{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T22:35:46Z","timestamp":1791326146840,"version":"4.3.1"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2007,4,1]],"date-time":"2007-04-01T00:00:00Z","timestamp":1175385600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nat Rev Endocrinol"],"published-print":{"date-parts":[[2007,4]]},"DOI":"10.1038\/ncpendmet0450","type":"journal-article","created":{"date-parts":[[2007,3,22]],"date-time":"2007-03-22T10:17:17Z","timestamp":1174558637000},"page":"338-344","source":"Crossref","is-referenced-by-count":66,"title":["Male pubertal development and the role of androgen therapy"],"prefix":"10.1038","volume":"3","author":[{"given":"Erick J","family":"Richmond","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan D","family":"Rogol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"BFncpendmet0450_CR1","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1542\/peds.99.4.505","volume":"99","author":"ME Herman-Giddens","year":"1997","unstructured":"Herman-Giddens ME et al. (1997) Secondary sexual characteristics and menses in young girls seen in office practice: a study from the Pediatric Research in Office Settings network. Pediatrics 99: 505\u2013512","journal-title":"Pediatrics"},{"key":"BFncpendmet0450_CR2","doi-asserted-by":"publisher","first-page":"936","DOI":"10.1542\/peds.104.4.936","volume":"104","author":"PB Kaplowitz","year":"1999","unstructured":"Kaplowitz PB and Oberfield SE (1999) Reexamination of the age limit for defining when puberty is precocious in girls in the United States: implications for evaluation and treatment. Drug and Therapeutics and Executive Committees of the Lawson Wilkins Pediatric Endocrine Society. Pediatrics 104: 936\u2013941","journal-title":"Pediatrics"},{"key":"BFncpendmet0450_CR3","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1016\/S0022-3476(85)80489-3","volume":"106","author":"WA Sonis","year":"1985","unstructured":"Sonis WA et al. (1985) Behavior problems and social competence in girls with true precocious puberty. J Pediatr 106: 156\u2013160","journal-title":"J Pediatr"},{"key":"BFncpendmet0450_CR4","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1016\/S0022-3476(95)70265-2","volume":"127","author":"FM Biro","year":"1995","unstructured":"Biro FM et al. (1995) Pubertal staging in boys. J Pediatr 127: 100\u2013102","journal-title":"J Pediatr"},{"key":"BFncpendmet0450_CR5","volume-title":"Growth at Adolescence","author":"JM Tanner","year":"1962","unstructured":"Tanner JM (1962) Growth at Adolescence. Springfield: Charles C Thomas"},{"key":"BFncpendmet0450_CR6","first-page":"61","volume":"29","author":"M Zachmann","year":"1974","unstructured":"Zachmann M et al. (1974) Testicular volume during adolescence: cross-sectional and longitudinal studies. Helv Paediatr Acta 29: 61\u201372","journal-title":"Helv Paediatr Acta"},{"key":"BFncpendmet0450_CR7","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1016\/S0022-5347(01)65814-2","volume":"156","author":"RS Sutherland","year":"1996","unstructured":"Sutherland RS et al. (1996) The effect of prepubertal androgen exposure on adult penile length. J Urol 156: 783\u2013787","journal-title":"J Urol"},{"key":"BFncpendmet0450_CR8","first-page":"1","volume":"258","author":"P Karlberg","year":"1976","unstructured":"Karlberg P and Taranger J (1976) The somatic development of children in a Swedish urban community. Acta Paediatr Scand Suppl 258: 1\u201348","journal-title":"Acta Paediatr Scand Suppl"},{"key":"BFncpendmet0450_CR9","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1080\/03014467600001231","volume":"3","author":"JM Tanner","year":"1976","unstructured":"Tanner JM et al. (1976) The adolescent growth spurt of boys and girls of the Harpenden growth study. Ann Hum Biol 3: 109\u2013126","journal-title":"Ann Hum Biol"},{"key":"BFncpendmet0450_CR10","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1080\/03014467800003071","volume":"5","author":"RH Largo","year":"1978","unstructured":"Largo RH et al. (1978) Analysis of the adolescent growth spurt using smoothing spline functions. Ann Hum Biol 5: 421\u2013434","journal-title":"Ann Hum Biol"},{"key":"BFncpendmet0450_CR11","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1542\/peds.102.S3.507","volume":"102","author":"V Abbassi","year":"1998","unstructured":"Abbassi V (1998) Growth and normal puberty. Pediatrics 102: 507\u2013511","journal-title":"Pediatrics"},{"key":"BFncpendmet0450_CR12","volume-title":"Radiograph Atlas of Skeletal Development of the Hand and Wrist","author":"WS Greulich","year":"1959","unstructured":"Greulich WS and Pyle SI (1959) Radiograph Atlas of Skeletal Development of the Hand and Wrist. Stanford: Stanford University Press"},{"key":"BFncpendmet0450_CR13","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1210\/er.2003-0038","volume":"26","author":"JD