{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T04:24:09Z","timestamp":1784780649260,"version":"3.55.0"},"reference-count":98,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2008,8,5]],"date-time":"2008-08-05T00:00:00Z","timestamp":1217894400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nat Rev Gastroenterol Hepatol"],"published-print":{"date-parts":[[2008,9]]},"DOI":"10.1038\/ncpgasthep1203","type":"journal-article","created":{"date-parts":[[2008,8,5]],"date-time":"2008-08-05T04:43:23Z","timestamp":1217911403000},"page":"498-507","source":"Crossref","is-referenced-by-count":17,"title":["Efficient diagnosis of suspected functional bowel disorders"],"prefix":"10.1038","volume":"5","author":[{"given":"Jenny","family":"Gunnarsson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magnus","family":"Simr\u00e9n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2008,8,5]]},"reference":[{"key":"BFncpgasthep1203_CR1","doi-asserted-by":"crossref","unstructured":"American Gastroenterological Association (2002) American Gastroenterological Association medical position statement: irritable bowel syndrome. Gastroenterology 123: 2105\u20132107","DOI":"10.1053\/gast.2002.37095b"},{"key":"BFncpgasthep1203_CR2","doi-asserted-by":"publisher","first-page":"2108","DOI":"10.1053\/gast.2002.37095","volume":"123","author":"DA Drossman","year":"2002","unstructured":"Drossman DA  et al. (2002) AGA technical review on irritable bowel syndrome. Gastroenterology 123: 2108\u20132131","journal-title":"Gastroenterology"},{"key":"BFncpgasthep1203_CR3","doi-asserted-by":"publisher","first-page":"1770","DOI":"10.1136\/gut.2007.119446","volume":"56","author":"R Spiller","year":"2007","unstructured":"Spiller R  et al. (2007) Guidelines on the irritable bowel syndrome: mechanisms and practical management. Gut 56: 1770\u20131798","journal-title":"Gut"},{"key":"BFncpgasthep1203_CR4","doi-asserted-by":"publisher","first-page":"1480","DOI":"10.1053\/j.gastro.2005.11.061","volume":"130","author":"GF Longstreth","year":"2006","unstructured":"Longstreth GF  et al. (2006) Functional bowel disorders. Gastroenterology 130: 1480\u20131491","journal-title":"Gastroenterology"},{"key":"BFncpgasthep1203_CR5","doi-asserted-by":"publisher","first-page":"632","DOI":"10.1016\/S0140-6736(83)91802-0","volume":"1","author":"RF Harvey","year":"1983","unstructured":"Harvey RF  et al. (1983) Organic and functional disorders in 2000 gastroenterology outpatients. Lancet 1: 632\u2013634","journal-title":"Lancet"},{"key":"BFncpgasthep1203_CR6","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1097\/MEG.0b013e32801140e2","volume":"19","author":"AD Sperber","year":"2007","unstructured":"Sperber AD  et al. (2007) A comparative reappraisal of the Rome II and Rome III diagnostic criteria: are we getting closer to the 'true' prevalence of irritable bowel syndrome? Eur J Gastroenterol Hepatol 19: 441\u2013447","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"BFncpgasthep1203_CR7","doi-asserted-by":"publisher","first-page":"799","DOI":"10.1053\/j.gastro.2007.06.010","volume":"133","author":"SL Halder","year":"2007","unstructured":"Halder SL  et al. (2007) Natural history of functional gastrointestinal disorders: a 12-year longitudinal population-based study. Gastroenterology 133: 799\u2013807","journal-title":"Gastroenterology"},{"key":"BFncpgasthep1203_CR8","doi-asserted-by":"publisher","first-page":"895","DOI":"10.1016\/0016-5085(92)90175-X","volume":"102","author":"NJ Talley","year":"1992","unstructured":"Talley NJ  et al. (1992) Prevalence of gastrointestinal symptoms in the elderly: a population-based study. Gastroenterology 102: 895\u2013901","journal-title":"Gastroenterology"},{"key":"BFncpgasthep1203_CR9","doi-asserted-by":"publisher","first-page":"1736","DOI":"10.1016\/0016-5085(95)90738-6","volume":"109","author":"NJ Talley","year":"1995","unstructured":"Talley NJ  et al. (1995) Medical costs in community subjects with irritable bowel syndrome. Gastroenterology 109: 1736\u20131741","journal-title":"Gastroenterology"},{"key":"BFncpgasthep1203_CR10","doi-asserted-by":"publisher","first-page":"787","DOI":"10.1016\/S1542-3565(04)00350-7","volume":"2","author":"CS North","year":"2004","unstructured":"North CS  et al. (2004) The presentation of irritable bowel syndrome in the context of somatization disorder. Clin Gastroenterol Hepatol 2: 787\u2013795","journal-title":"Clin Gastroenterol Hepatol"},{"key":"BFncpgasthep1203_CR11","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1136\/gut.27.1.37","volume":"27","author":"PJ Whorwell","year":"1986","unstructured":"Whorwell PJ  et al. (1986) Non-colonic features of irritable bowel