-asserted-by":"publisher","first-page":"3091","DOI":"10.1161\/01.CIR.0000041430.32233.5B","volume":"106","author":"ZK Wu","year":"2002","unstructured":"Wu ZK et al. (2002) Ischemic preconditioning suppresses ventricular tachyarrhythmias after myocardial revascularization. Circulation 106: 3091\u20133096","journal-title":"Circulation"},{"key":"BFncpcardio0047_CR37","doi-asserted-by":"publisher","first-page":"1477","DOI":"10.1016\/S0022-5223(03)00749-9","volume":"126","author":"ZU Wu","year":"2003","unstructured":"Wu ZU et al. (2003) Fibrillation in patients subjected to coronary artery bypass grafting. J Thorac Cardiovasc Surg 126: 1477\u20131482","journal-title":"J Thorac Cardiovasc Surg"},{"key":"BFncpcardio0047_CR38","doi-asserted-by":"publisher","first-page":"772","DOI":"10.1016\/j.ejcts.2004.02.011","volume":"25","author":"G Carr-White","year":"2004","unstructured":"Carr-White G et al. (2004) Chronic stable ischaemia protects against myocyte damage during beating heart coronary surgery. Eur J Cardiothorac Surg 25: 772\u2013778","journal-title":"Eur J Cardiothorac Surg"},{"key":"BFncpcardio0047_CR39","doi-asserted-by":"publisher","first-page":"941","DOI":"10.1056\/NEJM199804023381402","volume":"338","author":"H Shiraki","year":"1998","unstructured":"Shiraki H et al. (1998) Association between preinfarction angina and a lower risk of right ventricular infarction. N Engl J Med 338: 941\u2013947","journal-title":"N Engl J Med"},{"key":"BFncpcardio0047_CR40","doi-asserted-by":"publisher","first-page":"947","DOI":"10.1016\/S0735-1097(97)00256-8","volume":"30","author":"P Abete","year":"1997","unstructured":"Abete P et al. (1997) Angina-induced protection against myocardial infarction in adult and elderly patients: a loss of preconditioning mechanism in the aging heart? J Am Coll Cardiol 30: 947\u2013954","journal-title":"J Am Coll Cardiol"},{"key":"BFncpcardio0047_CR41","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1023\/A:1008833101817","volume":"6","author":"RA Kloner","year":"1998","unstructured":"Kloner RA et al. (1998) Protection conferred by preinfarct angina is manifest in the aged heart: evidence from the TIMI 4 trial. J Thromb Thrombolysis 6: 89\u201392","journal-title":"J Thromb Thrombolysis"},{"key":"BFncpcardio0047_CR42","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1016\/S0002-9149(02)02182-3","volume":"89","author":"M Jimenez-Navarro","year":"2002","unstructured":"Jimenez-Navarro M et al. (2002) Cardioprotective effects of preinfarction angina in elderly: same patients, different results? Am J Cardiol 89: 651","journal-title":"Am J Cardiol"},{"key":"BFncpcardio0047_CR43","doi-asserted-by":"publisher","first-page":"1357","DOI":"10.1016\/S0735-1097(01)01560-1","volume":"38","author":"P Abete","year":"2001","unstructured":"Abete P et al. (2001) High level of physical activity preserves the cardioprotective effect of preinfarction angina in elderly patients. J Am Coll Cardiol 38: 1357\u20131365","journal-title":"J Am Coll Cardiol"},{"key":"BFncpcardio0047_CR44","doi-asserted-by":"publisher","first-page":"1616","DOI":"10.1016\/S0735-1097(96)00371-3","volume":"28","author":"T Miki","year":"1996","unstructured":"Miki T et al. (1996) Captopril potentiates the myocardial infarct size-limiting effect of ischemic preconditioning through bradykinin B2 receptor activation. J Am Coll Cardiol 28: 1616\u20131622","journal-title":"J Am Coll Cardiol"},{"key":"BFncpcardio0047_CR45","doi-asserted-by":"publisher","first-page":"694","DOI":"10.1161\/hc3201.092218","volume":"104","author":"M Hill","year":"2001","unstructured":"Hill M et al. (2001) Nitroglycerin induces late preconditioning against myocardial infarction in conscious rabbits despite development of nitrate tolerance. Circulation 104: 694\u2013699","journal-title":"Circulation"},{"key":"BFncpcardio0047_CR46","doi-asserted-by":"publisher","first-page":"678","DOI":"10.1253\/jcj.65.678","volume":"65","author":"ZW Zhang","year":"2001","unstructured":"Zhang ZW et al. (2001) Ischemic preconditioning and nicorandil