Veldhuis","year":"2005","unstructured":"Veldhuis JD et al. (2005) Endocrine control of body composition in infancy, childhood, and puberty. Endocr Rev 26: 114\u2013146","journal-title":"Endocr Rev"},{"issue":"Suppl 1","key":"BFncpendmet0450_CR14","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1007\/BF01623429","volume":"4","author":"JP Bonjour","year":"1994","unstructured":"Bonjour JP et al. (1994) Peak bone mass. Osteoporos Int 4 (Suppl 1): 7\u201313","journal-title":"Osteoporos Int"},{"key":"BFncpendmet0450_CR15","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1111\/j.1651-2227.1991.tb17964.x","volume":"372","author":"HA Delemarre-Van De Waal","year":"1991","unstructured":"Delemarre-Van De Waal HA et al. (1991) Gonadotrophin and growth hormone secretion throughout puberty. Acta Paediatr Scand Suppl 372: 26\u201331","journal-title":"Acta Paediatr Scand Suppl"},{"key":"BFncpendmet0450_CR16","first-page":"53","volume":"36","author":"E Knobil","year":"1980","unstructured":"Knobil E (1980) The neuroendocrine control of the menstrual cycle. Recent Prog Horm Res 36: 53\u201388","journal-title":"Recent Prog Horm Res"},{"key":"BFncpendmet0450_CR17","first-page":"541","volume":"82","author":"K Albertsson-Wikland","year":"1997","unstructured":"Albertsson-Wikland K et al. (1997) Twenty-four-hour profiles of luteinizing hormone, follicle-stimulating hormone, testosterone, and estradiol levels: a semi-longitudinal study throughout puberty in healthy boys. J Clin Endocrinol Metab 82: 541\u2013549","journal-title":"J Clin Endocrinol Metab"},{"key":"BFncpendmet0450_CR18","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1172\/JCI107798","volume":"54","author":"RM Boyar","year":"1974","unstructured":"Boyar RM et al. (1974) Human puberty. Simultaneous augmented secretion of luteinizing hormone and testosterone during sleep. J Clin Invest 54: 609\u2013618","journal-title":"J Clin Invest"},{"key":"BFncpendmet0450_CR19","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1210\/jcem-34-2-319","volume":"34","author":"GP August","year":"1972","unstructured":"August GP et al. (1972) Hormonal changes in puberty. 3. Correlation of plasma testosterone, LH, FSH, testicular size, and bone age with male pubertal development. J Clin Endocrinol Metab 34: 319\u2013326","journal-title":"J Clin Endocrinol Metab"},{"key":"BFncpendmet0450_CR20","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1530\/acta.0.0750181","volume":"75","author":"D Knorr","year":"1974","unstructured":"Knorr D et al. (1974) Plasma testosterone in male puberty. I. Physiology of plasma testosterone. Acta Endocrinol (Copenh) 75: 181\u2013194","journal-title":"Acta Endocrinol (Copenh)"},{"key":"BFncpendmet0450_CR21","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1172\/JCI107526","volume":"53","author":"RL Weinstein","year":"1974","unstructured":"Weinstein RL et al. (1974) Secretion of unconjugated androgens and estrogens by the normal and abnormal human testis before and after human chorionic gonadotropin. J Clin Invest 53: 1\u20136","journal-title":"J Clin Invest"},{"key":"BFncpendmet0450_CR22","first-page":"1686","volume":"85","author":"N Mauras","year":"2000","unstructured":"Mauras N et al. (2000) Insulin-like growth factor I and growth hormone (GH) treatment in GH-deficient humans: differential effects on protein, glucose, lipid, and calcium metabolism. J Clin Endocrinol Metab 85: 1686\u20131694","journal-title":"J Clin Endocrinol Metab"},{"key":"BFncpendmet0450_CR23","first-page":"3203","volume":"81","author":"KO Klein","year":"1996","unstructured":"Klein KO et al. (1996) A longitudinal assessment of hormonal and physical alterations during normal puberty in boys. II. Estrogen levels as determined by an ultrasensitive bioassay. J Clin Endocrinol Metab 81: 3203\u20133207","journal-title":"J Clin Endocrinol Metab"},{"key":"BFncpendmet0450_CR24","doi-asserted-by":"publisher","first-page":"548","DOI":"10.1210\/jcem-51-3-548","volume":"51","author":"CA Sklar","year":"1980","unstructured":"Sklar CA et al. (1980) Evidence for dissociation between adrenarche and gonadarche: studies in patients with idiopathic precocious puberty, gonadal dysgenesis, isolated gonadotropin deficiency, and constitutionally delayed growth and adolescence. J Clin Endocrinol Metab 51: 548\u2013556","journal-title":"J Clin Endocrinol Metab"},{"key":"BFncpendmet0450_CR25","first-page":"2385","volume":"85","author":"JD Veldhuis","year":"2000","unstructured":"Veldhuis JD et al. (2000) Gender and sexual maturation-dependent contrasts in the neuroregulation of growth hormone secretion in prepubertal and late adolescent males and females\u2014a general clinical research center-based study. J Clin Endocrinol Metab 85: 2385\u20132394","journal-title":"J Clin Endocrinol