syndrome. Gut 27: 37\u201340","journal-title":"Gut"},{"key":"BFncpgasthep1203_CR12","doi-asserted-by":"publisher","first-page":"2454","DOI":"10.1111\/j.1572-0241.2003.07699.x","volume":"98","author":"NJ Talley","year":"2003","unstructured":"Talley NJ  et al. (2003) Overlapping upper and lower gastrointestinal symptoms in irritable bowel syndrome patients with constipation or diarrhea. Am J Gastroenterol 98: 2454\u20132459","journal-title":"Am J Gastroenterol"},{"key":"BFncpgasthep1203_CR13","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1136\/bmj.2.6138.653","volume":"2","author":"AP Manning","year":"1978","unstructured":"Manning AP  et al. (1978) Towards positive diagnosis of the irritable bowel. Br Med J 2: 653\u2013654","journal-title":"Br Med J"},{"key":"BFncpgasthep1203_CR14","first-page":"159","volume":"3","author":"DA Drossman","year":"1990","unstructured":"Drossman DA  et al. (1990) Identification of subgroups of functional gastrointestinal disorders. Gastroenterol Int 3: 159\u2013172","journal-title":"Gastroenterol Int"},{"issue":"Suppl 2","key":"BFncpgasthep1203_CR15","first-page":"II43","volume":"45","author":"WG Thompson","year":"1999","unstructured":"Thompson WG  et al. (1999) Functional bowel disorders and functional abdominal pain. Gut 45 (Suppl 2): II43\u2013II47","journal-title":"Gut"},{"key":"BFncpgasthep1203_CR16","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1111\/j.1365-2982.2004.00581.x","volume":"17","author":"GR Locke","year":"2005","unstructured":"Locke GR  et al. (2005) Overlap of gastrointestinal symptom complexes in a US community. Neurogastroenterol Motil 17: 29\u201334","journal-title":"Neurogastroenterol Motil"},{"key":"BFncpgasthep1203_CR17","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1007\/s10620-006-3112-4","volume":"51","author":"A Minocha","year":"2006","unstructured":"Minocha A  et al. (2006) Racial differences in epidemiology of irritable bowel syndrome alone, un-investigated dyspepsia alone, and \u201coverlap syndrome\u201d among african americans compared to Caucasians: a population-based study. Dig Dis Sci 51: 218\u2013226","journal-title":"Dig Dis Sci"},{"key":"BFncpgasthep1203_CR18","doi-asserted-by":"publisher","first-page":"580","DOI":"10.1053\/j.gastro.2004.12.006","volume":"128","author":"DA Drossman","year":"2005","unstructured":"Drossman DA  et al. (2005) A prospective assessment of bowel habit in irritable bowel syndrome in women: defining an alternator. Gastroenterology 128: 580\u2013589","journal-title":"Gastroenterology"},{"key":"BFncpgasthep1203_CR19","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1046\/j.1572-0241.2003.04023.x","volume":"99","author":"F Mearin","year":"2004","unstructured":"Mearin F  et al. (2004) Clinical patterns over time in irritable bowel syndrome: symptom instability and severity variability. Am J Gastroenterol 99: 113\u2013121","journal-title":"Am J Gastroenterol"},{"key":"BFncpgasthep1203_CR20","doi-asserted-by":"publisher","first-page":"2905","DOI":"10.1111\/j.1572-0241.2001.04680.x","volume":"96","author":"L Agreus","year":"2001","unstructured":"Agreus L  et al. (2001) Natural history of gastroesophageal reflux disease and functional abdominal disorders: a population-based study. Am J Gastroenterol 96: 2905\u20132914","journal-title":"Am J Gastroenterol"},{"key":"BFncpgasthep1203_CR21","doi-asserted-by":"publisher","first-page":"102","DOI":"10.3109\/00365529409090447","volume":"29","author":"L Agreus","year":"1994","unstructured":"Agreus L  et al. (1994) The epidemiology of abdominal symptoms: prevalence and demographic characteristics in a Swedish adult population. A report from the Abdominal Symptom Study. Scand J Gastroenterol 29: 102\u2013109","journal-title":"Scand J Gastroenterol"},{"key":"BFncpgasthep1203_CR22","doi-asserted-by":"publisher","first-page":"1377","DOI":"10.1053\/j.gastro.2006.03.008","volume":"130","author":"DA Drossman","year":"2006","unstructured":"Drossman DA (2006) The functional gastrointestinal disorders and the Rome III process. Gastroenterology 130: 1377\u20131390","journal-title":"Gastroenterology"},{"issue":"Suppl 2","key":"BFncpgasthep1203_CR23","first-page":"II25","volume":"45","author":"DA Drossman","year":"1999","unstructured":"Drossman DA  et al. (1999) Psychosocial aspects of the functional gastrointestinal disorders. Gut 45 (Suppl 2): II25\u2013II30","journal-title":"Gut"},{"key":"BFncpgasthep1203_CR24","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1097\/00045391-200301000-00014","volume":"10","author":"A Garakani","year":"2003","unstructured":"Garakani A  et al. (2003) Comorbidity of irritable bowel syndrome in psychiatric patients: a