{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T12:25:04Z","timestamp":1696335904270},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nat Rev Gastroenterol Hepatol"],"published-print":{"date-parts":[[2007,1]]},"DOI":"10.1038\/ncpgasthep0685","type":"journal-article","created":{"date-parts":[[2007,1,4]],"date-time":"2007-01-04T20:58:08Z","timestamp":1167944288000},"page":"35-42","source":"Crossref","is-referenced-by-count":14,"title":["How to manage the difficult-to-treat dyspeptic patient"],"prefix":"10.1038","volume":"4","author":[{"given":"Nicholas J","family":"Talley","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"BFncpgasthep0685_CR1","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1016\/S1542-3565(05)00153-9","volume":"3","author":"M Camilleri","year":"2005","unstructured":"Camilleri M  et al. (2005) Prevalence and socioeconomic impact of upper gastrointestinal disorders in the United States: results of the US Upper Gastrointestinal Study. Clin Gastroenterol Hepatol 3: 543\u2013552","journal-title":"Clin Gastroenterol Hepatol"},{"key":"BFncpgasthep0685_CR2","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1111\/j.1365-2036.2005.02525.x","volume":"22","author":"Ahlawat","year":"2005","unstructured":"Ahlawat  et al. (2005) Dyspepsia consulters and patterns of management: a population-based study. Aliment Pharmacol Ther 22: 251\u2013259","journal-title":"Aliment Pharmacol Ther"},{"key":"BFncpgasthep0685_CR3","doi-asserted-by":"publisher","first-page":"1370","DOI":"10.1136\/gut.2004.053355","volume":"54","author":"J Tack","year":"2005","unstructured":"Tack J  et al. (2005) Prevalence of acid reflux in functional dyspepsia and its association with symptom profile. Gut 54: 1370\u20131376","journal-title":"Gut"},{"key":"BFncpgasthep0685_CR4","doi-asserted-by":"publisher","first-page":"2324","DOI":"10.1111\/j.1572-0241.2005.00225.x","volume":"100","author":"NJ Talley","year":"2005","unstructured":"Talley NJ and Vakil N (2005) Practice Parameters Committee of the American College of Gastroenterology. Guidelines for the management of dyspepsia. Am J Gastroenterol 100: 2324\u20132337","journal-title":"Am J Gastroenterol"},{"key":"BFncpgasthep0685_CR5","doi-asserted-by":"publisher","first-page":"1481","DOI":"10.1046\/j.1365-2036.2003.01646.x","volume":"17","author":"AB Thomson","year":"2003","unstructured":"Thomson AB  et al. (2003) The prevalence of clinically significant endoscopic findings in primary care patients with uninvestigated dyspepsia: the Canadian Adult Dyspepsia Empiric Treatment\u2014Prompt Endoscopy (CADET-PE) study. Aliment Pharmacol Ther 17: 1481\u20131491","journal-title":"Aliment Pharmacol Ther"},{"key":"BFncpgasthep0685_CR6","doi-asserted-by":"publisher","first-page":"518","DOI":"10.7326\/0003-4819-140-7-200404060-00011","volume":"140","author":"ME Numans","year":"2004","unstructured":"Numans ME  et al. (2004) Short-term treatment with proton-pump inhibitors as a test for gastroesophageal reflux disease: a meta-analysis of diagnostic test characteristics. Ann Intern Med 140: 518\u2013527","journal-title":"Ann Intern Med"},{"key":"BFncpgasthep0685_CR7","doi-asserted-by":"publisher","first-page":"1956","DOI":"10.1111\/j.1572-0241.2006.00711.x","volume":"101","author":"F Zerbib","year":"2006","unstructured":"Zerbib F  et al. (2006) Esophageal pH-impedance monitoring and symptom analysis in GERD: a study in ptients off and on therapy. Am J Gastroenterol 101: 1956\u20131963","journal-title":"Am J Gastroenterol"},{"key":"BFncpgasthep0685_CR8","doi-asserted-by":"publisher","first-page":"2616","DOI":"10.1111\/j.1572-0241.2005.00340.x","volume":"100","author":"M Solaymani-Dodaran","year":"2005","unstructured":"Solaymani-Dodaran M  et al. (2005) Mortality associated with Barrett's esophagus and gastroesophageal reflux disease diagnoses\u2014a population-based cohort study. Am J Gastroenterol 100: 2616\u20132621","journal-title":"Am J Gastroenterol"},{"key":"BFncpgasthep0685_CR9","doi-asserted-by":"publisher","first-page":"1756","DOI":"10.1053\/j.gastro.2005.09.020","volume":"129","author":"NJ Talley","year":"2005","unstructured":"Talley NJ  et al. (2005) AGA technical review on the evaluation of dyspepsia. Gastroenterology 129: 1756\u20131780","journal-title":"Gastroenterology"},{"key":"BFncpgasthep0685_CR10","doi-asserted-by":"publisher","first-page":"855","DOI":"10.1111\/j.1365-2036.2005.02651.x","volume":"22","author":"D Chitkara","year":"2005","unstructured":"Chitkara D  et al. (2005) Aerophagia in adults: a comparison with functional dyspepsia. Aliment Pharmacol Ther 22: 