{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T03:57:23Z","timestamp":1767153443706,"version":"build-2238731810"},"reference-count":76,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2008,9,16]],"date-time":"2008-09-16T00:00:00Z","timestamp":1221523200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2008,9,16]],"date-time":"2008-09-16T00:00:00Z","timestamp":1221523200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nat Rev Gastroenterol Hepatol"],"published-print":{"date-parts":[[2008,10]]},"DOI":"10.1038\/ncpgasthep1235","type":"journal-article","created":{"date-parts":[[2008,9,16]],"date-time":"2008-09-16T12:53:21Z","timestamp":1221569601000},"page":"569-582","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Managing hereditary gastrointestinal cancer syndromes: the partnership between genetic counselors and gastroenterologists"],"prefix":"10.1038","volume":"5","author":[{"given":"Wendy S","family":"Rubinstein","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott M","family":"Weissman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2008,9,16]]},"reference":[{"key":"BFncpgasthep1235_CR1","doi-asserted-by":"publisher","first-page":"6857s","DOI":"10.1158\/1078-0432.CCR-07-1124","volume":"13","author":"PM Lynch","year":"2007","unstructured":"Lynch PM (2007) New issues in genetic counseling of hereditary colon cancer. Clin Cancer Res 13: 6857s\u20136861s","journal-title":"Clin Cancer Res"},{"key":"BFncpgasthep1235_CR2","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1016\/S1542-3565(04)00352-0","volume":"2","author":"S Grover","year":"2004","unstructured":"Grover S  et al. (2004) Physician assessment of family cancer history and referral for genetic evaluation in colorectal cancer patients. Clin Gastroenterol Hepatol 2: 813\u2013819","journal-title":"Clin Gastroenterol Hepatol"},{"key":"BFncpgasthep1235_CR3","doi-asserted-by":"publisher","first-page":"2540","DOI":"10.1002\/(SICI)1097-0142(19991201)86:11+<2540::AID-CNCR11>3.0.CO;2-8","volume":"86","author":"GM Petersen","year":"1999","unstructured":"Petersen GM  et al. (1999) Genetic testing and counseling for hereditary forms of colorectal cancer. Cancer 86: 2540\u20132550","journal-title":"Cancer"},{"key":"BFncpgasthep1235_CR4","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1034\/j.1399-0004.2000.580201.x","volume":"58","author":"H Hampel","year":"2000","unstructured":"Hampel H  et al. (2000) Hereditary colorectal cancer: risk assessment and management. Clin Genet 58: 89\u201397","journal-title":"Clin Genet"},{"key":"BFncpgasthep1235_CR5","doi-asserted-by":"crossref","unstructured":"American Gastroenterological Association (2001) American Gastroenterological Association medical position statement: hereditary colorectal cancer and genetic testing. Gastroenterology 121: 195\u2013197","DOI":"10.1053\/gast.2001.25580"},{"key":"BFncpgasthep1235_CR6","doi-asserted-by":"crossref","unstructured":"Standard Task Force; American Society of Colon and Rectal Surgeons; Collaborative Group of the Americas on Inherited Colorectal Cancer (2001) Practice parameters for the identification and testing of patients at risk for dominantly inherited colorectal cancer. Dis Colon Rectum 44: 1403","DOI":"10.1007\/BF02234588"},{"key":"BFncpgasthep1235_CR7","doi-asserted-by":"crossref","unstructured":"American Society of Clinical Oncology (2003) American Society of Clinical Oncology policy statement update: genetic testing for cancer susceptibility. J Clin Oncol 21: 2397\u20132406","DOI":"10.1200\/JCO.2003.03.189"},{"key":"BFncpgasthep1235_CR8","doi-asserted-by":"publisher","first-page":"3534","DOI":"10.1200\/JCO.2006.10.3119","volume":"25","author":"HT