review. Am J Ther 10: 61\u201367","journal-title":"Am J Ther"},{"key":"BFncpgasthep1203_CR25","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1023\/A:1024209111909","volume":"26","author":"MA Sykes","year":"2003","unstructured":"Sykes MA  et al. (2003) Psychopathology in irritable bowel syndrome: support for a psychophysiological model. J Behav Med 26: 361\u2013372","journal-title":"J Behav Med"},{"key":"BFncpgasthep1203_CR26","doi-asserted-by":"publisher","first-page":"1140","DOI":"10.1053\/gast.2002.32392","volume":"122","author":"WE Whitehead","year":"2002","unstructured":"Whitehead WE  et al. (2002) Systematic review of the comorbidity of irritable bowel syndrome with other disorders: What are the causes and implications? Gastroenterology 122: 1140\u20131156","journal-title":"Gastroenterology"},{"key":"BFncpgasthep1203_CR27","doi-asserted-by":"publisher","first-page":"1014","DOI":"10.1136\/gut.27.9.1014","volume":"27","author":"PJ Whorwell","year":"1986","unstructured":"Whorwell PJ  et al. (1986) Bladder smooth muscle dysfunction in patients with irritable bowel syndrome. Gut 27: 1014\u20131017","journal-title":"Gut"},{"key":"BFncpgasthep1203_CR28","doi-asserted-by":"publisher","first-page":"784","DOI":"10.1136\/gut.32.7.784","volume":"32","author":"DG Maxton","year":"1991","unstructured":"Maxton DG  et al. (1991) More accurate diagnosis of irritable bowel syndrome by the use of 'non- colonic' symptomatology [see comments]. Gut 32: 784\u2013786","journal-title":"Gut"},{"key":"BFncpgasthep1203_CR29","doi-asserted-by":"publisher","first-page":"500","DOI":"10.1111\/j.1365-2982.2005.00666.x","volume":"17","author":"LA Houghton","year":"2005","unstructured":"Houghton LA and Whorwell PJ (2005) Towards a better understanding of abdominal bloating and distension in functional gastrointestinal disorders. Neurogastroenterol Motil 17: 500\u2013511","journal-title":"Neurogastroenterol Motil"},{"key":"BFncpgasthep1203_CR30","doi-asserted-by":"publisher","first-page":"1492","DOI":"10.1053\/j.gastro.2005.11.062","volume":"130","author":"RE Clouse","year":"2006","unstructured":"Clouse RE  et al. (2006) Functional abdominal pain syndrome. Gastroenterology 130: 1492\u20131497","journal-title":"Gastroenterology"},{"key":"BFncpgasthep1203_CR31","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1080\/00365520310008782","volume":"39","author":"PO Vandvik","year":"2004","unstructured":"Vandvik PO  et al. (2004) Diagnosing irritable bowel syndrome: poor agreement between general practitioners and the Rome II criteria. Scand J Gastroenterol 39: 448\u2013453","journal-title":"Scand J Gastroenterol"},{"key":"BFncpgasthep1203_CR32","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1046\/j.1572-0241.2003.04024.x","volume":"99","author":"F Mearin","year":"2004","unstructured":"Mearin F  et al. (2004) Splitting irritable bowel syndrome: from original Rome to Rome II criteria. Am J Gastroenterol 99: 122\u2013130","journal-title":"Am J Gastroenterol"},{"key":"BFncpgasthep1203_CR33","doi-asserted-by":"publisher","first-page":"1155","DOI":"10.1080\/00365520152584770","volume":"36","author":"F Mearin","year":"2001","unstructured":"Mearin F  et al. (2001) Irritable bowel syndrome prevalence varies enormously depending on the employed diagnostic criteria: comparison of Rome II versus previous criteria in a general population. Scand J Gastroenterol 36: 1155\u20131161","journal-title":"Scand J Gastroenterol"},{"key":"BFncpgasthep1203_CR34","doi-asserted-by":"publisher","first-page":"953","DOI":"10.1111\/j.1365-2036.2007.03422.x","volume":"26","author":"A Ersryd","year":"2007","unstructured":"Ersryd A  et al. (2007) Subtyping the irritable bowel syndrome by predominant bowel habit: Rome II versus Rome III. Aliment Pharmacol Ther 26: 953\u2013961","journal-title":"Aliment Pharmacol Ther"},{"key":"BFncpgasthep1203_CR35","doi-asserted-by":"publisher","first-page":"2081","DOI":"10.1001\/archinte.161.17.2081","volume":"161","author":"R Fass","year":"2001","unstructured":"Fass R  et al. (2001) Evidence- and consensus-based practice guidelines for the diagnosis of irritable bowel syndrome. Arch Intern Med 161: 2081\u20132088","journal-title":"Arch Intern Med"},{"key":"BFncpgasthep1203_CR36","doi-asserted-by":"publisher","first-page":"666","DOI":"10.1136\/gut.2003.021857","volume":"53","author":"J Hammer","year":"2004","unstructured":"Hammer J  et al. (2004) Diagnostic yield of alarm features in irritable bowel syndrome and functional dyspepsia. Gut 53: 666\u2013672","journal-title":"Gut"},{"key":"BFncpgasthep1203_CR37","doi-asserted-by":"publisher","first-page":"2912","DOI":"10.1111\/j.1572-0241.1999.01437.x","volume":"94","author":"SJ Vanner","year":"1999","unstructured":"Vanner SJ  et al. (1999) Predictive value of the Rome criteria for diagnosing the irritable bowel syndrome. Am J Gastroenterol 94: 2912\u20132917","journal-title":"Am J Gastroenterol"},{"key":"BFncpgasthep1203_CR38","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1111\/j.1365-2036.2006.02956.x","volume":"24","author":"WE Whitehead","year":"2006","unstructured":"Whitehead WE  et al. (2006) Utility of red flag symptom exclusions in the diagnosis of irritable bowel syndrome. Aliment Pharmacol Ther 24: 137\u2013146","journal-title":"Aliment Pharmacol Ther"},{"key":"BFncpgasthep1203_CR39","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1155\/2003\/532138","volume":"17","author":"CJ Bijkerk","year":"2003","unstructured":"Bijkerk CJ  et al. (2003) Irritable bowel syndrome in primary care: the patients' and doctors' views on symptoms, etiology and management. Can J Gastroenterol 17: 363\u2013368; quiz 405\u2013406","journal-title":"Can J Gastroenterol"},{"key":"BFncpgasthep1203_CR40","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1177\/0272989X9401400302","volume":"14","author":"R Starmans","year":"1994","unstructured":"Starmans R  et al. (1994) The diagnostic value of scoring models for organic and non-organic gastrointestinal disease, including the irritable-bowel syndrome. Med Decis Making 14: 208\u2013216","journal-title":"Med Decis Making"},{"key":"BFncpgasthep1203_CR41","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1093\/fampra\/cml050","volume":"23","author":"G Rubin","year":"2006","unstructured":"Rubin G  et al. (2006) The diagnosis of IBS in primary care: consensus development using nominal group technique. Fam Pract 23: 687\u2013692","journal-title":"Fam Pract"},{"key":"BFncpgasthep1203_CR42","doi-asserted-by":"publisher","first-page":"415","DOI":"10.3109\/00365528509089673","volume":"20","author":"JH Svendsen","year":"1985","unstructured":"Svendsen JH  et al. (1985) Irritable bowel syndrome\u2014prognosis and diagnostic safety. A 5-year follow-up study. Scand J Gastroenterol 20: 415\u2013418","journal-title":"Scand J Gastroenterol"},{"key":"BFncpgasthep1203_CR43","doi-asserted-by":"publisher","first-page":"963","DOI":"10.1016\/S0140-6736(87)90304-7","volume":"1","author":"RF Harvey","year":"1987","unstructured":"Harvey RF  et al. (1987) Prognosis in the irritable bowel syndrome: a 5-year prospective study. Lancet 1: 963\u2013965","journal-title":"Lancet"},{"key":"BFncpgasthep1203_CR44","doi-asserted-by":"publisher","first-page":"107","DOI":"10.7326\/0003-4819-122-2-199501150-00005","volume":"122","author":"DM Owens","year":"1995","unstructured":"Owens DM  et al. (1995) The irritable bowel syndrome: long-term prognosis and the physician\u2013patient interaction. Ann Intern Med 122: 107\u2013112","journal-title":"Ann Intern Med"},{"key":"BFncpgasthep1203_CR45","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1093\/fampra\/7.4.307","volume":"7","author":"S Bellentani","year":"1990","unstructured":"Bellentani S  et al. (1990) A simple score for the identification of patients at high risk of organic diseases of the colon in the family doctor consulting room. The Local IBS Study Group. Fam Pract 7: 307\u2013312","journal-title":"Fam Pract"},{"key":"BFncpgasthep1203_CR46","doi-asserted-by":"publisher","first-page":"1195","DOI":"10.1111\/j.1572-0241.2000.02009.x","volume":"95","author":"R Fass","year":"2000","unstructured":"Fass R  et al. (2000) Sleep disturbances in clinic patients with functional bowel disorders. Am J Gastroenterol 95: 1195\u20132000","journal-title":"Am J Gastroenterol"},{"key":"BFncpgasthep1203_CR47","first-page":"176","volume":"89","author":"BA Tolliver","year":"1994","unstructured":"Tolliver BA  et al. (1994) Evaluation of patients who meet clinical criteria for irritable bowel syndrome. Am J Gastroenterol 89: 176\u2013178","journal-title":"Am J Gastroenterol"},{"key":"BFncpgasthep1203_CR48","doi-asserted-by":"publisher","first-page":"1279","DOI":"10.1111\/j.1572-0241.1999.01077.x","volume":"94","author":"LR Hamm","year":"1999","unstructured":"Hamm LR  et al. (1999) Additional investigations fail to alter the diagnosis of irritable bowel syndrome in subjects fulfilling the Rome criteria. Am J Gastroenterol 94: 1279\u20131282","journal-title":"Am J Gastroenterol"},{"key":"BFncpgasthep1203_CR49","doi-asserted-by":"publisher","first-page":"450","DOI":"10.1053\/gast.2002.34755","volume":"123","author":"JA Tibble","year":"2002","unstructured":"Tibble JA  et al. (2002) Use of surrogate markers of inflammation and Rome criteria to distinguish organic from nonorganic intestinal disease. Gastroenterology 