{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T15:51:27Z","timestamp":1789055487300,"version":"build-2803163510"},"reference-count":57,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2005,10,1]],"date-time":"2005-10-01T00:00:00Z","timestamp":1128124800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nat Rev Gastroenterol Hepatol"],"published-print":{"date-parts":[[2005,10]]},"DOI":"10.1038\/ncpgasthep0293","type":"journal-article","created":{"date-parts":[[2005,10,13]],"date-time":"2005-10-13T15:56:04Z","timestamp":1129218964000},"page":"473-483","source":"Crossref","is-referenced-by-count":78,"title":["Current management of acute pancreatitis"],"prefix":"10.1038","volume":"2","author":[{"given":"Julia","family":"Mayerle","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Verena","family":"Hlouschek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus M","family":"Lerch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"BFncpgasthep0293_CR1","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1016\/S0016-5107(02)70016-3","volume":"56","author":"PA Banks","year":"2002","unstructured":"Banks PA (2002) Epidemiology, natural history, and predictors of disease outcome in acute and chronic pancreatitis. Gastrointest Endoscopy 56: 226\u2013230","journal-title":"Gastrointest Endoscopy"},{"key":"BFncpgasthep0293_CR2","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1097\/00004836-200207000-00012","volume":"35","author":"S Bank","year":"2002","unstructured":"Bank S et al. (2002) Evaluation of factors that have reduced mortality from acute pancreatitis over the past 20 years. J Clin Gastroenterol 35: 50\u201360","journal-title":"J Clin Gastroenterol"},{"key":"BFncpgasthep0293_CR3","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1148\/radiology.174.2.2296641","volume":"174","author":"EJ Balthazar","year":"1990","unstructured":"Balthazar EJ et al. (1990) Acute pancreatitis: value of CT in establishing prognosis. Radiology 174: 331\u2013336","journal-title":"Radiology"},{"key":"BFncpgasthep0293_CR4","doi-asserted-by":"publisher","first-page":"1340","DOI":"10.1136\/gut.2004.039883","volume":"53","author":"CD Johnson","year":"2004","unstructured":"Johnson CD et al. (2004) Persistent organ failure during the first week as a marker of fatal outcome in acute pancreatitis. Gut 53: 1340\u20131344","journal-title":"Gut"},{"key":"BFncpgasthep0293_CR5","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1148\/radiology.193.2.7972730","volume":"193","author":"EJ Balthazar","year":"1994","unstructured":"Balthazar EJ et al. (1994) Imaging and intervention in acute pancreatitis. Radiology 193: 297\u2013306","journal-title":"Radiology"},{"key":"BFncpgasthep0293_CR6","doi-asserted-by":"publisher","first-page":"1261","DOI":"10.2214\/ajr.183.5.1831261","volume":"183","author":"KJ Mortele","year":"2004","unstructured":"Mortele KJ et al. (2004) A modified CT severity index for evaluating acute pancreatitis: improved correlation with patient outcome. Am J Roentgenol 183: 1261\u20131265","journal-title":"Am J Roentgenol"},{"key":"BFncpgasthep0293_CR7","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1097\/00006676-200203000-00011","volume":"24","author":"W Uhl","year":"2002","unstructured":"Uhl W et al. (2002) Influence of contrast-enhanced computed tomography on the course and outcome in patients with acute pancreatitis. Pancreas 24: 191\u2013197","journal-title":"Pancreas"},{"key":"BFncpgasthep0293_CR8","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1053\/j.gastro.2003.12.006","volume":"126","author":"Arvanitakis","year":"2004","unstructured":"Arvanitakis et al. (2004) Computed tomography and magnetic resonance imaging in the assessment of acute pancreatitis. Gastroenterology 126: 715\u2013723","journal-title":"Gastroenterology"},{"key":"BFncpgasthep0293_CR9","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1148\/radiol.2233010680","volume":"223","author":"EJ Balthazar","year":"2002","unstructured":"Balthazar EJ (2002) Acute pancreatitis: assessment of severity with clinical and CT evaluation. Radiology 223: 603\u2013613","journal-title":"Radiology"},{"key":"BFncpgasthep0293_CR10","first-page":"100","volume":"24","author":"M Buchler","year":"1986","unstructured":"Buchler M et al. (1986) Value of biochemical and imaging procedures for the diagnosis of acute pancreatitis\u2014results of a prospective clinical study. Z Gastroenterol 24: 