855\u2013858","journal-title":"Aliment Pharmacol Ther"},{"key":"BFncpgasthep0685_CR11","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1046\/j.1523-5378.2002.00104.x","volume":"7","author":"D McNamara","year":"2002","unstructured":"McNamara D  et al. (2002) Does Helicobacter pylori eradication affect symptoms in nonulcer dyspepsia: a 5-year follow-up study. Helicobacter 7: 317\u2013321","journal-title":"Helicobacter"},{"key":"BFncpgasthep0685_CR12","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1046\/j.1365-2036.2002.01169.x","volume":"16","author":"P Malfertheiner","year":"2002","unstructured":"Malfertheiner P  et al. (2002) Current concepts in the management of Helicobacter pylori infection\u2014the Maastricht 2-2000 Consensus Report. Aliment Pharmacol Ther 16: 167\u2013180","journal-title":"Aliment Pharmacol Ther"},{"key":"BFncpgasthep0685_CR13","doi-asserted-by":"publisher","first-page":"1329","DOI":"10.1053\/j.gastro.2004.08.026","volume":"127","author":"P Moayyedi","year":"2004","unstructured":"Moayyedi P  et al. (2004) The efficacy of proton pump inhibitors in non-ulcer dyspepsia: a systematic review and economic analysis. Gastroenterology 127: 1329\u20131337","journal-title":"Gastroenterology"},{"key":"BFncpgasthep0685_CR14","doi-asserted-by":"publisher","first-page":"2086","DOI":"10.1016\/S0140-6736(06)68932-0","volume":"367","author":"P Moayyedi","year":"2006","unstructured":"Moayyedi P and Talley NJ (2006) Gastro-oesophageal reflux disease. Lancet 367: 2086\u20132100","journal-title":"Lancet"},{"key":"BFncpgasthep0685_CR15","doi-asserted-by":"publisher","first-page":"2096","DOI":"10.1111\/j.1572-0241.2006.00751.x","volume":"101","author":"SV Van Zanten","year":"2006","unstructured":"Van Zanten SV  et al. (2006) Esomeprazole 40 mg once a day in patients with functional dyspepsia: the randomized, placebo-controlled \u201cENTER\u201d trial. Am J Gastroenterol 101: 2096\u20132106","journal-title":"Am J Gastroenterol"},{"key":"BFncpgasthep0685_CR16","doi-asserted-by":"publisher","first-page":"1466","DOI":"10.1053\/j.gastro.2005.11.059","volume":"130","author":"J Tack","year":"2006","unstructured":"Tack J  et al. (2006) Functional gastroduodenal disorders. Gastroenterology 130: 1466\u20131479","journal-title":"Gastroenterology"},{"key":"BFncpgasthep0685_CR17","doi-asserted-by":"publisher","first-page":"933","DOI":"10.1136\/gut.2005.078634","volume":"55","author":"NJ Talley","year":"2006","unstructured":"Talley NJ  et al. (2006) Functional dyspepsia, delayed gastric emptying and impaired quality of life. Gut 55: 933\u2013939","journal-title":"Gut"},{"key":"BFncpgasthep0685_CR18","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1111\/j.1365-2982.2004.00516.x","volume":"16","author":"M Camilleri","year":"2004","unstructured":"Camilleri M and Talley NJ (2004) Pathophysiology as a basis for understanding symptom complexes and therapeutic targets. Neurogastroenterol Motil 16: 135\u2013142","journal-title":"Neurogastroenterol Motil"},{"key":"BFncpgasthep0685_CR19","doi-asserted-by":"publisher","first-page":"1346","DOI":"10.1016\/S0016-5085(98)70012-5","volume":"115","author":"J Tack","year":"1998","unstructured":"Tack J  et al. (1998) Role of impaired gastric accommodation to a meal in functional dyspepsia. Gastroenterology 115: 1346\u20131352","journal-title":"Gastroenterology"},{"key":"BFncpgasthep0685_CR20","doi-asserted-by":"publisher","first-page":"1239","DOI":"10.1053\/j.gastro.2004.05.030","volume":"127","author":"J Tack","year":"2004","unstructured":"Tack J  et al. (2004) Pathophysiology and treatment of functional dyspepsia. Gastroenterology 127: 1239\u20131255","journal-title":"Gastroenterology"},{"key":"BFncpgasthep0685_CR21","doi-asserted-by":"publisher","first-page":"1685","DOI":"10.1053\/j.gastro.2004.09.006","volume":"127","author":"S Delgado-Aros","year":"2004","unstructured":"Delgado-Aros S  et al. (2004) Contributions of gastric volumes and gastric emptying to meal size and postmeal symptoms in functional dyspepsia. Gastroenterology 127: 1685\u20131694","journal-title":"Gastroenterology"},{"key":"BFncpgasthep0685_CR22","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1111\/j.1365-2982.2004.00497.x","volume":"16","author":"HU De Schepper","year":"2004","unstructured":"De Schepper HU  et al. (2004) Assessment of gastric accommodation: overview and evaluation of current methods. Neurogastroenterol Motil 16: 275\u2013285","journal-title":"Neurogastroenterol Motil"},{"key":"BFncpgasthep0685_CR23","doi-asserted-by":"publisher","first-page":"1271","DOI":"10.1136\/gut.52.9.1271","volume":"52","author":"J