123: 450\u2013460","journal-title":"Gastroenterology"},{"key":"BFncpgasthep1203_CR50","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1002\/ibd.20275","volume":"14","author":"AM Schoepfer","year":"2008","unstructured":"Schoepfer AM  et al. (2008) Discriminating IBD from IBS: comparison of the test performance of fecal markers, blood leukocytes, CRP, and IBD antibodies. Inflamm Bowel Dis 14: 32\u201339","journal-title":"Inflamm Bowel Dis"},{"key":"BFncpgasthep1203_CR51","doi-asserted-by":"publisher","first-page":"2812","DOI":"10.1111\/j.1572-0241.2002.07027.x","volume":"97","author":"BD Cash","year":"2002","unstructured":"Cash BD  et al. (2002) The utility of diagnostic tests in irritable bowel syndrome patients: a systematic review. Am J Gastroenterol 97: 2812\u20132819","journal-title":"Am J Gastroenterol"},{"key":"BFncpgasthep1203_CR52","doi-asserted-by":"publisher","first-page":"476","DOI":"10.4065\/79.4.476","volume":"79","author":"GR Locke","year":"2004","unstructured":"Locke GR  et al. (2004) Celiac disease serology in irritable bowel syndrome and dyspepsia: a population-based case-control study. Mayo Clin Proc 79: 476\u2013482","journal-title":"Mayo Clin Proc"},{"key":"BFncpgasthep1203_CR53","doi-asserted-by":"publisher","first-page":"1504","DOI":"10.1016\/S0140-6736(01)06581-3","volume":"358","author":"DS Sanders","year":"2001","unstructured":"Sanders DS  et al. (2001) Association of adult coeliac disease with irritable bowel syndrome: a case-control study in patients fulfilling ROME II criteria referred to secondary care. Lancet 358: 1504\u20131508","journal-title":"Lancet"},{"key":"BFncpgasthep1203_CR54","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1097\/00042737-200304000-00012","volume":"15","author":"DS Sanders","year":"2003","unstructured":"Sanders DS  et al. (2003) A primary care cross-sectional study of undiagnosed adult coeliac disease. Eur J Gastroenterol Hepatol 15: 407\u2013413","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"BFncpgasthep1203_CR55","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1046\/j.1365-2036.2003.01666.x","volume":"18","author":"B Shahbazkhani","year":"2003","unstructured":"Shahbazkhani B  et al. (2003) Coeliac disease presenting with symptoms of irritable bowel syndrome. Aliment Pharmacol Ther 18: 231\u2013235","journal-title":"Aliment Pharmacol Ther"},{"issue":"4 Suppl 1","key":"BFncpgasthep1203_CR56","doi-asserted-by":"publisher","first-page":"S38","DOI":"10.1053\/j.gastro.2005.02.028","volume":"128","author":"A Rostom","year":"2005","unstructured":"Rostom A  et al. (2005) The diagnostic accuracy of serologic tests for celiac disease: a systematic review. Gastroenterology 128 (4 Suppl 1): S38\u2013S46","journal-title":"Gastroenterology"},{"key":"BFncpgasthep1203_CR57","doi-asserted-by":"publisher","first-page":"1199","DOI":"10.1111\/j.1365-2036.2004.01958.x","volume":"19","author":"SM Mein","year":"2004","unstructured":"Mein SM and Ladabaum U (2004) Serological testing for coeliac disease in patients with symptoms of irritable bowel syndrome: a cost-effectiveness analysis. Aliment Pharmacol Ther 19: 1199\u20131210","journal-title":"Aliment Pharmacol Ther"},{"key":"BFncpgasthep1203_CR58","doi-asserted-by":"publisher","first-page":"1721","DOI":"10.1053\/j.gastro.2004.03.012","volume":"126","author":"BM Spiegel","year":"2004","unstructured":"Spiegel BM  et al. (2004) Testing for celiac sprue in irritable bowel syndrome with predominant diarrhea: a cost-effectiveness analysis. Gastroenterology 126: 1721\u20131732","journal-title":"Gastroenterology"},{"key":"BFncpgasthep1203_CR59","doi-asserted-by":"publisher","first-page":"934","DOI":"10.1016\/j.dld.2005.06.011","volume":"37","author":"M Bellini","year":"2005","unstructured":"Bellini M  et al. (2005) The general practitioner's approach to irritable bowel syndrome: from intention to practice. Dig Liver Dis 37: 934\u2013939","journal-title":"Dig Liver Dis"},{"key":"BFncpgasthep1203_CR60","first-page":"585","volume":"7","author":"BP Yawn","year":"2001","unstructured":"Yawn BP  et al. (2001) Diagnosis and care of irritable bowel syndrome in a community-based population. Am J Manag Care 7: 585\u2013592","journal-title":"Am J Manag Care"},{"key":"BFncpgasthep1203_CR61","doi-asserted-by":"publisher","first-page":"2467","DOI":"10.1016\/j.ejca.2007.08.023","volume":"43","author":"M Ramos","year":"2007","unstructured":"Ramos M  et al. (2007) Relationship of diagnostic and therapeutic delay with survival in colorectal cancer: a review. Eur J Cancer 43: 2467\u20132478","journal-title":"Eur J Cancer"},{"key":"BFncpgasthep1203_CR62","doi-asserted-by":"publisher","first-page":"892","DOI":"10.1016\/j.gie.2005.08.016","volume":"62","author":"BM