100\u2013109","journal-title":"Z Gastroenterol"},{"key":"BFncpgasthep0293_CR11","doi-asserted-by":"publisher","first-page":"1955","DOI":"10.1016\/S0140-6736(00)02327-8","volume":"355","author":"JP Neoptolemos","year":"2000","unstructured":"Neoptolemos JP et al. (2000) Early prediction of severity in acute pancreatitis by urinary trypsinogen activation peptide: a multicentre study. Lancet 355: 1955\u20131960","journal-title":"Lancet"},{"key":"BFncpgasthep0293_CR12","doi-asserted-by":"crossref","first-page":"2103","DOI":"10.1093\/clinchem\/47.12.2103","volume":"47","author":"M Lempinen","year":"2001","unstructured":"Lempinen M et al. (2001) Predicting the severity of acute pancreatitis by rapid measurement of trypsinogen-2 in urine. Clin Chem 47: 2103\u20132107","journal-title":"Clin Chem"},{"key":"BFncpgasthep0293_CR13","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1097\/00006676-200005000-00005","volume":"20","author":"A Brown","year":"2000","unstructured":"Brown A et al. (2000) Hemoconcentration is an early marker for organ failure and necrotizing pancreatitis. Pancreas 20: 367\u2013372","journal-title":"Pancreas"},{"key":"BFncpgasthep0293_CR14","doi-asserted-by":"publisher","first-page":"2081","DOI":"10.1111\/j.1572-0241.2001.03966.x","volume":"96","author":"PG Lankisch","year":"2001","unstructured":"Lankisch PG et al. (2001) Hemoconcentration: an early marker of severe and\/or necrotizing pancreatitis? A critical appraisal. Am J Gastroenterol 96: 2081\u20132085","journal-title":"Am J Gastroenterol"},{"key":"BFncpgasthep0293_CR15","first-page":"231","volume":"6","author":"N Shafiq","year":"2005","unstructured":"Shafiq N et al. (2005) Estimating the diagnostic accuracy of procalcitonin as a marker of the severity of acute pancreatitis: a meta-analytic approach. JOP 6: 231\u2013237","journal-title":"JOP"},{"key":"BFncpgasthep0293_CR16","unstructured":"Rau BM et al. (2005) Assessment of major complications and overall prognosis by the SOFA, APACHE II and MOF Score in severe acute pancreatitis [abstract #98]. Pancreatology 5"},{"key":"BFncpgasthep0293_CR17","first-page":"144","volume":"176","author":"E Klar","year":"1993","unstructured":"Klar E et al. (1993) Improvement of impaired pancreatic microcirculation by isovolemic hemodilution protects pancreatic morphology in acute biliary pancreatitis. Surg Gynecol Obstet 176: 144\u2013150","journal-title":"Surg Gynecol Obstet"},{"key":"BFncpgasthep0293_CR18","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1159\/000055899","volume":"2","author":"A Brown","year":"2002","unstructured":"Brown A et al. (2002) Can fluid resuscitation prevent pancreatic necrosis in severe acute pancreatitis? Pancreatology 2: 104\u2013107","journal-title":"Pancreatology"},{"key":"BFncpgasthep0293_CR19","doi-asserted-by":"publisher","first-page":"1375","DOI":"10.1046\/j.1365-2168.2000.01558.x","volume":"87","author":"JJ Powell","year":"2000","unstructured":"Powell JJ et al. (2000) Randomized controlled trial of the effect of early enteral nutrition on markers of the inflammatory response in predicted severe acute pancreatitis. Br J Surg 87: 1375\u20131381","journal-title":"Br J Surg"},{"key":"BFncpgasthep0293_CR20","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/S0899-9007(00)00508-6","volume":"17","author":"G Pupelis","year":"2001","unstructured":"Pupelis G et al. (2001) Jejunal feeding, even when instituted late, improves outcomes in patients with severe pancreatitis and peritonitis. Nutrition 17: 91\u201394","journal-title":"Nutrition"},{"key":"BFncpgasthep0293_CR21","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1136\/gut.42.3.431","volume":"42","author":"AC Windsor","year":"1998","unstructured":"Windsor AC et al. (1998) Compared with parenteral nutrition, enteral feeding attenuates acute phase response and improves disease severity in acute pancreatitis. Gut 42: 431\u2013435","journal-title":"Gut"},{"key":"BFncpgasthep0293_CR22","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1111\/j.1753-4887.1997.tb01618.x","volume":"55","author":"N Karamitsios","year":"1997","unstructured":"Karamitsios N et al. (1997) Enteral nutrition in acute pancreatitis. Nutr Rev 55: 279\u2013282","journal-title":"Nutr Rev"},{"key":"BFncpgasthep0293_CR23","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1177\/014860719702100114","volume":"21","author":"SA McClave","year":"1997","unstructured":"McClave SA et al. (1997) Comparison