Lynch","year":"2007","unstructured":"Lynch HT  et al. (2007) Who should be sent for genetic testing in hereditary colorectal cancer syndromes. J Clin Oncol 25: 3534\u20133542","journal-title":"J Clin Oncol"},{"key":"BFncpgasthep1235_CR9","unstructured":"National Comprehensive Cancer Network (v.2 online 17 June 2008) NCCN clinical practice guidelines in oncology: colorectal cancer screening [\n                    http:\/\/www.nccn.org\/professionals\/physician_gls\/PDF\/colorectal_screening.pdf\n                    \n                  ] (v.1 accessed 20 April 2008)"},{"key":"BFncpgasthep1235_CR10","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1053\/gast.2001.25581","volume":"121","author":"FM Giardiello","year":"2001","unstructured":"Giardiello FM  et al. (2001) AGA technical review on hereditary colorectal cancer and genetic testing. Gastroenterology 121: 198\u2013213","journal-title":"Gastroenterology"},{"key":"BFncpgasthep1235_CR11","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.cgh.2007.09.017","volume":"6","author":"DW Neklason","year":"2008","unstructured":"Neklason DW  et al. (2008) American founder mutation for attenuated familial adenomatous polyposis. Clin Gastroenterol Hepatol 6: 46\u201352","journal-title":"Clin Gastroenterol Hepatol"},{"key":"BFncpgasthep1235_CR12","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1023\/B:JOGC.0000018821.48330.77","volume":"13","author":"A Trepanier","year":"2004","unstructured":"Trepanier A  et al. (2004) Genetic cancer risk assessment and counseling: recommendations of the national society of genetic counselors. J Genet Couns 13: 83\u2013114","journal-title":"J Genet Couns"},{"key":"BFncpgasthep1235_CR13","doi-asserted-by":"publisher","first-page":"476","DOI":"10.1111\/j.1572-0241.2005.40237.x","volume":"100","author":"IR Schreibman","year":"2005","unstructured":"Schreibman IR  et al. (2005) The hamartomatous polyposis syndromes: a clinical and molecular review. Am J Gastroenterol 100: 476\u2013490","journal-title":"Am J Gastroenterol"},{"key":"BFncpgasthep1235_CR14","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1111\/j.1365-2559.1988.tb02093.x","volume":"13","author":"JR Jass","year":"1988","unstructured":"Jass JR  et al. (1988) Juvenile polyposis\u2014a precancerous condition. Histopathology 13: 619\u2013630","journal-title":"Histopathology"},{"key":"BFncpgasthep1235_CR15","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1023\/A:1023286520725","volume":"2","author":"AL Knudsen","year":"2003","unstructured":"Knudsen AL  et al. (2003) Attenuated familial adenomatous polyposis (AFAP): a review of the literature. Fam Cancer 2: 43\u201355","journal-title":"Fam Cancer"},{"key":"BFncpgasthep1235_CR16","volume-title":"World Health Organization classification of tumours. Pathology & genetics. Tumours of the digestive system","author":"RW Burt","year":"2000","unstructured":"Burt RW and Jass JR (2000) Hyperplastic Polyposis. In World Health Organization classification of tumours. Pathology & genetics. Tumours of the digestive system (Eds Hamilton SR  et al.) Lyon, France: IARC Press"},{"key":"BFncpgasthep1235_CR17","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1093\/jnci\/djh034","volume":"96","author":"A Umar","year":"2004","unstructured":"Umar A  et al. (2004) Revised Bethesda guidelines for hereditary nonpolyposis colorectal cancer (Lynch syndrome) and microsatellite instability. J Natl Cancer Inst 96: 261\u2013268","journal-title":"J Natl Cancer Inst"},{"key":"BFncpgasthep1235_CR18","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1007\/BF02053699","volume":"34","author":"HF