Spiegel","year":"2005","unstructured":"Spiegel BM  et al. (2005) Is a negative colonoscopy associated with reassurance or improved health-related quality of life in irritable bowel syndrome? Gastrointest Endosc 62: 892\u2013899","journal-title":"Gastrointest Endosc"},{"key":"BFncpgasthep1203_CR63","first-page":"CR363","volume":"12","author":"AJ Akhtar","year":"2006","unstructured":"Akhtar AJ  et al. (2006) Organic colonic lesions in patients with irritable bowel syndrome (IBS). Med Sci Monit 12: CR363\u2013CR367","journal-title":"Med Sci Monit"},{"key":"BFncpgasthep1203_CR64","first-page":"1348","volume":"91","author":"CY Francis","year":"1996","unstructured":"Francis CY  et al. (1996) Does routine abdominal ultrasound enhance diagnostic accuracy in irritable bowel syndrome? Am J Gastroenterol 91: 1348\u20131350","journal-title":"Am J Gastroenterol"},{"key":"BFncpgasthep1203_CR65","first-page":"1","volume":"10","author":"A Lasson","year":"2007","unstructured":"Lasson A  et al. (2007) Diagnostic yield of colonoscopy based on symptoms. Scand J Gastroenterol 10: 1\u20137","journal-title":"Scand J Gastroenterol"},{"key":"BFncpgasthep1203_CR66","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1159\/000079150","volume":"69","author":"M Muller","year":"2004","unstructured":"Muller M  et al. (2004) Colonoscopy and SeHCAT for investigation of chronic diarrhea. Digestion 69: 211\u2013218","journal-title":"Digestion"},{"key":"BFncpgasthep1203_CR67","first-page":"353","volume":"90","author":"DK Rex","year":"1995","unstructured":"Rex DK (1995) Colonoscopy: a review of its yield for cancers and adenomas by indication. Am J Gastroenterol 90: 353\u2013365","journal-title":"Am J Gastroenterol"},{"key":"BFncpgasthep1203_CR68","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1016\/S0016-5107(95)70069-2","volume":"42","author":"DK Rex","year":"1995","unstructured":"Rex DK  et al. (1995) Flexible sigmoidoscopy plus air-contrast barium enema versus colonoscopy for evaluation of symptomatic patients without evidence of bleeding. Gastrointest Endosc 42: 132\u2013138","journal-title":"Gastrointest Endosc"},{"key":"BFncpgasthep1203_CR69","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1001\/archinte.161.3.369","volume":"161","author":"S Suleiman","year":"2001","unstructured":"Suleiman S and Sonnenberg A (2001) Cost-effectiveness of endoscopy in irritable bowel syndrome. Arch Intern Med 161: 369\u2013375","journal-title":"Arch Intern Med"},{"key":"BFncpgasthep1203_CR70","doi-asserted-by":"publisher","first-page":"1658","DOI":"10.1046\/j.1365-2168.2000.01596.x","volume":"87","author":"TM Kennedy","year":"2000","unstructured":"Kennedy TM and Jones RH (2000) Epidemiology of cholecystectomy and irritable bowel syndrome in a UK population. Br J Surg 87: 1658\u20131663","journal-title":"Br J Surg"},{"key":"BFncpgasthep1203_CR71","doi-asserted-by":"publisher","first-page":"1665","DOI":"10.1053\/j.gastro.2004.02.020","volume":"126","author":"GF Longstreth","year":"2004","unstructured":"Longstreth GF and Yao JF (2004) Irritable bowel syndrome and surgery: a multivariable analysis. Gastroenterology 126: 1665\u20131673","journal-title":"Gastroenterology"},{"key":"BFncpgasthep1203_CR72","doi-asserted-by":"publisher","first-page":"1004","DOI":"10.1136\/gut.32.9.1004","volume":"32","author":"AJ Williams","year":"1991","unstructured":"Williams AJ  et al. (1991) Idiopathic bile acid malabsorption\u2014a review of clinical presentation, diagnosis, and response to treatment. Gut 32: 1004\u20131006","journal-title":"Gut"},{"issue":"Suppl 2","key":"BFncpgasthep1203_CR73","first-page":"A682","volume":"132","author":"A Bajor","year":"2007","unstructured":"Bajor A  et al. (2007) Overweight, high age and the presence of loose and frequent stools are suggestive of bile acid malabsorption in patients with the irritable bowel syndrome (IBS). Gastroenterology 132 (Suppl 2): A682","journal-title":"Gastroenterology"},{"key":"BFncpgasthep1203_CR74","first-page":"533","volume":"4","author":"G Galatola","year":"1992","unstructured":"Galatola G (1992) The prevalence of bile acid malabsorption in irritable bowel syndrome and the effect of cholestyramine: an uncontrolled open multicentre study. Eur J Gastroenterol Hepatol 4: 533\u2013537","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"BFncpgasthep1203_CR75","first-page":"448","volume":"34","author":"MJ Smith","year":"2000","unstructured":"Smith MJ (2000) Bile acid malabsorption in persistent diarrhoea. J R Coll Physicians Lond 34: 448\u2013451","journal-title":"J R Coll Physicians