Tack","year":"2003","unstructured":"Tack J  et al. (2003) Assessment of meal induced gastric accommodation by a satiety drinking test in health and in severe functional dyspepsia. Gut 52: 1271\u20131277","journal-title":"Gut"},{"key":"BFncpgasthep0685_CR24","doi-asserted-by":"publisher","first-page":"1489","DOI":"10.1111\/j.1572-0241.2005.40280.x","volume":"100","author":"SJ Veldhuyzen van Zanten","year":"2005","unstructured":"Veldhuyzen van Zanten SJ  et al. (2005) A randomized trial comparing omeprazole, ranitidine, cisapride, or placebo in Helicobacteri pylori negative, primary care patients with dyspepsia: the CADET-HN Study. Am J Gastroenterol 100: 1489\u20131490","journal-title":"Am J Gastroenterol"},{"key":"BFncpgasthep0685_CR25","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1007\/s11894-005-0073-2","volume":"7","author":"J Tack","year":"2005","unstructured":"Tack J and Kindt S (2005) Pathogenesis and therapy for idiopathic dyspepsia. Curr Gastroenterol Rep 7: 437\u2013444","journal-title":"Curr Gastroenterol Rep"},{"key":"BFncpgasthep0685_CR26","doi-asserted-by":"publisher","first-page":"832","DOI":"10.1056\/NEJMoa052639","volume":"354","author":"G Holtmann","year":"2006","unstructured":"Holtmann G  et al. (2006) A placebo-controlled trial of itopride in functional dyspepsia. N Engl J Med 354: 832\u2013840","journal-title":"N Engl J Med"},{"key":"BFncpgasthep0685_CR27","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1111\/j.1365-2982.2005.00732.x","volume":"18","author":"Z Lin","year":"2006","unstructured":"Lin Z  et al. (2006) Symptom responses, long-term outcomes and adverse events beyond 3 years of high-frequency gastric electrical stimulation for gastroparesis. Neurogastroenterol Motil 18: 18\u201327","journal-title":"Neurogastroenterol Motil"},{"key":"BFncpgasthep0685_CR28","doi-asserted-by":"publisher","first-page":"859","DOI":"10.1111\/j.1365-2036.2006.03049.x","volume":"24","author":"NJ Talley","year":"2006","unstructured":"Talley NJ  et al. (2006) Double-blind, randomized, placebo-controlled study to evaluate the effects of tegaserod on gastric motor, sensory and myoelectric function in healthy volunteers. Aliment Pharmacol Ther 24: 859\u2013867","journal-title":"Aliment Pharmacol Ther"},{"key":"BFncpgasthep0685_CR29","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1111\/j.1365-2982.2004.00613.x","volume":"17","author":"AN James","year":"2005","unstructured":"James AN  et al. (2005) Effects of the selective serotonin reuptake inhibitor, fluoxetine, on regional gastric contractility. Neurogastroenterol Motil 17: 76\u201382","journal-title":"Neurogastroenterol Motil"},{"key":"BFncpgasthep0685_CR30","doi-asserted-by":"publisher","first-page":"1817","DOI":"10.1111\/j.1572-0241.2004.30086.x","volume":"99","author":"S Soo","year":"2004","unstructured":"Soo S  et al. (2004) A systematic review of psychological therapies for nonulcer dyspepsia. Am J Gastroenterol 99: 1817\u20131822","journal-title":"Am J Gastroenterol"},{"key":"BFncpgasthep0685_CR31","doi-asserted-by":"publisher","first-page":"1778","DOI":"10.1053\/gast.2002.37071","volume":"123","author":"EL Calvert","year":"2002","unstructured":"Calvert EL  et al. (2002) Long-term improvement in functional dyspepsia using hypnotherapy. Gastroenterology 123: 1778\u20131785","journal-title":"Gastroenterology"},{"key":"BFncpgasthep0685_CR32","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1111\/j.1572-0241.1998.00160.x","volume":"93","author":"H Mertz","year":"1998","unstructured":"Mertz H  et al. (1998) Effect of amitriptyline on symptoms, sleep, and visceral perception in patients with functional dyspepsia. Am J Gastroenterol 93: 160\u2013165","journal-title":"Am J Gastroenterol"}],"container-title":["Nature Clinical Practice Gastroenterology &amp; Hepatology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/ncpgasthep0685.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ncpgasthep0685","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ncpgasthep0685.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T20:04:44Z","timestamp":1684440284000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/ncpgasthep0685"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,1]]},"references-count":32,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2007,1]]}},"alternative-id":["BFncpgasthep0685"],"URL":"https:\/\/doi.org\/10.1038\/ncpgasthep0685","relation":{},"ISSN":["1743-4378","1743-4386"],"issn-type":[{"value":"1743-4378","type":"print"},{"value":"1743-4386","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,1]]}}}