Vasen","year":"1991","unstructured":"Vasen HF  et al. (1991) The International Collaborative Group on Hereditary Non-Polyposis Colorectal Cancer (ICG-HNPCC). Dis Colon Rectum 34: 424\u2013425","journal-title":"Dis Colon Rectum"},{"key":"BFncpgasthep1235_CR19","doi-asserted-by":"publisher","first-page":"1453","DOI":"10.1016\/S0016-5085(99)70510-X","volume":"116","author":"HF Vasen","year":"1999","unstructured":"Vasen HF  et al. (1999) New clinical criteria for hereditary nonpolyposis colorectal cancer (HNPCC, Lynch syndrome) proposed by the International Collaborative group on HNPCC. Gastroenterology 116: 1453\u20131456","journal-title":"Gastroenterology"},{"key":"BFncpgasthep1235_CR20","doi-asserted-by":"publisher","first-page":"2028","DOI":"10.1001\/jama.293.16.2028","volume":"293","author":"HF Vasen","year":"2005","unstructured":"Vasen HF  et al. (2005) Progress in genetic testing, classification, and identification of Lynch syndrome. JAMA 293: 2028\u20132030","journal-title":"JAMA"},{"key":"BFncpgasthep1235_CR21","doi-asserted-by":"publisher","first-page":"1584","DOI":"10.1016\/j.ijrobp.2007.04.045","volume":"68","author":"MY Choi","year":"2007","unstructured":"Choi MY  et al. (2007) Microsatellite instability is frequently observed in rectal cancer and influenced by neoadjuvant chemoradiation. Int J Radiat Oncol Biol Phys 68: 1584","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"BFncpgasthep1235_CR22","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1053\/j.gastro.2007.10.042","volume":"134","author":"F Balaguer","year":"2008","unstructured":"Balaguer F  et al. (2008) Validation and extension of the PREMM1,2 model in a population-based cohort of colorectal cancer patients. Gastroenterology 134: 39\u201346","journal-title":"Gastroenterology"},{"key":"BFncpgasthep1235_CR23","doi-asserted-by":"publisher","first-page":"1953","DOI":"10.1016\/S0002-9440(10)61144-3","volume":"160","author":"SA Kuismanen","year":"2002","unstructured":"Kuismanen SA  et al. (2002) Endometrial and colorectal tumors from patients with hereditary nonpolyposis colon cancer display different patterns of microsatellite instability. Am J Pathol 160: 1953\u20131958","journal-title":"Am J Pathol"},{"key":"BFncpgasthep1235_CR24","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1002\/ijc.1206","volume":"92","author":"MJ Berends","year":"2001","unstructured":"Berends MJ  et al. (2001) MLH1 and MSH2 protein expression as a pre-screening marker in hereditary and non-hereditary endometrial hyperplasia and cancer. Int J Cancer 92: 398\u2013403","journal-title":"Int J Cancer"},{"key":"BFncpgasthep1235_CR25","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1002\/ijc.10429","volume":"99","author":"AJ Whelan","year":"2002","unstructured":"Whelan AJ  et al. (2002) MSI in endometrial carcinoma: absence of MLH1 promoter methylation is associated with increased familial risk for cancers. Int J Cancer 99: 697\u2013704","journal-title":"Int J Cancer"},{"key":"BFncpgasthep1235_CR26","doi-asserted-by":"publisher","first-page":"5908","DOI":"10.1073\/pnas.1030231100","volume":"100","author":"PJ Goodfellow","year":"2003","unstructured":"Goodfellow PJ  et al. (2003) Prevalence of defective DNA mismatch repair and MSH6 mutation in an unselected series of endometrial cancers. Proc Natl Acad Sci USA 100: 5908\u20135913","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFncpgasthep1235_CR27","doi-asserted-by":"publisher","first-page":"1018","DOI":"10.1002\/cncr.20873","volume":"103","author":"G Ponti","year":"2005","unstructured":"Ponti G  et al. (2005) Identification of Muir-Torre syndrome among patients with sebaceous tumors and