Lond"},{"key":"BFncpgasthep1203_CR76","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1136\/gut.2005.075127","volume":"55","author":"M Simr\u00e9n","year":"2006","unstructured":"Simr\u00e9n M and Stotzer PO (2006) Use and abuse of hydrogen breath tests. Gut 55: 297\u2013303","journal-title":"Gut"},{"key":"BFncpgasthep1203_CR77","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1080\/00365520410005405","volume":"39","author":"PG Farup","year":"2004","unstructured":"Farup PG  et al. (2004) Lactose malabsorption in a population with irritable bowel syndrome: prevalence and symptoms. A case-control study. Scand J Gastroenterol 39: 645\u2013649","journal-title":"Scand J Gastroenterol"},{"key":"BFncpgasthep1203_CR78","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1097\/00004836-199607000-00005","volume":"23","author":"BA Tolliver","year":"1996","unstructured":"Tolliver BA  et al. (1996) Does lactose maldigestion really play a role in the irritable bowel? J Clin Gastroenterol 23: 15\u201317","journal-title":"J Clin Gastroenterol"},{"key":"BFncpgasthep1203_CR79","doi-asserted-by":"publisher","first-page":"996","DOI":"10.1016\/j.clnu.2003.12.005","volume":"23","author":"P Vernia","year":"2004","unstructured":"Vernia P  et al. (2004) Self-reported milk intolerance in irritable bowel syndrome: what should we believe? Clin Nutr 23: 996\u20131000","journal-title":"Clin Nutr"},{"key":"BFncpgasthep1203_CR80","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1097\/00042737-200103000-00001","volume":"13","author":"TJ Parker","year":"2001","unstructured":"Parker TJ  et al. (2001) Irritable bowel syndrome: is the search for lactose intolerance justified? Eur J Gastroenterol Hepatol 13: 219\u2013225","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"BFncpgasthep1203_CR81","doi-asserted-by":"publisher","first-page":"3503","DOI":"10.1111\/j.1572-0241.2000.03368.x","volume":"95","author":"M Pimentel","year":"2000","unstructured":"Pimentel M  et al. (2000) Eradication of small intestinal bacterial overgrowth reduces symptoms of irritable bowel syndrome. Am J Gastroenterol 95: 3503\u20133506","journal-title":"Am J Gastroenterol"},{"key":"BFncpgasthep1203_CR82","doi-asserted-by":"publisher","first-page":"557","DOI":"10.7326\/0003-4819-145-8-200610170-00004","volume":"145","author":"M Pimentel","year":"2006","unstructured":"Pimentel M  et al. (2006) The effect of a nonabsorbed oral antibiotic (rifaximin) on the symptoms of the irritable bowel syndrome: a randomized trial. Ann Intern Med 145: 557\u2013563","journal-title":"Ann Intern Med"},{"key":"BFncpgasthep1203_CR83","doi-asserted-by":"crossref","unstructured":"Vanner S (2008) The small intestinal bacterial overgrowth-irritable bowel syndrome hypothesis: implications for treatment. Gut [10.1136\/gut.2007.133629]","DOI":"10.1136\/gut.2007.133629"},{"key":"BFncpgasthep1203_CR84","doi-asserted-by":"publisher","first-page":"802","DOI":"10.1136\/gut.2006.108712","volume":"56","author":"I Posserud","year":"2007","unstructured":"Posserud I  et al. (2007) Small intestinal bacterial overgrowth in patients with irritable bowel syndrome. Gut 56: 802\u2013808","journal-title":"Gut"},{"key":"BFncpgasthep1203_CR85","doi-asserted-by":"publisher","first-page":"1566","DOI":"10.1111\/j.1572-0241.2005.40795.x","volume":"100","author":"B Walters","year":"2005","unstructured":"Walters B and Vanner SJ (2005) Detection of bacterial overgrowth in IBS using the lactulose H breath test: comparison with C-D-xylose and healthy controls. Am J Gastroenterol 100: 1566\u20131570","journal-title":"Am J Gastroenterol"},{"key":"BFncpgasthep1203_CR86","doi-asserted-by":"publisher","first-page":"958","DOI":"10.1111\/j.1572-0241.2008.01785.x","volume":"103","author":"JR Bratten","year":"2008","unstructured":"Bratten JR  et al. (2008) Lactulose breath testing does not discriminate patients with irritable bowel syndrome from healthy controls. Am J Gastroenterol 103: 958\u2013963","journal-title":"Am J Gastroenterol"},{"key":"BFncpgasthep1203_CR87","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1111\/j.1572-0241.2002.05428.x","volume":"97","author":"PR Maxwell","year":"2002","unstructured":"Maxwell PR  et al. (2002) Antibiotics increase functional abdominal symptoms. Am J Gastroenterol 97: 104\u2013108","journal-title":"Am J Gastroenterol"},{"key":"BFncpgasthep1203_CR88","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1016\/j.dld.2006.10.014","volume":"39","author":"L \u00d6hman","year":"2007","unstructured":"\u00d6hman L and Simren M (2007) New insights into the pathogenesis and pathophysiology of irritable bowel syndrome. Dig Liver Dis 39: 201\u2013215","journal-title":"Dig Liver