of the safety of early enteral vs parenteral nutrition in mild acute pancreatitis. J Parenter Enteral Nutr 21: 14\u201320","journal-title":"J Parenter Enteral Nutr"},{"key":"BFncpgasthep0293_CR24","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1016\/S0899-9007(01)00755-9","volume":"18","author":"A Olah","year":"2002","unstructured":"Olah A et al. (2002) Early nasojejunal feeding in acute pancreatitis is associated with a lower complication rate. Nutrition 18: 259\u2013262","journal-title":"Nutrition"},{"key":"BFncpgasthep0293_CR25","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1159\/000073657","volume":"3","author":"R Gupta","year":"2003","unstructured":"Gupta R et al. (2003) A randomised clinical trial to assess the effect of total enteral and total parenteral nutritional support on metabolic, inflammatory and oxidative markers in patients with predicted severe acute pancreatitis (APACHE II &gt; or =6). Pancreatology 3: 406\u2013413","journal-title":"Pancreatology"},{"key":"BFncpgasthep0293_CR26","doi-asserted-by":"publisher","first-page":"1407","DOI":"10.1136\/bmj.38118.593900.55","volume":"328","author":"PE Marik","year":"2004","unstructured":"Marik PE (2004) Meta-analysis of parenteral nutrition versus enteral nutrition in patients with acute pancreatitis. BMJ 328: 1407","journal-title":"BMJ"},{"key":"BFncpgasthep0293_CR27","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1054\/clnu.2002.0569","volume":"21","author":"J Ockenga","year":"2002","unstructured":"Ockenga J et al. (2002) Effect of glutamine-enriched total parenteral nutrition in patients with acute pancreatitis. Clin Nutr 21: 409\u2013416","journal-title":"Clin Nutr"},{"key":"BFncpgasthep0293_CR28","first-page":"500","volume":"100","author":"MG Sarr","year":"1986","unstructured":"Sarr MG et al. (1986) Prospective, randomized trial of nasogastric suction in patients with acute pancreatitis. Surgery 100: 500\u2013504","journal-title":"Surgery"},{"key":"BFncpgasthep0293_CR29","doi-asserted-by":"publisher","first-page":"432","DOI":"10.1111\/j.1572-0241.2005.40587.x","volume":"100","author":"FC Eatock","year":"2005","unstructured":"Eatock FC et al. (2005) A randomized study of early nasogastric versus nasojejunal feeding in severe acute pancreatitis. Am J Gastroenterol 100: 432\u2013439","journal-title":"Am J Gastroenterol"},{"key":"BFncpgasthep0293_CR30","doi-asserted-by":"publisher","first-page":"1763","DOI":"10.1016\/0016-5085(90)90485-J","volume":"99","author":"M Boivin","year":"1990","unstructured":"Boivin M (1990) Are diets associated with different rates of human interdigestive and postprandial pancreatic enzyme secretion? Gastroenterology 99: 1763\u20131771","journal-title":"Gastroenterology"},{"key":"BFncpgasthep0293_CR31","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1159\/000076541","volume":"69","author":"S Kahl","year":"2004","unstructured":"Kahl S et al. (2004) Procaine hydrochloride fails to relieve pain in patients with acute pancreatitis. Digestion 69: 5\u20139","journal-title":"Digestion"},{"key":"BFncpgasthep0293_CR32","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1159\/000076540","volume":"69","author":"MM Lerch","year":"2004","unstructured":"Lerch MM (2004) No more intravenous procaine for pancreatitis pain? Digestion 69: 2\u20134","journal-title":"Digestion"},{"key":"BFncpgasthep0293_CR33","doi-asserted-by":"publisher","first-page":"1266","DOI":"10.1111\/j.1572-0241.2001.03536.x","volume":"96","author":"DR Thompson","year":"2001","unstructured":"Thompson DR (2001) Narcotic analgesic effects on the sphincter of Oddi: a review of the data and therapeutic implications in treating pancreatitis. Am J Gastroenterol 96: 1266\u20131272","journal-title":"Am J Gastroenterol"},{"key":"BFncpgasthep0293_CR34","first-page":"16","volume":"27","author":"A Bernhardt","year":"2002","unstructured":"Bernhardt A et al. (2002) Using epidural anesthesia in patients with acute pancreatitis\u2013prospective study of 121 patients. Anaesthesiol Reanim 27: 16\u201322","journal-title":"Anaesthesiol Reanim"},{"key":"BFncpgasthep0293_CR35","volume-title":"The Cochrane Database of Systematic Reviews","author":"H Jorgensen","year":"2000","unstructured":"Jorgensen H et al. (2000) Epidural local anaesthetics versus opioid-based analgesic regimens on postoperative gastrointestinal paralysis, PONV and pain after abdominal surgery. The Cochrane Database of Systematic