keratoacanthomas: role of clinical features, microsatellite instability, and immunohistochemistry. Cancer 103: 1018\u20131025","journal-title":"Cancer"},{"key":"BFncpgasthep1235_CR28","doi-asserted-by":"publisher","first-page":"4642","DOI":"10.1200\/JCO.2005.04.5260","volume":"24","author":"JG Guillem","year":"2006","unstructured":"Guillem JG  et al. (2006) ASCO\/SSO review of current role of risk-reducing surgery in common hereditary cancer syndromes. J Clin Oncol 24: 4642\u20134660","journal-title":"J Clin Oncol"},{"key":"BFncpgasthep1235_CR29","doi-asserted-by":"publisher","first-page":"1752","DOI":"10.1136\/gut.52.12.1752","volume":"52","author":"WH de Vos tot Nederveen Cappel","year":"2003","unstructured":"de Vos tot Nederveen Cappel WH  et al. (2003) Decision analysis in the surgical treatment of colorectal cancer due to a mismatch repair gene defect. Gut 52: 1752\u20131755","journal-title":"Gut"},{"key":"BFncpgasthep1235_CR30","doi-asserted-by":"publisher","first-page":"787","DOI":"10.7326\/0003-4819-129-10-199811150-00007","volume":"129","author":"S Syngal","year":"1998","unstructured":"Syngal S  et al. (1998) Benefits of colonoscopic surveillance and prophylactic colectomy in patients with hereditary nonpolyposis colorectal cancer mutations. Ann Intern Med 129: 787\u2013796","journal-title":"Ann Intern Med"},{"key":"BFncpgasthep1235_CR31","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1056\/NEJMoa052627","volume":"354","author":"KM Schmeler","year":"2006","unstructured":"Schmeler KM  et al. (2006) Prophylactic surgery to reduce the risk of gynecologic cancers in the Lynch syndrome. N Engl J Med 354: 261\u2013269","journal-title":"N Engl J Med"},{"key":"BFncpgasthep1235_CR32","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1097\/01.AOG.0000267500.27329.85","volume":"110","author":"LM Chen","year":"2007","unstructured":"Chen LM  et al. (2007) Gynecologic cancer prevention in Lynch syndrome\/hereditary nonpolyposis colorectal cancer families. Obstet Gynecol 110: 18\u201325","journal-title":"Obstet Gynecol"},{"key":"BFncpgasthep1235_CR33","unstructured":"American Society of Human Genetics (1975) Genetic counseling. Am J Hum Genet 27: 240\u2013242"},{"key":"BFncpgasthep1235_CR34","unstructured":"National Society of Genetic Counselors [\n                    http:\/\/www.nsgc.org\n                    \n                  ]"},{"key":"BFncpgasthep1235_CR35","unstructured":"National Cancer Institute Genetic Services Directory [\n                    http:\/\/cancer.gov\/search\/genetics_services\n                    \n                  ]"},{"key":"BFncpgasthep1235_CR36","doi-asserted-by":"publisher","DOI":"10.1002\/0471223913","volume-title":"The Practical Guide to the Genetic Family History","author":"RL Bennett","year":"1999","unstructured":"Bennett RL (1999) The Practical Guide to the Genetic Family History. New York: Wiley-Liss"},{"key":"BFncpgasthep1235_CR37","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1007\/s10689-005-8351-6","volume":"4","author":"P Bandipalliam","year":"2005","unstructured":"Bandipalliam P (2005) Syndrome of early onset colon cancers, hematologic malignancies and features of neurofibromatosis in HNPCC families with homozygous mismatch repair gene mutations. Fam Cancer 4: 323\u2013333","journal-title":"Fam Cancer"},{"key":"BFncpgasthep1235_CR38","doi-asserted-by":"publisher","first-page":"1480","DOI":"10.1001\/jama.292.12.1480","volume":"292","author":"HJ Murff","year":"2004","unstructured":"Murff HJ  et al. (2004) Does this patient have a family history of cancer? An evidence-based analysis of the accuracy of family cancer history. JAMA 292: 1480\u20131489","journal-title":"JAMA"},{"key":"BFncpgasthep1235_CR39","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1002\/cncr.11912","volume":"100","author":"HT Lynch","year":"2004","unstructured":"Lynch HT  et al. (2004) Hereditary nonpolyposis colorectal carcinoma (HNPCC) and HNPCC-like families: problems in diagnosis, surveillance, and management. Cancer 100: 53\u201364","journal-title":"Cancer"},{"key":"BFncpgasthep1235_CR40","doi-asserted-by":"publisher","first-page":"1851","DOI":"10.1056\/NEJMoa043146","volume":"352","author":"H Hampel","year":"2005","unstructured":"Hampel H  et al. (2005) Screening for the Lynch syndrome (hereditary nonpolyposis colorectal cancer). N Engl J Med 352: 1851\u20131860","journal-title":"N Engl J Med"},{"key":"BFncpgasthep1235_CR41","doi-asserted-by":"publisher","first-page":"7810","DOI":"10.1158\/0008-5472.CAN-06-1114","volume":"66","author":"H Hampel","year":"2006","unstructured":"Hampel H  et al. (2006) Screening for Lynch syndrome (hereditary nonpolyposis colorectal cancer) among endometrial cancer patients. Cancer Res 66: 7810\u20137817","journal-title":"Cancer Res"},{"key":"BFncpgasthep1235_CR42","doi-asserted-by":"publisher","first-page":"1920","DOI":"10.1056\/NEJMe058058","volume":"352","author":"HT Lynch","year":"2005","unstructured":"Lynch HT  et al. (2005) Molecular screening for the Lynch syndrome\u2014better than family history. N Engl J Med 352: 1920\u20131922","journal-title":"N Engl J Med"},{"key":"BFncpgasthep1235_CR43","doi-asserted-by":"publisher","first-page":"1898","DOI":"10.1158\/1055-9965.EPI-07-0151","volume":"16","author":"L Madlensky","year":"2007","unstructured":"Madlensky L  et al. (2007) Accuracy of colorectal polyp self-reports: findings from the colon cancer family registry. Cancer Epidemiol Biomarkers Prev 16: 1898\u20131901","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"BFncpgasthep1235_CR44","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1136\/jmg.40.8.591","volume":"40","author":"P Watson","year":"2003","unstructured":"Watson P  et al. (2003) Carrier risk status changes resulting from mutation testing in hereditary non-polyposis colorectal cancer and hereditary breast-ovarian cancer. J Med Genet 40: 591\u2013596","journal-title":"J Med Genet"},{"key":"BFncpgasthep1235_CR45","doi-asserted-by":"publisher","first-page":"718","DOI":"10.1001\/jama.291.6.718","volume":"291","author":"HT Lynch","year":"2004","unstructured":"Lynch HT  et al. (2004) A founder mutation of the MSH2 gene and hereditary nonpolyposis colorectal cancer in the United States. JAMA 291: 718\u2013724","journal-title":"JAMA"},{"key":"BFncpgasthep1235_CR46","doi-asserted-by":"publisher","first-page":"1088","DOI":"10.1086\/373963","volume":"72","author":"A Wagner","year":"2003","unstructured":"Wagner A  et al. (2003) Molecular analysis of hereditary nonpolyposis colorectal cancer in the United States: high mutation detection rate among clinically selected families and characterization of an American founder genomic deletion of the MSH2 gene. Am J Hum Genet 72: 1088\u20131100","journal-title":"Am J Hum Genet"},{"key":"BFncpgasthep1235_CR47","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1093\/hmg\/10.7.735","volume":"10","author":"P Peltomaki","year":"2001","unstructured":"Peltomaki P (2001) Deficient DNA mismatch repair: a common etiologic factor for colon cancer. Hum Mol Genet 10: 735\u2013740","journal-title":"Hum Mol Genet"},{"key":"BFncpgasthep1235_CR48","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1086\/424388","volume":"75","author":"DE Goldgar","year":"2004","unstructured":"Goldgar DE  et al. (2004) Integrated evaluation of