Metab"},{"key":"BFncpendmet0450_CR26","first-page":"513","volume":"79","author":"DL Metzger","year":"1994","unstructured":"Metzger DL and Kerrigan JR (1994) Estrogen receptor blockade with tamoxifen diminishes growth hormone secretion in boys: evidence for a stimulatory role of endogenous estrogens during male adolescence. J Clin Endocrinol Metab 79: 513\u2013518","journal-title":"J Clin Endocrinol Metab"},{"key":"BFncpendmet0450_CR27","first-page":"996","volume":"76","author":"BS Keenan","year":"1993","unstructured":"Keenan BS et al. (1993) Androgen-stimulated pubertal growth: the effects of testosterone and dihydrotestosterone on growth hormone and insulin-like growth factor-I in the treatment of short stature and delayed puberty. J Clin Endocrinol Metab 76: 996\u20131001","journal-title":"J Clin Endocrinol Metab"},{"key":"BFncpendmet0450_CR28","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1016\/S0950-351X(98)80172-9","volume":"12","author":"LD Houchin","year":"1998","unstructured":"Houchin LD and Rogol AD (1998) Androgen replacement in children with constitutional delay of puberty: the case for aggressive therapy. Baillieres Clin Endocrinol Metab 12: 427\u2013440","journal-title":"Baillieres Clin Endocrinol Metab"},{"key":"BFncpendmet0450_CR29","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1507\/endocrj1954.34.627","volume":"34","author":"K Sanayama","year":"1987","unstructured":"Sanayama K et al. (1987) Spontaneous growth hormone secretion and plasma somatomedin-C in children of short stature. Endocrinol Jpn 34: 627\u2013633","journal-title":"Endocrinol Jpn"},{"key":"BFncpendmet0450_CR30","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1203\/00006450-199007000-00003","volume":"28","author":"JR Kerrigan","year":"1990","unstructured":"Kerrigan JR et al. (1990) Variations of pulsatile growth hormone release in healthy short prepubertal boys. Pediatr Res 28: 11\u201314","journal-title":"Pediatr Res"},{"key":"BFncpendmet0450_CR31","doi-asserted-by":"publisher","first-page":"1109","DOI":"10.1136\/adc.65.10.1109","volume":"65","author":"EC Crowne","year":"1990","unstructured":"Crowne EC et al. (1990) Final height in boys with untreated constitutional delay in growth and puberty. Arch Dis Child 65: 1109\u20131112","journal-title":"Arch Dis Child"},{"key":"BFncpendmet0450_CR32","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1542\/peds.87.1.82","volume":"87","author":"S LaFranchi","year":"1991","unstructured":"LaFranchi S et al. (1991) Constitutional delay of growth: expected versus final adult height. Pediatrics 87: 82\u201387","journal-title":"Pediatrics"},{"key":"BFncpendmet0450_CR33","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1016\/S0022-3476(95)70347-0","volume":"126","author":"A Albanese","year":"1995","unstructured":"Albanese A and Stanhope R (1995) Predictive factors in the determination of final height in boys with constitutional delay of growth and puberty. J Pediatr 126: 545\u2013550","journal-title":"J Pediatr"},{"key":"BFncpendmet0450_CR34","doi-asserted-by":"publisher","first-page":"1488","DOI":"10.1002\/jbmr.5650101009","volume":"10","author":"S Bertelloni","year":"1995","unstructured":"Bertelloni S et al. (1995) Short-term effect of testosterone treatment on reduced bone density in boys with constitutional delay of puberty. J Bone Miner Res 10: 1488\u20131495","journal-title":"J Bone Miner Res"},{"key":"BFncpendmet0450_CR35","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1159\/000076635","volume":"61","author":"E Schoenau","year":"2004","unstructured":"Schoenau E et al (2004) From bone biology to bone analysis. Horm Res 61: 257\u2013269","journal-title":"Horm Res"},{"key":"BFncpendmet0450_CR36","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1210\/edrv-9-4-467","volume":"9","author":"JP Bourguignon","year":"1988","unstructured":"Bourguignon JP (1988) Linear growth as a function of age at onset of puberty and sex steroid dosage: therapeutic implications. Endocr Rev 9: 467\u201348855","journal-title":"Endocr Rev"}],"container-title":["Nature Clinical Practice Endocrinology & Metabolism"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/ncpendmet0450.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ncpendmet0450","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ncpendmet0450.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T19:52:18Z","timestamp":1684439538000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/ncpendmet0450"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,4]]},"references-count":36,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2007,4]]}},"alternative-id":["BFncpendmet0450"],"URL":"https:\/\/doi.org\/10.1038\/ncpendmet0450","relation":{},"ISSN":["1745-8366","1745-8374"],"issn-type":[{"value":"1745-8366","type":"print"},{"value":"1745-8374","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,4]]}}}