Reviews, Issue 4, Art. No CD001893"},{"key":"BFncpgasthep0293_CR36","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1007\/s001340050593","volume":"24","author":"EJ Luiten","year":"1998","unstructured":"Luiten EJ et al. (1998) Prognostic importance of gram-negative intestinal colonization preceding pancreatic infection in severe acute pancreatitis. Results of a controlled clinical trial of selective decontamination. Intensive Care Med 24: 438\u2013445","journal-title":"Intensive Care Med"},{"key":"BFncpgasthep0293_CR37","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1186\/1471-2482-4-12","volume":"4","author":"MGH Besselink","year":"2004","unstructured":"Besselink MGH et al. (2004) Probiotic prophylaxis in patients with predicted severe acute pancreatitis (PROPATRIA): design and rationale of a double-blind, placebo-controlled randomised multicenter trial. BMC Surgery 4: 12","journal-title":"BMC Surgery"},{"key":"BFncpgasthep0293_CR38","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1056\/NEJM198109173051201","volume":"305","author":"SG Gerzof","year":"1981","unstructured":"Gerzof SG et al. (1981) Percutaneous catheter drainage of abdominal abscesses: a five-year experience. N Engl J Med 305: 653\u2013657","journal-title":"N Engl J Med"},{"key":"BFncpgasthep0293_CR39","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1016\/0016-5085(86)90579-2","volume":"91","author":"HG Beger","year":"1986","unstructured":"Beger HG et al. (1986) Bacterial contamination of pancreatic necrosis. A prospective clinical study. Gastroenterology 91: 433\u2013438","journal-title":"Gastroenterology"},{"key":"BFncpgasthep0293_CR40","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1016\/S1091-255X(98)80048-6","volume":"2","author":"R Golub","year":"1998","unstructured":"Golub R et al. (1998) Role of antibiotics in acute pancreatitis: A meta-analysis. J Gastrointest Surg 2: 496\u2013503","journal-title":"J Gastrointest Surg"},{"key":"BFncpgasthep0293_CR41","doi-asserted-by":"publisher","first-page":"997","DOI":"10.1053\/j.gastro.2003.12.050","volume":"126","author":"R Isenmann","year":"2004","unstructured":"Isenmann R et al. (2004) Prophylactic treatment in patients with predicted severe acute pancreatitis: a placebo controlled, double blind trial. Gastroenterology 126: 997\u20131004","journal-title":"Gastroenterology"},{"key":"BFncpgasthep0293_CR42","unstructured":"Bassi C et al. (2003) Antibiotic therapy for prophylaxis against infection of pancreatic necrosis in acute pancreatitis. The Cochrane Database of Systematic Reviews, Issue 4, Art No. CD002941"},{"key":"BFncpgasthep0293_CR43","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1080\/003655298750026534","volume":"228","author":"G Farkas","year":"1998","unstructured":"Farkas G et al. (1998) Progress in the management and treatment of infected pancreatic necrosis. Scand J Gastroenterol 228: 31\u201337","journal-title":"Scand J Gastroenterol"},{"key":"BFncpgasthep0293_CR44","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1086\/375603","volume":"37","author":"JJ De Waele","year":"2003","unstructured":"De Waele JJ et al. (2003) Fungal infections in patients with severe acute pancreatitis and the use of prophylactic therapy. Clin Infect Dis 37: 208\u2013213","journal-title":"Clin Infect Dis"},{"key":"BFncpgasthep0293_CR45","doi-asserted-by":"publisher","first-page":"2569","DOI":"10.1128\/AAC.44.9.2569-2571.2000","volume":"44","author":"S Shrikande","year":"2000","unstructured":"Shrikande S et al. (2000) Fulconazole penetration into the pancreas. Antimicrob Agents Chemother 44: 2569\u20132571","journal-title":"Antimicrob Agents Chemother"},{"key":"BFncpgasthep0293_CR46","first-page":"979","volume":"2","author":"JP Neoptolemos","year":"1998","unstructured":"Neoptolemos JP et al. (1998) Controlled trial of urgent endoscopic retrograde cholangiopancreatography and endoscopic sphincterotomy versus conservative treatment for acute pancreatitis due to gallstones. Lancet 2: 979\u2013983","journal-title":"Lancet"},{"key":"BFncpgasthep0293_CR47","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1056\/NEJM199701233360401","volume":"336","author":"UR Folsch","year":"1997","unstructured":"Folsch UR et al. (1997) Early ERCP and papillotomy compared with conservative treatment for acute biliary pancreatitis. The German study group on Acute Biliary Pancreatitis. N Engl J Med 336: 237\u2013242","journal-title":"N