DNA sequence variants of unknown clinical significance: application to BRCA1 and BRCA2. Am J Hum Genet 75: 535\u2013544","journal-title":"Am J Hum Genet"},{"key":"BFncpgasthep1235_CR49","doi-asserted-by":"publisher","first-page":"1088","DOI":"10.7326\/0003-4819-124-12-199606150-00012","volume":"124","author":"B Weber","year":"1996","unstructured":"Weber B (1996) Breast cancer susceptibility genes: current challenges and future promises. Ann Intern Med 124: 1088\u20131090","journal-title":"Ann Intern Med"},{"key":"BFncpgasthep1235_CR50","doi-asserted-by":"publisher","first-page":"577","DOI":"10.7326\/0003-4819-135-8_Part_1-200110160-00008","volume":"135","author":"SD Ramsey","year":"2001","unstructured":"Ramsey SD  et al. (2001) Cost-effectiveness of microsatellite instability screening as a method for detecting hereditary nonpolyposis colorectal cancer. Ann Intern Med 135: 577\u2013588","journal-title":"Ann Intern Med"},{"key":"BFncpgasthep1235_CR51","doi-asserted-by":"publisher","first-page":"1469","DOI":"10.1001\/jama.292.12.1469","volume":"292","author":"K Offit","year":"2004","unstructured":"Offit K  et al. (2004) The \u201cduty to warn\u201d a patient's family members about hereditary disease risks. JAMA 292: 1469\u20131473","journal-title":"JAMA"},{"key":"BFncpgasthep1235_CR52","unstructured":"GovTrack.us (online April 2007) HR 493: Genetic Information Nondiscrimination Act of 2008 [\n                    http:\/\/www.govtrack.us\/congress\/bill.xpd?bill=h110-493\n                    \n                  ]"},{"key":"BFncpgasthep1235_CR53","doi-asserted-by":"publisher","first-page":"2661","DOI":"10.1056\/NEJMp0803964","volume":"358","author":"KL Hudson","year":"2008","unstructured":"Hudson KL  et al. (2008) Keeping pace with the times\u2014the Genetic Information Nondiscrimination Act of 2008. N Engl J Med 358: 2661\u20132663","journal-title":"N Engl J Med"},{"key":"BFncpgasthep1235_CR54","doi-asserted-by":"publisher","first-page":"865","DOI":"10.1056\/NEJMp058116","volume":"353","author":"HT Greely","year":"2005","unstructured":"Greely HT (2005) Banning genetic discrimination. N Engl J Med 353: 865\u2013867","journal-title":"N Engl J Med"},{"key":"BFncpgasthep1235_CR55","doi-asserted-by":"publisher","first-page":"1507","DOI":"10.1001\/jama.296.12.1507","volume":"296","author":"NM Lindor","year":"2006","unstructured":"Lindor NM  et al. (2006) Recommendations for the care of individuals with an inherited predisposition to Lynch syndrome: a systematic review. JAMA 296: 1507\u20131517","journal-title":"JAMA"},{"key":"BFncpgasthep1235_CR56","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1007\/s10689-007-9159-3","volume":"7","author":"PM Lynch","year":"2008","unstructured":"Lynch PM (2008) Standards of care in diagnosis and testing for hereditary colon cancer. Fam Cancer 7: 65\u201372","journal-title":"Fam Cancer"},{"key":"BFncpgasthep1235_CR57","doi-asserted-by":"publisher","first-page":"1039","DOI":"10.1093\/jnci\/90.14.1039","volume":"90","author":"NM Lindor","year":"1998","unstructured":"Lindor NM  et al. (1998) The concise handbook of family cancer syndromes: Mayo Familial Cancer Program. J Natl Cancer Inst 90: 1039\u20131071","journal-title":"J Natl Cancer Inst"},{"key":"BFncpgasthep1235_CR58","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1200\/JCO.2005.10.042","volume":"23","author":"JE Garber","year":"2005","unstructured":"Garber JE  et al. (2005) Hereditary cancer predisposition syndromes. J Clin Oncol 23: 276\u2013292","journal-title":"J Clin Oncol"},{"key":"BFncpgasthep1235_CR59","volume-title":"Counseling About Cancer: Strategies for Genetic Counseling","author":"K