Dis"},{"key":"BFncpgasthep1203_CR89","doi-asserted-by":"publisher","first-page":"2830","DOI":"10.3748\/wjg.v12.i18.2830","volume":"12","author":"I Posserud","year":"2006","unstructured":"Posserud I  et al. (2006) Functional findings in irritable bowel syndrome. World J Gastroenterol 12: 2830\u20132838","journal-title":"World J Gastroenterol"},{"key":"BFncpgasthep1203_CR90","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1038\/ncpgasthep0406","volume":"3","author":"A Wald","year":"2006","unstructured":"Wald A (2006) Pathophysiology, diagnosis and current management of chronic constipation. Nat Clin Pract Gastroenterol Hepatol 3: 90\u2013100","journal-title":"Nat Clin Pract Gastroenterol Hepatol"},{"key":"BFncpgasthep1203_CR91","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1111\/j.1365-2982.2007.00902.x","volume":"19","author":"V Stanghellini","year":"2007","unstructured":"Stanghellini V  et al. (2007) Chronic intestinal pseudo-obstruction: manifestations, natural history and management. Neurogastroenterol Motil 19: 440\u2013452","journal-title":"Neurogastroenterol Motil"},{"issue":"Suppl 1","key":"BFncpgasthep1203_CR92","doi-asserted-by":"publisher","first-page":"i67","DOI":"10.1136\/gut.51.suppl_1.i67","volume":"51","author":"M Delvaux","year":"2002","unstructured":"Delvaux M (2002) Role of visceral sensitivity in the pathophysiology of irritable bowel syndrome. Gut 51 (Suppl 1): i67\u2013i71","journal-title":"Gut"},{"key":"BFncpgasthep1203_CR93","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1159\/000051878","volume":"63","author":"M Simr\u00e9n","year":"2001","unstructured":"Simr\u00e9n M  et al. (2001) Food-related gastrointestinal symptoms in the irritable bowel syndrome. Digestion 63: 108\u2013115","journal-title":"Digestion"},{"key":"BFncpgasthep1203_CR94","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1111\/j.1365-2982.2005.00745.x","volume":"18","author":"MI Park","year":"2006","unstructured":"Park MI and Camilleri M (2006) Is there a role of food allergy in irritable bowel syndrome and functional dyspepsia? A systematic review. Neurogastroenterol Motil 18: 595\u2013607","journal-title":"Neurogastroenterol Motil"},{"key":"BFncpgasthep1203_CR95","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/S1081-1206(10)60404-8","volume":"100","author":"MC Tobin","year":"2008","unstructured":"Tobin MC  et al. (2008) Atopic irritable bowel syndrome: a novel subgroup of irritable bowel syndrome with allergic manifestations. Ann Allergy Asthma Immunol 100: 49\u201353","journal-title":"Ann Allergy Asthma Immunol"},{"key":"BFncpgasthep1203_CR96","doi-asserted-by":"publisher","first-page":"800","DOI":"10.1080\/00365520510015593","volume":"40","author":"S Zar","year":"2005","unstructured":"Zar S  et al. (2005) Food-specific IgG4 antibody-guided exclusion diet improves symptoms and rectal compliance in irritable bowel syndrome. Scand J Gastroenterol 40: 800\u2013807","journal-title":"Scand J Gastroenterol"},{"key":"BFncpgasthep1203_CR97","doi-asserted-by":"publisher","first-page":"1459","DOI":"10.1136\/gut.2003.037697","volume":"53","author":"W Atkinson","year":"2004","unstructured":"Atkinson W  et al. (2004) Food elimination based on IgG antibodies in irritable bowel syndrome: a randomised controlled trial. Gut 53: 1459\u20131464","journal-title":"Gut"},{"key":"BFncpgasthep1203_CR98","doi-asserted-by":"publisher","first-page":"1892","DOI":"10.1111\/j.1572-0241.1999.01226.x","volume":"94","author":"R Dainese","year":"1999","unstructured":"Dainese R  et al. (1999) Discrepancies between reported food intolerance and sensitization test findings in irritable bowel syndrome patients. Am J Gastroenterol 94: 1892\u20131897","journal-title":"Am J Gastroenterol"}],"container-title":["Nature Clinical Practice Gastroenterology &amp; Hepatology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/ncpgasthep1203.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ncpgasthep1203","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/doifinder\/10.1038\/ncpgasthep1203","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/www.nature.com\/articles\/ncpgasthep1203.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T20:08:59Z","timestamp":1684440539000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/ncpgasthep1203"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,8,5]]},"references-count":98,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2008,9]]}},"alternative-id":["BFncpgasthep1203"],"URL":"https:\/\/doi.org\/10.1038\/ncpgasthep1203","relation":{},"ISSN":["1743-4378","1743-4386"],"issn-type":[{"value":"1743-4378","type":"print"},{"value":"1743-4386","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,8,5]]}}}