Engl J Med"},{"key":"BFncpgasthep0293_CR48","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1056\/NEJM199301283280402","volume":"328","author":"ST Fan","year":"1993","unstructured":"Fan ST (1993) Early treatment of acute biliary pancreatitis by endoscopic papillotomy. N Engl J Med 328: 228\u2013232","journal-title":"N Engl J Med"},{"key":"BFncpgasthep0293_CR49","doi-asserted-by":"publisher","first-page":"3211","DOI":"10.1111\/j.1572-0241.1999.01520.x","volume":"94","author":"VK Sharma","year":"1999","unstructured":"Sharma VK et al. (1999) Metaanalysis of randomized controlled trials of endoscopic retrograde cholangiography and endoscopic sphincterotomy for the treatment of acute biliary pancreatitis. Am J Gastroenterol 94: 3211\u20133214","journal-title":"Am J Gastroenterol"},{"key":"BFncpgasthep0293_CR50","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1080\/00365520310008377","volume":"39","author":"J Thorboll","year":"2004","unstructured":"Thorboll J et al. (2004) Endoscopic ultrasonography in detection of cholelithiasis in patients with biliary pain and negative transabdominal ultrasonography. Scand J Gastroenterol 39: 267\u2013269","journal-title":"Scand J Gastroenterol"},{"key":"BFncpgasthep0293_CR51","doi-asserted-by":"publisher","first-page":"1206","DOI":"10.1111\/j.1440-1746.2004.03462.x","volume":"19","author":"VA Saraswat","year":"2004","unstructured":"Saraswat VA et al. (2004) Biliary microlithiasis in patients with idiopathic acute pancreatitis and unexplained biliary pain: response to therapy. J Gastroenterol Hepatol 19: 1206\u20131211","journal-title":"J Gastroenterol Hepatol"},{"key":"BFncpgasthep0293_CR52","doi-asserted-by":"crossref","unstructured":"UK working party on acute pancreatitis (2005) UK guidelines for the management of acute pancreatitis. Gut 54: 1\u20139","DOI":"10.1136\/gut.2004.057026"},{"key":"BFncpgasthep0293_CR53","doi-asserted-by":"publisher","first-page":"1070","DOI":"10.1007\/s004649901175","volume":"13","author":"W Uhl","year":"1999","unstructured":"Uhl W et al. (1999) Acute gallstone pancreatitis: timing of laparoscopic cholecystectomy in mild and severe disease. Surg Endosc 13: 1070\u20131076","journal-title":"Surg Endosc"},{"key":"BFncpgasthep0293_CR54","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1016\/S1091-255X(02)00008-2","volume":"6","author":"W Hartwig","year":"2002","unstructured":"Hartwig W et al. (2002) Reduction in mortality with delayed surgical therapy of severe pancreatitis. J Gastrointest Surg 6: 481\u2013487","journal-title":"J Gastrointest Surg"},{"key":"BFncpgasthep0293_CR55","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/S0002-9610(96)00425-4","volume":"173","author":"J Mier","year":"1997","unstructured":"Mier J et al. (1997) Early versus late necrosectomy in severe necrotising pancreatitis. Am J Surg 173: 71\u201375","journal-title":"Am J Surg"},{"key":"BFncpgasthep0293_CR56","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1136\/gut.2003.035907","volume":"54","author":"J Werner","year":"2005","unstructured":"Werner J et al. (2005) Management of acute pancreatitis: from surgery to interventional intensive care. Gut 54: 426\u2013436","journal-title":"Gut"},{"key":"BFncpgasthep0293_CR57","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1007\/s00270-004-0037-1","volume":"27","author":"S Shankar","year":"2004","unstructured":"Shankar S et al. (2004) Imaging and percutaneous management of acute complicated pancreatitis. Cardiocasc Intervent Radiol 27: 567\u2013580","journal-title":"Cardiocasc Intervent Radiol"}],"container-title":["Nature Clinical Practice Gastroenterology &amp; Hepatology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/ncpgasthep0293.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ncpgasthep0293","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ncpgasthep0293.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T20:01:15Z","timestamp":1684440075000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/ncpgasthep0293"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,10]]},"references-count":57,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2005,10]]}},"alternative-id":["BFncpgasthep0293"],"URL":"https:\/\/doi.org\/10.1038\/ncpgasthep0293","relation":{},"ISSN":["1743-4378","1743-4386"],"issn-type":[{"value":"1743-4378","type":"print"},{"value":"1743-4386","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,10]]}}}