Schneider","year":"2002","unstructured":"Schneider K (2002) Counseling About Cancer: Strategies for Genetic Counseling, edn 2. New York: Wiley-Liss"},{"key":"BFncpgasthep1235_CR60","unstructured":"Online Mendelian Inheritance in Man [\n                    http:\/\/www.ncbi.nlm.nih.gov\/sites\/entrez?db=omim\n                    \n                  ]"},{"key":"BFncpgasthep1235_CR61","doi-asserted-by":"publisher","first-page":"1979","DOI":"10.1001\/jama.293.16.1979","volume":"293","author":"NM Lindor","year":"2005","unstructured":"Lindor NM  et al. (2005) Lower cancer incidence in Amsterdam-I criteria families without mismatch repair deficiency: familial colorectal cancer type X. JAMA 293: 1979\u20131985","journal-title":"JAMA"},{"key":"BFncpgasthep1235_CR62","first-page":"873","volume":"36","author":"C Caldas","year":"1999","unstructured":"Caldas C  et al. (1999) Familial gastric cancer: overview and guidelines for management. J Med Genet 36: 873\u2013880","journal-title":"J Med Genet"},{"key":"BFncpgasthep1235_CR63","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1177\/106689690601400105","volume":"14","author":"C Oliveira","year":"2006","unstructured":"Oliveira C  et al. (2006) Genetics, pathology, and clinics of familial gastric cancer. Int J Surg Pathol 14: 21\u201333","journal-title":"Int J Surg Pathol"},{"key":"BFncpgasthep1235_CR64","doi-asserted-by":"publisher","first-page":"1904","DOI":"10.1056\/NEJM200106213442504","volume":"344","author":"DG Huntsman","year":"2001","unstructured":"Huntsman DG  et al. (2001) Early gastric cancer in young, asymptomatic carriers of germ-line E-cadherin mutations. N Engl J Med 344: 1904\u20131909","journal-title":"N Engl J Med"},{"key":"BFncpgasthep1235_CR65","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1093\/jnci\/djm291","volume":"100","author":"CD South","year":"2008","unstructured":"South CD  et al. (2008) The frequency of Muir-Torre syndrome among Lynch syndrome families. J Natl Cancer Inst 100: 277\u2013281","journal-title":"J Natl Cancer Inst"},{"key":"BFncpgasthep1235_CR66","unstructured":"Gene Tests Website [\n                    http:\/\/www.genetests.org\/\n                    \n                  ]"},{"key":"BFncpgasthep1235_CR67","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/0165-4608(91)90119-F","volume":"53","author":"R Seruca","year":"1991","unstructured":"Seruca R  et al. (1991) Familial gastric polyposis revisited: autosomal dominant inheritance confirmed. Cancer Genet Cytogenet 53: 97\u2013100","journal-title":"Cancer Genet Cytogenet"},{"key":"BFncpgasthep1235_CR68","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1002\/1097-0142(19930715)72:2<323::AID-CNCR2820720204>3.0.CO;2-G","volume":"72","author":"F Carneiro","year":"1993","unstructured":"Carneiro F  et al. (1993) Hyperplastic polyposis and diffuse carcinoma of the stomach: a study of a family. Cancer 72: 323\u2013329","journal-title":"Cancer"},{"key":"BFncpgasthep1235_CR69","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1016\/S0016-5085(99)70061-2","volume":"116","author":"I Tomlinson","year":"1999","unstructured":"Tomlinson I  et al. (1999) Inherited susceptibility to colorectal adenomas and carcinomas: evidence for a new predisposition gene on 15q14-q22. Gastroenterology 116: 789\u2013795","journal-title":"Gastroenterology"},{"key":"BFncpgasthep1235_CR70","doi-asserted-by":"publisher","first-page":"1261","DOI":"10.1086\/375144","volume":"72","author":"EE Jaeger","year":"2003","unstructured":"Jaeger EE  et al. (2003) An ancestral Ashkenazi haplotype at the HMPS\/CRAC1 locus on 15q13-q14 is associated with hereditary mixed polyposis syndrome. Am J