pretreatment improve donor heart preservation. Jpn Circ J 65: 678\u2013682","journal-title":"Jpn Circ J"},{"key":"BFncpcardio0047_CR47","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1016\/S0008-6363(02)00334-6","volume":"55","author":"R Domenech","year":"2002","unstructured":"Domenech R et al. (2002) Exercise induces early and late myocardial preconditioning in dogs. Cardiovasc Res 55: 561\u2013566","journal-title":"Cardiovasc Res"},{"key":"BFncpcardio0047_CR48","first-page":"161","volume":"36","author":"D Zdrenghea","year":"1998","unstructured":"Zdrenghea D et al. (1998) Ischemic preconditioning during successive exercise testing. Rom J Intern Med 36: 161\u2013165","journal-title":"Rom J Intern Med"},{"key":"BFncpcardio0047_CR49","doi-asserted-by":"publisher","first-page":"1174","DOI":"10.1016\/S0735-1097(03)00055-X","volume":"41","author":"PD Lambiase","year":"2003","unstructured":"Lambiase PD et al. (2003) Exercise-induced ischemia initiates the second window of protection in humans independent of collateral recruitment. J Am Coll Cardiol 41: 1174\u20131182","journal-title":"J Am Coll Cardiol"},{"key":"BFncpcardio0047_CR50","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1016\/0002-9149(94)90428-6","volume":"74","author":"T Anzai","year":"1994","unstructured":"Anzai T et al. (1994) Effect on short-term prognosis and left ventricular function of angina pectoris prior to first Q-wave anterior wall acute myocardial infarction. Am J Cardiol 74: 755\u2013759","journal-title":"Am J Cardiol"},{"key":"BFncpcardio0047_CR51","doi-asserted-by":"publisher","first-page":"1076","DOI":"10.1016\/0735-1097(94)00542-X","volume":"25","author":"Y Nakagawa","year":"1995","unstructured":"Nakagawa Y et al. (1995) Effect of angina pectoris on myocardial protection in patients with reperfused anterior wall myocardial infarction: retrospective clinical evidence of \u201cpreconditioning\u201d. J Am Coll Cardiol 25: 1076\u20131083","journal-title":"J Am Coll Cardiol"},{"key":"BFncpcardio0047_CR52","doi-asserted-by":"publisher","first-page":"970","DOI":"10.1016\/S0735-1097(97)00238-6","volume":"30","author":"M Ishihara","year":"1997","unstructured":"Ishihara M et al. (1997) Implications of prodromal angina pectoris in anterior wall acute myocardial infarction: acute angiographic findings and long-term prognosis. J Am Coll Cardiol 30: 970\u2013975","journal-title":"J Am Coll Cardiol"},{"key":"BFncpcardio0047_CR53","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1016\/S0002-9149(99)00405-1","volume":"84","author":"H Tomoda","year":"1999","unstructured":"Tomoda H and Aoki N (1999) Comparison of protective effects of preinfarction angina pectoris in acute myocardial infarction treated by thrombolysis versus by primary coronary angioplasty with stenting. Am J Cardiol 84: 621\u2013625","journal-title":"Am J Cardiol"},{"key":"BFncpcardio0047_CR54","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/S0300-8932(00)75062-7","volume":"53","author":"I Iglesias-Garriz","year":"2000","unstructured":"Iglesias-Garriz I et al. (2000) The effect of pre-infarction unstable angina on the size of myocardial necrosis. Rev Esp Cardiol 53: 43\u201348","journal-title":"Rev Esp Cardiol"}],"container-title":["Nature Clinical Practice Cardiovascular Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/ncpcardio0047.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ncpcardio0047","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ncpcardio0047.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T19:32:38Z","timestamp":1684438358000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/ncpcardio0047"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,12]]},"references-count":54,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2004,12]]}},"alternative-id":["BFncpcardio0047"],"URL":"https:\/\/doi.org\/10.1038\/ncpcardio0047","relation":{},"ISSN":["1743-4297","1743-4300"],"issn-type":[{"value":"1743-4297","type":"print"},{"value":"1743-4300","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,12]]}}}