Hum Genet 72: 1261\u20131267","journal-title":"Am J Hum Genet"},{"key":"BFncpgasthep1235_CR71","doi-asserted-by":"publisher","first-page":"e13","DOI":"10.1136\/jmg.2005.034827","volume":"43","author":"X Cao","year":"2006","unstructured":"Cao X  et al. (2006) Mapping of hereditary mixed polyposis syndrome (HMPS) to chromosome 10q23 by genomewide high-density single nucleotide polymorphism (SNP) scan and identification of BMPR1A loss of function. J Med Genet 43: e13","journal-title":"J Med Genet"},{"key":"BFncpgasthep1235_CR72","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1053\/gast.2000.9361","volume":"119","author":"A Rashid","year":"2000","unstructured":"Rashid A  et al. (2000) Phenotypic and molecular characteristics of hyperplastic polyposis. Gastroenterology 119: 323\u2013332","journal-title":"Gastroenterology"},{"key":"BFncpgasthep1235_CR73","doi-asserted-by":"publisher","first-page":"2012","DOI":"10.1111\/j.1572-0241.2004.30021.x","volume":"99","author":"A Ferrandez","year":"2004","unstructured":"Ferrandez A  et al. (2004) Phenotypic characteristics and risk of cancer development in hyperplastic polyposis: case series and literature review. Am J Gastroenterol 99: 2012\u20132018","journal-title":"Am J Gastroenterol"},{"key":"BFncpgasthep1235_CR74","doi-asserted-by":"publisher","first-page":"852","DOI":"10.1016\/S0140-6736(04)15732-2","volume":"363","author":"CJ Gallione","year":"2004","unstructured":"Gallione CJ  et al. (2004) A combined syndrome of juvenile polyposis and hereditary haemorrhagic telangiectasia associated with mutations in MADH4 (SMAD4). Lancet 363: 852\u2013859","journal-title":"Lancet"},{"key":"BFncpgasthep1235_CR75","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1016\/S1542-3565(04)00286-1","volume":"2","author":"L Lipton","year":"2004","unstructured":"Lipton L  et al. (2004) The multiple colorectal adenoma phenotype and MYH, a base excision repair gene. Clin Gastroenterol Hepatol 2: 633\u2013638","journal-title":"Clin Gastroenterol Hepatol"},{"key":"BFncpgasthep1235_CR76","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1007\/s10689-005-5673-3","volume":"5","author":"L Lipton","year":"2006","unstructured":"Lipton L  et al. (2006) The genetics of FAP and FAP-like syndromes. Fam Cancer 5: 221\u2013226","journal-title":"Fam Cancer"}],"updated-by":[{"DOI":"10.1038\/nrgastro.2010.133","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2010,9,1]],"date-time":"2010-09-01T00:00:00Z","timestamp":1283299200000}}],"container-title":["Nature Clinical Practice Gastroenterology &amp; Hepatology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/ncpgasthep1235.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ncpgasthep1235","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ncpgasthep1235.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T16:09:18Z","timestamp":1684426158000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/ncpgasthep1235"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,9,16]]},"references-count":76,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2008,10]]}},"alternative-id":["BFncpgasthep1235"],"URL":"https:\/\/doi.org\/10.1038\/ncpgasthep1235","relation":{},"ISSN":["1743-4378","1743-4386"],"issn-type":[{"value":"1743-4378","type":"print"},{"value":"1743-4386","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,9,16]]},"assertion":[{"value":"25 April 2008","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 July 2008","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 September 2008","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing financial interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}